NOAEL Studies
Cosmetic Ingredient
PEG-3 Sorbitan Stearate NOAEL Studies
INCI: PEG-3 SORBITAN STEARATE
CAS: 9005-67-8
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS_DB 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS_DB | NOAEL | 5000 | mg/kg bw/day | rat | oral | 720 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 15000 | mg/kg bw/day | mouse | oral | 120 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 7500 | mg/kg bw/day | hamster | oral | 354 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 2500 | mg/kg bw/day | rat | oral | 720 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 7693 | mg/kg bw/day | rat | oral | 8 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
ToxValDB_ECHA_IUCLID 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LOAEL | =5000 | ppm | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab87e4b0a7c65d1ba9ad; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/11403?documentUUID=bf7712db-97ed-41c7-a3d4-85e11bfea5c7; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=F1: viability; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECHA IUCLID:15859911:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d4985cd93fe3e3f33f7bc02604feb150 |
| ToxValDB_ECHA_IUCLID | NOAEL | =52000 | mg/kg bw/day | Mouse | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac86e4b0a7c65d1bf9b1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/11403?documentUUID=bf7712db-97ed-41c7-a3d4-85e11bfea5c7; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes|fetus: external malformations|fetus: skeletal malformations|fetus: visceral malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15825285:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8b807a1751ab52e35da14fc1944b0a88 |
| ToxValDB_ECHA_IUCLID | NOAEL | =7693 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac86e4b0a7c65d1bf9bc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/11403?documentUUID=bf7712db-97ed-41c7-a3d4-85e11bfea5c7; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15825287:F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6c9df63fc515646c7b374da80555818c |
| ToxValDB_ECHA_IUCLID | NOAEL | =960 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac86e4b0a7c65d1bf9bc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/11403?documentUUID=bf7712db-97ed-41c7-a3d4-85e11bfea5c7; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain|maternal: dead fetuses|maternal: early or late resorptions|maternal: effects on pregnancy duration|maternal: food consumption and compound intake|maternal: maternal abnormalities|maternal: number of abortions|maternal: organ weights and organ / body weight ratios|maternal: pre and post implantation loss|maternal: total litter losses by resorption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|development|food and/or water consumption|organ weight|other|reproduction; STUDY_GROUP=ECHA IUCLID:15825288:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a1f3029257d5e06c1db24b67c67fccb0 |
| ToxValDB_ECHA_IUCLID | NOAEL | =5000 | mg/kg bw/day | Mouse | oral | chronic; 22 months | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf51e4b0a7c65d1cd748; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/11403?documentUUID=bf7712db-97ed-41c7-a3d4-85e11bfea5c7; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15848570:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_747fcfd32ce112f3ff9cb91e800a0a90 |
| ToxValDB_ECHA_IUCLID | NOAEL | =1000 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf51e4b0a7c65d1cd741; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/11403?documentUUID=bf7712db-97ed-41c7-a3d4-85e11bfea5c7; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15849979:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_012301a8c3e9bb87eb91b8097c8aa5ec |
| ToxValDB_ECHA_IUCLID | NOAEL | =10000000 | ppm | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab87e4b0a7c65d1ba9a5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/11403?documentUUID=bf7712db-97ed-41c7-a3d4-85e11bfea5c7; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=ECHA IUCLID:15856949:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_df176e137e1a6d53273bf1d2a16ea4ab |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =98.7 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634905:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2583f40476bbf8620e54336c08bd1bbd |
ToxValDB_WHO_JECFA_ADI 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_WHO_JECFA_ADI | ADI | <=25 | mg/kg | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650b0339e4b0d99f5a8876c1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/397; YEAR=2014; ORIGINAL_YEAR=2014; STUDY_GROUP=WHO JECFA ADI:15715681:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_18ebf022f166f62f8a790bdfd48cb1e7 |
openFDA substances 24 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | CAL22UVI4M | UNII | - | - | - | mixture | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"CAL22UVI4M"} |
| openFDA substances | FDA UNII substance identifier | HD40WR33LC | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"HD40WR33LC"} |
| openFDA substances | FDA UNII substance identifier | 3453J8557N | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"3453J8557N"} |
| openFDA substances | FDA UNII substance identifier | 90SOR12GHG | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C32H62O10","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"90SOR12GHG"} |
| openFDA substances | FDA UNII substance identifier | X61U1UH01B | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"X61U1UH01B"} |
| openFDA substances | FDA UNII substance identifier | 073G38N8GC | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"073G38N8GC"} |
| openFDA substances | FDA UNII substance identifier | CAL22UVI4M | UNII | - | - | - | mixture | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"CAL22UVI4M"} |
| openFDA substances | FDA UNII substance identifier | CAL22UVI4M | UNII | - | - | - | mixture | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"CAL22UVI4M"} |
| openFDA substances | FDA UNII substance identifier | HD40WR33LC | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"HD40WR33LC"} |
| openFDA substances | FDA UNII substance identifier | HD40WR33LC | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"HD40WR33LC"} |
| openFDA substances | FDA UNII substance identifier | 3453J8557N | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"3453J8557N"} |
| openFDA substances | FDA UNII substance identifier | 3453J8557N | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"3453J8557N"} |
| openFDA substances | FDA UNII substance identifier | 90SOR12GHG | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C32H62O10","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"90SOR12GHG"} |
| openFDA substances | FDA UNII substance identifier | 90SOR12GHG | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C32H62O10","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"90SOR12GHG"} |
| openFDA substances | FDA UNII substance identifier | CAL22UVI4M | UNII | - | - | - | mixture | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"CAL22UVI4M"} |
| openFDA substances | FDA UNII substance identifier | HD40WR33LC | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"HD40WR33LC"} |
| openFDA substances | FDA UNII substance identifier | 3453J8557N | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"3453J8557N"} |
| openFDA substances | FDA UNII substance identifier | X61U1UH01B | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"X61U1UH01B"} |
| openFDA substances | FDA UNII substance identifier | X61U1UH01B | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"X61U1UH01B"} |
| openFDA substances | FDA UNII substance identifier | 90SOR12GHG | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C32H62O10","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"90SOR12GHG"} |
| openFDA substances | FDA UNII substance identifier | 073G38N8GC | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"073G38N8GC"} |
| openFDA substances | FDA UNII substance identifier | 073G38N8GC | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"073G38N8GC"} |
| openFDA substances | FDA UNII substance identifier | X61U1UH01B | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"X61U1UH01B"} |
| openFDA substances | FDA UNII substance identifier | 073G38N8GC | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"073G38N8GC"} |