Pentapeptide-14

INCI: PENTAPEPTIDE-14

CAS Number
Proprietary/not publicly assigned a universal CAS (peptide sequence-specific)
Function
Skin conditioning agent, anti-aging (modulates cellular senescence)
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes CIR reviewed pentapeptide ingredients (including KTTKS and KTSKS sequences) and concluded safe in present practices of use and concentration

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Minimal safety concern. All tested concentrations improved tissue viability compared to untreated controls; palmitoylated versions may have different penetration profiles.

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Concern Level: Low

Frequently Asked Questions

Is Pentapeptide-14 safe in cosmetics?

Minimal safety concern. All tested concentrations improved tissue viability compared to untreated controls; palmitoylated versions may have different penetration profiles. The EU classifies Pentapeptide-14 as "permitted". Safety rating: EXCELLENT.

Is Pentapeptide-14 allowed in the EU?

Pentapeptide-14 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Pentapeptide-14 do in cosmetics?

Pentapeptide-14 functions as: Skin conditioning agent, anti-aging (modulates cellular senescence). It is classified as a cosmetic ingredient in our database. CAS number: Proprietary/not publicly assigned a universal CAS (peptide sequence-specific).

What is the Margin of Safety for Pentapeptide-14?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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