Pentamethyl-Spirobicycloheptane-Dioxane

INCI: PENTAMETHYL-SPIROBICYCLOHEPTANE-DIOXANE

CAS Number
121251-67-0 (Spirambrene / amber carane type)
Function
Fragrance — amber type odor
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted as fragrance ingredient

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

RIFM evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, skin sensitization, and phototoxicity. Cleared with no restrictions. Environmentally persistent fragrance typical of polycyclic musks and amber types.

⚠️
Concern Level: Low

Regulatory Flags

potential-allergen fragrance-component

Frequently Asked Questions

Is Pentamethyl-Spirobicycloheptane-Dioxane safe in cosmetics?

RIFM evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, skin sensitization, and phototoxicity. Cleared with no restrictions. Environmentally persistent fragrance typical of polycyclic musks and amber types. The EU classifies Pentamethyl-Spirobicycloheptane-Dioxane as "permitted". Safety rating: GOOD.

Is Pentamethyl-Spirobicycloheptane-Dioxane allowed in the EU?

Pentamethyl-Spirobicycloheptane-Dioxane EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Pentamethyl-Spirobicycloheptane-Dioxane do in cosmetics?

Pentamethyl-Spirobicycloheptane-Dioxane functions as: Fragrance — amber type odor. It is classified as a cosmetic ingredient in our database. CAS number: 121251-67-0 (Spirambrene / amber carane type).

What is the Margin of Safety for Pentamethyl-Spirobicycloheptane-Dioxane?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

📱

Is Pentamethyl-Spirobicycloheptane-Dioxane in Your Products?

Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free →

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Pentamethyl-Spirobicycloheptane-Dioxane in your formulation.