Regulatory Status
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Safety Data
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Expert Verdict
Contains pyrrolizidine alkaloids (senkirkine, petasitenine, neopetasitenine) with hepatotoxic, genotoxic, and potentially carcinogenic properties; EMA HMPC public statement applies; must use PA-depleted/certified extracts with analytical verification.
Regulatory Flags
Frequently Asked Questions
Is Petasites Hybridus Leaf Extract safe in cosmetics?
Contains pyrrolizidine alkaloids (senkirkine, petasitenine, neopetasitenine) with hepatotoxic, genotoxic, and potentially carcinogenic properties; EMA HMPC public statement applies; must use PA-depleted/certified extracts with analytical verification. The EU classifies Petasites Hybridus Leaf Extract as "permitted". Safety rating: POOR.
Is Petasites Hybridus Leaf Extract allowed in the EU?
Petasites Hybridus Leaf Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Petasites Hybridus Leaf Extract do in cosmetics?
Petasites Hybridus Leaf Extract functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 90082-63-6.
What is the Margin of Safety for Petasites Hybridus Leaf Extract?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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