Good Active Ingredient

Palmitoyl Tetrapeptide-7

INCI: PALMITOYL TETRAPEPTIDE-7

CAS Number
221227-05-0
Function
Skin-conditioning agent; anti-inflammatory peptide
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Explicitly named in CIR safety assessment as safe as used in cosmetics. Covered under same CIR review as Tripeptide-1 and Hexapeptide-12 derivatives.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
high
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Palmitoyl Tetrapeptide-7 is confirmed safe as used in cosmetics by CIR Expert Panel. The peptide decreases IL-6 secretion after UVB exposure and stimulates collagen synthesis; in clinical studies it demonstrated significant reductions in wrinkle depth, volume, and number with no regulatory restrictions.

⚠️
Concern Level: Low

Regulatory Flags

peptide matrikine collagen-stimulating anti-inflammatory anti-aging eye-area matrixyl eyeliss

Frequently Asked Questions

Is Palmitoyl Tetrapeptide-7 safe in cosmetics?

Palmitoyl Tetrapeptide-7 is confirmed safe as used in cosmetics by CIR Expert Panel. The peptide decreases IL-6 secretion after UVB exposure and stimulates collagen synthesis; in clinical studies it demonstrated significant reductions in wrinkle depth, volume, and number with no regulatory restrictions. The EU classifies Palmitoyl Tetrapeptide-7 as "permitted". Safety rating: GOOD.

Is Palmitoyl Tetrapeptide-7 allowed in the EU?

Palmitoyl Tetrapeptide-7 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Palmitoyl Tetrapeptide-7 do in cosmetics?

Palmitoyl Tetrapeptide-7 functions as: Skin-conditioning agent; anti-inflammatory peptide. It is classified as a Active Ingredient in our database. CAS number: 221227-05-0.

What is the Margin of Safety for Palmitoyl Tetrapeptide-7?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Palmitoyl Tetrapeptide-7 compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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