Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Pentaerythrityl Rosinates. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOEL | 3000 ppm | oral | rat | oral | REACH |
| NOEL | 3000 ppm | oral | - | oral | REACH |
| NOAEL | 18000 other | oral | rat | oral | REACH |
| NOAEL | 18000 other | oral | - | oral | REACH |
| NOEL | 500 other | oral | rat | oral | REACH |
| NOEL | 500 other | oral | - | oral | REACH |
| NOEL | 500 other | oral | rat | oral | REACH |
| NOEL | 500 other | oral | - | oral | REACH |
| NOEL | 10000 ppm | oral | rat | oral | REACH |
| NOEL | 10000 ppm | oral | - | oral | REACH |
Expert Verdict
CIR determined insufficient data. Missing genotoxicity assays (≥1 mammalian), dermal absorption study, and chemical properties including structure and impurities. Formulations at 7–9.6% were non-irritating and non-sensitizing in HRIPT, but genotoxicity and impurity data gaps remain unresolved.
Regulatory Flags
Frequently Asked Questions
Is Pentaerythrityl Rosinates safe in cosmetics?
CIR determined insufficient data. Missing genotoxicity assays (≥1 mammalian), dermal absorption study, and chemical properties including structure and impurities. Formulations at 7–9.6% were non-irritating and non-sensitizing in HRIPT, but genotoxicity and impurity data gaps remain unresolved. The EU classifies Pentaerythrityl Rosinates as "permitted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.
Is Pentaerythrityl Rosinates allowed in the EU?
Pentaerythrityl Rosinates EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Pentaerythrityl Rosinates do in cosmetics?
Pentaerythrityl Rosinates functions as: Skin conditioning – emollient; viscosity increasing – nonaqueous; film forming. It is classified as a cosmetic ingredient in our database. CAS number: 8050-26-8.
What is the Margin of Safety for Pentaerythrityl Rosinates?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Pentaerythrityl Rosinates?
The NOAEL (No Observed Adverse Effect Level) for Pentaerythrityl Rosinates is 3000 ppm based on a oral study via oral route in rat. A total of 10 study endpoints are available. Source: REACH.
Compliance Tools
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