NOAEL Studies Cosmetic Ingredient

P-PHENYLENEDIAMINE NOAEL Studies

CAS: 106-50-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 8 mg/kg bw/day rat oral 90 day Subchronic SCCP; Paraphenylenediamine -13-week oral (gavage) toxicity study in the rat. Report n° LRL/44/94; Toxicol Laboratories Limited, Herefordshire, England
COSMOS DB NOAEL 4 mg/kg bw/day rat oral 90 day Subchronic SCCP; Paraphenylenediamine -13-week oral (gavage) toxicity study in the rat. Report n° LRL/44/94; Toxicol Laboratories Limited, Herefordshire, England
IARC Monographs 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 1987 IARC Monographs -
NTP ICE acute inhalation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute inhalation LC50 0.92 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=5025; Record_ID=acute_inhalation_1092; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.92; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE cancer 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE cancer IARC group 3 unitless - - - WOE; IARC Carcinogenicity sheet=Data; excel_row=9844; Record_ID=cancer_2745; Data_Type=WOE; Formulation_Name=1,4-Benzenediamine; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/34; http://publications.iarc.fr/139; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE endocrine 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine AC50 11.975099352854 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=782; RecordID=ERPathway2016_338; DatasetName=ERPathway2016; DTXSID=DTXSID9021138; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=11.975099352854; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE endocrine ACC 9.1374189282653 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=783; RecordID=ERPathway2016_338; DatasetName=ERPathway2016; DTXSID=DTXSID9021138; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=9.1374189282653; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=778; RecordID=ARPathway2016_478; DatasetName=ARPathway2016; DTXSID=DTXSID9021138; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE endocrine Model Score 0.0158 unitless - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=785; RecordID=ERPathway2016_338; DatasetName=ERPathway2016; DTXSID=DTXSID9021138; Assay=ER Pathway Model, Antagonist; Endpoint=Model Score; Response=0.0158; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE endocrine Model Score 0.0201 unitless - - - ERPathway2016; ER Pathway Model, Agonist sheet=Integrated_approaches; excel_row=784; RecordID=ERPathway2016_338; DatasetName=ERPathway2016; DTXSID=DTXSID9021138; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.0201; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization 189 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization CD54, EC200 30.2 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=3709; Record_ID=skin_sensitization_invitro_846; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=30.2; Reported_Response_Unit=ug/mL; Response=30.2; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization CD54, EC200 46.8 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=3730; Record_ID=skin_sensitization_invitro_850; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=46.8; Reported_Response_Unit=ug/mL; Response=46.8; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization CD86, EC120 0.573 ug/mL - Dermal - In Vitro; Urbisch_SkinSensitization2020; mMUSST sheet=Data_invitro; excel_row=7796; Record_ID=skin_sensitization_invitro_1894; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=mMUSST; Endpoint=CD86, EC120; Reported_Response=5.3; Reported_Response_Unit=uM; Conversion_Factor_Value=108.144; Conversion_Factor_Source=EPA Dashboard; Converted_Response=0.573; Converted_Response_Unit=ug/mL; Response=0.573; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization CD86, EC150 1.4 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=3741; Record_ID=skin_sensitization_invitro_853; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=1.4; Reported_Response_Unit=ug/mL; Response=1.4; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization CD86, EC150 2 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=3681; Record_ID=skin_sensitization_invitro_841; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=2; Reported_Response_Unit=ug/mL; Response=2; Response_Unit=ug/mL; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization CD86, EC150 2.09 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=2001; Record_ID=skin_sensitization_invitro_503; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=2.09; Reported_Response_Unit=ug/mL; Response=2.09; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization CD86, EC150 2.36 ug/mL - Dermal - In Vitro; CE_USENSE2018; U-SENS sheet=Data_invitro; excel_row=8492; Record_ID=skin_sensitization_invitro_2340; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=2.36; Reported_Response_Unit=ug/mL; Response=2.36; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization CD86, EC150 3.1 ug/mL - Dermal - In Vitro; Urbisch_SkinSensitization2020; U-SENS sheet=Data_invitro; excel_row=8338; Record_ID=skin_sensitization_invitro_2312; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=28.66654337; Reported_Response_Unit=uM; Conversion_Factor_Value=108.144; Conversion_Factor_Source=EPA Dashboard; Converted_Response=3.1; Converted_Response_Unit=ug/mL; Response=3.1; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization CD86, EC150 7.2 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=3718; Record_ID=skin_sensitization_invitro_848; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=7.2; Reported_Response_Unit=ug/mL; Response=7.2; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization CD86, EC150 <9 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=3711; Record_ID=skin_sensitization_invitro_846; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=h-CLAT; Endpoint=CD86, EC150; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=9; Reported_Response_Unit=ug/mL; Response=9; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization CD86, EC150 21.1 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=3728; Record_ID=skin_sensitization_invitro_850; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=21.1; Reported_Response_Unit=ug/mL; Response=21.1; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization CV70 20.83 ug/mL - Dermal - In Vitro; CE_USENSE2018; U-SENS sheet=Data_invitro; excel_row=8494; Record_ID=skin_sensitization_invitro_2340; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=U-SENS; Endpoint=CV70; Reported_Response=20.83; Reported_Response_Unit=ug/mL; Response=20.83; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization CV75 1.6 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=3679; Record_ID=skin_sensitization_invitro_841; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=h-CLAT; Endpoint=CV75; Reported_Response=1.6; Reported_Response_Unit=ug/mL; Response=1.6; Response_Unit=ug/mL; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization CV75 20.8 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=3720; Record_ID=skin_sensitization_invitro_848; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=h-CLAT; Endpoint=CV75; Reported_Response=20.8; Reported_Response_Unit=ug/mL; Response=20.8; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization CV75 27 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=3708; Record_ID=skin_sensitization_invitro_846; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=h-CLAT; Endpoint=CV75; Reported_Response=27; Reported_Response_Unit=ug/mL; Response=27; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization CV75 36.7 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=2003; Record_ID=skin_sensitization_invitro_503; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=h-CLAT; Endpoint=CV75; Reported_Response=36.700000000000003; Reported_Response_Unit=ug/mL; Response=36.7; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization CV75 48.3 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=3732; Record_ID=skin_sensitization_invitro_850; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=h-CLAT; Endpoint=CV75; Reported_Response=48.3; Reported_Response_Unit=ug/mL; Response=48.3; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization CV75 50.3 ug/mL - Dermal - In Vitro; hCLAT2015; h-CLAT sheet=Data_invitro; excel_row=3743; Record_ID=skin_sensitization_invitro_853; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=h-CLAT; Endpoint=CV75; Reported_Response=50.3; Reported_Response_Unit=ug/mL; Response=50.3; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 0.006929 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=3129; Record_ID=skin_sensitization_invivo_811; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.01; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.006929; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 0.023 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3089; Record_ID=skin_sensitization_invivo_805; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.2; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=2.3E-2; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 0.024 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3090; Record_ID=skin_sensitization_invivo_799; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.024; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 0.03 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3075; Record_ID=skin_sensitization_invivo_803; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.2; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.03; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 0.03429 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3061; Record_ID=skin_sensitization_invivo_801; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.2; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.03429; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 0.04455 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=3144; Record_ID=skin_sensitization_invivo_812; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.04455; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 0.07353 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3100; Record_ID=skin_sensitization_invivo_806; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.07353; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 0.09362 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=3160; Record_ID=skin_sensitization_invivo_814; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.09362; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 0.2604 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3102; Record_ID=skin_sensitization_invivo_807; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.2604; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 0.2727 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3115; Record_ID=skin_sensitization_invivo_808; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.2727; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Concentration, 5% incidence of positive responses 0.5 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3119; Record_ID=skin_sensitization_invivo_809; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=0.5; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Concentration, one positive response 0.001429 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=3163; Record_ID=skin_sensitization_invivo_811; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.01; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=0.001429; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Concentration, one positive response 0.009091 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=3141; Record_ID=skin_sensitization_invivo_812; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=0.009091; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Concentration, one positive response 0.02 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3085; Record_ID=skin_sensitization_invivo_805; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.2; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=0.02; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Concentration, one positive response 0.02128 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=3156; Record_ID=skin_sensitization_invivo_814; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=0.02128; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Concentration, one positive response 0.025 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3071; Record_ID=skin_sensitization_invivo_803; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.2; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=0.025; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Concentration, one positive response 0.02857 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3058; Record_ID=skin_sensitization_invivo_801; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.2; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=0.02857; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Concentration, one positive response 0.05882 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3096; Record_ID=skin_sensitization_invivo_806; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=0.05882; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Concentration, one positive response 0.2083 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3097; Record_ID=skin_sensitization_invivo_807; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=0.2083; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Concentration, one positive response 0.2273 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3111; Record_ID=skin_sensitization_invivo_808; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=0.2273; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Concentration, one positive response 0.4167 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3114; Record_ID=skin_sensitization_invivo_809; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=0.4167; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Concentration, one positive response 1.25 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3147; Record_ID=skin_sensitization_invivo_813; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=1.25; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Depletion Cys 80.2 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1404; Record_ID=skin_sensitization_invitro_375; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=80.2; Reported_Response_Unit=%; Response=80.2; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Depletion Cys 83.3 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1552; Record_ID=skin_sensitization_invitro_435; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=83.3; Reported_Response_Unit=%; Response=83.3; Response_Unit=%; Reference=Jaworska 2011; 23670904; 10.1002/jat.2869; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Depletion Cys 85.1 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1560; Record_ID=skin_sensitization_invitro_437; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=85.1; Reported_Response_Unit=%; Response=85.1; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Depletion Cys 92.3 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1556; Record_ID=skin_sensitization_invitro_436; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=92.3; Reported_Response_Unit=%; Response=92.3; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Depletion Cys 93 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1392; Record_ID=skin_sensitization_invitro_372; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=93; Reported_Response_Unit=%; Response=93; Response_Unit=%; Reference=Jaworska supp A 2013; 21993957; 10.14573/altex.2011.3.211; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Depletion Cys 99.8 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1548; Record_ID=skin_sensitization_invitro_434; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=99.8; Reported_Response_Unit=%; Response=99.8; Response_Unit=%; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Depletion Cys 100 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1388; Record_ID=skin_sensitization_invitro_371; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=100; Reported_Response_Unit=%; Response=100; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Depletion Lys 11.5 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1403; Record_ID=skin_sensitization_invitro_375; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=11.5; Reported_Response_Unit=%; Response=11.5; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Depletion Lys 14.9 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1555; Record_ID=skin_sensitization_invitro_436; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=14.9; Reported_Response_Unit=%; Response=14.9; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Depletion Lys 19.6 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1559; Record_ID=skin_sensitization_invitro_437; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=19.600000000000001; Reported_Response_Unit=%; Response=19.6; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Depletion Lys 23.5 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1391; Record_ID=skin_sensitization_invitro_372; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=23.5; Reported_Response_Unit=%; Response=23.5; Response_Unit=%; Reference=Jaworska supp A 2013; 21993957; 10.14573/altex.2011.3.211; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Depletion Lys 29.9 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1387; Record_ID=skin_sensitization_invitro_371; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=29.9; Reported_Response_Unit=%; Response=29.9; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Depletion Lys 37.5 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1551; Record_ID=skin_sensitization_invitro_435; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=37.5; Reported_Response_Unit=%; Response=37.5; Response_Unit=%; Reference=Jaworska 2011; 23670904; 10.1002/jat.2869; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Depletion Lys 42.2 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1547; Record_ID=skin_sensitization_invitro_434; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=42.2; Reported_Response_Unit=%; Response=42.2; Response_Unit=%; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Depletion Lys + Cys 46 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1405; Record_ID=skin_sensitization_invitro_375; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=46; Reported_Response_Unit=%; Response=46; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Depletion Lys + Cys 52.35 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1561; Record_ID=skin_sensitization_invitro_437; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=52.35; Reported_Response_Unit=%; Response=52.35; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Depletion Lys + Cys 53.6 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1557; Record_ID=skin_sensitization_invitro_436; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=53.6; Reported_Response_Unit=%; Response=53.6; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Depletion Lys + Cys 58.25 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1393; Record_ID=skin_sensitization_invitro_372; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=58.25; Reported_Response_Unit=%; Response=58.25; Response_Unit=%; Reference=Jaworska supp A 2013; 21993957; 10.14573/altex.2011.3.211; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Depletion Lys + Cys 60.4 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1553; Record_ID=skin_sensitization_invitro_435; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=60.4; Reported_Response_Unit=%; Response=60.4; Response_Unit=%; Reference=Jaworska 2011; 23670904; 10.1002/jat.2869; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Depletion Lys + Cys 64.95 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1389; Record_ID=skin_sensitization_invitro_371; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=64.95; Reported_Response_Unit=%; Response=64.95; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Depletion Lys + Cys 71 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1549; Record_ID=skin_sensitization_invitro_434; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=71; Reported_Response_Unit=%; Response=71; Response_Unit=%; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC1.5 3.2 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4363; Record_ID=skin_sensitization_invitro_1003; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=3.2; Reported_Response_Unit=uM; Response=3.2; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC1.5 3.6 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4364; Record_ID=skin_sensitization_invitro_1014; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=3.6; Reported_Response_Unit=uM; Response=3.6; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC1.5 5 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4371; Record_ID=skin_sensitization_invitro_1016; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=5; Reported_Response_Unit=uM; Response=5; Response_Unit=uM; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC1.5 5.015 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4374; Record_ID=skin_sensitization_invitro_1017; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=5.0149999999999997; Reported_Response_Unit=uM; Response=5.015; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC1.5 5.2 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4377; Record_ID=skin_sensitization_invitro_999; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=5.2; Reported_Response_Unit=uM; Response=5.2; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC1.5 5.56 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4379; Record_ID=skin_sensitization_invitro_1001; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=5.56; Reported_Response_Unit=uM; Response=5.56; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC1.5 6 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4382; Record_ID=skin_sensitization_invitro_1009; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=6; Reported_Response_Unit=uM; Response=6; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC1.5 6.18 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4384; Record_ID=skin_sensitization_invitro_1002; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=6.18; Reported_Response_Unit=uM; Response=6.18; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC1.5 6.38 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4388; Record_ID=skin_sensitization_invitro_1000; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=6.38; Reported_Response_Unit=uM; Response=6.38; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC1.5 6.4 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4390; Record_ID=skin_sensitization_invitro_1019; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=6.4; Reported_Response_Unit=uM; Response=6.4; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC1.5 7.3 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4401; Record_ID=skin_sensitization_invitro_998; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=7.3; Reported_Response_Unit=uM; Response=7.3; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC1.5 8.39 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4404; Record_ID=skin_sensitization_invitro_996; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=8.39; Reported_Response_Unit=uM; Response=8.39; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC1.5 8.4 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4407; Record_ID=skin_sensitization_invitro_1008; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=8.4; Reported_Response_Unit=uM; Response=8.4; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC1.5 8.8 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4454; Record_ID=skin_sensitization_invitro_992; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=8.8000000000000007; Reported_Response_Unit=uM; Response=8.8; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC1.5 9.16 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4455; Record_ID=skin_sensitization_invitro_1006; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=9.16; Reported_Response_Unit=uM; Response=9.16; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC1.5 9.9 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4456; Record_ID=skin_sensitization_invitro_1020; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=9.9; Reported_Response_Unit=uM; Response=9.9; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC1.5 10.1 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4349; Record_ID=skin_sensitization_invitro_1011; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=10.1; Reported_Response_Unit=uM; Response=10.1; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC1.5 11.3 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4353; Record_ID=skin_sensitization_invitro_995; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=11.3; Reported_Response_Unit=uM; Response=11.3; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC1.5 12.7 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4355; Record_ID=skin_sensitization_invitro_1004; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=12.7; Reported_Response_Unit=uM; Response=12.7; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC1.5 13.55 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4357; Record_ID=skin_sensitization_invitro_994; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=13.55; Reported_Response_Unit=uM; Response=13.55; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC1.5 15.83 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4359; Record_ID=skin_sensitization_invitro_997; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=15.83; Reported_Response_Unit=uM; Response=15.83; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC1.5 25.65 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4361; Record_ID=skin_sensitization_invitro_1005; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=25.65; Reported_Response_Unit=uM; Response=25.65; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC1.5 <53.05 uM - Dermal - In Vitro; Urbisch_SkinSensitization2020; LuSens sheet=Data_invitro; excel_row=7613; Record_ID=skin_sensitization_invitro_1855; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=LuSens; Endpoint=EC1.5; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=53.05; Reported_Response_Unit=uM; Response=53.05; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC3 0.001 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13552; Record_ID=skin_sensitization_invivo_3761; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=LLNA; Endpoint=EC3; Response=1.00E-03; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kimber et al. 1991; 1998208; 10.1016/0378-4274(91)90135-s; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC3 0.05 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13567; Record_ID=skin_sensitization_invivo_3782; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=LLNA; Endpoint=EC3; Response=0.05; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Montelius et al. 1994; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC3 0.07 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13559; Record_ID=skin_sensitization_invivo_3774; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=LLNA; Endpoint=EC3; Response=7.00E-02; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Warbrick et al. 1999; 10439339; 10.1002/(sici)1099-1263(199907/08)19:4<255::aid-jat573>3.0.co;2-s; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC3 0.1 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13547; Record_ID=skin_sensitization_invivo_3755; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=LLNA; Endpoint=EC3; Response=0.1; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2004; 15209809; 10.1111/j.0105-1873.2004.00290.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC3 0.11 % Mouse Dermal - In Vivo; LLNA2013; LLNA sheet=Data_invivo; excel_row=12861; Record_ID=skin_sensitization_invivo_488; Data_Type=In Vivo; Internal_Data_Source=LLNA2013; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=LLNA; Endpoint=EC3; Response=0.11; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC3 0.13 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13563; Record_ID=skin_sensitization_invivo_3778; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=LLNA; Endpoint=EC3; Response=0.13; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=White et al. 2006; 17014438; 10.1111/j.1365-2222.2006.02561.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC3 0.15 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13565; Record_ID=skin_sensitization_invivo_3780; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=LLNA; Endpoint=EC3; Response=0.15; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Warbrick et al. 1999; 10439339; 10.1002/(sici)1099-1263(199907/08)19:4<255::aid-jat573>3.0.co;2-s; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC3 0.16 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13554; Record_ID=skin_sensitization_invivo_3763; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=LLNA; Endpoint=EC3; Response=0.16; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC3 0.2 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13555; Record_ID=skin_sensitization_invivo_3766; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=LLNA; Endpoint=EC3; Response=0.2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kimber et al. 1991; 1998208; 10.1016/0378-4274(91)90135-s; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC3 0.4 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13550; Record_ID=skin_sensitization_invivo_3759; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=LLNA; Endpoint=EC3; Response=0.4; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kimber et al. 1991; 1998208; 10.1016/0378-4274(91)90135-s; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC3 2.2 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13548; Record_ID=skin_sensitization_invivo_3757; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=LLNA; Endpoint=EC3; Response=2.2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kimber et al. 1991; 1998208; 10.1016/0378-4274(91)90135-s; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization EC3 46.74 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4458; Record_ID=skin_sensitization_invitro_1017; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=EC3; Reported_Response=46.743000000000002; Reported_Response_Unit=uM; Response=46.74; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization IC50 >132 uM - Dermal - In Vitro; Urbisch_SkinSensitization2020; LuSens sheet=Data_invitro; excel_row=7682; Record_ID=skin_sensitization_invitro_1855; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=LuSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=132; Reported_Response_Unit=uM; Response=132; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization IC50 192.22 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4459; Record_ID=skin_sensitization_invitro_1003; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=192.22; Reported_Response_Unit=uM; Response=192.22; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization IC50 302 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4460; Record_ID=skin_sensitization_invitro_1016; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=302; Reported_Response_Unit=uM; Response=302; Response_Unit=uM; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization IC50 380.32 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4461; Record_ID=skin_sensitization_invitro_993; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=380.32; Reported_Response_Unit=uM; Response=380.32; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization IC50 392.86 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4462; Record_ID=skin_sensitization_invitro_994; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=392.86; Reported_Response_Unit=uM; Response=392.86; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization IC50 394.21 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4463; Record_ID=skin_sensitization_invitro_999; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=394.21; Reported_Response_Unit=uM; Response=394.21; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization IC50 396.4 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4464; Record_ID=skin_sensitization_invitro_1011; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=396.4; Reported_Response_Unit=uM; Response=396.4; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization IC50 397.28 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4465; Record_ID=skin_sensitization_invitro_1006; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=397.28; Reported_Response_Unit=uM; Response=397.28; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization IC50 399.12 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4466; Record_ID=skin_sensitization_invitro_996; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=399.12; Reported_Response_Unit=uM; Response=399.12; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization IC50 399.98 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4391; Record_ID=skin_sensitization_invitro_992; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=399.98; Reported_Response_Unit=uM; Response=399.98; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization IC50 400.7 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4392; Record_ID=skin_sensitization_invitro_1020; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=400.7; Reported_Response_Unit=uM; Response=400.7; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization IC50 422.93 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4393; Record_ID=skin_sensitization_invitro_995; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=422.93; Reported_Response_Unit=uM; Response=422.93; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization IC50 427 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4394; Record_ID=skin_sensitization_invitro_1010; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=427; Reported_Response_Unit=uM; Response=427; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization IC50 438.95 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4395; Record_ID=skin_sensitization_invitro_1017; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=438.95; Reported_Response_Unit=uM; Response=438.95; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization IC50 447.39 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4396; Record_ID=skin_sensitization_invitro_1000; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=447.39; Reported_Response_Unit=uM; Response=447.39; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization IC50 464.55 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4397; Record_ID=skin_sensitization_invitro_1004; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=464.55; Reported_Response_Unit=uM; Response=464.55; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization IC50 577.2 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4398; Record_ID=skin_sensitization_invitro_1008; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=577.20000000000005; Reported_Response_Unit=uM; Response=577.2; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization IC50 648.9 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4399; Record_ID=skin_sensitization_invitro_1009; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=648.9; Reported_Response_Unit=uM; Response=648.9; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization IC50 662.35 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4400; Record_ID=skin_sensitization_invitro_998; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=662.35; Reported_Response_Unit=uM; Response=662.35; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization IC50 704.25 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4402; Record_ID=skin_sensitization_invitro_1001; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=704.25; Reported_Response_Unit=uM; Response=704.25; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization IC50 736.41 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4403; Record_ID=skin_sensitization_invitro_997; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=736.41; Reported_Response_Unit=uM; Response=736.41; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization IC50 867.33 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4405; Record_ID=skin_sensitization_invitro_1002; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=867.33; Reported_Response_Unit=uM; Response=867.33; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization IC50 872.11 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4406; Record_ID=skin_sensitization_invitro_1005; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=872.11; Reported_Response_Unit=uM; Response=872.11; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Imax 11.44 ratio - Dermal - In Vitro; Urbisch_SkinSensitization2020; LuSens sheet=Data_invitro; excel_row=7900; Record_ID=skin_sensitization_invitro_1855; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=LuSens; Endpoint=Imax; Reported_Response=11.43842112; Reported_Response_Unit=Unitless; Response=11.44; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Imax 11.73 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4408; Record_ID=skin_sensitization_invitro_994; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=11.733000000000001; Reported_Response_Unit=Unitless; Response=11.73; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Imax 12.589 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4409; Record_ID=skin_sensitization_invitro_1003; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=12.589; Reported_Response_Unit=Unitless; Response=12.589; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Imax 16.459 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4411; Record_ID=skin_sensitization_invitro_997; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=16.459; Reported_Response_Unit=Unitless; Response=16.459; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Imax 17.77 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4412; Record_ID=skin_sensitization_invitro_1005; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=17.774000000000001; Reported_Response_Unit=Unitless; Response=17.77; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Imax 19.02 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4413; Record_ID=skin_sensitization_invitro_998; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=19.021999999999998; Reported_Response_Unit=Unitless; Response=19.02; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Imax 19.4 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4414; Record_ID=skin_sensitization_invitro_1008; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=19.399999999999999; Reported_Response_Unit=Unitless; Response=19.4; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Imax 20 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4415; Record_ID=skin_sensitization_invitro_1010; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=20; Reported_Response_Unit=Unitless; Response=20; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Imax 22.21 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4416; Record_ID=skin_sensitization_invitro_992; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=22.21; Reported_Response_Unit=Unitless; Response=22.21; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Imax 22.61 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4417; Record_ID=skin_sensitization_invitro_996; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=22.611999999999998; Reported_Response_Unit=Unitless; Response=22.61; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Imax 22.66 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4418; Record_ID=skin_sensitization_invitro_999; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=22.655999999999999; Reported_Response_Unit=Unitless; Response=22.66; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Imax 23.2 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4419; Record_ID=skin_sensitization_invitro_1011; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=23.2; Reported_Response_Unit=Unitless; Response=23.2; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Imax 25.06 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4420; Record_ID=skin_sensitization_invitro_1019; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=25.06; Reported_Response_Unit=Unitless; Response=25.06; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Imax 26.8 ratio - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4421; Record_ID=skin_sensitization_invitro_1017; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=26.8; Reported_Response_Unit=Unitless; Response=26.8; Response_Unit=Ratio; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Imax 28.55 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4422; Record_ID=skin_sensitization_invitro_1014; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=28.547000000000001; Reported_Response_Unit=Unitless; Response=28.55; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Imax 29.558 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4423; Record_ID=skin_sensitization_invitro_1004; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=29.558; Reported_Response_Unit=Unitless; Response=29.558; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Imax 31.494 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4424; Record_ID=skin_sensitization_invitro_1001; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=31.494; Reported_Response_Unit=Unitless; Response=31.494; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Imax 32.61 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4425; Record_ID=skin_sensitization_invitro_1002; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=32.612000000000002; Reported_Response_Unit=Unitless; Response=32.61; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Imax 35.23 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4426; Record_ID=skin_sensitization_invitro_1006; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=35.229999999999997; Reported_Response_Unit=Unitless; Response=35.23; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Imax 37.28 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4427; Record_ID=skin_sensitization_invitro_993; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=37.277000000000001; Reported_Response_Unit=Unitless; Response=37.28; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Imax 39 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4428; Record_ID=skin_sensitization_invitro_1009; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=39; Reported_Response_Unit=Unitless; Response=39; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Imax 45.2 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4429; Record_ID=skin_sensitization_invitro_1020; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=45.2; Reported_Response_Unit=Unitless; Response=45.2; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Imax 52.887 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4430; Record_ID=skin_sensitization_invitro_1000; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=52.887; Reported_Response_Unit=Unitless; Response=52.887; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Imax 76.003 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4431; Record_ID=skin_sensitization_invitro_995; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=76.003; Reported_Response_Unit=Unitless; Response=76.003; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Imax 131.7 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4410; Record_ID=skin_sensitization_invitro_1016; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=131.69999999999999; Reported_Response_Unit=Unitless; Response=131.7; Response_Unit=Ratio; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Incidence of positive responses 7.216 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=3159; Record_ID=skin_sensitization_invivo_811; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.01; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=7.216; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Incidence of positive responses 11.22 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=3137; Record_ID=skin_sensitization_invivo_812; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=11.22; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Incidence of positive responses 20.83 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3081; Record_ID=skin_sensitization_invivo_799; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=20.83; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Incidence of positive responses 29.17 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3054; Record_ID=skin_sensitization_invivo_801; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.2; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=29.17; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Incidence of positive responses 33.33 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3068; Record_ID=skin_sensitization_invivo_803; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.2; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=33.33; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Incidence of positive responses 43.48 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3082; Record_ID=skin_sensitization_invivo_805; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.2; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=43.48; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Incidence of positive responses 53.41 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=3152; Record_ID=skin_sensitization_invivo_814; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=53.41; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Incidence of positive responses 68 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3094; Record_ID=skin_sensitization_invivo_806; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=68; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Incidence of positive responses 91.67 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3108; Record_ID=skin_sensitization_invivo_808; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=91.67; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Incidence of positive responses 96 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3122; Record_ID=skin_sensitization_invivo_807; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=96; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Incidence of positive responses 100 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3110; Record_ID=skin_sensitization_invivo_809; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=100; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Induction dose per skin area 6.975 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=3157; Record_ID=skin_sensitization_invivo_811; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.01; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=6.975; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Induction dose per skin area 62.07 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3079; Record_ID=skin_sensitization_invivo_799; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=62.07; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Induction dose per skin area 69.75 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=3135; Record_ID=skin_sensitization_invivo_812; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=69.75; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Induction dose per skin area 124.1 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3052; Record_ID=skin_sensitization_invivo_801; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.2; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=124.1; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Induction dose per skin area 620.7 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3093; Record_ID=skin_sensitization_invivo_806; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=620.7; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Induction dose per skin area 697.5 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=3150; Record_ID=skin_sensitization_invivo_814; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=697.5; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Induction dose per skin area 3103 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3105; Record_ID=skin_sensitization_invivo_808; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=3103; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Induction dose per skin area 6207 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3107; Record_ID=skin_sensitization_invivo_809; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=6207; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Induction dose per skin area 15520 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3140; Record_ID=skin_sensitization_invivo_813; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=15520; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 4.833 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=3131; Record_ID=skin_sensitization_invivo_811; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.01; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=4.833; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 14.28 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3091; Record_ID=skin_sensitization_invivo_805; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.2; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=14.28; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 14.9 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3048; Record_ID=skin_sensitization_invivo_799; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=14.9; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 18.62 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3077; Record_ID=skin_sensitization_invivo_803; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.2; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=18.62; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 21.28 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3063; Record_ID=skin_sensitization_invivo_801; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.2; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=21.28; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 31.07 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=3146; Record_ID=skin_sensitization_invivo_812; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=31.07; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 45.64 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3101; Record_ID=skin_sensitization_invivo_806; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=45.64; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 65.3 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=3161; Record_ID=skin_sensitization_invivo_814; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=65.3; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 161.6 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3104; Record_ID=skin_sensitization_invivo_807; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=161.6; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 169.3 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3117; Record_ID=skin_sensitization_invivo_808; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=169.3; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Induction dose per skin area, 5% incidence of positive responses 310.3 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3121; Record_ID=skin_sensitization_invivo_809; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=310.3; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Induction dose per skin area, one positive response 0.9964 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=3127; Record_ID=skin_sensitization_invivo_811; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.01; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, one positive response; Response=0.9964; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Induction dose per skin area, one positive response 6.341 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=3142; Record_ID=skin_sensitization_invivo_812; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, one positive response; Response=6.341; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Induction dose per skin area, one positive response 12.41 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3087; Record_ID=skin_sensitization_invivo_805; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.2; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=12.41; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Induction dose per skin area, one positive response 14.84 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=3158; Record_ID=skin_sensitization_invivo_814; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, one positive response; Response=14.84; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Induction dose per skin area, one positive response 15.52 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3073; Record_ID=skin_sensitization_invivo_803; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.2; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=15.52; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Induction dose per skin area, one positive response 17.73 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3060; Record_ID=skin_sensitization_invivo_801; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.2; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=17.73; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Induction dose per skin area, one positive response 36.51 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3098; Record_ID=skin_sensitization_invivo_806; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=36.51; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Induction dose per skin area, one positive response 129.3 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3099; Record_ID=skin_sensitization_invivo_807; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=129.3; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Induction dose per skin area, one positive response 141.1 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3113; Record_ID=skin_sensitization_invivo_808; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=141.1; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Induction dose per skin area, one positive response 258.6 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3116; Record_ID=skin_sensitization_invivo_809; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=258.6; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Induction dose per skin area, one positive response 775.9 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3149; Record_ID=skin_sensitization_invivo_813; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=775.9; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Max stimulation index 26.4 ratio Mouse Dermal - In Vivo; LLNA2013; LLNA sheet=Data_invivo; excel_row=12860; Record_ID=skin_sensitization_invivo_488; Data_Type=In Vivo; Internal_Data_Source=LLNA2013; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=LLNA; Endpoint=Max stimulation index; Response=26.4; Response_Unit=Ratio; Species=Mouse; Route=Dermal; Reference=ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Relative reliability score 1 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3050; Record_ID=skin_sensitization_invivo_799; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.1; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=1; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
NTP ICE skin sensitization Relative reliability score 2 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=3133; Record_ID=skin_sensitization_invivo_811; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=0.01; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021138; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=2; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002|Basketter et al. 2005; 16283904; 10.1111/j.0105-1873.2005.00707.x|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021138
SCCNFP Opinion 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCNFP Opinion NOAEL =4 mg/kg/day rat oral 12-week NOAEL study p.6
SCCNFP Opinion NOAEL =4 mg/kg bw human - - irritation p.24
SCCNFP Opinion NOAEL =5 mg/kg bw/day rat oral Sub-chronic repeated dose toxicity Ref. : 120 2, p.5
SCCNFP Opinion NOAEL =8 mg/kg rabbit dermal 13weeks repeated dose toxicity Ref. : 47 2, p.6
SCCNFP Opinion NOAEL =16 mg/kg bw rabbit dermal Sub-chronic repeated dose toxicity Ref. : 47 2, p.6
SCCNFP Opinion NOAEL =50 mg/kg bw rat oral 13-week NOAEL study p.6
SCCS Opinion 27 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.04 mg/kg bw/d rat oral subchronic repeated dose toxicity p.59
SCCS Opinion NOAEL =0.052 mg/kg bw rat oral subchronic repeated dose toxicity p.52
SCCS Opinion NOAEL =1 % rat oral - NOAEL study (Ref. 14, subm. V), p.61
SCCS Opinion NOAEL =2 % rat - - NOAEL study (Reference 14), p.53
SCCS Opinion NOAEL =4 mg/kg bw rat oral subchronic repeated dose toxicity p.52
SCCS Opinion NOAEL =4 mg/kg rat oral 90-day NOAEL study p.53
SCCS Opinion NOAEL =4 mg/kg bw rat - - carcinogenicity p.5
SCCS Opinion NOAEL =4 mg/kg bw/day - - - NOAEL study p.16
SCCS Opinion NOAEL =4 mg/kg bw/d - oral 90 days NOAEL study p.59
SCCS Opinion NOAEL <5 mg/kg bw/day - - - NOAEL study p.13
SCCS Opinion NOAEL =5 mg/kg bw human - developmental developmental toxicity Ref.: 8, subm, p.46
SCCS Opinion NOAEL <5 mg/kg bw/day rat oral Sub-chronic repeated dose toxicity p.16
SCCS Opinion NOAEL =6.45 mg/kg bw rat oral - NOAEL study p.61
SCCS Opinion NOAEL =8 mg/kg rabbit dermal 90 day NOAEL study p.15
SCCS Opinion NOAEL =8 mg/kg bw rat oral 3 days NOAEL study (Ref. 120), p.17
SCCS Opinion NOAEL =8 mg/kg bw/d rabbit dermal 90 day NOAEL study p.17
SCCS Opinion NOAEL =8 mg/kg bw/day rat - - NOAEL study p.66
SCCS Opinion NOAEL =8 - - oral - NOAEL study p.61
SCCS Opinion NOAEL =14 - rat - - NOAEL study p.58
SCCS Opinion NOAEL =16 mg/kg bw rat oral 12-week NOAEL study p.14
SCCS Opinion NOAEL =16 mg/kg bw - - - NOAEL study p.16
SCCS Opinion NOAEL =16 mg/kg bw/d rabbit dermal 90 day NOAEL study p.17
SCCS Opinion NOAEL =16 - - oral - NOAEL study p.61
SCCS Opinion NOAEL =50 mg/kg bw rat oral - NOAEL study p.14
SCCS Opinion NOAEL =50 mg/kg bw rat oral 13-week NOAEL study p.17
SCCS Opinion NOAEL =50 - - oral - NOAEL study p.61
SCCS Opinion NOAEL =61 - - oral - NOAEL study p.61
ECHA 36 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LEL >=1 mg/kg bw/day Dog oral - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/3/2?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Oral_15800395_15801350:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8f59c7fa8fad5784b16af70f537722d2
ECHA LEL >=10 mg/kg bw/day Rat oral - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61cbce4b096bca877335f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/3/5?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Other Routes_15815961_15815962:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4251e5bef86f2fcddf5f5e533da4c95d
ECHA LEL =12.5 mg/kg bw/day Rat injection - chronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c7fbe4b0a7c65d215ea1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/8?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15818249_15818250:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a193c47b5037cae32c6dfc8320b9fdcc
ECHA LEL >=20 mg/kg bw/day Cat oral - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/3/2?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15808949:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ee921decd061d2e8528acc5a68c67ade
ECHA LEL =30 mg/kg bw/day Dog injection - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61c24e4b096bca8770d11; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/3/5?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Other Routes_15815249_15815256_15815283_15815637:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_909402e62e53e469401d480bc07515ee
ECHA LEL =50 mg/kg bw/day Rat injection - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61c13e4b096bca8770883; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/3/5?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Other Routes_15815191_15815192:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8cdfd7cad7f6d7c41d0757ba5828467d
ECHA LEL >=52 mg/kg bw/day Rabbit injection - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61c66e4b096bca8771d9c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/3/5?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Other Routes_15815423_15815500_15815630_15815823_15815979_15815980:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_afbb032d0628bd6db497c736833ca251
ECHA LEL =70 mg/kg bw/day Dog injection - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61ccce4b096bca877377a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/3/5?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Other Routes_15815249_15815256_15815283_15815637:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_33b79ef49dc6cd5d1bb343de6cae1427
ECHA LEL =75 mg/kg bw/day Rat oral - acute QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/3/2?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15804937:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_03dab6d91bb5ee835936ad2ec4989762
ECHA LEL =100 mg/kg bw/day Dog injection - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61bdfe4b096bca876fc38; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/3/5?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15815063:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_80251e807643e9c0cb7365b38daa0fc4
ECHA LEL =105 mg/kg bw/day Rabbit oral chronic; 30 weeks chronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c620c0e4b096bca8782884; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/6/5?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15853941:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b9de624a0b115088e8c0b2935c71000f
ECHA LEL =140 mg/kg bw/day Mouse injection - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61d0de4b096bca877465f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/3/5?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15815773:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6cfad608d1829482649330ba39fc4395
ECHA LEL >=150 mg/kg bw/day Rabbit injection - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61c02e4b096bca8770494; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/3/5?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Other Routes_15815282_15815867_15815868:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a53f89983990de8054ed3c067bb240f6
ECHA LEL >=200 mg/kg bw/day Rabbit oral - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/3/2?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Oral_15807683_15814669_15814670:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b24b3d80e41ec552181dc948ce92c4d6
ECHA LEL =215 mg/kg bw/day Cat injection - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61bdfe4b096bca876fc4c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/3/5?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Other Routes_15815067_15815310:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_604d3c76a7ef431953983081fbdd4f87
ECHA LEL <=270 mg/kg bw/day Rabbit oral - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/3/2?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Oral_15807683_15814669_15814670:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d7b8add6be0ff0a2d9590bf576464053
ECHA LEL >=300 mg/kg bw/day Rabbit injection - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61cdce4b096bca87739d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/3/5?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Other Routes_15815423_15815500_15815630_15815823_15815979_15815980:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f21755a95c907daf38c15c86bae48f7a
ECHA LEL =357 mg/kg bw/day Dog oral - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/3/2?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Oral_15800395_15801350:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bbc4987e3c3d126be7566b54a8adfc31
ECHA LEL =400 mg/kg bw/day Rabbit injection - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61ccce4b096bca8773706; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/3/5?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Other Routes_15815423_15815500_15815630_15815823_15815979_15815980:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0147e3913e3e6b235c73c524a9d16166
ECHA LEL <=500 mg/kg bw/day Rabbit injection - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61cdce4b096bca87739d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/3/5?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Other Routes_15815423_15815500_15815630_15815823_15815979_15815980:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b89db330a540ed705bb75eb569ea5051
ECHA LEL =600 mg/kg bw/day Rat injection - acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61c35e4b096bca877109a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/3/5?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Other Routes_15815276_15815520_15816015_15816016:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_efd548b6f44931d525a5ccb8b0123bcd
ECHA LEL =1050 mg/kg bw/day Rat oral chronic; 30 weeks chronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c62039e4b096bca8780807; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/6/5?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15852179:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_73f0e96cc8a3d9055af730a7fd88602d
ECHA LEL =5000 mg/kg bw/day Rabbit dermal acute; 24 hours acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c6183ae4b096bca876266c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/3/4?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15792534:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9d88c86b33fb505a6ce2cb6c6eac5154
ECHA LEL =28000 mg/kg bw/day Rat oral chronic; 80 weeks chronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c6206ae4b096bca87813e1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/6/5?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15852809:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7f6da65c1543506fd8e07d9e80a6a3c2
ECHA LOAEL =1 mg/kg bw/day Rat dermal subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61ef6e4b096bca877bccf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/6/4?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=spleen; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826703_15826781:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c3fb5b3f62f5743588a080d9af9f9581
ECHA NOAEL =10 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabace4b0a7c65d1bb3d1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/9/3?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15821891:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ffbf0eaa81f05999e74a4c79314337c0
ECHA NOAEL =16 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacc0e4b0a7c65d1c0a83; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/6/2?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15835146:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_48bc68ddb3c74ecb7b602dd1842393d5
ECHA NOAEL <20 ppm Rat oral - repeat dose other QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa3ee4b0a7c65d1b4ec2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/10/1?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15825549:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_80b7467f3dac829a53a5cd282fbc781f
ECHA NOEL =5 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabace4b0a7c65d1bb3d1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/9/3?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15823161:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4c60b607b759284976183d41c4678d69
ECHA NOEL =8 mg/kg bw/day Rat oral - repeat dose other GUIDELINE=EPA OTS 798.6050 (Neurotoxicity Screening Battery); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d2180ce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/10/1?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825550_15825846_15825847:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f890bcf50e6ce082cf1e268503941eda
ECHA NOEL =10 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabace4b0a7c65d1bb3cf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/9/3?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15823113:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2c61c596f687f60a38bf4a170a7d0411
ECHA NOEL =16 mg/kg bw/day Rat oral - repeat dose other GUIDELINE=EPA OTS 798.6050 (Neurotoxicity Screening Battery); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d2180ce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/10/1?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825550_15825846_15825847:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8445d310e2473200a69bf67a0da12608
ECHA NOEL =30 mg/kg bw/day Rat oral - developmental QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabace4b0a7c65d1bb3cd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/9/3?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820880_15821833:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8450a383d2ac83dfb77550774ceaea69
ECHA NOEL =65.376 mg/kg bw/day Rat oral subchronic; 7 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacc0e4b0a7c65d1c0a85; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/6/2?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15844240:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2e31cedf8f129f9420464ebf745e10e3
ECHA NOEL =80 mg/kg bw/day Rat oral - repeat dose other QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa3ee4b0a7c65d1b4ec2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/10/1?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825550_15825846_15825847:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f7e71407d0dc90e0b31ba194bcc30652
ECHA NOEL =96 mg/kg bw/day Rat oral subchronic; 7 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacc0e4b0a7c65d1c0a85; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22562/7/6/2?documentUUID=62c6f81b-e4db-4e99-8e98-f7a3329411b2; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15844241:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a30d134ea81113df18b9e4213c3c3223
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =0.23 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634099:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_50d6e807e662de5ae757a030dfba488a
ToxValDB PPRTV (CPHEA) 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB PPRTV (CPHEA) BMDL (HED) =0.96 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic LONG_REF=Toxicol Laboratories, Limited, . (1995). Paraphenylenedianitne: 13 week oral (Gavage) toxicity study in the rat - Volume I and II. (LRL/44/94). Ledbury, England.; AUTHOR=Toxicol Laboratories, Limited,; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754fce4b08a6b3934bd22; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1850; TOXICOLOGICAL_EFFECT=increased relative liver weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=PPRTV (CPHEA):15653765:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_00d508b9461406cc18a585b222203a0f
ToxValDB PPRTV (CPHEA) RfD (provisional) =0.001 mg/kg bw/day Human oral - Toxicity Value LONG_REF=Toxicol Laboratories, Limited, . (1995). Paraphenylenedianitne: 13 week oral (Gavage) toxicity study in the rat - Volume I and II. (LRL/44/94). Ledbury, England.; AUTHOR=Toxicol Laboratories, Limited,; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754fce4b08a6b3934bd22; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1850; TOXICOLOGICAL_EFFECT=increased relative liver weight in female rats; STUDY_GROUP=PPRTV (CPHEA):15653326:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_25112d867c1c5f5985141b8a658b212d
ToxValDB RSL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB RSL RfD =0.01 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15663671:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_06a952912d0ca8e0e3aaa3d47dab4f33
Regulatory source 59 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 4 mg/kg/day rat oral 12-week - p.6
Regulatory source - 4 mg/kg bw - - - - p.24
Regulatory source - 50 mg/kg bw rat oral 13-week - p.6
Regulatory source irritation =4 mg/kg bw human - - irritation p.24
Regulatory source irritation 4 % human - - irritation p.24
Regulatory source repeated dose toxicity 5 mg/kg bw/day rat oral Sub-chronic repeated dose toxicity p.5
Regulatory source repeated dose toxicity 8 mg/kg rabbit dermal 13weeks repeated dose toxicity p.6
Regulatory source repeated dose toxicity 16 mg/kg bw rabbit dermal Sub-chronic repeated dose toxicity p.6
Regulatory source reproductive toxicity 4 mg/kg bw rat oral 90 day reproductive toxicity p.24
Regulatory source - 1 % rat oral - - p.61
Regulatory source - 2 % rat - - - p.53
Regulatory source - 4 mg/kg rat oral 90-day - p.53
Regulatory source - 4 mg/kg bw/day - - - - p.16
Regulatory source - 4 mg/kg bw/d - - - - p.17
Regulatory source - 4 mg/kg bw/d - oral 90 days - p.59
Regulatory source - 4 mg/kg bw/d - - 90 days - p.59
Regulatory source - 4 mg/kg bw/d rat oral 90-day - p.60
Regulatory source - 4 mg/kg bw rat oral 90-day - p.60
Regulatory source - 4 mg/kg bw/d rat oral 90 day - p.62
Regulatory source - 4 mg/kg bw/d - - 3 days - p.62
Regulatory source - 4 - - oral - - p.61
Regulatory source - <5 mg/kg bw/day - - - - p.13
Regulatory source - 6.45 mg/kg bw rat oral - - p.61
Regulatory source - 8 mg/kg rabbit dermal 90 day - p.15
Regulatory source - 8 mg/kg bw rat oral 3 days - p.17
Regulatory source - 8 mg/kg bw/d rabbit dermal 90 day - p.17
Regulatory source - 8 mg/kg bw/day rat - - - p.66
Regulatory source - 8 - - oral - - p.61
Regulatory source - 14 - rat - - - p.58
Regulatory source - 16 mg/kg bw rat oral 12-week - p.14
Regulatory source - 16 mg/kg bw rabbit dermal 90 day - p.15
Regulatory source - 16 mg/kg bw - - - - p.16
Regulatory source - 16 mg/kg bw/d - - 3 days - p.17
Regulatory source - 16 mg/kg bw/d rabbit dermal 90 day - p.17
Regulatory source - 16 mg/kg bw/d - - 90 days - p.59
Regulatory source - 16 - - oral - - p.61
Regulatory source - 50 mg/kg bw rat oral - - p.14
Regulatory source - 50 - - oral - - p.61
Regulatory source - 61 - - oral - - p.61
Regulatory source carcinogenicity 4 mg/kg bw rat dermal 90 day carcinogenicity p.56
Regulatory source carcinogenicity 4 mg/kg rat - - carcinogenicity p.57
Regulatory source carcinogenicity 4 mg/kg bw rat - - carcinogenicity p.5
Regulatory source developmental toxicity 4 mg/kg bw rat oral 90 day developmental toxicity p.54
Regulatory source developmental toxicity 5 mg/kg bw human - developmental developmental toxicity p.46
Regulatory source developmental toxicity 5 mg/kg bw rat oral 90 day developmental toxicity p.54
Regulatory source developmental toxicity 5 mg/kg bw/day rat oral 3 days developmental toxicity p.51
Regulatory source repeated dose toxicity =0.04 mg/kg bw/d rat oral subchronic repeated dose toxicity p.59
Regulatory source repeated dose toxicity =0.052 mg/kg bw rat oral subchronic repeated dose toxicity p.52
Regulatory source repeated dose toxicity =4 mg/kg bw rat oral subchronic repeated dose toxicity p.52
Regulatory source repeated dose toxicity 4 mg/kg/day rat oral subchronic repeated dose toxicity p.53
Regulatory source repeated dose toxicity 4 mg/kg bw/day rat oral subchronic repeated dose toxicity p.60
Regulatory source repeated dose toxicity 5 mg/kg bw/day rat oral 90-day repeated dose toxicity p.63
Regulatory source repeated dose toxicity 5 mg/kg bw/d rat oral subchronic repeated dose toxicity p.65
Regulatory source repeated dose toxicity 8 mg/kg bw/d human dermal 3 days repeated dose toxicity p.59
Regulatory source repeated dose toxicity =8 mg/kg bw/d rat oral subchronic repeated dose toxicity p.59
Regulatory source repeated dose toxicity 8 mg/kg bw/d rat - subchronic repeated dose toxicity p.62
Regulatory source repeated dose toxicity 8 mg/kg bw/d rat oral 90-day repeated dose toxicity p.63
Regulatory source repeated dose toxicity 8 mg/kg bw/d human - subchronic repeated dose toxicity p.65
Regulatory source repeated dose toxicity 8 mg/kg bw/day rat oral subchronic repeated dose toxicity p.65
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier U770QIT64J UNII - - - chemical -