NOAEL Studies Cosmetic Ingredient

Phenol NOAEL Studies

INCI: PHENOL

CAS: 108-95-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 19 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB LOAEL 2500 ppm rat oral 103 week Chronic REACH; NTP TR 203, 1980
COSMOS_DB NOAEL 1.8 mg/kg bw/day mouse oral 28 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 20 mg/kg bw/day rat oral 261 day Multigeneration Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 40 mg/kg bw/day rat oral 14 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 86.2 mg/kg bw/day rat oral 28 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 120 mg/kg bw/day rat oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 160 mg/kg bw/day rat oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 167 mg/kg bw/day rat oral 136 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 180 mg/kg bw/day rat oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 224 mg/kg bw/day rat oral 365 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 230 mg/kg bw/day mouse oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 280 mg/kg bw/day mouse oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 308 mg/kg bw/day rat oral 91 day Neurotoxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 500 mg/kg bw/day rat oral 721 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 625 mg/kg bw/day mouse oral 721 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 667 mg/kg bw/day rat oral 1 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 750 mg/kg bw/day mouse oral 255 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1000 mg/kg bw/day rat oral 91 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 2500 mg/kg bw/day mouse oral 91 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip 21 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 260 mg/kg bw/day rabbit - - short-term repeated dose toxicity: dermal dossier=11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6z; document=68521c0a-ba56-4382-87f5-661d17752938_11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6d; document_key=68521c0a-ba56-4382-87f5-661d17752938/11a1f031-f1a8-4bcc-a543-ab5834bb5458; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1950; basis=other:; key_result=false; entry_uuid=4d9028ce-5975-4613-a710-740788844f35
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 260 mg/kg bw/day rabbit - - short-term repeated dose toxicity: dermal dossier=11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6z; document=68521c0a-ba56-4382-87f5-661d17752938_11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6d; document_key=68521c0a-ba56-4382-87f5-661d17752938/11a1f031-f1a8-4bcc-a543-ab5834bb5458; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1950; basis=other:; key_result=false; entry_uuid=4d9028ce-5975-4613-a710-740788844f35
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 260 mg/kg bw/day rabbit - - short-term repeated dose toxicity: dermal dossier=11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6z; document=68521c0a-ba56-4382-87f5-661d17752938_11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6d; document_key=68521c0a-ba56-4382-87f5-661d17752938/11a1f031-f1a8-4bcc-a543-ab5834bb5458; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1950; basis=other:; key_result=false; entry_uuid=4d9028ce-5975-4613-a710-740788844f35
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 130 mg/kg bw/day rabbit - - short-term repeated dose toxicity: dermal dossier=11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6z; document=68521c0a-ba56-4382-87f5-661d17752938_11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6d; document_key=68521c0a-ba56-4382-87f5-661d17752938/11a1f031-f1a8-4bcc-a543-ab5834bb5458; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1950; basis=other:; key_result=false; entry_uuid=ef0a9886-ca70-4f5d-8830-5e312779ff27
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 140 mg/kg bw/day mouse oral: gavage - developmental toxicity dossier=11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6z; document=9e4f67c4-a934-474c-bb1f-4b5432343a38_11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6d; document_key=9e4f67c4-a934-474c-bb1f-4b5432343a38/11a1f031-f1a8-4bcc-a543-ab5834bb5458; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1983; ReportDate=1983-07-23; basis=other:; key_result=false; entry_uuid=6a901bd7-7fe9-45d4-b126-00c8d595526c
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 60 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6z; document=7d4dcf62-6c06-4025-87b5-3783ab4b4561_11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6d; document_key=7d4dcf62-6c06-4025-87b5-3783ab4b4561/11a1f031-f1a8-4bcc-a543-ab5834bb5458; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2002; basis=other:; key_result=false; entry_uuid=f701027f-900e-4ed7-bae9-45c090a35400
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 120 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6z; document=7d4dcf62-6c06-4025-87b5-3783ab4b4561_11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6d; document_key=7d4dcf62-6c06-4025-87b5-3783ab4b4561/11a1f031-f1a8-4bcc-a543-ab5834bb5458; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2002; basis=other:; key_result=false; entry_uuid=4d3e3f5d-b067-419a-b281-2e1b25e995b8
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 30 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6z; document=3846c7ae-0420-4e7a-bff4-59fd5815ebec_11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6d; document_key=3846c7ae-0420-4e7a-bff4-59fd5815ebec/11a1f031-f1a8-4bcc-a543-ab5834bb5458; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2020; basis=mortality; key_result=false; entry_uuid=089c5f30-48d5-4a5f-af8d-99a2eed0e72b
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 15 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6z; document=3846c7ae-0420-4e7a-bff4-59fd5815ebec_11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6d; document_key=3846c7ae-0420-4e7a-bff4-59fd5815ebec/11a1f031-f1a8-4bcc-a543-ab5834bb5458; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2020; basis=other:; key_result=false; entry_uuid=811fec91-d8f7-4d76-9825-e96b91e8c982
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 130 mg/kg bw/day rabbit - - short-term repeated dose toxicity: dermal dossier=11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6z; document=68521c0a-ba56-4382-87f5-661d17752938_11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6d; document_key=68521c0a-ba56-4382-87f5-661d17752938/11a1f031-f1a8-4bcc-a543-ab5834bb5458; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1950; basis=other:; key_result=false; entry_uuid=ef0a9886-ca70-4f5d-8830-5e312779ff27
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 140 mg/kg bw/day mouse oral: gavage - developmental toxicity dossier=11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6z; document=9e4f67c4-a934-474c-bb1f-4b5432343a38_11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6d; document_key=9e4f67c4-a934-474c-bb1f-4b5432343a38/11a1f031-f1a8-4bcc-a543-ab5834bb5458; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1983; ReportDate=1983-07-23; basis=other:; key_result=false; entry_uuid=6a901bd7-7fe9-45d4-b126-00c8d595526c
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 60 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6z; document=7d4dcf62-6c06-4025-87b5-3783ab4b4561_11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6d; document_key=7d4dcf62-6c06-4025-87b5-3783ab4b4561/11a1f031-f1a8-4bcc-a543-ab5834bb5458; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2002; basis=other:; key_result=false; entry_uuid=f701027f-900e-4ed7-bae9-45c090a35400
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 120 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6z; document=7d4dcf62-6c06-4025-87b5-3783ab4b4561_11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6d; document_key=7d4dcf62-6c06-4025-87b5-3783ab4b4561/11a1f031-f1a8-4bcc-a543-ab5834bb5458; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2002; basis=other:; key_result=false; entry_uuid=4d3e3f5d-b067-419a-b281-2e1b25e995b8
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 30 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6z; document=3846c7ae-0420-4e7a-bff4-59fd5815ebec_11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6d; document_key=3846c7ae-0420-4e7a-bff4-59fd5815ebec/11a1f031-f1a8-4bcc-a543-ab5834bb5458; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2020; basis=mortality; key_result=false; entry_uuid=089c5f30-48d5-4a5f-af8d-99a2eed0e72b
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 15 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6z; document=3846c7ae-0420-4e7a-bff4-59fd5815ebec_11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6d; document_key=3846c7ae-0420-4e7a-bff4-59fd5815ebec/11a1f031-f1a8-4bcc-a543-ab5834bb5458; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2020; basis=other:; key_result=false; entry_uuid=811fec91-d8f7-4d76-9825-e96b91e8c982
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 130 mg/kg bw/day rabbit - - short-term repeated dose toxicity: dermal dossier=11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6z; document=68521c0a-ba56-4382-87f5-661d17752938_11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6d; document_key=68521c0a-ba56-4382-87f5-661d17752938/11a1f031-f1a8-4bcc-a543-ab5834bb5458; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1950; basis=other:; key_result=false; entry_uuid=ef0a9886-ca70-4f5d-8830-5e312779ff27
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 140 mg/kg bw/day mouse oral: gavage - developmental toxicity dossier=11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6z; document=9e4f67c4-a934-474c-bb1f-4b5432343a38_11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6d; document_key=9e4f67c4-a934-474c-bb1f-4b5432343a38/11a1f031-f1a8-4bcc-a543-ab5834bb5458; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1983; ReportDate=1983-07-23; basis=other:; key_result=false; entry_uuid=6a901bd7-7fe9-45d4-b126-00c8d595526c
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 60 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6z; document=7d4dcf62-6c06-4025-87b5-3783ab4b4561_11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6d; document_key=7d4dcf62-6c06-4025-87b5-3783ab4b4561/11a1f031-f1a8-4bcc-a543-ab5834bb5458; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2002; basis=other:; key_result=false; entry_uuid=f701027f-900e-4ed7-bae9-45c090a35400
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 120 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6z; document=7d4dcf62-6c06-4025-87b5-3783ab4b4561_11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6d; document_key=7d4dcf62-6c06-4025-87b5-3783ab4b4561/11a1f031-f1a8-4bcc-a543-ab5834bb5458; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2002; basis=other:; key_result=false; entry_uuid=4d3e3f5d-b067-419a-b281-2e1b25e995b8
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 30 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6z; document=3846c7ae-0420-4e7a-bff4-59fd5815ebec_11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6d; document_key=3846c7ae-0420-4e7a-bff4-59fd5815ebec/11a1f031-f1a8-4bcc-a543-ab5834bb5458; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2020; basis=mortality; key_result=false; entry_uuid=089c5f30-48d5-4a5f-af8d-99a2eed0e72b
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL 15 mg/kg bw/day rat oral: gavage - developmental toxicity dossier=11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6z; document=3846c7ae-0420-4e7a-bff4-59fd5815ebec_11a1f031-f1a8-4bcc-a543-ab5834bb5458.i6d; document_key=3846c7ae-0420-4e7a-bff4-59fd5815ebec/11a1f031-f1a8-4bcc-a543-ab5834bb5458; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=2020; basis=other:; key_result=false; entry_uuid=811fec91-d8f7-4d76-9825-e96b91e8c982
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx LOAEL =1.8 mg/kg bw/day Mouse oral: drinking water 28 days short-term toxicity EFSA AFC - 2008 - OutputID 2285 - haematology - systemic - Flavouring Group Evaluation 88, (FGE.88). Consideration of Phenol and Phenol Derivatives evaluated by JECFA (55th meeting). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food - doi:10.2903/j.efsa.2008.857
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx LOAEL =1.8 mg/kg bw/day Mouse oral: drinking water 28 days short-term toxicity EFSA AFC - 2008 - OutputID 2285 - haematology - systemic - Flavouring Group Evaluation 88, (FGE.88). Consideration of Phenol and Phenol Derivatives evaluated by JECFA (55th meeting). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food - doi:10.2903/j.efsa.2008.857
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =60 mg/kg bw Rat oral: gavage 10 days reproduction toxicity EFSA CEF - 2013 - OutputID 2220 - body weight - reproductive - Scientific Opinion on the toxicological evaluation of phenol - doi:10.2903/j.efsa.2013.3189
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =120 mg/kg bw Rat oral: gavage 10 days reproduction toxicity EFSA CEF - 2013 - OutputID 2220 - development - teratogenic - Scientific Opinion on the toxicological evaluation of phenol - doi:10.2903/j.efsa.2013.3189
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =60 mg/kg bw Rat oral: gavage 10 days reproduction toxicity EFSA CEF - 2013 - OutputID 2220 - body weight - reproductive - Scientific Opinion on the toxicological evaluation of phenol - doi:10.2903/j.efsa.2013.3189
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =120 mg/kg bw Rat oral: gavage 10 days reproduction toxicity EFSA CEF - 2013 - OutputID 2220 - development - teratogenic - Scientific Opinion on the toxicological evaluation of phenol - doi:10.2903/j.efsa.2013.3189
EPA_IRIS_iris_rfd_systems.csv 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EPA_IRIS_iris_rfd_systems.csv BMDL =93 mg/kg/day - oral chronic IRIS chronic oral RfD system PoD row_hash=499e8263a9b18a0c; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=BMDL : 93 mg/kg-day; system=Other; basis=Decreased maternal weight gain; point_of_departure=BMDL : 93 mg/kg-day; composite_uf=300; confidence=Medium/High; dtxsid=DTXSID5021124; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=88; rfd_last_updated=09/30/2002; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0088_summary.pdf
EPA_IRIS_iris_rfd_systems.csv RfD =0.3 mg/kg/day - oral chronic IRIS chronic oral RfD system row_hash=31cf35155df7813e; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=3e-1; system=Other; basis=Decreased maternal weight gain; point_of_departure=BMDL : 93 mg/kg-day; composite_uf=300; confidence=Medium/High; dtxsid=DTXSID5021124; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=88; rfd_last_updated=09/30/2002; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0088_summary.pdf
IARC Monographs 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 1998 IARC Monographs {"additional_info":"volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"47, 71"}
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 1998 IARC Monographs {"additional_info":"volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"47, 71"}
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 1998 IARC Monographs {"additional_info":"volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"47, 71"}
INCHEM_WHO_ehc_ehc_ehc161 24 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
INCHEM_WHO_ehc_ehc_ehc161 LOAEL =120 mg/kg bw/day Rat - - Toxicology study document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=ba1baf8ab962d474; raw_unit=mg/kg per day; context=In two multiple dose rat studies, NOAEL values of 40 mg/kg per day (the lowest-observed-adverse-effect level (LOAEL) was 53 mg/kg per day) and 60 mg/kg per day (the LOAEL was 120 mg/kg per day) have been reported.
INCHEM_WHO_ehc_ehc_ehc161 LOAEL =280 mg/kg bw/day Mouse - - Toxicology study document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=a118e25adbdc21d0; raw_unit=mg/kg per day; context=In the mouse, the NOAEL was 140 mg/kg per day (the LOAEL was 280 mg/kg per day).
INCHEM_WHO_ehc_ehc_ehc161 LOAEL =53 mg/kg bw/day Rat - - Toxicology study document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=ed71aff4d6f83276; raw_unit=mg/kg per day; context=In two multiple-dose rat studies, NOAELs of 40 mg/kg per day (the LOAEL was 53 mg/kg per day) and 60 mg/kg per day (the LOAEL was 120 mg/kg per day) have been reported.
INCHEM_WHO_ehc_ehc_ehc161 LOAEL =53 mg/kg bw - - - Toxicology study document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=db310d27d665eb10; raw_unit=mg/kg; context=En dos estudios de dosis múltiples en ratas, se han notificado NOAEL de 40 mg/kg al día (el más bajo nivel sin efectos adversos observados (LOAEL) fue de 53 mg/kg al día) y de 60 mg/kg al día (el LOAEL fue de 120 mg/kg al día).
INCHEM_WHO_ehc_ehc_ehc161 LOAEL =280 mg/kg bw - - - Toxicology study document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=97a47c116cb2f0fe; raw_unit=mg/kg; context=En el ratón, el NOAEL fue de 140 mg/kg al día (el LOAEL fue de 280 mg/kg al día).
INCHEM_WHO_ehc_ehc_ehc161 LOAEL =120 mg/kg bw/day Rat - - Toxicology study document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=ba1baf8ab962d474; raw_unit=mg/kg per day; context=In two multiple dose rat studies, NOAEL values of 40 mg/kg per day (the lowest-observed-adverse-effect level (LOAEL) was 53 mg/kg per day) and 60 mg/kg per day (the LOAEL was 120 mg/kg per day) have been reported.
INCHEM_WHO_ehc_ehc_ehc161 LOAEL =280 mg/kg bw/day Mouse - - Toxicology study document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=a118e25adbdc21d0; raw_unit=mg/kg per day; context=In the mouse, the NOAEL was 140 mg/kg per day (the LOAEL was 280 mg/kg per day).
INCHEM_WHO_ehc_ehc_ehc161 LOAEL =53 mg/kg bw/day Rat - - Toxicology study document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=ed71aff4d6f83276; raw_unit=mg/kg per day; context=In two multiple-dose rat studies, NOAELs of 40 mg/kg per day (the LOAEL was 53 mg/kg per day) and 60 mg/kg per day (the LOAEL was 120 mg/kg per day) have been reported.
INCHEM_WHO_ehc_ehc_ehc161 LOAEL =53 mg/kg bw - - - Toxicology study document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=db310d27d665eb10; raw_unit=mg/kg; context=En dos estudios de dosis múltiples en ratas, se han notificado NOAEL de 40 mg/kg al día (el más bajo nivel sin efectos adversos observados (LOAEL) fue de 53 mg/kg al día) y de 60 mg/kg al día (el LOAEL fue de 120 mg/kg al día).
INCHEM_WHO_ehc_ehc_ehc161 LOAEL =280 mg/kg bw - - - Toxicology study document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=97a47c116cb2f0fe; raw_unit=mg/kg; context=En el ratón, el NOAEL fue de 140 mg/kg al día (el LOAEL fue de 280 mg/kg al día).
INCHEM_WHO_ehc_ehc_ehc161 NOAEL =40 mg/kg bw/day Rat - - Toxicology study document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=9d74c3c65623b1bd; raw_unit=mg/kg per day; context=In two multiple dose rat studies, NOAEL values of 40 mg/kg per day (the lowest-observed-adverse-effect level (LOAEL) was 53 mg/kg per day) and 60 mg/kg per day (the LOAEL was 120 mg/kg per day) have been reported.
INCHEM_WHO_ehc_ehc_ehc161 NOAEL =140 mg/kg bw/day Mouse - - Toxicology study document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=0c1d1a6b165ca9f0; raw_unit=mg/kg per day; context=In the mouse, the NOAEL was 140 mg/kg per day (the LOAEL was 280 mg/kg per day).
INCHEM_WHO_ehc_ehc_ehc161 NOAEL =12 mg/kg bw/day Rat oral 14-day Toxicology study document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=21c23c3a4c83793a; raw_unit=mg/kg per day; context=In a limited 14-day study on rats, an oral NOAEL of 12 mg/kg per day was reported based on kidney effects.
INCHEM_WHO_ehc_ehc_ehc161 NOAEL =12 mg/kg bw - oral - Toxicology study document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=dea590bedec34595; raw_unit=mg/kg; context=En un estudio limitado de 14 días de duración realizado en ratas se notificó un nivel sin efectos adversos observados (NOAEL) de 12 mg/kg al día por vía oral, basado en los efectos renales.
INCHEM_WHO_ehc_ehc_ehc161 NOAEL =40 mg/kg bw - - - Toxicology study document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=a6c5ecee2eec53c2; raw_unit=mg/kg; context=En dos estudios de dosis múltiples en ratas, se han notificado NOAEL de 40 mg/kg al día (el más bajo nivel sin efectos adversos observados (LOAEL) fue de 53 mg/kg al día) y de 60 mg/kg al día (el LOAEL fue de 120 mg/kg al día).
INCHEM_WHO_ehc_ehc_ehc161 NOAEL =140 mg/kg bw - - - Toxicology study document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=b1bc61944ef38ca4; raw_unit=mg/kg; context=En el ratón, el NOAEL fue de 140 mg/kg al día (el LOAEL fue de 280 mg/kg al día).
INCHEM_WHO_ehc_ehc_ehc161 NOAEL =40 mg/kg bw/day Rat - - Toxicology study document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=9d74c3c65623b1bd; raw_unit=mg/kg per day; context=In two multiple dose rat studies, NOAEL values of 40 mg/kg per day (the lowest-observed-adverse-effect level (LOAEL) was 53 mg/kg per day) and 60 mg/kg per day (the LOAEL was 120 mg/kg per day) have been reported.
INCHEM_WHO_ehc_ehc_ehc161 NOAEL =140 mg/kg bw/day Mouse - - Toxicology study document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=0c1d1a6b165ca9f0; raw_unit=mg/kg per day; context=In the mouse, the NOAEL was 140 mg/kg per day (the LOAEL was 280 mg/kg per day).
INCHEM_WHO_ehc_ehc_ehc161 NOAEL =12 mg/kg bw/day Rat oral 14-day Toxicology study document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=21c23c3a4c83793a; raw_unit=mg/kg per day; context=In a limited 14-day study on rats, an oral NOAEL of 12 mg/kg per day was reported based on kidney effects.
INCHEM_WHO_ehc_ehc_ehc161 NOAEL =12 mg/kg bw - oral - Toxicology study document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=dea590bedec34595; raw_unit=mg/kg; context=En un estudio limitado de 14 días de duración realizado en ratas se notificó un nivel sin efectos adversos observados (NOAEL) de 12 mg/kg al día por vía oral, basado en los efectos renales.
INCHEM_WHO_ehc_ehc_ehc161 NOAEL =40 mg/kg bw - - - Toxicology study document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=a6c5ecee2eec53c2; raw_unit=mg/kg; context=En dos estudios de dosis múltiples en ratas, se han notificado NOAEL de 40 mg/kg al día (el más bajo nivel sin efectos adversos observados (LOAEL) fue de 53 mg/kg al día) y de 60 mg/kg al día (el LOAEL fue de 120 mg/kg al día).
INCHEM_WHO_ehc_ehc_ehc161 NOAEL =140 mg/kg bw - - - Toxicology study document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=b1bc61944ef38ca4; raw_unit=mg/kg; context=En el ratón, el NOAEL fue de 140 mg/kg al día (el LOAEL fue de 280 mg/kg al día).
INCHEM_WHO_ehc_ehc_ehc161 TDI range:60-2000.2 mg/kg bw/day - - - Health guidance value document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=430066a4f116bdfa; raw_unit=ug/kg body weight per day; unit_normalization=converted from micrograms; context=Using an uncertainty factor of 200, a range of 60-200 ug/kg body weight per day is recommended as the upper limit of the total daily intake (TDI).
INCHEM_WHO_ehc_ehc_ehc161 TDI range:60-2000.2 mg/kg bw/day - - - Health guidance value document_id=ehc_ehc_ehc161; title=Phenol (EHC 161, 1994); path=mirror/documents/ehc/ehc/ehc161.htm; row_hash=430066a4f116bdfa; raw_unit=ug/kg body weight per day; unit_normalization=converted from micrograms; context=Using an uncertainty factor of 200, a range of 60-200 ug/kg body weight per day is recommended as the upper limit of the total daily intake (TDI).
INCHEM_WHO_jecfa_jecmono_v46je09 26 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
INCHEM_WHO_jecfa_jecmono_v46je09 ADI range:0-0.20.2 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=5f056c3c35e01b09; raw_unit=mg/kg bw; context=735) was evaluated by the Committee at its eighth meeting, when an ADI of 0-0.2 mg/kg bw was established (Annex 1, reference 8).
INCHEM_WHO_jecfa_jecmono_v46je09 ADI range:0-0.20.2 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=5f056c3c35e01b09; raw_unit=mg/kg bw; context=735) was evaluated by the Committee at its eighth meeting, when an ADI of 0-0.2 mg/kg bw was established (Annex 1, reference 8).
INCHEM_WHO_jecfa_jecmono_v46je09 ADI range:0-0.40.4 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=3c4335801aea9cf2; raw_unit=mg/kg bw; context=All intake values are expressed in ug/day. c An ADI of 0-0.4 mg/kg bw has been established for 2-phenylphenol (FAO, 1999).
INCHEM_WHO_jecfa_jecmono_v46je09 ADI range:0-0.40.4 mg/kg bw/day - - - Health guidance value document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=3c4335801aea9cf2; raw_unit=mg/kg bw; context=All intake values are expressed in ug/day. c An ADI of 0-0.4 mg/kg bw has been established for 2-phenylphenol (FAO, 1999).
INCHEM_WHO_jecfa_jecmono_v46je09 NOEL =0.06 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=49ad2253a8971057; raw_unit=mg/kg bw per day; context=The NOEL was 0.06 mg/kg bw per day (Maasik, 1970).
INCHEM_WHO_jecfa_jecmono_v46je09 NOEL =0.06 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=49ad2253a8971057; raw_unit=mg/kg bw per day; context=The NOEL was 0.06 mg/kg bw per day (Maasik, 1970).
INCHEM_WHO_jecfa_jecmono_v46je09 NOEL =0.14 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=fe8e980f0a109609; raw_unit=mg/kg bw per day; context=The NOEL was 0.14 mg/kg bw per day (Maasik, 1970).
INCHEM_WHO_jecfa_jecmono_v46je09 NOEL =0.14 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=fe8e980f0a109609; raw_unit=mg/kg bw per day; context=The NOEL was 0.14 mg/kg bw per day (Maasik, 1970).
INCHEM_WHO_jecfa_jecmono_v46je09 NOEL =0.2 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=20ad78967d133183; raw_unit=mg/kg bw per day; context=The NOEL was 0.20 mg/kg bw per day (Posternak & Linder, 1969).
INCHEM_WHO_jecfa_jecmono_v46je09 NOEL =0.2 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=20ad78967d133183; raw_unit=mg/kg bw per day; context=The NOEL was 0.20 mg/kg bw per day (Posternak & Linder, 1969).
INCHEM_WHO_jecfa_jecmono_v46je09 NOEL =6 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=9e8692fc33a732ee; raw_unit=mg/kg bw per day; context=The NOEL was 6.0 mg/kg bw per day (Posternak & Linder, 1969).
INCHEM_WHO_jecfa_jecmono_v46je09 NOEL =6 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=9e8692fc33a732ee; raw_unit=mg/kg bw per day; context=The NOEL was 6.0 mg/kg bw per day (Posternak & Linder, 1969).
INCHEM_WHO_jecfa_jecmono_v46je09 NOEL =50 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=6d09c13147bf76aa; raw_unit=mg/kg bw per day; context=The NOEL was 50 mg/kg bw per day (Environmental Protection Agency, 1988b). para- Ethylphenol (No.
INCHEM_WHO_jecfa_jecmono_v46je09 NOEL =50 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=6d09c13147bf76aa; raw_unit=mg/kg bw per day; context=The NOEL was 50 mg/kg bw per day (Environmental Protection Agency, 1988b). para- Ethylphenol (No.
INCHEM_WHO_jecfa_jecmono_v46je09 NOEL =180 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=0218ff170998ea9f; raw_unit=mg/kg bw per day; context=The NOEL was 180 mg/kg bw per day (Environmental Protection Agency, 1988a).
INCHEM_WHO_jecfa_jecmono_v46je09 NOEL =180 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=0218ff170998ea9f; raw_unit=mg/kg bw per day; context=The NOEL was 180 mg/kg bw per day (Environmental Protection Agency, 1988a).
INCHEM_WHO_jecfa_jecmono_v46je09 NOEL =220 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=4e9e3546a563071b; raw_unit=mg/kg; context=The NOEL was 220 mg/kg, bw per day (National Toxicology Program, 1992b).
INCHEM_WHO_jecfa_jecmono_v46je09 NOEL =220 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=4e9e3546a563071b; raw_unit=mg/kg; context=The NOEL was 220 mg/kg, bw per day (National Toxicology Program, 1992b).
INCHEM_WHO_jecfa_jecmono_v46je09 NOEL =250 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=8bcf2d93c4020df6; raw_unit=mg/kg bw per day; context=The NOEL for both ortho -cresol and meta/para- cresol was 250 mg/kg bw per day (National Toxicology Program, 1992a).
INCHEM_WHO_jecfa_jecmono_v46je09 NOEL =250 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=8bcf2d93c4020df6; raw_unit=mg/kg bw per day; context=The NOEL for both ortho -cresol and meta/para- cresol was 250 mg/kg bw per day (National Toxicology Program, 1992a).
INCHEM_WHO_jecfa_jecmono_v46je09 NOEL =280 mg/kg bw/day Rat - 13-week Subchronic toxicity document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=5a7a72264318c57e; raw_unit=mg/kg bw per day; context=The NOEL of 280 mg/kg bw per day in a 13-week study in rats given multiple doses (Gaunt et al., 1970) is > 1000 times the daily intakes of 46 ug/kg bw in Europe and 63 ug/kg bw in the USA.
INCHEM_WHO_jecfa_jecmono_v46je09 NOEL =280 mg/kg bw/day Rat - 13-week Subchronic toxicity document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=5a7a72264318c57e; raw_unit=mg/kg bw per day; context=The NOEL of 280 mg/kg bw per day in a 13-week study in rats given multiple doses (Gaunt et al., 1970) is > 1000 times the daily intakes of 46 ug/kg bw in Europe and 63 ug/kg bw in the USA.
INCHEM_WHO_jecfa_jecmono_v46je09 NOEL =300 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=db8413174608fd5f; raw_unit=mg/kg bw per day; context=The NOEL was 300 mg/kg bw per day (National Toxicology Program, 1980). ortho- Cresol (No.
INCHEM_WHO_jecfa_jecmono_v46je09 NOEL =300 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=db8413174608fd5f; raw_unit=mg/kg bw per day; context=The NOEL was 300 mg/kg bw per day (National Toxicology Program, 1980). ortho- Cresol (No.
INCHEM_WHO_jecfa_jecmono_v46je09 NOEL =1000 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=5ac3a83ca54faee4; raw_unit=mg/kg bw per day; context=The NOEL was 1000 mg/kg bw per day (Hagan et al., 1967).
INCHEM_WHO_jecfa_jecmono_v46je09 NOEL =1000 mg/kg bw/day - - - Toxicology study document_id=jecfa_jecmono_v46je09; title=PHENOL AND PHENOL DERIVATIVES; path=mirror/documents/jecfa/jecmono/v46je09.htm; row_hash=5ac3a83ca54faee4; raw_unit=mg/kg bw per day; context=The NOEL was 1000 mg/kg bw per day (Hagan et al., 1967).
INCHEM_WHO_pims_chemical_pim412 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
INCHEM_WHO_pims_chemical_pim412 NOAEL =60 mg/kg bw/day Rat - - Developmental toxicity document_id=pims_chemical_pim412; title=Phenol (PIM 412); path=mirror/documents/pims/chemical/pim412.htm; row_hash=9f77d5760b74f219; raw_unit=mg/kg/day; context=However, according to IRIS (Integrated Risk Information Sytem, 1996), the reference dose (Rfd) is 0.6 mg/kg/day, using the NOAEL (reduced fetal body weight in rats) of 60 mg/kg/day, with an uncertainty factor (Uf) of 100.
INCHEM_WHO_pims_chemical_pim412 NOAEL =60 mg/kg bw/day Rat - - Developmental toxicity document_id=pims_chemical_pim412; title=Phenol (PIM 412); path=mirror/documents/pims/chemical/pim412.htm; row_hash=9f77d5760b74f219; raw_unit=mg/kg/day; context=However, according to IRIS (Integrated Risk Information Sytem, 1996), the reference dose (Rfd) is 0.6 mg/kg/day, using the NOAEL (reduced fetal body weight in rats) of 60 mg/kg/day, with an uncertainty factor (Uf) of 100.
INCHEM_WHO_pims_chemical_pim412 NOAEL =60 mg/kg bw/day Rat - - Developmental toxicity document_id=pims_chemical_pim412; title=Phenol (PIM 412); path=mirror/documents/pims/chemical/pim412.htm; row_hash=9f77d5760b74f219; raw_unit=mg/kg/day; context=However, according to IRIS (Integrated Risk Information Sytem, 1996), the reference dose (Rfd) is 0.6 mg/kg/day, using the NOAEL (reduced fetal body weight in rats) of 60 mg/kg/day, with an uncertainty factor (Uf) of 100.
INCHEM_WHO_pims_chemical_pim412 NOAEL =60 mg/kg bw/day Rat - - Developmental toxicity document_id=pims_chemical_pim412; title=Phenol (PIM 412); path=mirror/documents/pims/chemical/pim412.htm; row_hash=9f77d5760b74f219; raw_unit=mg/kg/day; context=However, according to IRIS (Integrated Risk Information Sytem, 1996), the reference dose (Rfd) is 0.6 mg/kg/day, using the NOAEL (reduced fetal body weight in rats) of 60 mg/kg/day, with an uncertainty factor (Uf) of 100.
INCHEM_WHO_pims_chemical_pim412 TDI =0.1 mg/kg bw/day - - - Health guidance value document_id=pims_chemical_pim412; title=Phenol (PIM 412); path=mirror/documents/pims/chemical/pim412.htm; row_hash=0fc008bcaa5e2021; raw_unit=mg/kg body weight per day; context=With an uncertainty factor of 200, the range of 60 to 200 ug/kg/day was recommended as the upper limit of the TDI (WHO, 1994) The estimated maximal total daily intake of phenol for a 70 kg individual is calculated to be 0.1 mg/kg body weight per day (WHO, 1994).
INCHEM_WHO_pims_chemical_pim412 TDI =0.1 mg/kg bw/day - - - Health guidance value document_id=pims_chemical_pim412; title=Phenol (PIM 412); path=mirror/documents/pims/chemical/pim412.htm; row_hash=0fc008bcaa5e2021; raw_unit=mg/kg body weight per day; context=With an uncertainty factor of 200, the range of 60 to 200 ug/kg/day was recommended as the upper limit of the TDI (WHO, 1994) The estimated maximal total daily intake of phenol for a 70 kg individual is calculated to be 0.1 mg/kg body weight per day (WHO, 1994).
INCHEM_WHO_pims_chemical_pim412 TDI =0.1 mg/kg bw/day - - - Health guidance value document_id=pims_chemical_pim412; title=Phenol (PIM 412); path=mirror/documents/pims/chemical/pim412.htm; row_hash=0fc008bcaa5e2021; raw_unit=mg/kg body weight per day; context=With an uncertainty factor of 200, the range of 60 to 200 ug/kg/day was recommended as the upper limit of the TDI (WHO, 1994) The estimated maximal total daily intake of phenol for a 70 kg individual is calculated to be 0.1 mg/kg body weight per day (WHO, 1994).
INCHEM_WHO_pims_chemical_pim412 TDI =0.1 mg/kg bw/day - - - Health guidance value document_id=pims_chemical_pim412; title=Phenol (PIM 412); path=mirror/documents/pims/chemical/pim412.htm; row_hash=0fc008bcaa5e2021; raw_unit=mg/kg body weight per day; context=With an uncertainty factor of 200, the range of 60 to 200 ug/kg/day was recommended as the upper limit of the TDI (WHO, 1994) The estimated maximal total daily intake of phenol for a 70 kg individual is calculated to be 0.1 mg/kg body weight per day (WHO, 1994).
NTP_ICE_acute_inhalation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_inhalation LC50 0.316 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=2796; Record_ID=acute_inhalation_2588; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.316; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021124
NTP_ICE_acute_oral 16 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =400 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_803; row=8549; data_type=In Vivo; mixture=Chemical; chemical_name=Phenol; preferred_name=Phenol; dtxsid=DTXSID5021124; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021124; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 >410 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_804; row=8550; data_type=In Vivo; mixture=Chemical; chemical_name=Phenol; preferred_name=Phenol; dtxsid=DTXSID5021124; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021124; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =414 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_805; row=8551; data_type=In Vivo; mixture=Chemical; chemical_name=Phenol; preferred_name=Phenol; dtxsid=DTXSID5021124; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021124; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =445 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_806; row=8552; data_type=In Vivo; mixture=Chemical; chemical_name=Phenol; preferred_name=Phenol; dtxsid=DTXSID5021124; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021124; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =512 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_807; row=8553; data_type=In Vivo; mixture=Chemical; chemical_name=Phenol; preferred_name=Phenol; dtxsid=DTXSID5021124; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021124; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =520 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_808; row=8554; data_type=In Vivo; mixture=Chemical; chemical_name=Phenol; preferred_name=Phenol; dtxsid=DTXSID5021124; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021124; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =550 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_813; row=8555; data_type=In Vivo; mixture=Chemical; chemical_name=Phenol; preferred_name=Phenol; dtxsid=DTXSID5021124; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021124; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =540 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_812; row=8556; data_type=In Vivo; mixture=Chemical; chemical_name=Phenol; preferred_name=Phenol; dtxsid=DTXSID5021124; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021124; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =530 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_811; row=8557; data_type=In Vivo; mixture=Chemical; chemical_name=Phenol; preferred_name=Phenol; dtxsid=DTXSID5021124; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021124; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =527 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_809; row=8558; data_type=In Vivo; mixture=Chemical; chemical_name=Phenol; preferred_name=Phenol; dtxsid=DTXSID5021124; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021124; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =650 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_814; row=8559; data_type=In Vivo; mixture=Chemical; chemical_name=Phenol; preferred_name=Phenol; dtxsid=DTXSID5021124; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021124; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =1030 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_815; row=8560; data_type=In Vivo; mixture=Chemical; chemical_name=Phenol; preferred_name=Phenol; dtxsid=DTXSID5021124; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021124; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =1500 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_816; row=8561; data_type=In Vivo; mixture=Chemical; chemical_name=Phenol; preferred_name=Phenol; dtxsid=DTXSID5021124; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021124; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =316 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_800; row=8563; data_type=In Vivo; mixture=Chemical; chemical_name=Phenol; preferred_name=Phenol; dtxsid=DTXSID5021124; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021124; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =317 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_801; row=8564; data_type=In Vivo; mixture=Chemical; chemical_name=Phenol; preferred_name=Phenol; dtxsid=DTXSID5021124; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021124; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =340 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_802; row=8565; data_type=In Vivo; mixture=Chemical; chemical_name=Phenol; preferred_name=Phenol; dtxsid=DTXSID5021124; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021124; source_file=acute_oral.xlsx
NTP_ICE_adme_parameters 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_adme_parameters Clint 5.496 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=1956; Record_ID=adme_parameters_255; Data_Type=Measured; DTXSID=DTXSID5021124; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=5.496; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021124
NTP_ICE_adme_parameters Fu 0.6201 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=1957; Record_ID=adme_parameters_255; Data_Type=Measured; DTXSID=DTXSID5021124; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.6201; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021124
NTP_ICE_cancer 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_cancer IARC group 3 unitless - - - WOE; IARC Carcinogenicity sheet=Data; excel_row=5635; Record_ID=cancer_5218; Data_Type=WOE; Formulation_Name=Phenol; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/65; http://publications.iarc.fr/89; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021124
NTP_ICE_cancer Top dose 5000 ppm Rat - - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=5627; Record_ID=cancer_5221; Data_Type=In Vivo; Formulation_Name=Phenol; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=5000; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Female; Reference=TR-203; URL=https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr203/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021124
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=13234; RecordID=ARPathway2016_523; DatasetName=ARPathway2016; DTXSID=DTXSID5021124; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124
NTP_ICE_skin_irritation 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_irritation Viability (240 minutes) 23.1 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=3464; Record_ID=skin_irritation_invitro_2219; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=23.1; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021124
NTP_ICE_skin_irritation Viability (240 minutes) 18.5 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=3465; Record_ID=skin_irritation_invitro_2220; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=18.5; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021124
NTP_ICE_skin_irritation Viability (3 minutes) 29.8 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=3459; Record_ID=skin_irritation_invitro_2219; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=29.8; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021124
NTP_ICE_skin_irritation Viability (3 minutes) 22 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=3460; Record_ID=skin_irritation_invitro_2220; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=22; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021124
NTP_ICE_skin_irritation Viability (3 minutes) 21.4 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=3467; Record_ID=skin_irritation_invitro_2221; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=21.4; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021124
NTP_ICE_skin_irritation Viability (60 minutes) 21.8 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=3461; Record_ID=skin_irritation_invitro_2219; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=21.8; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021124
NTP_ICE_skin_irritation Viability (60 minutes) 18.4 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=3462; Record_ID=skin_irritation_invitro_2220; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=18.40; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021124
NTP_ICE_skin_irritation Viability (60 minutes) 17.2 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=3463; Record_ID=skin_irritation_invitro_2221; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=17.2; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021124
NTP_ICE_skin_sensitization 10 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization CD54, EC200 130.2 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=2369; Record_ID=skin_sensitization_invitro_577; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=130.19999999999999; Reported_Response_Unit=ug/mL; Response=130.2; Response_Unit=ug/mL; Reference=Miyazawa personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124
NTP_ICE_skin_sensitization CD86, EC150 173 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=2371; Record_ID=skin_sensitization_invitro_577; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=173; Reported_Response_Unit=ug/mL; Response=173; Response_Unit=ug/mL; Reference=Miyazawa personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124
NTP_ICE_skin_sensitization CD86, EC150 21.74 ug/mL - Dermal - In Vitro; CE_USENSE2018; U-SENS sheet=Data_invitro; excel_row=8697; Record_ID=skin_sensitization_invitro_2408; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=21.74; Reported_Response_Unit=ug/mL; Response=21.74; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124
NTP_ICE_skin_sensitization CV70 101.68 ug/mL - Dermal - In Vitro; CE_USENSE2018; U-SENS sheet=Data_invitro; excel_row=8695; Record_ID=skin_sensitization_invitro_2408; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=U-SENS; Endpoint=CV70; Reported_Response=101.68; Reported_Response_Unit=ug/mL; Response=101.68; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124
NTP_ICE_skin_sensitization CV75 308.8 ug/mL - Dermal - In Vitro; CE_hCLAT2018; h-CLAT sheet=Data_invitro; excel_row=2373; Record_ID=skin_sensitization_invitro_577; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=h-CLAT; Endpoint=CV75; Reported_Response=308.8; Reported_Response_Unit=ug/mL; Response=308.8; Response_Unit=ug/mL; Reference=Miyazawa personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124
NTP_ICE_skin_sensitization EC1.5 >2000 uM - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4705; Record_ID=skin_sensitization_invitro_1087; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124
NTP_ICE_skin_sensitization Imax 1.3 ratio - Dermal - In Vitro; CE_KeratinoSense2018; KeratinoSens sheet=Data_invitro; excel_row=4711; Record_ID=skin_sensitization_invitro_1087; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.3; Reported_Response_Unit=Unitless; Response=1.3; Response_Unit=Ratio; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3373; Record_ID=skin_sensitization_invivo_853; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Gad et al. (1986; 3715870; 10.1016/0041-008X(86)90419-9|Basketter et al. 1996; 9012774; 10.1016/s0278-6915(96)00059-2|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Basketter et al. 2014; 24407057; 10.1097/der.0000000000000003; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124
NTP_ICE_skin_sensitization Induction dose per skin area 1241 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3371; Record_ID=skin_sensitization_invivo_853; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=1241; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Gad et al. (1986; 3715870; 10.1016/0041-008X(86)90419-9|Basketter et al. 1996; 9012774; 10.1016/s0278-6915(96)00059-2|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Basketter et al. 2014; 24407057; 10.1097/der.0000000000000003; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124
NTP_ICE_skin_sensitization Relative reliability score 1 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3375; Record_ID=skin_sensitization_invivo_853; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021124; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=1; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Gad et al. (1986; 3715870; 10.1016/0041-008X(86)90419-9|Basketter et al. 1996; 9012774; 10.1016/s0278-6915(96)00059-2|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Basketter et al. 2014; 24407057; 10.1097/der.0000000000000003; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021124
ToxRefDB_ToxRefDB_v3_pod.csv 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxRefDB_ToxRefDB_v3_pod.csv LEL =250 mg/kg bw/day rat (fischer; Fischer 344) oral 0 week to 103 week CHR study_id=2527; toxval_study_source_id=studyid2527_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-water consumption-water consumption; dose_level=2; study_year=1980; study_citation=Bioassay of Phenol for Possible Carcinogenicity: Phenol: Hazleton Laboratories, Vienna, VA. Study #: NIH Pub.# 80-1759: August 1980; dsstox_substance_id=DTXSID5021124; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv LEL =375 mg/kg bw/day mouse (b6c3f1; B6C3F1) oral 0 week to 103 week CHR study_id=2528; toxval_study_source_id=studyid2528_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-water consumption-water consumption|pathology microscopic-uterus-interstitial stromal tumor; dose_level=1; study_year=1980; study_citation=Bioassay of Phenol for Possible Carcinogenicity: Study #: NIH PUB.#: 80-1759, Hazleton Laboratories, Vienna, VA August 1980; dsstox_substance_id=DTXSID5021124; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv NEL =125 mg/kg bw/day rat (fischer; Fischer 344) oral 0 week to 103 week CHR study_id=2527; toxval_study_source_id=studyid2527_Adult_F0_F_systemic; toxval_effect_list=in life observation-water consumption-water consumption|in life observation-body weight-body weight; dose_level=1; study_year=1980; study_citation=Bioassay of Phenol for Possible Carcinogenicity: Phenol: Hazleton Laboratories, Vienna, VA. Study #: NIH Pub.# 80-1759: August 1980; dsstox_substance_id=DTXSID5021124; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxRefDB_ToxRefDB_v3_pod.csv NEL >0 mg/kg bw/day rat (fischer; Fischer 344) oral 0 week to 103 week CHR study_id=2527; toxval_study_source_id=studyid2527_Adult_F0_M_systemic; toxval_effect_list=pathology gross-full gross necropsy-lymphoma malignant|pathology microscopic-[other]-lymphoma malignant|in life observation-water consumption-water consumption|pathology microscopic-adrenal gland-pheochromocytoma nos|pathology microscopic-bone marrow-leukemia|in life observation-body weight-body weight; dose_level=0; study_year=1980; study_citation=Bioassay of Phenol for Possible Carcinogenicity: Phenol: Hazleton Laboratories, Vienna, VA. Study #: NIH Pub.# 80-1759: August 1980; dsstox_substance_id=DTXSID5021124; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5
ToxValDB_ATSDR_MRLs 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ATSDR_MRLs BMDL =125 mg/kg bw/day Rat oral short-term (developmental); 10 days reproduction developmental LONG_REF=York. 1997. Oral (gavage) developmental toxicity study of phenol in rats. Procter & Gamble Co. Submitted to the U.S. Environmental Protection Agency under TSCA Section 8D. OTS0573686.; TITLE=Oral (gavage) developmental toxicity study of phenol in rats; AUTHOR=York; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f4e4b063812d5857db; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp115.pdf; TOXICOLOGICAL_EFFECT=body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ATSDR MRLs:15447761:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_318d3f780a0921d289980cc9f9119d94
ToxValDB_ATSDR_MRLs MRL =1 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=body weight in male/female rats; STUDY_GROUP=ATSDR MRLs:15447202:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_971b7828a20a4567aff0b11fb50f62c0
ToxValDB_Alaska_DEC 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_Alaska_DEC RfD =0.27 mg/kg bw/day Human dermal - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445787:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=0b939b18309d047fa0f9e56a02faa2c7
ToxValDB_Alaska_DEC RfD =0.3 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445788:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=db4aebf653658b521cf23b9d099a2dab
ToxValDB_Alaska_DEC RfD =0.27 mg/kg bw/day Human dermal - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445787:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=0b939b18309d047fa0f9e56a02faa2c7
ToxValDB_Alaska_DEC RfD =0.3 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445788:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=db4aebf653658b521cf23b9d099a2dab
ToxValDB_Cal_OEHHA_REL_derivations 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_Cal_OEHHA_REL_derivations NOAEL =20.016 mg/m3 Human inhalation acute; 8 hours clinical LONG_REF=Piotrowski JK. Evaluation of exposure to phenol: absorption of phenol vapor in the lungs and through the skin and excretion of phenol in urine. Br J Ind Med 1971;28:172-178; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32b8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd2final.pdf; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=irritation of the eyes, nose, and throat; STUDY_GROUP=Cal OEHHA REL derivations:15951965:-:-volunteers; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_24b113ba30f6dcdad75c2fdd262cdc35
ToxValDB_Cal_OEHHA_REL_derivations NOAEL =19.2461 mg/m3 Mouse inhalation subchronic; 90 days subchronic LONG_REF=Sandage C. 1961. Tolerance criteria for continuous inhalation exposure to toxic material. I. Effects on animals of 90-day exposure to phenol, CCl4 and a mixture of indole, skatole, H2S and methyl mercaptan. ASD technical report 61-519(I). Wright Patterson Air Force Base, OH: U.S. Air Force Systems Command, Aeronautical Systems Division; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32ce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd3final.pdf; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Systemic effects including liver and nervous system effects; STUDY_GROUP=Cal OEHHA REL derivations:15952123:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_82ce196a66db36dbb1209091b4decd2b
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_DOE_Protective_Action_Criteria LEL =69286 mg/m3 Human inhalation - acute LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=DOE Protective Action Criteria:15518317:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d126b768e9e2c7975296cf02d735fd14
ToxValDB_ECOTOX 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX LOEL =50 mg/kg bw/day Rat injection short-term; 15 days short-term LONG_REF=Regulatory Pept.119(3): 155-161 Deng,P.Y., F. Ye, W.J. Cai, H.W. Deng, and Y.J. Li Role of Calcitonin Gene-Related Peptide in the Phenol-Induced Neurogenic Hypertension in Rats 2004; TITLE=Role of Calcitonin Gene-Related Peptide in the Phenol-Induced Neurogenic Hypertension in Rats; AUTHOR=Deng,P.Y., F. Ye, W.J. Cai, H.W. Deng, and Y.J. Li; DOI=10.1016/j.regpep.2004.01.011; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=107000; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Biochemistry: Calcitonin Gene-Related Peptide|Genetics: Gene expression|Physiology: Blood pressure; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|other; STUDY_GROUP=ECOTOX:15594781:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=31c1951e78b9037d956754f3e687e8c1
ToxValDB_ECOTOX NOEL =160 mg/kg bw/day Rat oral acute; 1 days acute LONG_REF=Mutat. Res.320(3): 189-205 Uno,Y., H. Takasawa, M. Miyagawa, Y. Inoue, T. Murata, and K. Yoshikawa An In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test Using Rat Hepatocytes as an Early Prediction Assay for Nongenotoxic Hepatocarcinogens Screening of 22 Known Positive and 25 Noncarcinogens 1994; TITLE=An In Vivo-In Vitro Replicative DNA Synthesis (RDS) Test Using Rat Hepatocytes as an Early Prediction Assay for Nongenotoxic Hepatocarcinogens Screening of 22 Known Positive and 25 Noncarcinogens; AUTHOR=Uno,Y., H. Takasawa, M. Miyagawa, Y. Inoue, T. Murata, and K. Yoshikawa; DOI=10.1016/0165-1218(94)90046-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75058; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Cell(s): Viability; STUDY_GROUP=ECOTOX:15606801:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d8a1069fb94c4627bcf553a8c8c6c654
ToxValDB_ECOTOX NOEL =53.3 mg/kg bw/day Rat oral short-term (developmental); 14 days reproduction developmental LONG_REF=J. Toxicol. Environ. Health45:145-171 Narotsky,M.G., and R.J. Kavlock A Multidisciplinary Approach to Toxicological Screening: II. Developmental Toxicity 1995; TITLE=A Multidisciplinary Approach to Toxicological Screening: II. Developmental Toxicity; AUTHOR=Narotsky,M.G., and R.J. Kavlock; DOI=10.1080/15287399509531987; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98654; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Growth: Weight|Reproduction: Viability; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|reproduction; STUDY_GROUP=ECOTOX:15612220:F:F1-; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=5c1aab71ae3349fbac413f2ca05d81a2
ToxValDB_EFSA 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA BMDL (10) =52 mg/kg bw/day Rat oral short-term; 10 days reproduction developmental LONG_REF=EFSA CEF (2013). Scientific Opinion on the toxicological evaluation of phenol. doi:10.2903/j.efsa.2013.3189.; TITLE=Scientific Opinion on the toxicological evaluation of phenol; AUTHOR=EFSA CEF; DOI=doi:10.2903/j.efsa.2013.3189; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA:15620862:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e32fcf14baa2da3b9b5f8e486d1452e6
ToxValDB_EFSA LOAEL =1.8 mg/kg bw/day Mouse oral short-term; 28 days short-term LONG_REF=EFSA AFC (2008). Flavouring Group Evaluation 88, (FGE.88). Consideration of Phenol and Phenol Derivatives evaluated by JECFA (55th meeting). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food. doi:10.2903/j.efsa.2008.857.; TITLE=Flavouring Group Evaluation 88, (FGE.88). Consideration of Phenol and Phenol Derivatives evaluated by JECFA (55th meeting). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food; AUTHOR=EFSA AFC; DOI=doi:10.2903/j.efsa.2008.857; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=hematological; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=EFSA:15620863:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6b42b419e0d52162251ffaaa7cfabe09
ToxValDB_EFSA NOAEL =60 mg/kg bw/day Rat oral short-term; 10 days reproduction developmental LONG_REF=EFSA CEF (2013). Scientific Opinion on the toxicological evaluation of phenol. doi:10.2903/j.efsa.2013.3189.; TITLE=Scientific Opinion on the toxicological evaluation of phenol; AUTHOR=EFSA CEF; DOI=doi:10.2903/j.efsa.2013.3189; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA:15620860:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fbd60d8a396e6e37826662e6e7ed0a56
ToxValDB_EFSA NOAEL =120 mg/kg bw/day Rat oral short-term; 10 days developmental LONG_REF=EFSA CEF (2013). Scientific Opinion on the toxicological evaluation of phenol. doi:10.2903/j.efsa.2013.3189.; TITLE=Scientific Opinion on the toxicological evaluation of phenol; AUTHOR=EFSA CEF; DOI=doi:10.2903/j.efsa.2013.3189; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=development; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=EFSA:15620861:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e662810fb23b5b4a2f8d5edd753554f1
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =8 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634051:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a2ce347e878dea1b86e922570ec8b044
ToxValDB_Health_Canada 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_Health_Canada NOAEL =12 mg/kg bw/day Rat oral short-term; 14 days short-term LONG_REF=CSQG: CCME, 1997b (based on WHO, 1994; Schlicht et al., 1992; Berman et al., 1995); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/61003a57e4b01a90a3f9c305; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://publications.gc.ca/site/eng/9.694269/publication.html; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=neurotoxic, nephrotoxic, hepatotoxic; TOXICOLOGICAL_EFFECT_CATEGORY=multiple; STUDY_GROUP=Health Canada:15637564:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ca855a300e2ca3b1a398c55d40cd75c0
ToxValDB_Health_Canada TDI =0.06 mg/kg bw/day Human oral short-term; 14 days Toxicity Value LONG_REF=CSQG: CCME, 1997b (based on WHO, 1994; Schlicht et al., 1992; Berman et al., 1995); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/61003a57e4b01a90a3f9c305; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://publications.gc.ca/site/eng/9.694269/publication.html; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=neurotoxic, nephrotoxic, hepatotoxic; STUDY_GROUP=Health Canada:15637462:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_feee51c86c0f16b57864de3e6004db75
ToxValDB_IRIS 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_IRIS BMD =157 mg/kg bw/day Rat oral short-term (developmental); 10 days developmental LONG_REF=Argus Research Laboratories. (1997) Oral (gavage) developmental toxicity study of phenol in rats. Horsham, PA. Protocol number: 916-011.; TITLE=Oral (gavage) developmental toxicity study of phenol in rats; AUTHOR=Argus Research Laboratories; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4d60; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=88; TOXICOLOGICAL_EFFECT=reduced maternal weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=IRIS_dup_IRIS Summary_15644855_15644860:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ceb60559703fedc1707cfad1e9a91c5c
ToxValDB_IRIS BMDL =93 mg/kg bw/day Rat oral short-term (developmental); 10 days developmental LONG_REF=Argus Research Laboratories. (1997) Oral (gavage) developmental toxicity study of phenol in rats. Horsham, PA. Protocol number: 916-011.; TITLE=Oral (gavage) developmental toxicity study of phenol in rats; AUTHOR=Argus Research Laboratories; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4d60; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=88; TOXICOLOGICAL_EFFECT=reduced maternal weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=IRIS_dup_IRIS Summary_15644855_15644860:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_34078d59dd336196c18c9cfb059e86be
ToxValDB_Pennsylvania_DEP_ToxValues 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_Pennsylvania_DEP_ToxValues RfC =0.2 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67599fbae4b0a7c65d37b2e3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://files.dep.state.pa.us/EnvironmentalCleanupBrownfields/LandRecyclingProgram/LandRecyclingProgramPortalFiles/GuidanceTechTools/VaporIntrusion/November_2021/Table%205a.pdf; STUDY_GROUP=Pennsylvania DEP ToxValues:15650301:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1a42a54c35678d6a9cd35036717037c5
ToxValDB_RSL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_RSL RfD =0.6 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15663667:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_40def3ba8726cf9b9fb2ffbe2213b5d2
ToxValDB_TX_TCEQ 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_TX_TCEQ LOAEL =18.1683 mg/m3 Rat inhalation subchronic; 90 days subchronic LONG_REF=2014 Revised Odor Value, September 14, 2015; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5ad3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/phenol.pdf; YEAR=2014 Revised Odor Value, September 14, 2015; ORIGINAL_YEAR=2014 Revised Odor Value, September 14, 2015; TOXICOLOGICAL_EFFECT=liver and kidney pathology; STUDY_GROUP=TX TCEQ:15954620:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bd696d8793933f918aaaa4746eb944c9
ToxValDB_TX_TCEQ NOAEL =96.2305 mg/m3 Rat inhalation short-term; 60 hours short-term STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5ad3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/phenol.pdf; YEAR=2014 Revised Odor Value, September 14, 2015; ORIGINAL_YEAR=2014 Revised Odor Value, September 14, 2015; TOXICOLOGICAL_EFFECT=Nasal and ocular irritation, CNS effects; STUDY_GROUP=TX TCEQ:15954622:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_786126f3dee88439cd5cbc55fdda3524
ToxValDB_ToxRefDB 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ToxRefDB LEL =250 mg/kg bw/day Rat oral chronic; 103 weeks chronic LONG_REF=Bioassay of Phenol for Possible Carcinogenicity: Phenol: Hazleton Laboratories, Vienna, VA. Study #: NIH Pub.# 80-1759: August 1980; TITLE=Bioassay of Phenol for Possible Carcinogenicity: Phenol; AUTHOR=Hazleton Laboratories; EXTERNAL_SOURCE_ID=2527; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: in life observation-water consumption-water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15694932_15694933:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_143ac0d581164e12eeae39b1481e6eb3
ToxValDB_ToxRefDB LEL =375 mg/kg bw/day Mouse oral chronic; 103 weeks chronic LONG_REF=Bioassay of Phenol for Possible Carcinogenicity: Study #: NIH PUB.#: 80-1759, Hazleton Laboratories, Vienna, VA August 1980; TITLE=Bioassay of Phenol for Possible Carcinogenicity; AUTHOR=Hazleton Laboratories; EXTERNAL_SOURCE_ID=2528; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-uterus-interstitial stromal tumor; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|food and/or water consumption; STUDY_GROUP=ToxRefDB:15694935:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_beb1c1a7b0bfdf0563d79ab8405e85c3
ToxValDB_ToxRefDB NEL =125 mg/kg bw/day Rat oral chronic; 103 weeks chronic LONG_REF=Bioassay of Phenol for Possible Carcinogenicity: Phenol: Hazleton Laboratories, Vienna, VA. Study #: NIH Pub.# 80-1759: August 1980; TITLE=Bioassay of Phenol for Possible Carcinogenicity: Phenol; AUTHOR=Hazleton Laboratories; EXTERNAL_SOURCE_ID=2527; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15694932_15694933:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_37ab242d573c9e54f11f6ff4e3be477c
openFDA substances 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 339NCG44TV UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H6O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"339NCG44TV"}
openFDA substances FDA UNII substance identifier 339NCG44TV UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H6O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"339NCG44TV"}
openFDA substances FDA UNII substance identifier 339NCG44TV UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H6O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"339NCG44TV"}
openFDA substances FDA UNII substance identifier 339NCG44TV UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H6O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"339NCG44TV"}
openFDA substances FDA UNII substance identifier concept identifier - - - concept {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null}
openFDA substances FDA UNII substance identifier concept identifier - - - concept {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null}
openFDA substances FDA UNII substance identifier concept identifier - - - concept {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null}
openFDA substances FDA UNII substance identifier concept identifier - - - concept {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null}