NOAEL Studies Cosmetic Ingredient

PEG-5 COCAMINE NOAEL Studies

CAS: 61791-14-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR Safety Assessment 17 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR Safety Assessment NOAEL =0.015 % dog oral 90 days repeated dose toxicity 0; 5; 015, p.23
CIR Safety Assessment NOAEL =1 ppm rat oral 28 days reproductive toxicity 1,500; 4,500; 500, p.23
CIR Safety Assessment NOAEL =5 mg/kg/d rat oral 4-week developmental toxicity 100; 2; 100, 300, p.43
CIR Safety Assessment NOAEL =12 mg/kg/d rat oral 90-day repeated dose toxicity 23; 10; 2, p.41
CIR Safety Assessment NOAEL =13 mg/kg/d rat oral 90-day repeated dose toxicity 13; 50; 2, p.23
CIR Safety Assessment NOAEL =15 mg/kg/d rat oral 90-day repeated dose toxicity 150; 30; 15, p.24
CIR Safety Assessment NOAEL =23 mg/kg/d rat oral 72 days repeated dose toxicity 12; 1; 2, p.41
CIR Safety Assessment NOAEL =30 mg/kg/d rat oral 28-day repeated dose toxicity 28; 0; 1, p.41
CIR Safety Assessment NOAEL =33 mg/kg/d rat oral 90-day repeated dose toxicity 14; 3; 10, p.43
CIR Safety Assessment NOAEL =40 mg/kg/d mouse - 28-day NOAEL study 9; 28; 10, p.44
CIR Safety Assessment NOAEL =50 mg/kg/d rat oral 72 days repeated dose toxicity 2, 8, 23, 134; 3, 9, 26, 148; 69, p.41
CIR Safety Assessment NOAEL =75 mg/kg/d rat oral 4-week repeated dose toxicity 15; 4; 14, p.44
CIR Safety Assessment NOAEL =100 mg/kg/d rat oral 70 days developmental toxicity 15; 100; 300, p.26
CIR Safety Assessment NOAEL =134 mg/kg/d rat oral 72 days repeated dose toxicity 12; 1; 2, p.41
CIR Safety Assessment NOAEL =300 ppm rat oral - developmental toxicity 300; (23; 16, p.26
CIR Safety Assessment NOAEL =500 ppm rat oral 28-day oral toxicity 500; (33; 40, p.24
CIR Safety Assessment NOAEL =1000 ppm - - - developmental toxicity 1,000; (65; 66, p.26
Regulatory source 18 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 40 mg/kg/d mouse - 28-day - p.44
Regulatory source developmental toxicity 1 ppm rat oral 70 days developmental toxicity p.26
Regulatory source developmental toxicity 5 mg/kg/d rat oral 4-week developmental toxicity p.43
Regulatory source developmental toxicity 100 mg/kg/d rat oral 70 days developmental toxicity p.26
Regulatory source developmental toxicity 300 ppm rat oral - developmental toxicity p.26
Regulatory source developmental toxicity 1000 ppm - - - developmental toxicity p.26
Regulatory source oral toxicity 500 ppm rat oral 28-day oral toxicity p.24
Regulatory source repeated dose toxicity 0.015 % dog oral 90 days repeated dose toxicity p.23
Regulatory source repeated dose toxicity 12 mg/kg/d rat oral 90-day repeated dose toxicity p.41
Regulatory source repeated dose toxicity 13 mg/kg/d rat oral 90-day repeated dose toxicity p.23
Regulatory source repeated dose toxicity 15 mg/kg/d rat oral 90-day repeated dose toxicity p.24
Regulatory source repeated dose toxicity 23 mg/kg/d rat oral 72 days repeated dose toxicity p.41
Regulatory source repeated dose toxicity 30 mg/kg/d rat oral 28-day repeated dose toxicity p.41
Regulatory source repeated dose toxicity 33 mg/kg/d rat oral 90-day repeated dose toxicity p.43
Regulatory source repeated dose toxicity 50 mg/kg/d rat oral 72 days repeated dose toxicity p.41
Regulatory source repeated dose toxicity 75 mg/kg/d rat oral 4-week repeated dose toxicity p.44
Regulatory source repeated dose toxicity 134 mg/kg/d rat oral 72 days repeated dose toxicity p.41
Regulatory source reproductive toxicity 1 ppm rat oral 28 days reproductive toxicity p.23
openFDA substances 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier ZA36V5XS8F UNII - - - mixture -
openFDA substances FDA UNII substance identifier 28053HD34J UNII - - - mixture -
openFDA substances FDA UNII substance identifier 2F9J4Q575K UNII - - - mixture -
openFDA substances FDA UNII substance identifier 8L6LB12TSJ UNII - - - mixture -
openFDA substances FDA UNII substance identifier KTM00873VC UNII - - - mixture -
openFDA substances FDA UNII substance identifier PMT39AFQ4Z UNII - - - mixture -
openFDA substances FDA UNII substance identifier Z99UKQ29D9 UNII - - - mixture -