Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for PEG/PPG-10/2 Copolymer. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 25000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 30000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 480 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 3000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 200 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
| NOAEL | 40 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
Expert Verdict
PEG/PPG-10/2 Copolymer is a permitted emulsifier with adequate safety margin; residual impurities such as 1,4-dioxane and ethylene oxide from ethoxylation manufacturing should be controlled.
Regulatory Flags
Frequently Asked Questions
Is PEG/PPG-10/2 Copolymer safe in cosmetics?
PEG/PPG-10/2 Copolymer is a permitted emulsifier with adequate safety margin; residual impurities such as 1,4-dioxane and ethylene oxide from ethoxylation manufacturing should be controlled. The EU classifies PEG/PPG-10/2 Copolymer as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is PEG/PPG-10/2 Copolymer allowed in the EU?
PEG/PPG-10/2 Copolymer EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does PEG/PPG-10/2 Copolymer do in cosmetics?
PEG/PPG-10/2 Copolymer functions as: Emulsifier. It is classified as a cosmetic ingredient in our database. CAS number: 9003-11-6.
What is the Margin of Safety for PEG/PPG-10/2 Copolymer?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for PEG/PPG-10/2 Copolymer?
The NOAEL (No Observed Adverse Effect Level) for PEG/PPG-10/2 Copolymer is 25000 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check PEG/PPG-10/2 Copolymer compliance across multiple jurisdictions:
Related Ingredients
Is PEG/PPG-10/2 Copolymer in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for PEG/PPG-10/2 Copolymer in your formulation.