NOAEL Studies Cosmetic Ingredient

PABA NOAEL Studies

CAS: 150-13-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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IARC Monographs 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 1987 IARC Monographs -
NTP ICE adme parameters 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE adme parameters Clint 0 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=2504; Record_ID=adme_parameters_865; Data_Type=Measured; DTXSID=DTXSID6024466; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=0.0; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE adme parameters Fu 0.766 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=2503; Record_ID=adme_parameters_865; Data_Type=Measured; DTXSID=DTXSID6024466; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.766; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE cancer 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE cancer IARC group 3 unitless - - - WOE; IARC Carcinogenicity sheet=Data; excel_row=6967; Record_ID=cancer_7072; Data_Type=WOE; Formulation_Name=4-Aminobenzoic acid; Mixture=Chemical; DTXSID=DTXSID6024466; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/34; http://publications.iarc.fr/139; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=3608; RecordID=ARPathway2016_879; DatasetName=ARPathway2016; DTXSID=DTXSID6024466; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE skin sensitization 33 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization CD86, EC150 >200 ug/mL - Dermal - In Vitro; CE_USENSE2018; U-SENS sheet=Data_invitro; excel_row=8646; Record_ID=skin_sensitization_invitro_2392; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID6024466; Assay=U-SENS; Endpoint=CD86, EC150; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=200; Reported_Response_Unit=ug/mL; Response=200; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE skin sensitization CV75 >1000 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=2290; Record_ID=skin_sensitization_invitro_561; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID6024466; Assay=h-CLAT; Endpoint=CV75; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=1000; Reported_Response_Unit=ug/mL; Response=1000; Response_Unit=ug/mL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE skin sensitization Depletion Cys 1 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=5594; Record_ID=skin_sensitization_invitro_1312; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024466; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=1; Reported_Response_Unit=%; Response=1; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE skin sensitization Depletion Cys 1.4 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=5552; Record_ID=skin_sensitization_invitro_1302; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024466; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=1.4; Reported_Response_Unit=%; Response=1.4; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE skin sensitization Depletion Cys 3.9 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=5529; Record_ID=skin_sensitization_invitro_1296; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024466; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=3.9; Reported_Response_Unit=%; Response=3.9; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE skin sensitization Depletion Cys 4.6 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=5543; Record_ID=skin_sensitization_invitro_1300; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024466; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=4.5999999999999996; Reported_Response_Unit=%; Response=4.6; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE skin sensitization Depletion Cys 5.9 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=5515; Record_ID=skin_sensitization_invitro_1294; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024466; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=5.9; Reported_Response_Unit=%; Response=5.9; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE skin sensitization Depletion Cys 10.6 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=5535; Record_ID=skin_sensitization_invitro_1298; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024466; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=10.6; Reported_Response_Unit=%; Response=10.6; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE skin sensitization Depletion Cys 10.7 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=5525; Record_ID=skin_sensitization_invitro_1295; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024466; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=10.7; Reported_Response_Unit=%; Response=10.7; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE skin sensitization Depletion Lys 0 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=5558; Record_ID=skin_sensitization_invitro_1304; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024466; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0; Reported_Response_Unit=%; Response=0; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE skin sensitization Depletion Lys 0.1 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=5541; Record_ID=skin_sensitization_invitro_1300; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024466; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0.1; Reported_Response_Unit=%; Response=0.1; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE skin sensitization Depletion Lys 0.4 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=5522; Record_ID=skin_sensitization_invitro_1295; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024466; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0.4; Reported_Response_Unit=%; Response=0.4; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE skin sensitization Depletion Lys 0.5 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=5513; Record_ID=skin_sensitization_invitro_1294; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024466; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0.5; Reported_Response_Unit=%; Response=0.5; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE skin sensitization Depletion Lys 0.6 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=5533; Record_ID=skin_sensitization_invitro_1298; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024466; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0.6; Reported_Response_Unit=%; Response=0.6; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE skin sensitization Depletion Lys 0.7 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=5550; Record_ID=skin_sensitization_invitro_1302; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024466; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0.7; Reported_Response_Unit=%; Response=0.7; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE skin sensitization Depletion Lys 0.9 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=5528; Record_ID=skin_sensitization_invitro_1296; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024466; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0.9; Reported_Response_Unit=%; Response=0.9; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE skin sensitization Depletion Lys + Cys 0.35 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=5588; Record_ID=skin_sensitization_invitro_1310; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024466; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=0.35; Reported_Response_Unit=%; Response=0.35; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE skin sensitization Depletion Lys + Cys 0.45 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=5562; Record_ID=skin_sensitization_invitro_1304; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024466; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=0.45; Reported_Response_Unit=%; Response=0.45; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE skin sensitization Depletion Lys + Cys 1.05 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=5554; Record_ID=skin_sensitization_invitro_1302; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024466; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=1.05; Reported_Response_Unit=%; Response=1.05; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE skin sensitization Depletion Lys + Cys 2.3 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=5570; Record_ID=skin_sensitization_invitro_1306; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024466; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=2.2999999999999998; Reported_Response_Unit=%; Response=2.3; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE skin sensitization Depletion Lys + Cys 2.35 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=5546; Record_ID=skin_sensitization_invitro_1300; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024466; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=2.35; Reported_Response_Unit=%; Response=2.35; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE skin sensitization Depletion Lys + Cys 2.4 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=5530; Record_ID=skin_sensitization_invitro_1296; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024466; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=2.4; Reported_Response_Unit=%; Response=2.4; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE skin sensitization Depletion Lys + Cys 3.2 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=5518; Record_ID=skin_sensitization_invitro_1294; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024466; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=3.2; Reported_Response_Unit=%; Response=3.2; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE skin sensitization Depletion Lys + Cys 5.55 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=5526; Record_ID=skin_sensitization_invitro_1295; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024466; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=5.55; Reported_Response_Unit=%; Response=5.55; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE skin sensitization Depletion Lys + Cys 5.6 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=5537; Record_ID=skin_sensitization_invitro_1298; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID6024466; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=5.6; Reported_Response_Unit=%; Response=5.6; Response_Unit=%; Reference=Joint Research Centre of the European Union 2013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE skin sensitization EC1.5 >2000 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=5228; Record_ID=skin_sensitization_invitro_1221; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID6024466; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Joint Research Centre of the European Union 2014|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE skin sensitization IC50 >2400 uM - Dermal - In Vitro; Urbisch_SkinSensitization2020; LuSens sheet=Data_invitro; excel_row=7642; Record_ID=skin_sensitization_invitro_1810; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID6024466; Assay=LuSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2400; Reported_Response_Unit=uM; Response=2400; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE skin sensitization Imax 1.107 ratio - Dermal - In Vitro; Urbisch_SkinSensitization2020; LuSens sheet=Data_invitro; excel_row=7544; Record_ID=skin_sensitization_invitro_1810; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID6024466; Assay=LuSens; Endpoint=Imax; Reported_Response=1.106609205; Reported_Response_Unit=Unitless; Response=1.107; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE skin sensitization Imax 1.21 ratio - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=5233; Record_ID=skin_sensitization_invitro_1221; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID6024466; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.21; Reported_Response_Unit=Unitless; Response=1.21; Response_Unit=Ratio; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868|Joint Research Centre of the European Union 2014|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE skin sensitization Imax 1.23 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=5234; Record_ID=skin_sensitization_invitro_1222; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID6024466; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.23; Reported_Response_Unit=Unitless; Response=1.23; Response_Unit=Ratio; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE skin sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=5607; Record_ID=skin_sensitization_invivo_1297; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024466; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Basketter et al. 1994; 8045461; 10.1016/0278-6915(94)90112-0|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE skin sensitization Induction dose per skin area 15520 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=5605; Record_ID=skin_sensitization_invivo_1297; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024466; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=15520; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Basketter et al. 1994; 8045461; 10.1016/0278-6915(94)90112-0|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
NTP ICE skin sensitization Relative reliability score 1 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=5610; Record_ID=skin_sensitization_invivo_1297; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6024466; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=1; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Basketter et al. 1994; 8045461; 10.1016/0278-6915(94)90112-0|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6024466; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6024466
SCCS Opinion 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.1 % rat oral 51-year NOAEL study p.17
SCCS Opinion NOAEL =1 % rat oral 5 weeks NOAEL study p.17
SCCS Opinion NOAEL =100 mg/kg bw/d rat oral 2 weeks repeated dose toxicity p.47
SCCS Opinion NOAEL =108 - - oral 108 days NOAEL study p.18
ECHA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL >=1200 mg/kg bw/day Rat oral chronic; 108 days chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead7de4b0a7c65d1c470c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7095/7/6/2?documentUUID=2ff1de7d-7a75-41c5-89d9-7e3a25652645; YEAR=2016; ORIGINAL_YEAR=2016; STUDY_GROUP=ECHA IUCLID:15839933:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5e3ce39d9a151e738e14a6ee5f2eeb6b
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =10.58 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15629717:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_81b47b85fefc7ed055987bd887f58c47
Regulatory source 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 0.1 % rat oral 51-year - p.17
Regulatory source - 1 % rat oral 5 weeks - p.17
Regulatory source - 108 - - oral 108 days - p.18
Regulatory source repeated dose toxicity 100 mg/kg bw/d rat oral 2 weeks repeated dose toxicity p.47
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier TL2TJE8QTX UNII - - - chemical -