NOAEL Studies Cosmetic Ingredient

PEG-20 HYDROGENATED CASTOR OIL NOAEL Studies

CAS: 61788-85-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

NTP_ICE_eye_irritation 20 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_eye_irritation Draize rabbit irritation score 0 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2619; Record_ID=eye_irritation_180; Data_Type=In Vivo; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8044171; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=0; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8044171
NTP_ICE_eye_irritation Draize rabbit irritation score 0 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2619; Record_ID=eye_irritation_180; Data_Type=In Vivo; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8044171; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=0; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8044171
NTP_ICE_eye_irritation Draize rabbit irritation score 0 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2619; Record_ID=eye_irritation_180; Data_Type=In Vivo; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8044171; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=0; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8044171
NTP_ICE_eye_irritation Draize rabbit irritation score 0 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2619; Record_ID=eye_irritation_180; Data_Type=In Vivo; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8044171; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=0; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8044171
NTP_ICE_eye_irritation EPA Classification 4 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2621; Record_ID=eye_irritation_180; Data_Type=In Vivo; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8044171; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=4; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8044171
NTP_ICE_eye_irritation EPA Classification 4 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2621; Record_ID=eye_irritation_180; Data_Type=In Vivo; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8044171; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=4; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8044171
NTP_ICE_eye_irritation EPA Classification 4 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2621; Record_ID=eye_irritation_180; Data_Type=In Vivo; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8044171; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=4; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8044171
NTP_ICE_eye_irritation EPA Classification 4 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=2621; Record_ID=eye_irritation_180; Data_Type=In Vivo; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8044171; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=4; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8044171
NTP_ICE_eye_irritation Intensity 0.01 %/sec - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2617; Record_ID=eye_irritation_1308; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8044171; Assay=Vitrigel; Endpoint=Intensity; Response=0.01; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8044171
NTP_ICE_eye_irritation Intensity 0.01 %/sec - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2617; Record_ID=eye_irritation_1308; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8044171; Assay=Vitrigel; Endpoint=Intensity; Response=0.01; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8044171
NTP_ICE_eye_irritation Intensity 0.01 %/sec - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2617; Record_ID=eye_irritation_1308; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8044171; Assay=Vitrigel; Endpoint=Intensity; Response=0.01; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8044171
NTP_ICE_eye_irritation Intensity 0.01 %/sec - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2617; Record_ID=eye_irritation_1308; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8044171; Assay=Vitrigel; Endpoint=Intensity; Response=0.01; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8044171
NTP_ICE_eye_irritation Lag time >180 s - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2618; Record_ID=eye_irritation_1308; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8044171; Assay=Vitrigel; Endpoint=Lag time; Response_Modifier=>; Response=180; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8044171
NTP_ICE_eye_irritation Lag time >180 s - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2618; Record_ID=eye_irritation_1308; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8044171; Assay=Vitrigel; Endpoint=Lag time; Response_Modifier=>; Response=180; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8044171
NTP_ICE_eye_irritation Lag time >180 s - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2618; Record_ID=eye_irritation_1308; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8044171; Assay=Vitrigel; Endpoint=Lag time; Response_Modifier=>; Response=180; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8044171
NTP_ICE_eye_irritation Lag time >180 s - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2618; Record_ID=eye_irritation_1308; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8044171; Assay=Vitrigel; Endpoint=Lag time; Response_Modifier=>; Response=180; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8044171
NTP_ICE_eye_irritation Plateau level 0 % - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2616; Record_ID=eye_irritation_1308; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8044171; Assay=Vitrigel; Endpoint=Plateau level; Response=0; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8044171
NTP_ICE_eye_irritation Plateau level 0 % - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2616; Record_ID=eye_irritation_1308; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8044171; Assay=Vitrigel; Endpoint=Plateau level; Response=0; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8044171
NTP_ICE_eye_irritation Plateau level 0 % - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2616; Record_ID=eye_irritation_1308; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8044171; Assay=Vitrigel; Endpoint=Plateau level; Response=0; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8044171
NTP_ICE_eye_irritation Plateau level 0 % - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=2616; Record_ID=eye_irritation_1308; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8044171; Assay=Vitrigel; Endpoint=Plateau level; Response=0; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8044171
ToxValDB_ECHA_IUCLID 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac4ae4b0a7c65d1be501; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/14599?documentUUID=2f224799-939b-417d-a8f9-2e06b72fbc96; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15823434:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bc4211487ea3996b09e4a04d2c81b46a
ToxValDB_ECHA_IUCLID NOAEL =5000 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab1ae4b0a7c65d1b8e37; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/14599?documentUUID=2f224799-939b-417d-a8f9-2e06b72fbc96; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15860565:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_16cf6fbea2231278834a36d54863b32e
openFDA substances 36 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 0WZF1506N9 UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"0WZF1506N9"}
openFDA substances FDA UNII substance identifier WE09129TH5 UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"WE09129TH5"}
openFDA substances FDA UNII substance identifier 43SW2U113W UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"43SW2U113W"}
openFDA substances FDA UNII substance identifier MH590ECD4O UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"MH590ECD4O"}
openFDA substances FDA UNII substance identifier Y825U5K7BE UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"Y825U5K7BE"}
openFDA substances FDA UNII substance identifier 0ZNO9PJJ9J UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"0ZNO9PJJ9J"}
openFDA substances FDA UNII substance identifier 7YC686GQ8F UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"7YC686GQ8F"}
openFDA substances FDA UNII substance identifier 02NG325BQG UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"02NG325BQG"}
openFDA substances FDA UNII substance identifier R07D3A9614 UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"R07D3A9614"}
openFDA substances FDA UNII substance identifier 0WZF1506N9 UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"0WZF1506N9"}
openFDA substances FDA UNII substance identifier 0WZF1506N9 UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"0WZF1506N9"}
openFDA substances FDA UNII substance identifier WE09129TH5 UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"WE09129TH5"}
openFDA substances FDA UNII substance identifier WE09129TH5 UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"WE09129TH5"}
openFDA substances FDA UNII substance identifier 43SW2U113W UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"43SW2U113W"}
openFDA substances FDA UNII substance identifier 43SW2U113W UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"43SW2U113W"}
openFDA substances FDA UNII substance identifier MH590ECD4O UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"MH590ECD4O"}
openFDA substances FDA UNII substance identifier MH590ECD4O UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"MH590ECD4O"}
openFDA substances FDA UNII substance identifier Y825U5K7BE UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"Y825U5K7BE"}
openFDA substances FDA UNII substance identifier Y825U5K7BE UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"Y825U5K7BE"}
openFDA substances FDA UNII substance identifier 0WZF1506N9 UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"0WZF1506N9"}
openFDA substances FDA UNII substance identifier WE09129TH5 UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"WE09129TH5"}
openFDA substances FDA UNII substance identifier 43SW2U113W UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"43SW2U113W"}
openFDA substances FDA UNII substance identifier 0ZNO9PJJ9J UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"0ZNO9PJJ9J"}
openFDA substances FDA UNII substance identifier 0ZNO9PJJ9J UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"0ZNO9PJJ9J"}
openFDA substances FDA UNII substance identifier MH590ECD4O UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"MH590ECD4O"}
openFDA substances FDA UNII substance identifier Y825U5K7BE UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"Y825U5K7BE"}
openFDA substances FDA UNII substance identifier 7YC686GQ8F UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"7YC686GQ8F"}
openFDA substances FDA UNII substance identifier 7YC686GQ8F UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"7YC686GQ8F"}
openFDA substances FDA UNII substance identifier 02NG325BQG UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"02NG325BQG"}
openFDA substances FDA UNII substance identifier 02NG325BQG UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"02NG325BQG"}
openFDA substances FDA UNII substance identifier 0ZNO9PJJ9J UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"0ZNO9PJJ9J"}
openFDA substances FDA UNII substance identifier R07D3A9614 UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"R07D3A9614"}
openFDA substances FDA UNII substance identifier R07D3A9614 UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"R07D3A9614"}
openFDA substances FDA UNII substance identifier 7YC686GQ8F UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"7YC686GQ8F"}
openFDA substances FDA UNII substance identifier 02NG325BQG UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"02NG325BQG"}
openFDA substances FDA UNII substance identifier R07D3A9614 UNII - - - structurallyDiverse {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"structurallyDiverse","unii_code":"R07D3A9614"}