NOAEL Studies Cosmetic Ingredient

Peppermint Oil CO2 Extract NOAEL Studies

INCI: MENTHA PIPERITA OIL

CAS: 8006-90-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR Safety Assessment 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR Safety Assessment NOAEL =40 mg/kg/d rat - - NOAEL study 100; 40; 1, p.11
COSMOS DB 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB NOAEL 75 mg/kg bw/day rat oral 28 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 100 mg/kg bw/day rat oral 28 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 125 mg/kg bw/day dog oral 35 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 500 mg/kg bw/day rat oral 35 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 747 mg/kg bw/day rat oral 1 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP ICE endocrine 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine AC50 33.5252100339392 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=13002; RecordID=ERPathway2016_408; DatasetName=ERPathway2016; DTXSID=DTXSID6021113; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=33.5252100339392; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021113
NTP ICE endocrine ACC 67.2663767739755 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=13003; RecordID=ERPathway2016_408; DatasetName=ERPathway2016; DTXSID=DTXSID6021113; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=67.2663767739755; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021113
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=12998; RecordID=ARPathway2016_1596; DatasetName=ARPathway2016; DTXSID=DTXSID6021113; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021113
NTP ICE endocrine Model Score 0.00851 unitless - - - ERPathway2016; ER Pathway Model, Agonist sheet=Integrated_approaches; excel_row=13004; RecordID=ERPathway2016_408; DatasetName=ERPathway2016; DTXSID=DTXSID6021113; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.00851; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021113
Regulatory source 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 40 mg/kg/d rat - - - p.11
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier AV092KU4JH UNII - - - structurallyDiverse -