Poor Cosmetic Ingredient

Perillaldehyde

INCI: PERILLALDEHYDE

CAS Number
2111-75-3 (racemic); 18031-40-8 (S-enantiomer)
Function
Fragrance, denaturant
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status restricted
🇺🇸 US Status permitted
US Notes FEMA GRAS (No. 2786) for flavoring. FDA permits in cosmetics as fragrance; no specific concentration limit.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Strong skin sensitizer with pre-hapten characteristics that may auto-oxidize to more potent sensitizers; aldehyde reactivity with proteins drives sensitization. EU labelling thresholds: 0.001% leave-on / 0.01% rinse-off under Annex III fragrance allergen rules if included in expanded list. IFRA Category limits apply.

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Concern Level: High

Regulatory Flags

potential-allergen fragrance-component ifra_fragrance fda_food_additive eu_cosing_listed

Frequently Asked Questions

Is Perillaldehyde safe in cosmetics?

Strong skin sensitizer with pre-hapten characteristics that may auto-oxidize to more potent sensitizers; aldehyde reactivity with proteins drives sensitization. EU labelling thresholds: 0.001% leave-on / 0.01% rinse-off under Annex III fragrance allergen rules if included in expanded list. IFRA Category limits apply. The EU classifies Perillaldehyde as "restricted". Safety rating: POOR.

Is Perillaldehyde allowed in the EU?

Perillaldehyde EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Perillaldehyde do in cosmetics?

Perillaldehyde functions as: Fragrance, denaturant. It is classified as a cosmetic ingredient in our database. CAS number: 2111-75-3 (racemic); 18031-40-8 (S-enantiomer).

What is the Margin of Safety for Perillaldehyde?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Perillaldehyde compliance across multiple jurisdictions:

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Ingredient Decoder
Paste a full ingredient list for instant analysis
 🌸
82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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