NOAEL Studies Cosmetic Ingredient

PALLADIUM NOAEL Studies

CAS: 7440-05-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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INCHEM_WHO_ehc_ehc_ehc226 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
INCHEM_WHO_ehc_ehc_ehc226 NOAEL =0.08 mg/kg bw - - - Toxicology study document_id=ehc_ehc_ehc226; title=Palladium (EHC 226, 2002); path=mirror/documents/ehc/ehc/ehc226.htm; row_hash=3eb4f1302afba5bd; raw_unit=mg/kg body weight; context=Adverse effects were also observed with enteral exposures, the no-observed-adverse-effect level being given as 0.08 mg/kg body weight.
INCHEM_WHO_ehc_ehc_ehc226 NOEL =8 mg/kg bw - - - Toxicology study document_id=ehc_ehc_ehc226; title=Palladium (EHC 226, 2002); path=mirror/documents/ehc/ehc/ehc226.htm; row_hash=4958a219f437bd9c; raw_unit=mg/kg body weight; context=For enteral exposures, doses of 0.08 mg/kg body weight and 8 mg/kg body weight were considered to be the no-observed-effect level (NOEL) and the toxic concentration, respectively.
ToxValDB_ECHA_IUCLID 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab59e4b0a7c65d1b9caf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/18747/7/9/2?documentUUID=249c7f66-4816-4e76-b5f8-9dc37e8d45d2; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=P0: clinical signs|P0: body weight and weight gain|P0: food consumption and compound intake|P0: organ weights and organ / body weight ratios|P0: gross pathology|P0: histopathology: non-neoplastic|P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|gross pathology|nonneoplastic histopathology|organ weight|reproduction; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15857017_15857707:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_45e1822299d8d5bf8438e2a8f1369792
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 5TWQ1V240M UNII - - - chemical {"approval_status":null,"molecular_formula":"Pd","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5TWQ1V240M"}
openFDA substances FDA UNII substance identifier 5TWQ1V240M UNII - - - chemical {"approval_status":null,"molecular_formula":"Pd","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5TWQ1V240M"}
openFDA substances FDA UNII substance identifier 5TWQ1V240M UNII - - - chemical {"approval_status":null,"molecular_formula":"Pd","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5TWQ1V240M"}
openFDA substances FDA UNII substance identifier 5TWQ1V240M UNII - - - chemical {"approval_status":null,"molecular_formula":"Pd","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"5TWQ1V240M"}