NOAEL Studies Cosmetic Ingredient

PEG-4 NOAEL Studies

CAS: 25322-68-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB NOAEL 230 mg/kg bw/day rat oral 90 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP ICE eye irritation 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE eye irritation Draize rabbit irritation score 0 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=1277; Record_ID=eye_irritation_128; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID4027862; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=0; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4027862; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4027862
NTP ICE eye irritation EPA Classification 4 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=1278; Record_ID=eye_irritation_128; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID4027862; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=4; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4027862; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4027862
NTP ICE eye irritation Intensity 0.01 %/sec - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=1281; Record_ID=eye_irritation_1234; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID4027862; Assay=Vitrigel; Endpoint=Intensity; Response=0.01; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4027862; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4027862
NTP ICE eye irritation Lag time >180 s - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=1280; Record_ID=eye_irritation_1234; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID4027862; Assay=Vitrigel; Endpoint=Lag time; Response_Modifier=>; Response=180; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4027862; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4027862
NTP ICE eye irritation Plateau level 2 % - Ocular - In Vitro; Vitrigel sheet=Data; excel_row=1282; Record_ID=eye_irritation_1234; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID4027862; Assay=Vitrigel; Endpoint=Plateau level; Response=2; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4027862; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4027862
NTP ICE skin irritation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin irritation Positive reaction 0 % Human Dermal - In Vivo; Four-hour Human Patch Test sheet=Data_invivo; excel_row=878; Record_ID=skin_irritation_invivo_62; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID4027862; Assay=Four-hour Human Patch Test; Endpoint=Positive reaction; Response=0; Response_Unit=%; Species=Human; Reference=Basketter et al. 2004; 15291823; 10.1111/j.0105-1873.2004.00385.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4027862; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4027862
ECHA 31 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LEL >=750 mg/kg bw/day Dog oral chronic; 9 months chronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadede4b0a7c65d1c69c4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=1d2c2797-92ef-4900-9da2-53902f562599; YEAR=0; ORIGINAL_YEAR=0; TOXICOLOGICAL_EFFECT=histopathology: non-neoplastic: immature gonad|histopathology: non-neoplastic: prostate gland inflammation; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15851003:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_cef67eab3df84bfcef9fa0227442a0e5
ECHA LEL >=1500 mg/kg bw/day Mouse oral chronic; 104 weeks chronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9ffe4b0a7c65d1b3be1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=1d2c2797-92ef-4900-9da2-53902f562599; YEAR=0; ORIGINAL_YEAR=0; TOXICOLOGICAL_EFFECT=histopathology: non-neoplastic|mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816426_15816427_15820544:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7a7a8459690bcf0c4802b41a9085d41e
ECHA LEL >=3000 mg/kg bw/day Mouse oral chronic; 104 weeks chronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9ffe4b0a7c65d1b3be1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=1d2c2797-92ef-4900-9da2-53902f562599; TOXICOLOGICAL_EFFECT=clinical signs; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816426_15816427_15820544:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8a763a0541fd4ee5dfbfc5bf54a86b09
ECHA LEL >=5000 mg/kg bw/day Dog oral short-term; 2 weeks short-term STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7caabe4b0a7c65d22303a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=b47a82f7-ace5-4769-9e42-03270764a1bb; YEAR=0; ORIGINAL_YEAR=0; TOXICOLOGICAL_EFFECT=clinical signs: abnormal feces composition|clinical signs: vomiting; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15840762_15840763_15851030:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f99d23b61b56898259d3e20713164f75
ECHA LEL >=6000 mg/kg bw/day Dog oral short-term; 28 days short-term STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadede4b0a7c65d1c6a07; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=1d2c2797-92ef-4900-9da2-53902f562599; TOXICOLOGICAL_EFFECT=histopathology: non-neoplastic: Alveolar septal thickening|histopathology: non-neoplastic: histiocytosis|histopathology: non-neoplastic: lung hypertrophy|histopathology: non-neoplastic: lung inflammation|histopathology: non-neoplastic: pulmonary fibrosis|histopathology: non-neoplastic: pulmonary hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15844956_15850955:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_063399e13bca84bc1826508633d1b140
ECHA LEL >=10000 mg/kg bw/day Rat oral short-term; 2 weeks short-term STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca77e4b0a7c65d22203d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=b47a82f7-ace5-4769-9e42-03270764a1bb; YEAR=0; ORIGINAL_YEAR=0; TOXICOLOGICAL_EFFECT=food consumption and compound intake: decreased food intake|urinalysis: urine specific gravity high; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption|urinalysis; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15831433_15831434_15850873:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0b4fd8cc5886890672abfb448d76fe0b
ECHA LEL =20000 mg/kg bw/day Rat oral short-term; 2 weeks short-term STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca77e4b0a7c65d22203d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=b47a82f7-ace5-4769-9e42-03270764a1bb; TOXICOLOGICAL_EFFECT=clinical biochemistry: increased circulating alanine transaminase level|clinical biochemistry: increased circulating bilirubin level|clinical biochemistry: uremia|clinical signs: abnormal feces composition|mortality: abnormal survival|organ weights and organ / body weight ratios: increased kidney weight; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|clinical signs|mortality/survival|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15831433_15831434_15850873:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e0641e38ab25fbcda1bd32017830bde7
ECHA LEL >=40000 mg/kg bw/day Rat oral subchronic; 90 days subchronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadede4b0a7c65d1c6a0f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=b47a82f7-ace5-4769-9e42-03270764a1bb; TOXICOLOGICAL_EFFECT=body weight and weight gain: decreased susceptibility to weight gain|clinical biochemistry: increased circulating alanine transaminase level|clinical biochemistry: increased circulating bilirubin level|clinical biochemistry: increased circulating calcium level|clinical biochemistry: increased circulating chloride level|clinical biochemistry: increased circulating creatinine level|clinical biochemistry: increased circulating glucose level|clinical biochemistry: increased circulating potassium level|clinical biochemistry: increased circulating sodium level|clinical biochemistry: increased circulating total protein level|clinical biochemistry: uremia|clinical signs: abdominal distention|clinical signs: hypoactivity|food consumption and compound intake: decreased food intake|organ weights and organ / body weight ratios: decreased spleen weight|organ weights and organ / body weight ratios: decreased thymus weight|organ weights and organ / body weight ratios: increased adrenal gland weight|organ weights and organ / body weight ratios: increased kidney weight|urinalysis: increased urine ph|urinalysis: polyuria|urinalysis: urine specific gravity high; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|gross pathology|organ weight|urinalysis; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15844960_15844961_15844962_15844963_15850965:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2789bb85d123f496cfb1dab36e156309
ECHA LEL >=50000 mg/kg bw/day Dog oral subchronic; 90 days subchronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadede4b0a7c65d1c69ee; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=b47a82f7-ace5-4769-9e42-03270764a1bb; TOXICOLOGICAL_EFFECT=body weight and weight gain: decreased susceptibility to weight gain|gross pathology: abnormal spleen morphology|gross pathology: discoloration of lung|gross pathology: discoloration of spleen|gross pathology: gastrointestinal hemorrhage|gross pathology: large intestine hemorrhage|histopathology: non-neoplastic: abnormal spleen morphology|histopathology: non-neoplastic: abnormal stomach morphology|histopathology: non-neoplastic: decreased lymphocyte cell number|histopathology: non-neoplastic: thymus hypoplasia; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|gross pathology|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15841640_15841641_15841642_15851007:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1688be63c7d7f9287ae6dfac0f1bdf10
ECHA LEL =60000 mg/kg bw/day Rat oral subchronic; 90 days subchronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadede4b0a7c65d1c6a0f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=b47a82f7-ace5-4769-9e42-03270764a1bb; TOXICOLOGICAL_EFFECT=histopathology: non-neoplastic: cerebral hemorrhage|histopathology: non-neoplastic: thymus hemorrhage|mortality: abnormal survival; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology|mortality/survival|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15844960_15844961_15844962_15844963_15850965:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c7d61096ddbd25a9a7053d79631b3c6b
ECHA LOAEL =156 mg/kg bw/day Rat oral chronic; 2 years chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadede4b0a7c65d1c69f5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/11848?documentUUID=8f68c411-8fc7-41aa-81da-d3d6eabc393e; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15849322:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ecb262f5cfa8c5693602dd4dd4d6d26d
ECHA LOAEL =500 mg/kg bw/day Mouse oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac0de4b0a7c65d1bd1d4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/11848?documentUUID=8f68c411-8fc7-41aa-81da-d3d6eabc393e; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15824638:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_37bed34a6e8aa50f99f36722099ef74d
ECHA LOAEL =1536 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadede4b0a7c65d1c69b9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/11848?documentUUID=8f68c411-8fc7-41aa-81da-d3d6eabc393e; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15831006_15847402:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_245f40c35c84ce50b8590f727b6d052c
ECHA LOAEL =2800 ppm Rat oral subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadede4b0a7c65d1c69fd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/11848?documentUUID=8f68c411-8fc7-41aa-81da-d3d6eabc393e; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15844321_15844322:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b728b87036cb9f8e223ee03a558167fd
ECHA NOAEC =1000 mg/m3 Rat inhalation subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/11848?documentUUID=8f68c411-8fc7-41aa-81da-d3d6eabc393e; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15828657:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e44d561cfb09b3a4ac344694ccf1ab90
ECHA NOAEL =10 mg/kg bw/day Dog oral chronic; 1 years chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadede4b0a7c65d1c69d4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/11848?documentUUID=8f68c411-8fc7-41aa-81da-d3d6eabc393e; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15847544:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_54af8552414104db81f6d20d7ab193dd
ECHA NOAEL =60 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaad2e4b0a7c65d1b7a5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/11848?documentUUID=8f68c411-8fc7-41aa-81da-d3d6eabc393e; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15861782:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f604d81f73bef3643eff59093b4ea1ac
ECHA NOAEL =700 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac0de4b0a7c65d1bd1d4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/11848?documentUUID=8f68c411-8fc7-41aa-81da-d3d6eabc393e; YEAR=2018; ORIGINAL_YEAR=2018; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain|maternal: pre and post implantation loss|maternal: total litter losses by resorption|maternal: changes in number of pregnant|maternal: changes in pregnancy duration|maternal: early or late resorptions|maternal: effects on pregnancy duration|maternal: gross pathology|maternal: histopathology: non-neoplastic|maternal: necropsy findings|maternal: number of abortions|maternal: organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|gross pathology|nonneoplastic histopathology|organ weight|reproduction; STUDY_GROUP=ECHA IUCLID:15824637:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3ec0d18d983530e78e1159be0d3da82c
ECHA NOAEL =768 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadede4b0a7c65d1c69b9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/11848?documentUUID=8f68c411-8fc7-41aa-81da-d3d6eabc393e; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15831006_15847402:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_48ca37e42321d1c6a1cf8eae286ec438
ECHA NOAEL =1100 ppm Rat oral subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadede4b0a7c65d1c69fd; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/11848?documentUUID=8f68c411-8fc7-41aa-81da-d3d6eabc393e; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15844321_15844322:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fc71e3968749a10df8775a5212f8edca
ECHA NOAEL >=1500 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac0de4b0a7c65d1bd1e0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/11848?documentUUID=8f68c411-8fc7-41aa-81da-d3d6eabc393e; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15823201_15824639:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_591c683770e195e65779ec8227985af2
ECHA NOAEL =1667 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaad2e4b0a7c65d1b7a65; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/11848?documentUUID=8f68c411-8fc7-41aa-81da-d3d6eabc393e; YEAR=2018; ORIGINAL_YEAR=2018; TOXICOLOGICAL_EFFECT=P0: body weight and weight gain|P0: food consumption and compound intake|P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|reproduction; STUDY_GROUP=ECHA IUCLID:15861006:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e7e93c4d2c303bf3f6330eb1da9c73e8
ECHA NOAEL =1690 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaad2e4b0a7c65d1b7a5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/11848?documentUUID=8f68c411-8fc7-41aa-81da-d3d6eabc393e; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15862197:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_20f6fc3a6118e17775f576cf7107cc14
ECHA NOAEL <=5000 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac0de4b0a7c65d1bd1e0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/11848?documentUUID=8f68c411-8fc7-41aa-81da-d3d6eabc393e; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15823201_15824639:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a13a16e6239e6e8eef0eeb74d70e2d8a
ECHA NOAEL <5699 mg/kg bw/day Rat oral - reproduction developmental QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaad2e4b0a7c65d1b7a55; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/11848?documentUUID=8f68c411-8fc7-41aa-81da-d3d6eabc393e; YEAR=2018; ORIGINAL_YEAR=2018; TOXICOLOGICAL_EFFECT=P0: mortality|P0: gross pathology|P0: histopathology: non-neoplastic|P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology|mortality/survival|nonneoplastic histopathology|reproduction; STUDY_GROUP=ECHA IUCLID:15862041:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5168a4e0dba663ca7f3aa92444b9dbc4
ECHA NOEL <=3000 mg/kg bw/day Dog oral chronic; 9 months chronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadede4b0a7c65d1c69c4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=1d2c2797-92ef-4900-9da2-53902f562599; TOXICOLOGICAL_EFFECT=body weight and weight gain: no abnormal phenotype detected|clinical biochemistry: no abnormal phenotype detected|food consumption and compound intake: no abnormal phenotype detected|gross pathology: no abnormal phenotype detected|haematology: no abnormal phenotype detected|ophthalmological examination: no abnormal phenotype detected|organ weights and organ / body weight ratios: no abnormal phenotype detected|urinalysis: no abnormal phenotype detected; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833701_15851024:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_13c2641b69f1c405aa73b080a697bfdc
ECHA NOEL <=6000 mg/kg bw/day Mouse oral chronic; 104 weeks chronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9ffe4b0a7c65d1b3be1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=1d2c2797-92ef-4900-9da2-53902f562599; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical biochemistry|food consumption and compound intake|gross pathology|haematology|histopathology: neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|clinical chemistry|food and/or water consumption|gross pathology|hematology; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816426_15816427_15820544:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b77501ad67219e64e25401cd5e0408fa
ECHA NOEL <=8000 mg/kg bw/day Rat oral chronic; 2 years chronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9ffe4b0a7c65d1b3be7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=b47a82f7-ace5-4769-9e42-03270764a1bb; TOXICOLOGICAL_EFFECT=mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819798_15820539:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ba1080e5c7f7fe12b6198962301633b3
ECHA NOEL <=9300 mg/kg bw/day Dog oral short-term; 28 days short-term STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadede4b0a7c65d1c6a07; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=1d2c2797-92ef-4900-9da2-53902f562599; TOXICOLOGICAL_EFFECT=body weight and weight gain: no abnormal phenotype detected|clinical biochemistry: no abnormal phenotype detected|food consumption and compound intake: no abnormal phenotype detected|gross pathology: no abnormal phenotype detected|haematology: no abnormal phenotype detected|mortality: no abnormal phenotype detected|ophthalmological examination: no abnormal phenotype detected|organ weights and organ / body weight ratios: no abnormal phenotype detected|urinalysis: no abnormal phenotype detected; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15844955_15851017:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_53110a23c02b2dffe8a2dbd5e14eeec3
ECHA NOEL <=20000 mg/kg bw/day Dog oral short-term; 2 weeks short-term STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7caabe4b0a7c65d22303a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=b47a82f7-ace5-4769-9e42-03270764a1bb; TOXICOLOGICAL_EFFECT=body weight and weight gain: no abnormal phenotype detected|food consumption and compound intake: no abnormal phenotype detected|gross pathology: no abnormal phenotype detected|haematology: no abnormal phenotype detected|histopathology: non-neoplastic: no abnormal phenotype detected|mortality: no abnormal phenotype detected|ophthalmological examination: no abnormal phenotype detected|organ weights and organ / body weight ratios: no abnormal phenotype detected|urinalysis: no abnormal phenotype detected; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15840762_15840763_15851030:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_92b950bbee2c834beae9eed739598069
ECHA NOEL <=60000 mg/kg bw/day Dog oral subchronic; 90 days subchronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadede4b0a7c65d1c69ee; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=b47a82f7-ace5-4769-9e42-03270764a1bb; TOXICOLOGICAL_EFFECT=organ weights and organ / body weight ratios: no abnormal phenotype detected|urinalysis: no abnormal phenotype detected; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15841640_15841641_15841642_15851007:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5c10547b1b4fcd26e11d164e5c9409c6
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =40.2 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634211:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6f08f77f1780a5e9b00b6bcadd657e74
WHO/JECFA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
WHO/JECFA ADI <=10 mg/kg Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650affb8e4b0d99f5a8826cb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/4750; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=WHO JECFA ADI:15715642:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c32daa7fe6336763830f5eaf83460d6c
openFDA substances 53 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 11628IH70O UNII - - - polymer -
openFDA substances FDA UNII substance identifier 1212Z7S33A UNII - - - polymer -
openFDA substances FDA UNII substance identifier 16P9295IIL UNII - - - polymer -
openFDA substances FDA UNII substance identifier 2126FD486L UNII - - - polymer -
openFDA substances FDA UNII substance identifier 2L7WA456VA UNII - - - polymer -
openFDA substances FDA UNII substance identifier 30IQX730WE UNII - - - polymer -
openFDA substances FDA UNII substance identifier 3H4G04L531 UNII - - - polymer -
openFDA substances FDA UNII substance identifier 3IG9032SAH UNII - - - polymer -
openFDA substances FDA UNII substance identifier 3WJQ0SDW1A UNII - - - mixture -
openFDA substances FDA UNII substance identifier 439X29GCJZ UNII - - - polymer -
openFDA substances FDA UNII substance identifier 4QIB4U4CQR UNII - - - polymer -
openFDA substances FDA UNII substance identifier 4R4HFI6D95 UNII - - - polymer -
openFDA substances FDA UNII substance identifier 5246R0812J UNII - - - polymer -
openFDA substances FDA UNII substance identifier 5655G9Y8AQ UNII - - - polymer -
openFDA substances FDA UNII substance identifier 5IRA46LB71 UNII - - - polymer -
openFDA substances FDA UNII substance identifier 5K3991GVWI UNII - - - polymer -
openFDA substances FDA UNII substance identifier 5WKN5KL2O8 UNII - - - polymer -
openFDA substances FDA UNII substance identifier 74D3A2BP47 UNII - - - polymer -
openFDA substances FDA UNII substance identifier 761NX2Q08Y UNII - - - polymer -
openFDA substances FDA UNII substance identifier 762678AC5R UNII - - - polymer -
openFDA substances FDA UNII substance identifier 77HY82S0LG UNII - - - polymer -
openFDA substances FDA UNII substance identifier 7Z3ER739EB UNII - - - polymer -
openFDA substances FDA UNII substance identifier 8EIY1IHX76 UNII - - - polymer -
openFDA substances FDA UNII substance identifier 9XH9HVO466 UNII - - - polymer -
openFDA substances FDA UNII substance identifier B697894SGQ UNII - - - polymer -
openFDA substances FDA UNII substance identifier FVS1AZD90Y UNII - - - polymer -
openFDA substances FDA UNII substance identifier G2M7P15E5P UNII - - - polymer -
openFDA substances FDA UNII substance identifier G3MS6M810Y UNII - - - polymer -
openFDA substances FDA UNII substance identifier H57W405143 UNII - - - polymer -
openFDA substances FDA UNII substance identifier HAF0412YIT UNII - - - polymer -
openFDA substances FDA UNII substance identifier HZ58M6D839 UNII - - - polymer -
openFDA substances FDA UNII substance identifier NL4J9F21N9 UNII - - - polymer -
openFDA substances FDA UNII substance identifier OJ4Z5Z32L4 UNII - - - polymer -
openFDA substances FDA UNII substance identifier Q0JET65GEL UNII - - - polymer -
openFDA substances FDA UNII substance identifier Q662QK8M3B UNII - - - polymer -
openFDA substances FDA UNII substance identifier R0XY39567G UNII - - - polymer -
openFDA substances FDA UNII substance identifier R95B8J264J UNII - - - polymer -
openFDA substances FDA UNII substance identifier RU64142H6P UNII - - - polymer -
openFDA substances FDA UNII substance identifier RVV61677RZ UNII - - - polymer -
openFDA substances FDA UNII substance identifier SA1B764746 UNII - - - polymer -
openFDA substances FDA UNII substance identifier TU0XPZ7FZT UNII - - - polymer -
openFDA substances FDA UNII substance identifier TVH7653921 UNII - - - polymer -
openFDA substances FDA UNII substance identifier U076Q6Q621 UNII - - - polymer -
openFDA substances FDA UNII substance identifier U95VVU3IDQ UNII - - - polymer -
openFDA substances FDA UNII substance identifier UEP843BRCQ UNII - - - polymer -
openFDA substances FDA UNII substance identifier UH6KR4953D UNII - - - polymer -
openFDA substances FDA UNII substance identifier V146K8QJ07 UNII - - - polymer -
openFDA substances FDA UNII substance identifier V46Y6OJ5QB UNII - - - polymer -
openFDA substances FDA UNII substance identifier VM53EE110J UNII - - - polymer -
openFDA substances FDA UNII substance identifier X83H03O8BZ UNII - - - polymer -
openFDA substances FDA UNII substance identifier Y4QO2MSY3X UNII - - - polymer -
openFDA substances FDA UNII substance identifier ZBR3T82M2V UNII - - - polymer -
openFDA substances FDA UNII substance identifier concept identifier - - - concept -