NOAEL Studies
Cosmetic Ingredient
Phenol NOAEL Studies
INCI: PHENOL
CAS: 108-95-2
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS DB 19 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | LOAEL | 2500 | ppm | rat | oral | 103 week | Chronic | REACH; NTP TR 203, 1980 |
| COSMOS DB | NOAEL | 1.8 | mg/kg bw/day | mouse | oral | 28 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 20 | mg/kg bw/day | rat | oral | 261 day | Multigeneration Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 40 | mg/kg bw/day | rat | oral | 14 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 86.2 | mg/kg bw/day | rat | oral | 28 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 120 | mg/kg bw/day | rat | oral | 10 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 160 | mg/kg bw/day | rat | oral | 10 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 167 | mg/kg bw/day | rat | oral | 136 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 180 | mg/kg bw/day | rat | oral | 10 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 224 | mg/kg bw/day | rat | oral | 365 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 230 | mg/kg bw/day | mouse | oral | 10 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 280 | mg/kg bw/day | mouse | oral | 10 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 308 | mg/kg bw/day | rat | oral | 91 day | Neurotoxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 500 | mg/kg bw/day | rat | oral | 721 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 625 | mg/kg bw/day | mouse | oral | 721 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 667 | mg/kg bw/day | rat | oral | 1 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 750 | mg/kg bw/day | mouse | oral | 255 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 1000 | mg/kg bw/day | rat | oral | 91 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 2500 | mg/kg bw/day | mouse | oral | 91 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
ECHA 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | 260 | mg/kg bw/day | rabbit | - | - | short-term repeated dose toxicity: dermal | dossier=11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6z; document=68521c0a-ba56-4382-87f5-661d17752938_11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6d; document_key=68521c0a-ba56-4382-87f5-661d17752938/11a1f031-f1a8-4bcc-a543-ab5834bb5458; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1950; basis=other:; key_result=false; entry_uuid=4d9028ce-5975-4613-a710-740788844f35 |
| ECHA | NOAEL | 130 | mg/kg bw/day | rabbit | - | - | short-term repeated dose toxicity: dermal | dossier=11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6z; document=68521c0a-ba56-4382-87f5-661d17752938_11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6d; document_key=68521c0a-ba56-4382-87f5-661d17752938/11a1f031-f1a8-4bcc-a543-ab5834bb5458; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1950; basis=other:; key_result=false; entry_uuid=ef0a9886-ca70-4f5d-8830-5e312779ff27 |
| ECHA | NOAEL | 140 | mg/kg bw/day | mouse | oral: gavage | - | developmental toxicity | dossier=11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6z; document=9e4f67c4-a934-474c-bb1f-4b5432343a38_11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6d; document_key=9e4f67c4-a934-474c-bb1f-4b5432343a38/11a1f031-f1a8-4bcc-a543-ab5834bb5458; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1983; ReportDate=1983-07-23; basis=other:; key_result=false; entry_uuid=6a901bd7-7fe9-45d4-b126-00c8d595526c |
| ECHA | NOAEL | 60 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6z; document=7d4dcf62-6c06-4025-87b5-3783ab4b4561_11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6d; document_key=7d4dcf62-6c06-4025-87b5-3783ab4b4561/11a1f031-f1a8-4bcc-a543-ab5834bb5458; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2002; basis=other:; key_result=false; entry_uuid=f701027f-900e-4ed7-bae9-45c090a35400 |
| ECHA | NOAEL | 120 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6z; document=7d4dcf62-6c06-4025-87b5-3783ab4b4561_11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6d; document_key=7d4dcf62-6c06-4025-87b5-3783ab4b4561/11a1f031-f1a8-4bcc-a543-ab5834bb5458; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2002; basis=other:; key_result=false; entry_uuid=4d3e3f5d-b067-419a-b281-2e1b25e995b8 |
| ECHA | NOAEL | 30 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6z; document=3846c7ae-0420-4e7a-bff4-59fd5815ebec_11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6d; document_key=3846c7ae-0420-4e7a-bff4-59fd5815ebec/11a1f031-f1a8-4bcc-a543-ab5834bb5458; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2020; basis=mortality; key_result=false; entry_uuid=089c5f30-48d5-4a5f-af8d-99a2eed0e72b |
| ECHA | NOAEL | 15 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6z; document=3846c7ae-0420-4e7a-bff4-59fd5815ebec_11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6d; document_key=3846c7ae-0420-4e7a-bff4-59fd5815ebec/11a1f031-f1a8-4bcc-a543-ab5834bb5458; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2020; basis=other:; key_result=false; entry_uuid=811fec91-d8f7-4d76-9825-e96b91e8c982 |
EFSA 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | LOAEL | =1.8 | mg/kg bw/day | Mouse | oral: drinking water | 28 days | short-term toxicity | EFSA AFC - 2008 - OutputID 2285 - haematology - systemic - Flavouring Group Evaluation 88, (FGE.88). Consideration of Phenol and Phenol Derivatives evaluated by JECFA (55th meeting). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food - doi:10.2903/j.efsa.2008.857 |
| EFSA | NOAEL | =60 | mg/kg bw | Rat | oral: gavage | 10 days | reproduction toxicity | EFSA CEF - 2013 - OutputID 2220 - body weight - reproductive - Scientific Opinion on the toxicological evaluation of phenol - doi:10.2903/j.efsa.2013.3189 |
| EFSA | NOAEL | =120 | mg/kg bw | Rat | oral: gavage | 10 days | reproduction toxicity | EFSA CEF - 2013 - OutputID 2220 - development - teratogenic - Scientific Opinion on the toxicological evaluation of phenol - doi:10.2903/j.efsa.2013.3189 |
| EFSA | BMDL (10) | =52 | mg/kg bw/day | Rat | oral | short-term; 10 days | reproduction developmental | LONG_REF=EFSA CEF (2013). Scientific Opinion on the toxicological evaluation of phenol. doi:10.2903/j.efsa.2013.3189.; TITLE=Scientific Opinion on the toxicological evaluation of phenol; AUTHOR=EFSA CEF; DOI=doi:10.2903/j.efsa.2013.3189; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA:15620862:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e32fcf14baa2da3b9b5f8e486d1452e6 |
| EFSA | LOAEL | =1.8 | mg/kg bw/day | Mouse | oral | short-term; 28 days | short-term | LONG_REF=EFSA AFC (2008). Flavouring Group Evaluation 88, (FGE.88). Consideration of Phenol and Phenol Derivatives evaluated by JECFA (55th meeting). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food. doi:10.2903/j.efsa.2008.857.; TITLE=Flavouring Group Evaluation 88, (FGE.88). Consideration of Phenol and Phenol Derivatives evaluated by JECFA (55th meeting). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food; AUTHOR=EFSA AFC; DOI=doi:10.2903/j.efsa.2008.857; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=hematological; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=EFSA:15620863:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6b42b419e0d52162251ffaaa7cfabe09 |
| EFSA | NOAEL | =60 | mg/kg bw/day | Rat | oral | short-term; 10 days | reproduction developmental | LONG_REF=EFSA CEF (2013). Scientific Opinion on the toxicological evaluation of phenol. doi:10.2903/j.efsa.2013.3189.; TITLE=Scientific Opinion on the toxicological evaluation of phenol; AUTHOR=EFSA CEF; DOI=doi:10.2903/j.efsa.2013.3189; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA:15620860:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fbd60d8a396e6e37826662e6e7ed0a56 |
| EFSA | NOAEL | =120 | mg/kg bw/day | Rat | oral | short-term; 10 days | developmental | LONG_REF=EFSA CEF (2013). Scientific Opinion on the toxicological evaluation of phenol. doi:10.2903/j.efsa.2013.3189.; TITLE=Scientific Opinion on the toxicological evaluation of phenol; AUTHOR=EFSA CEF; DOI=doi:10.2903/j.efsa.2013.3189; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=development; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=EFSA:15620861:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e662810fb23b5b4a2f8d5edd753554f1 |
Regulatory source 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | BMDL | =93 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system PoD | row_hash=499e8263a9b18a0c; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=BMDL : 93 mg/kg-day; system=Other; basis=Decreased maternal weight gain; point_of_departure=BMDL : 93 mg/kg-day; composite_uf=300; confidence=Medium/High; dtxsid=DTXSID5021124; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=88; rfd_last_updated=09/30/2002; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0088_summary.pdf |
| Regulatory source | RfD | =0.3 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system | row_hash=31cf35155df7813e; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=3e-1; system=Other; basis=Decreased maternal weight gain; point_of_departure=BMDL : 93 mg/kg-day; composite_uf=300; confidence=Medium/High; dtxsid=DTXSID5021124; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=88; rfd_last_updated=09/30/2002; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0088_summary.pdf |
IARC Monographs 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1998 | IARC Monographs | - |
WHO/JECFA 27 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | LOAEL | =120 | mg/kg bw/day | Rat | - | - | Toxicology study | document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=ba1baf8ab962d474; raw_unit=mg/kg per day; context=In two multiple dose rat studies, NOAEL values of 40 mg/kg per day (the lowest-observed-adverse-effect level (LOAEL) was 53 mg/kg per day) and 60 mg/kg per day (the LOAEL was 120 mg/kg per day) have been reported. |
| WHO/JECFA | LOAEL | =280 | mg/kg bw/day | Mouse | - | - | Toxicology study | document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=a118e25adbdc21d0; raw_unit=mg/kg per day; context=In the mouse, the NOAEL was 140 mg/kg per day (the LOAEL was 280 mg/kg per day). |
| WHO/JECFA | LOAEL | =53 | mg/kg bw/day | Rat | - | - | Toxicology study | document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=ed71aff4d6f83276; raw_unit=mg/kg per day; context=In two multiple-dose rat studies, NOAELs of 40 mg/kg per day (the LOAEL was 53 mg/kg per day) and 60 mg/kg per day (the LOAEL was 120 mg/kg per day) have been reported. |
| WHO/JECFA | LOAEL | =53 | mg/kg bw | - | - | - | Toxicology study | document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=db310d27d665eb10; raw_unit=mg/kg; context=En dos estudios de dosis múltiples en ratas, se han notificado NOAEL de 40 mg/kg al día (el más bajo nivel sin efectos adversos observados (LOAEL) fue de 53 mg/kg al día) y de 60 mg/kg al día (el LOAEL fue de 120 mg/kg al día). |
| WHO/JECFA | LOAEL | =280 | mg/kg bw | - | - | - | Toxicology study | document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=97a47c116cb2f0fe; raw_unit=mg/kg; context=En el ratón, el NOAEL fue de 140 mg/kg al día (el LOAEL fue de 280 mg/kg al día). |
| WHO/JECFA | NOAEL | =40 | mg/kg bw/day | Rat | - | - | Toxicology study | document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=9d74c3c65623b1bd; raw_unit=mg/kg per day; context=In two multiple dose rat studies, NOAEL values of 40 mg/kg per day (the lowest-observed-adverse-effect level (LOAEL) was 53 mg/kg per day) and 60 mg/kg per day (the LOAEL was 120 mg/kg per day) have been reported. |
| WHO/JECFA | NOAEL | =140 | mg/kg bw/day | Mouse | - | - | Toxicology study | document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=0c1d1a6b165ca9f0; raw_unit=mg/kg per day; context=In the mouse, the NOAEL was 140 mg/kg per day (the LOAEL was 280 mg/kg per day). |
| WHO/JECFA | NOAEL | =12 | mg/kg bw/day | Rat | oral | 14-day | Toxicology study | document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=21c23c3a4c83793a; raw_unit=mg/kg per day; context=In a limited 14-day study on rats, an oral NOAEL of 12 mg/kg per day was reported based on kidney effects. |
| WHO/JECFA | NOAEL | =12 | mg/kg bw | - | oral | - | Toxicology study | document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=dea590bedec34595; raw_unit=mg/kg; context=En un estudio limitado de 14 días de duración realizado en ratas se notificó un nivel sin efectos adversos observados (NOAEL) de 12 mg/kg al día por vía oral, basado en los efectos renales. |
| WHO/JECFA | NOAEL | =40 | mg/kg bw | - | - | - | Toxicology study | document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=a6c5ecee2eec53c2; raw_unit=mg/kg; context=En dos estudios de dosis múltiples en ratas, se han notificado NOAEL de 40 mg/kg al día (el más bajo nivel sin efectos adversos observados (LOAEL) fue de 53 mg/kg al día) y de 60 mg/kg al día (el LOAEL fue de 120 mg/kg al día). |
| WHO/JECFA | NOAEL | =140 | mg/kg bw | - | - | - | Toxicology study | document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=b1bc61944ef38ca4; raw_unit=mg/kg; context=En el ratón, el NOAEL fue de 140 mg/kg al día (el LOAEL fue de 280 mg/kg al día). |
| WHO/JECFA | TDI | range:60-2000.2 | mg/kg bw/day | - | - | - | Health guidance value | document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=430066a4f116bdfa; raw_unit=ug/kg body weight per day; unit_normalization=converted from micrograms; context=Using an uncertainty factor of 200, a range of 60-200 ug/kg body weight per day is recommended as the upper limit of the total daily intake (TDI). |
| WHO/JECFA | ADI | range:0-0.20.2 | mg/kg bw/day | - | - | - | Health guidance value | document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=5f056c3c35e01b09; raw_unit=mg/kg bw; context=735) was evaluated by the Committee at its eighth meeting, when an ADI of 0-0.2 mg/kg bw was established (Annex 1, reference 8). |
| WHO/JECFA | ADI | range:0-0.40.4 | mg/kg bw/day | - | - | - | Health guidance value | document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=3c4335801aea9cf2; raw_unit=mg/kg bw; context=All intake values are expressed in ug/day. c An ADI of 0-0.4 mg/kg bw has been established for 2-phenylphenol (FAO, 1999). |
| WHO/JECFA | NOEL | =0.06 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=49ad2253a8971057; raw_unit=mg/kg bw per day; context=The NOEL was 0.06 mg/kg bw per day (Maasik, 1970). |
| WHO/JECFA | NOEL | =0.14 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=fe8e980f0a109609; raw_unit=mg/kg bw per day; context=The NOEL was 0.14 mg/kg bw per day (Maasik, 1970). |
| WHO/JECFA | NOEL | =0.2 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=20ad78967d133183; raw_unit=mg/kg bw per day; context=The NOEL was 0.20 mg/kg bw per day (Posternak & Linder, 1969). |
| WHO/JECFA | NOEL | =6 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=9e8692fc33a732ee; raw_unit=mg/kg bw per day; context=The NOEL was 6.0 mg/kg bw per day (Posternak & Linder, 1969). |
| WHO/JECFA | NOEL | =50 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=6d09c13147bf76aa; raw_unit=mg/kg bw per day; context=The NOEL was 50 mg/kg bw per day (Environmental Protection Agency, 1988b). para- Ethylphenol (No. |
| WHO/JECFA | NOEL | =180 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=0218ff170998ea9f; raw_unit=mg/kg bw per day; context=The NOEL was 180 mg/kg bw per day (Environmental Protection Agency, 1988a). |
| WHO/JECFA | NOEL | =220 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=4e9e3546a563071b; raw_unit=mg/kg; context=The NOEL was 220 mg/kg, bw per day (National Toxicology Program, 1992b). |
| WHO/JECFA | NOEL | =250 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=8bcf2d93c4020df6; raw_unit=mg/kg bw per day; context=The NOEL for both ortho -cresol and meta/para- cresol was 250 mg/kg bw per day (National Toxicology Program, 1992a). |
| WHO/JECFA | NOEL | =280 | mg/kg bw/day | Rat | - | 13-week | Subchronic toxicity | document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=5a7a72264318c57e; raw_unit=mg/kg bw per day; context=The NOEL of 280 mg/kg bw per day in a 13-week study in rats given multiple doses (Gaunt et al., 1970) is > 1000 times the daily intakes of 46 ug/kg bw in Europe and 63 ug/kg bw in the USA. |
| WHO/JECFA | NOEL | =300 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=db8413174608fd5f; raw_unit=mg/kg bw per day; context=The NOEL was 300 mg/kg bw per day (National Toxicology Program, 1980). ortho- Cresol (No. |
| WHO/JECFA | NOEL | =1000 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=5ac3a83ca54faee4; raw_unit=mg/kg bw per day; context=The NOEL was 1000 mg/kg bw per day (Hagan et al., 1967). |
| WHO/JECFA | NOAEL | =60 | mg/kg bw/day | Rat | - | - | Developmental toxicity | document_id=pims_chemical_pim412; title=Phenol (PIM 412); path=mirror/documents/pims/chemical/pim412.htm; row_hash=9f77d5760b74f219; raw_unit=mg/kg/day; context=However, according to IRIS (Integrated Risk Information Sytem, 1996), the reference dose (Rfd) is 0.6 mg/kg/day, using the NOAEL (reduced fetal body weight in rats) of 60 mg/kg/day, with an uncertainty factor (Uf) of 100. |
| WHO/JECFA | TDI | =0.1 | mg/kg bw/day | - | - | - | Health guidance value | document_id=pims_chemical_pim412; title=Phenol (PIM 412); path=mirror/documents/pims/chemical/pim412.htm; row_hash=0fc008bcaa5e2021; raw_unit=mg/kg body weight per day; context=With an uncertainty factor of 200, the range of 60 to 200 ug/kg/day was recommended as the upper limit of the TDI (WHO, 1994) The estimated maximal total daily intake of phenol for a 70 kg individual is calculated to be 0.1 mg/kg body weight per day (WHO, 1994). |
NTP ICE acute inhalation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | 0.316 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2796; Record_ID=acute_inhalation_2588; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.316; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021124 |
NTP ICE acute oral 16 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =400 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_803; row=8549; data_type=In Vivo; mixture=Chemical; chemical_name=Phenol; preferred_name=Phenol; dtxsid=DTXSID5021124; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021124; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >410 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_804; row=8550; data_type=In Vivo; mixture=Chemical; chemical_name=Phenol; preferred_name=Phenol; dtxsid=DTXSID5021124; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021124; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =414 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_805; row=8551; data_type=In Vivo; mixture=Chemical; chemical_name=Phenol; preferred_name=Phenol; dtxsid=DTXSID5021124; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021124; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =445 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_806; row=8552; data_type=In Vivo; mixture=Chemical; chemical_name=Phenol; preferred_name=Phenol; dtxsid=DTXSID5021124; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021124; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =512 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_807; row=8553; data_type=In Vivo; mixture=Chemical; chemical_name=Phenol; preferred_name=Phenol; dtxsid=DTXSID5021124; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021124; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =520 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_808; row=8554; data_type=In Vivo; mixture=Chemical; chemical_name=Phenol; preferred_name=Phenol; dtxsid=DTXSID5021124; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021124; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =550 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_813; row=8555; data_type=In Vivo; mixture=Chemical; chemical_name=Phenol; preferred_name=Phenol; dtxsid=DTXSID5021124; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021124; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =540 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_812; row=8556; data_type=In Vivo; mixture=Chemical; chemical_name=Phenol; preferred_name=Phenol; dtxsid=DTXSID5021124; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021124; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =530 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_811; row=8557; data_type=In Vivo; mixture=Chemical; chemical_name=Phenol; preferred_name=Phenol; dtxsid=DTXSID5021124; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021124; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =527 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_809; row=8558; data_type=In Vivo; mixture=Chemical; chemical_name=Phenol; preferred_name=Phenol; dtxsid=DTXSID5021124; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021124; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =650 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_814; row=8559; data_type=In Vivo; mixture=Chemical; chemical_name=Phenol; preferred_name=Phenol; dtxsid=DTXSID5021124; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021124; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =1030 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_815; row=8560; data_type=In Vivo; mixture=Chemical; chemical_name=Phenol; preferred_name=Phenol; dtxsid=DTXSID5021124; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021124; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =1500 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_816; row=8561; data_type=In Vivo; mixture=Chemical; chemical_name=Phenol; preferred_name=Phenol; dtxsid=DTXSID5021124; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021124; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =316 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_800; row=8563; data_type=In Vivo; mixture=Chemical; chemical_name=Phenol; preferred_name=Phenol; dtxsid=DTXSID5021124; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021124; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =317 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_801; row=8564; data_type=In Vivo; mixture=Chemical; chemical_name=Phenol; preferred_name=Phenol; dtxsid=DTXSID5021124; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021124; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =340 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_802; row=8565; data_type=In Vivo; mixture=Chemical; chemical_name=Phenol; preferred_name=Phenol; dtxsid=DTXSID5021124; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021124; source_file=acute_oral.xlsx |
NTP ICE adme parameters 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 5.496 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=1956; Record_ID=adme_parameters_255; Data_Type=Measured; DTXSID=DTXSID5021124; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=5.496; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021124 |
| NTP ICE adme parameters | Fu | 0.6201 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=1957; Record_ID=adme_parameters_255; Data_Type=Measured; DTXSID=DTXSID5021124; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.6201; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021124 |
NTP ICE cancer 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | IARC group | 3 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=5635; Record_ID=cancer_5218; Data_Type=WOE; Formulation_Name=Phenol; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/65; http://publications.iarc.fr/89; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021124 |
| NTP ICE cancer | Top dose | 5000 | ppm | Rat | - | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=5627; Record_ID=cancer_5221; Data_Type=In Vivo; Formulation_Name=Phenol; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=5000; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Female; Reference=TR-203; URL=https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr203/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021124 |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=13234; RecordID=ARPathway2016_523; DatasetName=ARPathway2016; DTXSID=DTXSID5021124; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124 |
NTP ICE skin irritation 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin irritation | Viability (240 minutes) | 23.1 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=3464; Record_ID=skin_irritation_invitro_2219; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=23.1; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021124 |
| NTP ICE skin irritation | Viability (240 minutes) | 18.5 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=3465; Record_ID=skin_irritation_invitro_2220; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=18.5; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021124 |
| NTP ICE skin irritation | Viability (3 minutes) | 29.8 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=3459; Record_ID=skin_irritation_invitro_2219; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=29.8; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021124 |
| NTP ICE skin irritation | Viability (3 minutes) | 22 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=3460; Record_ID=skin_irritation_invitro_2220; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=22; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021124 |
| NTP ICE skin irritation | Viability (3 minutes) | 21.4 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=3467; Record_ID=skin_irritation_invitro_2221; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=21.4; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021124 |
| NTP ICE skin irritation | Viability (60 minutes) | 21.8 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=3461; Record_ID=skin_irritation_invitro_2219; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=21.8; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021124 |
| NTP ICE skin irritation | Viability (60 minutes) | 18.4 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=3462; Record_ID=skin_irritation_invitro_2220; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=18.40; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021124 |
| NTP ICE skin irritation | Viability (60 minutes) | 17.2 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=3463; Record_ID=skin_irritation_invitro_2221; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=17.2; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021124 |
NTP ICE skin sensitization 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | CD54, EC200 | 130.2 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2369; Record_ID=skin_sensitization_invitro_577; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=130.19999999999999; Reported_Response_Unit=ug/mL; Response=130.2; Response_Unit=ug/mL; Reference=Miyazawa personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124 |
| NTP ICE skin sensitization | CD86, EC150 | 173 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2371; Record_ID=skin_sensitization_invitro_577; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=173; Reported_Response_Unit=ug/mL; Response=173; Response_Unit=ug/mL; Reference=Miyazawa personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124 |
| NTP ICE skin sensitization | CD86, EC150 | 21.74 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8697; Record_ID=skin_sensitization_invitro_2408; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=21.74; Reported_Response_Unit=ug/mL; Response=21.74; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124 |
| NTP ICE skin sensitization | CV70 | 101.68 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8695; Record_ID=skin_sensitization_invitro_2408; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=U-SENS; Endpoint=CV70; Reported_Response=101.68; Reported_Response_Unit=ug/mL; Response=101.68; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124 |
| NTP ICE skin sensitization | CV75 | 308.8 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2373; Record_ID=skin_sensitization_invitro_577; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=h-CLAT; Endpoint=CV75; Reported_Response=308.8; Reported_Response_Unit=ug/mL; Response=308.8; Response_Unit=ug/mL; Reference=Miyazawa personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124 |
| NTP ICE skin sensitization | EC1.5 | >2000 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=4705; Record_ID=skin_sensitization_invitro_1087; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124 |
| NTP ICE skin sensitization | Imax | 1.3 | ratio | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=4711; Record_ID=skin_sensitization_invitro_1087; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.3; Reported_Response_Unit=Unitless; Response=1.3; Response_Unit=Ratio; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124 |
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=3373; Record_ID=skin_sensitization_invivo_853; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Gad et al. (1986; 3715870; 10.1016/0041-008X(86)90419-9|Basketter et al. 1996; 9012774; 10.1016/s0278-6915(96)00059-2|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Basketter et al. 2014; 24407057; 10.1097/der.0000000000000003; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124 |
| NTP ICE skin sensitization | Induction dose per skin area | 1241 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=3371; Record_ID=skin_sensitization_invivo_853; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=1241; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Gad et al. (1986; 3715870; 10.1016/0041-008X(86)90419-9|Basketter et al. 1996; 9012774; 10.1016/s0278-6915(96)00059-2|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Basketter et al. 2014; 24407057; 10.1097/der.0000000000000003; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124 |
| NTP ICE skin sensitization | Relative reliability score | 1 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=3375; Record_ID=skin_sensitization_invivo_853; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=1; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Gad et al. (1986; 3715870; 10.1016/0041-008X(86)90419-9|Basketter et al. 1996; 9012774; 10.1016/s0278-6915(96)00059-2|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Basketter et al. 2014; 24407057; 10.1097/der.0000000000000003; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124 |
EPA ToxRefDB v3 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA ToxRefDB v3 | LEL | =250 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 103 week | CHR | study_id=2527; toxval_study_source_id=studyid2527_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-water consumption-water consumption; dose_level=2; study_year=1980; study_citation=Bioassay of Phenol for Possible Carcinogenicity: Phenol: Hazleton Laboratories, Vienna, VA. Study #: NIH Pub.# 80-1759: August 1980; dsstox_substance_id=DTXSID5021124; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =375 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 103 week | CHR | study_id=2528; toxval_study_source_id=studyid2528_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-water consumption-water consumption|pathology microscopic-uterus-interstitial stromal tumor; dose_level=1; study_year=1980; study_citation=Bioassay of Phenol for Possible Carcinogenicity: Study #: NIH PUB.#: 80-1759, Hazleton Laboratories, Vienna, VA August 1980; dsstox_substance_id=DTXSID5021124; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =125 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 103 week | CHR | study_id=2527; toxval_study_source_id=studyid2527_Adult_F0_F_systemic; toxval_effect_list=in life observation-water consumption-water consumption|in life observation-body weight-body weight; dose_level=1; study_year=1980; study_citation=Bioassay of Phenol for Possible Carcinogenicity: Phenol: Hazleton Laboratories, Vienna, VA. Study #: NIH Pub.# 80-1759: August 1980; dsstox_substance_id=DTXSID5021124; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | >0 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 103 week | CHR | study_id=2527; toxval_study_source_id=studyid2527_Adult_F0_M_systemic; toxval_effect_list=pathology gross-full gross necropsy-lymphoma malignant|pathology microscopic-[other]-lymphoma malignant|in life observation-water consumption-water consumption|pathology microscopic-adrenal gland-pheochromocytoma nos|pathology microscopic-bone marrow-leukemia|in life observation-body weight-body weight; dose_level=0; study_year=1980; study_citation=Bioassay of Phenol for Possible Carcinogenicity: Phenol: Hazleton Laboratories, Vienna, VA. Study #: NIH Pub.# 80-1759: August 1980; dsstox_substance_id=DTXSID5021124; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB ATSDR MRLs 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ATSDR MRLs | BMDL | =125 | mg/kg bw/day | Rat | oral | short-term (developmental); 10 days | reproduction developmental | LONG_REF=York. 1997. Oral (gavage) developmental toxicity study of phenol in rats. Procter & Gamble Co. Submitted to the U.S. Environmental Protection Agency under TSCA Section 8D. OTS0573686.; TITLE=Oral (gavage) developmental toxicity study of phenol in rats; AUTHOR=York; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f4e4b063812d5857db; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp115.pdf; TOXICOLOGICAL_EFFECT=body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ATSDR MRLs:15447761:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_318d3f780a0921d289980cc9f9119d94 |
| ToxValDB ATSDR MRLs | MRL | =1 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=body weight in male/female rats; STUDY_GROUP=ATSDR MRLs:15447202:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_971b7828a20a4567aff0b11fb50f62c0 |
ToxValDB Alaska DEC 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Alaska DEC | RfD | =0.27 | mg/kg bw/day | Human | dermal | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445787:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=0b939b18309d047fa0f9e56a02faa2c7 |
| ToxValDB Alaska DEC | RfD | =0.3 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445788:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=db4aebf653658b521cf23b9d099a2dab |
ToxValDB Cal OEHHA REL derivations 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Cal OEHHA REL derivations | NOAEL | =20.016 | mg/m3 | Human | inhalation | acute; 8 hours | clinical | LONG_REF=Piotrowski JK. Evaluation of exposure to phenol: absorption of phenol vapor in the lungs and through the skin and excretion of phenol in urine. Br J Ind Med 1971;28:172-178; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32b8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd2final.pdf; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=irritation of the eyes, nose, and throat; STUDY_GROUP=Cal OEHHA REL derivations:15951965:-:-volunteers; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_24b113ba30f6dcdad75c2fdd262cdc35 |
| ToxValDB Cal OEHHA REL derivations | NOAEL | =19.2461 | mg/m3 | Mouse | inhalation | subchronic; 90 days | subchronic | LONG_REF=Sandage C. 1961. Tolerance criteria for continuous inhalation exposure to toxic material. I. Effects on animals of 90-day exposure to phenol, CCl4 and a mixture of indole, skatole, H2S and methyl mercaptan. ASD technical report 61-519(I). Wright Patterson Air Force Base, OH: U.S. Air Force Systems Command, Aeronautical Systems Division; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32ce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd3final.pdf; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Systemic effects including liver and nervous system effects; STUDY_GROUP=Cal OEHHA REL derivations:15952123:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_82ce196a66db36dbb1209091b4decd2b |
ToxValDB DOE Protective Action Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Protective Action Criteria | LEL | =69286 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=DOE Protective Action Criteria:15518317:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d126b768e9e2c7975296cf02d735fd14 |
ToxValDB ECOTOX 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =50 | mg/kg bw/day | Rat | injection | short-term; 15 days | short-term | LONG_REF=Regulatory Pept.119(3): 155-161 Deng,P.Y., F. Ye, W.J. Cai, H.W. Deng, and Y.J. Li Role of Calcitonin Gene-Related Peptide in the Phenol-Induced Neurogenic Hypertension in Rats 2004; TITLE=Role of Calcitonin Gene-Related Peptide in the Phenol-Induced Neurogenic Hypertension in Rats; AUTHOR=Deng,P.Y., F. Ye, W.J. Cai, H.W. Deng, and Y.J. Li; DOI=10.1016/j.regpep.2004.01.011; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=107000; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Biochemistry: Calcitonin Gene-Related Peptide|Genetics: Gene expression|Physiology: Blood pressure; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|other; STUDY_GROUP=ECOTOX:15594781:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=31c1951e78b9037d956754f3e687e8c1 |
| ToxValDB ECOTOX | NOEL | =160 | mg/kg bw/day | Rat | oral | acute; 1 days | acute | LONG_REF=Mutat. Res.320(3): 189-205 Uno,Y., H. Takasawa, M. Miyagawa, Y. Inoue, T. Murata, and K. Yoshikawa An In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test Using Rat Hepatocytes as an Early Prediction Assay for Nongenotoxic Hepatocarcinogens Screening of 22 Known Positive and 25 Noncarcinogens 1994; TITLE=An In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test Using Rat Hepatocytes as an Early Prediction Assay for Nongenotoxic Hepatocarcinogens Screening of 22 Known Positive and 25 Noncarcinogens; AUTHOR=Uno,Y., H. Takasawa, M. Miyagawa, Y. Inoue, T. Murata, and K. Yoshikawa; DOI=10.1016/0165-1218(94)90046-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75058; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Cell(s): Viability; STUDY_GROUP=ECOTOX:15606801:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d8a1069fb94c4627bcf553a8c8c6c654 |
| ToxValDB ECOTOX | NOEL | =53.3 | mg/kg bw/day | Rat | oral | short-term (developmental); 14 days | reproduction developmental | LONG_REF=J. Toxicol. Environ. Health45:145-171 Narotsky,M.G., and R.J. Kavlock A Multidisciplinary Approach to Toxicological Screening: II. Developmental Toxicity 1995; TITLE=A Multidisciplinary Approach to Toxicological Screening: II. Developmental Toxicity; AUTHOR=Narotsky,M.G., and R.J. Kavlock; DOI=10.1080/15287399509531987; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98654; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Growth: Weight|Reproduction: Viability; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|reproduction; STUDY_GROUP=ECOTOX:15612220:F:F1-; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=5c1aab71ae3349fbac413f2ca05d81a2 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =8 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634051:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a2ce347e878dea1b86e922570ec8b044 |
ToxValDB Health Canada 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Health Canada | NOAEL | =12 | mg/kg bw/day | Rat | oral | short-term; 14 days | short-term | LONG_REF=CSQG: CCME, 1997b (based on WHO, 1994; Schlicht et al., 1992; Berman et al., 1995); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/61003a57e4b01a90a3f9c305; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://publications.gc.ca/site/eng/9.694269/publication.html; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=neurotoxic, nephrotoxic, hepatotoxic; TOXICOLOGICAL_EFFECT_CATEGORY=multiple; STUDY_GROUP=Health Canada:15637564:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ca855a300e2ca3b1a398c55d40cd75c0 |
| ToxValDB Health Canada | TDI | =0.06 | mg/kg bw/day | Human | oral | short-term; 14 days | Toxicity Value | LONG_REF=CSQG: CCME, 1997b (based on WHO, 1994; Schlicht et al., 1992; Berman et al., 1995); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/61003a57e4b01a90a3f9c305; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://publications.gc.ca/site/eng/9.694269/publication.html; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=neurotoxic, nephrotoxic, hepatotoxic; STUDY_GROUP=Health Canada:15637462:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_feee51c86c0f16b57864de3e6004db75 |
ToxValDB IRIS 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB IRIS | BMD | =157 | mg/kg bw/day | Rat | oral | short-term (developmental); 10 days | developmental | LONG_REF=Argus Research Laboratories. (1997) Oral (gavage) developmental toxicity study of phenol in rats. Horsham, PA. Protocol number: 916-011.; TITLE=Oral (gavage) developmental toxicity study of phenol in rats; AUTHOR=Argus Research Laboratories; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4d60; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=88; TOXICOLOGICAL_EFFECT=reduced maternal weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=IRIS_dup_IRIS Summary_15644855_15644860:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ceb60559703fedc1707cfad1e9a91c5c |
| ToxValDB IRIS | BMDL | =93 | mg/kg bw/day | Rat | oral | short-term (developmental); 10 days | developmental | LONG_REF=Argus Research Laboratories. (1997) Oral (gavage) developmental toxicity study of phenol in rats. Horsham, PA. Protocol number: 916-011.; TITLE=Oral (gavage) developmental toxicity study of phenol in rats; AUTHOR=Argus Research Laboratories; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4d60; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=88; TOXICOLOGICAL_EFFECT=reduced maternal weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=IRIS_dup_IRIS Summary_15644855_15644860:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_34078d59dd336196c18c9cfb059e86be |
ToxValDB Pennsylvania DEP ToxValues 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Pennsylvania DEP ToxValues | RfC | =0.2 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67599fbae4b0a7c65d37b2e3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://files.dep.state.pa.us/EnvironmentalCleanupBrownfields/LandRecyclingProgram/LandRecyclingProgramPortalFiles/GuidanceTechTools/VaporIntrusion/November_2021/Table%205a.pdf; STUDY_GROUP=Pennsylvania DEP ToxValues:15650301:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1a42a54c35678d6a9cd35036717037c5 |
ToxValDB RSL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB RSL | RfD | =0.6 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15663667:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_40def3ba8726cf9b9fb2ffbe2213b5d2 |
ToxValDB TX TCEQ 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB TX TCEQ | LOAEL | =18.1683 | mg/m3 | Rat | inhalation | subchronic; 90 days | subchronic | LONG_REF=2014 Revised Odor Value, September 14, 2015; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5ad3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/phenol.pdf; YEAR=2014 Revised Odor Value, September 14, 2015; ORIGINAL_YEAR=2014 Revised Odor Value, September 14, 2015; TOXICOLOGICAL_EFFECT=liver and kidney pathology; STUDY_GROUP=TX TCEQ:15954620:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bd696d8793933f918aaaa4746eb944c9 |
| ToxValDB TX TCEQ | NOAEL | =96.2305 | mg/m3 | Rat | inhalation | short-term; 60 hours | short-term | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5ad3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/phenol.pdf; YEAR=2014 Revised Odor Value, September 14, 2015; ORIGINAL_YEAR=2014 Revised Odor Value, September 14, 2015; TOXICOLOGICAL_EFFECT=Nasal and ocular irritation, CNS effects; STUDY_GROUP=TX TCEQ:15954622:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_786126f3dee88439cd5cbc55fdda3524 |
ToxValDB ToxRefDB 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ToxRefDB | LEL | =250 | mg/kg bw/day | Rat | oral | chronic; 103 weeks | chronic | LONG_REF=Bioassay of Phenol for Possible Carcinogenicity: Phenol: Hazleton Laboratories, Vienna, VA. Study #: NIH Pub.# 80-1759: August 1980; TITLE=Bioassay of Phenol for Possible Carcinogenicity: Phenol; AUTHOR=Hazleton Laboratories; EXTERNAL_SOURCE_ID=2527; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: in life observation-water consumption-water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15694932_15694933:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_143ac0d581164e12eeae39b1481e6eb3 |
| ToxValDB ToxRefDB | LEL | =375 | mg/kg bw/day | Mouse | oral | chronic; 103 weeks | chronic | LONG_REF=Bioassay of Phenol for Possible Carcinogenicity: Study #: NIH PUB.#: 80-1759, Hazleton Laboratories, Vienna, VA August 1980; TITLE=Bioassay of Phenol for Possible Carcinogenicity; AUTHOR=Hazleton Laboratories; EXTERNAL_SOURCE_ID=2528; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-uterus-interstitial stromal tumor; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|food and/or water consumption; STUDY_GROUP=ToxRefDB:15694935:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_beb1c1a7b0bfdf0563d79ab8405e85c3 |
| ToxValDB ToxRefDB | NEL | =125 | mg/kg bw/day | Rat | oral | chronic; 103 weeks | chronic | LONG_REF=Bioassay of Phenol for Possible Carcinogenicity: Phenol: Hazleton Laboratories, Vienna, VA. Study #: NIH Pub.# 80-1759: August 1980; TITLE=Bioassay of Phenol for Possible Carcinogenicity: Phenol; AUTHOR=Hazleton Laboratories; EXTERNAL_SOURCE_ID=2527; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15694932_15694933:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_37ab242d573c9e54f11f6ff4e3be477c |
openFDA substances 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 339NCG44TV | UNII | - | - | - | chemical | - |
| openFDA substances | FDA UNII substance identifier | concept | identifier | - | - | - | concept | - |