Pentadoxynol-200

INCI: PENTADOXYNOL-200

CAS Number
Not publicly assigned (ethoxylated pentadecylphenol, 200 mol EO)
Function
Skin conditioning – emollient; surfactant – cleansing
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not specifically regulated by FDA; no CIR review

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

1,4-Dioxane contamination risk from ethoxylation process must be tested and controlled; alkylphenol ethoxylate presents potential endocrine disruption concern for environmental discharge; monitor residual ethylene oxide.

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Concern Level: Moderate

Frequently Asked Questions

Is Pentadoxynol-200 safe in cosmetics?

1,4-Dioxane contamination risk from ethoxylation process must be tested and controlled; alkylphenol ethoxylate presents potential endocrine disruption concern for environmental discharge; monitor residual ethylene oxide. The EU classifies Pentadoxynol-200 as "permitted". Safety rating: MODERATE.

Is Pentadoxynol-200 allowed in the EU?

Pentadoxynol-200 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Pentadoxynol-200 do in cosmetics?

Pentadoxynol-200 functions as: Skin conditioning – emollient; surfactant – cleansing. It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned (ethoxylated pentadecylphenol, 200 mol EO).

What is the Margin of Safety for Pentadoxynol-200?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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