NOAEL Studies
Preservative
Phenoxyethanol NOAEL Studies
INCI: PHENOXYETHANOL
CAS: 122-99-6
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP ICE acute inhalation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | >1 | mg/L | - | Inhalation | Duration=>6 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=5050; Record_ID=acute_inhalation_3630; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID9021976; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=1; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15160/7/3/3/?documentUUID=b539cc86-0636-4010-90b2-afde0906484b; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021976 |
NTP ICE acute oral 19 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =1260 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_1741; row=15463; data_type=In Vivo; mixture=Chemical; chemical_name=2-Phenoxyethanol; preferred_name=2-Phenoxyethanol; dtxsid=DTXSID9021976; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9021976; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =1345 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1743; row=15465; data_type=In Vivo; mixture=Chemical; chemical_name=2-Phenoxyethanol; preferred_name=2-Phenoxyethanol; dtxsid=DTXSID9021976; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9021976; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >1400 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_1745; row=15468; data_type=In Vivo; mixture=Chemical; chemical_name=2-Phenoxyethanol; preferred_name=2-Phenoxyethanol; dtxsid=DTXSID9021976; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9021976; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =1440 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1749; row=15474; data_type=In Vivo; mixture=Chemical; chemical_name=2-Phenoxyethanol; preferred_name=2-Phenoxyethanol; dtxsid=DTXSID9021976; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9021976; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =1840 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_1751; row=15467; data_type=In Vivo; mixture=Chemical; chemical_name=2-Phenoxyethanol; preferred_name=2-Phenoxyethanol; dtxsid=DTXSID9021976; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9021976; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =1900 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_1752; row=15466; data_type=In Vivo; mixture=Chemical; chemical_name=2-Phenoxyethanol; preferred_name=2-Phenoxyethanol; dtxsid=DTXSID9021976; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9021976; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >2000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_1754; row=15459; data_type=In Vivo; mixture=Chemical; chemical_name=2-Phenoxyethanol; preferred_name=2-Phenoxyethanol; dtxsid=DTXSID9021976; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9021976; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | <2580 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_1758; row=15470; data_type=In Vivo; mixture=Chemical; chemical_name=2-Phenoxyethanol; preferred_name=2-Phenoxyethanol; dtxsid=DTXSID9021976; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9021976; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =2728 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1762; row=15477; data_type=In Vivo; mixture=Chemical; chemical_name=2-Phenoxyethanol; preferred_name=2-Phenoxyethanol; dtxsid=DTXSID9021976; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9021976; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =2740 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_1763; row=15464; data_type=In Vivo; mixture=Chemical; chemical_name=2-Phenoxyethanol; preferred_name=2-Phenoxyethanol; dtxsid=DTXSID9021976; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9021976; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =2937 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1765; row=15480; data_type=In Vivo; mixture=Chemical; chemical_name=2-Phenoxyethanol; preferred_name=2-Phenoxyethanol; dtxsid=DTXSID9021976; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9021976; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | <3000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_1767; row=15473; data_type=In Vivo; mixture=Chemical; chemical_name=2-Phenoxyethanol; preferred_name=2-Phenoxyethanol; dtxsid=DTXSID9021976; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9021976; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =3100 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1768; row=15475; data_type=In Vivo; mixture=Chemical; chemical_name=2-Phenoxyethanol; preferred_name=2-Phenoxyethanol; dtxsid=DTXSID9021976; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9021976; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =3400 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1770; row=15478; data_type=In Vivo; mixture=Chemical; chemical_name=2-Phenoxyethanol; preferred_name=2-Phenoxyethanol; dtxsid=DTXSID9021976; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9021976; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =4013 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1772; row=15479; data_type=In Vivo; mixture=Chemical; chemical_name=2-Phenoxyethanol; preferred_name=2-Phenoxyethanol; dtxsid=DTXSID9021976; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9021976; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =4070 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_1774; row=15462; data_type=In Vivo; mixture=Chemical; chemical_name=2-Phenoxyethanol; preferred_name=2-Phenoxyethanol; dtxsid=DTXSID9021976; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9021976; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =5550 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1776; row=15461; data_type=In Vivo; mixture=Chemical; chemical_name=2-Phenoxyethanol; preferred_name=2-Phenoxyethanol; dtxsid=DTXSID9021976; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9021976; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =7500 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_1777; row=15476; data_type=In Vivo; mixture=Chemical; chemical_name=2-Phenoxyethanol; preferred_name=2-Phenoxyethanol; dtxsid=DTXSID9021976; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9021976; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =13700 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_1779; row=15460; data_type=In Vivo; mixture=Chemical; chemical_name=2-Phenoxyethanol; preferred_name=2-Phenoxyethanol; dtxsid=DTXSID9021976; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9021976; source_file=acute_oral.xlsx |
NTP ICE adme parameters 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 17.89 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=3546; Record_ID=adme_parameters_204; Data_Type=Measured; DTXSID=DTXSID9021976; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=17.89; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wetmore 2012; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021976 |
| NTP ICE adme parameters | Fu | 0.2957 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=3547; Record_ID=adme_parameters_204; Data_Type=Measured; DTXSID=DTXSID9021976; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.2957; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wetmore 2012; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021976 |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=2710; RecordID=ARPathway2016_707; DatasetName=ARPathway2016; DTXSID=DTXSID9021976; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021976 |
NTP ICE skin sensitization 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | CD86, EC150 | 176.29 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8683; Record_ID=skin_sensitization_invitro_2404; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID9021976; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=176.29; Reported_Response_Unit=ug/mL; Response=176.29; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021976 |
| NTP ICE skin sensitization | CV70 | >200 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8684; Record_ID=skin_sensitization_invitro_2404; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID9021976; Assay=U-SENS; Endpoint=CV70; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=200; Reported_Response_Unit=ug/mL; Response=200; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021976 |
| NTP ICE skin sensitization | CV75 | >1000 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2339; Record_ID=skin_sensitization_invitro_571; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID9021976; Assay=h-CLAT; Endpoint=CV75; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=1000; Reported_Response_Unit=ug/mL; Response=1000; Response_Unit=ug/mL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021976 |
| NTP ICE skin sensitization | Concentration, 5% incidence of positive responses | 9 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4505; Record_ID=skin_sensitization_invivo_1082; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021976; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=9; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1982; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Scognamiglio et al. 2012; 22036980; 10.1016/j.fct.2011.10.030|Api et al. 2019; 31242430; 10.1016/j.fct.2019.110629; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021976 |
| NTP ICE skin sensitization | Concentration, one positive response | 10 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4501; Record_ID=skin_sensitization_invivo_1082; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021976; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=10; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1982; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Scognamiglio et al. 2012; 22036980; 10.1016/j.fct.2011.10.030|Api et al. 2019; 31242430; 10.1016/j.fct.2019.110629; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021976 |
| NTP ICE skin sensitization | EC1.5 | >2000 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=4969; Record_ID=skin_sensitization_invitro_1151; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID9021976; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021976 |
| NTP ICE skin sensitization | Imax | 1.09 | ratio | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=4972; Record_ID=skin_sensitization_invitro_1151; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID9021976; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.0900000000000001; Reported_Response_Unit=Unitless; Response=1.09; Response_Unit=Ratio; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021976 |
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4513; Record_ID=skin_sensitization_invivo_1085; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021976; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1982; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Scognamiglio et al. 2012; 22036980; 10.1016/j.fct.2011.10.030|Api et al. 2019; 31242430; 10.1016/j.fct.2019.110629; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021976 |
| NTP ICE skin sensitization | Incidence of positive responses | 5.556 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4544; Record_ID=skin_sensitization_invivo_1082; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021976; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=5.556; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1982; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Scognamiglio et al. 2012; 22036980; 10.1016/j.fct.2011.10.030|Api et al. 2019; 31242430; 10.1016/j.fct.2019.110629; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021976 |
| NTP ICE skin sensitization | Induction dose per skin area | 8267 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=4527; Record_ID=skin_sensitization_invivo_1089; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021976; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=8267; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1987; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Scognamiglio et al. 2012; 22036980; 10.1016/j.fct.2011.10.030; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021976 |
| NTP ICE skin sensitization | Induction dose per skin area | 12000 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=4535; Record_ID=skin_sensitization_invivo_1090; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=15.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021976; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=12000; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1978; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Scognamiglio et al. 2012; 22036980; 10.1016/j.fct.2011.10.030; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021976 |
| NTP ICE skin sensitization | Induction dose per skin area, 5% incidence of positive responses | 6075 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4507; Record_ID=skin_sensitization_invivo_1082; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021976; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=6075; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1982; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Scognamiglio et al. 2012; 22036980; 10.1016/j.fct.2011.10.030|Api et al. 2019; 31242430; 10.1016/j.fct.2019.110629; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021976 |
| NTP ICE skin sensitization | Induction dose per skin area, one positive response | 6750 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4503; Record_ID=skin_sensitization_invivo_1082; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021976; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=6750; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1982; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Scognamiglio et al. 2012; 22036980; 10.1016/j.fct.2011.10.030|Api et al. 2019; 31242430; 10.1016/j.fct.2019.110629; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021976 |
| NTP ICE skin sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4509; Record_ID=skin_sensitization_invivo_1082; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021976; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=RIFM 1982; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Scognamiglio et al. 2012; 22036980; 10.1016/j.fct.2011.10.030|Api et al. 2019; 31242430; 10.1016/j.fct.2019.110629; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021976; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021976 |
SCCS Opinion 43 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =0 | - | mouse | oral | 2 years | reproductive toxicity | (ref. 15), p.75 |
| SCCS Opinion | NOAEL | =0.2 | % | rat | oral | - | NOAEL study | p.22 |
| SCCS Opinion | NOAEL | =0.25 | % | mouse | oral | - | reproductive toxicity | p.42 |
| SCCS Opinion | NOAEL | =0.5 | % | rat | oral | 4 weeks | NOAEL study | p.21 |
| SCCS Opinion | NOAEL | =1 | % | rat | oral | - | NOAEL study | p.60 |
| SCCS Opinion | NOAEL | =1 | - | human | - | - | NOAEL study | p.61 |
| SCCS Opinion | NOAEL | =2 | - | rat | inhalation | 5 days | irritation | p.18 |
| SCCS Opinion | NOAEL | =2 | mg/kg | - | intravenous | - | NOAEL study | p.57 |
| SCCS Opinion | NOAEL | =2.5 | % | mouse | oral | - | reproductive toxicity | p.42 |
| SCCS Opinion | NOAEL | =2.69 | mg/kg/d | rat | dermal | - | NOAEL study | p.63 |
| SCCS Opinion | NOAEL | =2.69 | mg/kg bw/day | rabbit | dermal | 90-day | NOAEL study | p.72 |
| SCCS Opinion | NOAEL | =4.5 | - | - | - | - | NOAEL study | p.57 |
| SCCS Opinion | NOAEL | =5 | - | - | - | - | NOAEL study | p.57 |
| SCCS Opinion | NOAEL | =7 | % | - | - | - | NOAEL study | p.57 |
| SCCS Opinion | NOAEL | =9 | - | rat | oral | - | NOAEL study | p.100 |
| SCCS Opinion | NOAEL | =10 | - | - | - | - | NOAEL study | p.57 |
| SCCS Opinion | NOAEL | =13 | - | - | - | - | NOAEL study | p.74 |
| SCCS Opinion | NOAEL | =61 | - | rat | oral | - | NOAEL study | p.61 |
| SCCS Opinion | NOAEL | =75 | - | rat | oral | 90 days | NOAEL study | (ref. 10), p.75 |
| SCCS Opinion | NOAEL | =79 | % | rat | oral | 13-week | NOAEL study | p.78 |
| SCCS Opinion | NOAEL | =80 | mg/kg bw/day | rat | - | - | NOAEL study | p.23 |
| SCCS Opinion | NOAEL | =80 | - | rat | oral | 90 days | NOAEL study | (ref. 40), p.75 |
| SCCS Opinion | NOAEL | =164 | mg/kg bw/day | rat | oral | 90 days | NOAEL study | (ref. 16), p.75 |
| SCCS Opinion | NOAEL | =249 | - | rat | oral | 2 years | NOAEL study | p.75 |
| SCCS Opinion | NOAEL | =300 | mg/kg bw/day | - | dermal | developmental | developmental toxicity | p.46 |
| SCCS Opinion | NOAEL | =357 | mg/kg bw/day | - | - | Chronic | genotoxicity | p.29 |
| SCCS Opinion | NOAEL | =357 | mg/kg bw/d | rabbit | dermal | 90-day | NOAEL study | p.72 |
| SCCS Opinion | NOAEL | =369 | - | rat | oral | - | NOAEL study | p.100 |
| SCCS Opinion | NOAEL | =390 | - | mouse | oral | 90 days | NOAEL study | p.75 |
| SCCS Opinion | NOAEL | =400 | mg/kg bw/day | mouse | oral | - | reproductive toxicity | p.42 |
| SCCS Opinion | NOAEL | =468 | - | mouse | oral | 2 years | NOAEL study | p.75 |
| SCCS Opinion | NOAEL | =500 | mg/kg bw/day | rabbit | dermal | - | NOAEL study | p.28 |
| SCCS Opinion | NOAEL | =697 | - | rat | oral | 90 days | NOAEL study | (ref. 10), p.75 |
| SCCS Opinion | NOAEL | =950 | mg/kg bw/day | rat | oral | developmental | reproductive toxicity | p.79 |
| SCCS Opinion | NOAEL | =1000 | mg/kg bw/day | rabbit | - | developmental | developmental toxicity | p.44 |
| SCCS Opinion | NOAEL | =1575 | - | rat | oral | - | NOAEL study | p.61 |
| SCCS Opinion | NOAEL | =1977 | - | rat | oral | 90 days | NOAEL study | (ref. 40), p.75 |
| SCCS Opinion | NOAEL | =2002 | - | rat | oral | 90 days | NOAEL study | p.75 |
| SCCS Opinion | NOAEL | =2007 | - | mouse | oral | 2 years | reproductive toxicity | (ref. 15), p.75 |
| SCCS Opinion | NOAEL | =2015 | - | rat | oral | - | NOAEL study | p.80 |
| SCCS Opinion | NOAEL | =2500 | ppm | rabbit | dermal | Sub-chronic | repeated dose toxicity | p.27 |
| SCCS Opinion | NOAEL | =5000 | ppm | - | - | - | NOAEL study | p.25 |
| SCCS Opinion | NOAEL | =10000 | ppm | - | oral | - | NOAEL study | p.20 |
ECHA 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | =1000 | mg/kg bw/day | Rabbit | dermal | short-term; 14 days | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61f4ce4b096bca877d18e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/32058/7/6/4?documentUUID=ed3a9849-b514-4aa0-97af-c4687fb2d250; YEAR=1976; ORIGINAL_YEAR=1976; STUDY_GROUP=ECHA IUCLID:15826820:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d20257f2eb9ebd5b76f748d450039a23 |
| ECHA | LOAEL | ~1875 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa4ae4b0a7c65d1b5249; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/32058/7/9/2?documentUUID=ed3a9849-b514-4aa0-97af-c4687fb2d250; YEAR=1976; ORIGINAL_YEAR=1976; STUDY_GROUP=ECHA IUCLID:15860677:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3dc77314b2489851a1b994e807e94bc4 |
| ECHA | LOAEL | >3700 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa4ae4b0a7c65d1b5249; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/32058/7/9/2?documentUUID=ed3a9849-b514-4aa0-97af-c4687fb2d250; YEAR=1976; ORIGINAL_YEAR=1976; STUDY_GROUP=ECHA IUCLID:15860678:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1f0794fe8a8a94673f3fd7e0fe83ad37 |
| ECHA | NOAEL | ~375 | mg/kg bw/day | Mouse | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa4ae4b0a7c65d1b5249; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/32058/7/9/2?documentUUID=ed3a9849-b514-4aa0-97af-c4687fb2d250; YEAR=1976; ORIGINAL_YEAR=1976; STUDY_GROUP=ECHA IUCLID:15860831:M/F:F2-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_225c70b8cc0aa9613f62b7159f4e03ab |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL local | =5.7 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15634065_15634066:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4dee1f689934a633ee06c921a61c92d5 |
ToxValDB HESS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HESS | NOAEL | =80 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0de0e4b0a676289de198; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Clinical Observation: Lack of grooming Lethargy Prostration|Body Weight Changes: decrease|Food Consumption: decrease|Water Consumption: increase|Urinalysis: Volume increase, Epithelial cells increase, Polymorphonuclear leukocyte increase|Hematology: RBC decrease, HGB decrease, HCT decrease|Blood Chemistry: ALP increase|Absolute Organ Weight: Liver increase, Kidney increase, Thyroid increase|Relative Organ Weight: Liver increase, Kidney increase, Thyroid increase|Histopathology: Kidney: Inflammatory cell infiltration Kidney: Distention, tubules Kidney: Basophilic change Testes: Tubular atrophy Epididymis: Reduction of spermatozoa, tubules; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|hematology|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=HESS:15638261:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a00674bb048cb230995a64d0a131b8a5 |
Regulatory source 84 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | 0.2 | % | rat | oral | - | - | p.22 |
| Regulatory source | - | 0.5 | % | rat | oral | 4 weeks | - | p.21 |
| Regulatory source | - | 0.5 | % | - | oral | - | - | p.22 |
| Regulatory source | - | 0.5 | % | - | - | - | - | p.22 |
| Regulatory source | - | 1 | % | rat | oral | - | - | p.60 |
| Regulatory source | - | 1 | - | human | - | - | - | p.61 |
| Regulatory source | - | 1 | - | - | - | - | - | p.100 |
| Regulatory source | - | 2 | mg/kg | - | intravenous | - | - | p.57 |
| Regulatory source | - | 2 | - | rat | oral | - | - | p.100 |
| Regulatory source | - | 2 | mg/kg | - | - | - | - | p.57 |
| Regulatory source | - | 2 | - | human | - | - | - | p.61 |
| Regulatory source | - | 2 | - | - | - | - | - | p.100 |
| Regulatory source | - | 2.69 | mg/kg/d | rat | dermal | - | - | p.63 |
| Regulatory source | - | =2.69 | mg/kg bw/day | rabbit | dermal | 90-day | - | p.72 |
| Regulatory source | - | 4.5 | - | - | - | - | - | p.57 |
| Regulatory source | - | 5 | - | - | - | - | - | p.57 |
| Regulatory source | - | 7 | % | - | - | - | - | p.57 |
| Regulatory source | - | 9 | - | rat | oral | - | - | p.100 |
| Regulatory source | - | 10 | - | - | - | - | - | p.57 |
| Regulatory source | - | 13 | - | - | - | - | - | p.74 |
| Regulatory source | - | 13 | - | rabbit | dermal | - | - | p.74 |
| Regulatory source | - | 61 | - | rat | oral | - | - | p.61 |
| Regulatory source | - | 75 | - | rat | oral | 90 days | - | p.75 |
| Regulatory source | - | 75 | - | mouse | oral | 90 days | - | p.75 |
| Regulatory source | - | 75 | - | rat | oral | 2 years | - | p.75 |
| Regulatory source | - | 75 | - | mouse | oral | 2 years | - | p.75 |
| Regulatory source | - | 79 | % | rat | oral | 13-week | - | p.78 |
| Regulatory source | - | 80 | mg/kg bw/day | rat | - | - | - | p.23 |
| Regulatory source | - | 80 | - | rat | oral | 90 days | - | p.75 |
| Regulatory source | - | 164 | mg/kg bw/day | rat | oral | 90 days | - | p.75 |
| Regulatory source | - | 164 | mg/kg bw/day | rabbit | dermal | 3 years | - | p.81 |
| Regulatory source | - | 249 | - | rat | oral | 2 years | - | p.75 |
| Regulatory source | - | =357 | mg/kg bw/d | rabbit | dermal | 90-day | - | p.72 |
| Regulatory source | - | 357 | mg/kg bw/day | rabbit | dermal | 90-day | - | p.73 |
| Regulatory source | - | 357 | mg/kg bw/day | rat | oral | 77 day | - | p.77 |
| Regulatory source | - | 357 | mg/kg bw/day | rabbit | dermal | 3 years | - | p.81 |
| Regulatory source | - | 357 | mg/kg bw/day | rat | oral | 3 years | - | p.82 |
| Regulatory source | - | 357 | mg/kg bw/day | rabbit | oral | 90-day | - | p.82 |
| Regulatory source | - | 369 | - | rat | oral | - | - | p.100 |
| Regulatory source | - | 369 | - | rat | oral | 90 days | - | p.75 |
| Regulatory source | - | 390 | - | mouse | oral | 90 days | - | p.75 |
| Regulatory source | - | 468 | - | mouse | oral | 2 years | - | p.75 |
| Regulatory source | - | 500 | mg/kg bw/day | rabbit | dermal | - | - | p.28 |
| Regulatory source | - | 500 | mg/kg bw/day | rabbit | dermal | 90 days | - | p.74 |
| Regulatory source | - | 500 | mg/kg bw/day | rat | oral | 77 day | - | p.77 |
| Regulatory source | - | 697 | - | rat | oral | 90 days | - | p.75 |
| Regulatory source | - | 1000 | mg/kg bw/day | rabbit | dermal | 90 days | - | p.74 |
| Regulatory source | - | 1000 | mg/kg bw/day | rat | oral | 10 days | - | p.75 |
| Regulatory source | - | 1000 | mg/kg bw/day | rat | oral | - | - | p.75 |
| Regulatory source | - | 1000 | mg/kg bw/day | rabbit | oral | 10 days | - | p.75 |
| Regulatory source | - | 1575 | - | rat | oral | - | - | p.61 |
| Regulatory source | - | 1977 | - | rat | oral | 90 days | - | p.75 |
| Regulatory source | - | 2002 | - | rat | oral | 90 days | - | p.75 |
| Regulatory source | - | 2015 | - | rat | oral | - | - | p.80 |
| Regulatory source | - | 5000 | ppm | - | - | - | - | p.25 |
| Regulatory source | - | 5000 | ppm | - | oral | chronic | - | p.40 |
| Regulatory source | - | 10000 | ppm | - | oral | - | - | p.20 |
| Regulatory source | - | 10000 | ppm | - | - | - | - | p.25 |
| Regulatory source | - | 10000 | ppm | mouse | oral | 13-week | - | p.40 |
| Regulatory source | - | 10000 | ppm | rat | oral | 10 days | - | p.77 |
| Regulatory source | carcinogenicity | 2500 | ppm | mouse | oral | 13-week | carcinogenicity | p.78 |
| Regulatory source | carcinogenicity | 5000 | ppm | mouse | oral | - | carcinogenicity | p.38 |
| Regulatory source | carcinogenicity | 5000 | ppm | rat | oral | 90-day | carcinogenicity | p.78 |
| Regulatory source | carcinogenicity | 10000 | ppm | rat | oral | 90-day | carcinogenicity | p.77 |
| Regulatory source | developmental toxicity | 300 | mg/kg bw/day | - | dermal | developmental | developmental toxicity | p.46 |
| Regulatory source | developmental toxicity | 300 | mg/kg bw/day | rabbit | dermal | developmental | developmental toxicity | p.76 |
| Regulatory source | developmental toxicity | 1000 | mg/kg bw/day | rabbit | - | developmental | developmental toxicity | p.44 |
| Regulatory source | developmental toxicity | 1000 | mg/kg bw/day | rabbit | dermal | developmental | developmental toxicity | p.44 |
| Regulatory source | developmental toxicity | 1000 | mg/kg bw/day | - | dermal | developmental | developmental toxicity | p.46 |
| Regulatory source | genotoxicity | 357 | mg/kg bw/day | - | - | Chronic | genotoxicity | p.29 |
| Regulatory source | genotoxicity | 357 | mg/kg bw/day | - | - | - | genotoxicity | p.79 |
| Regulatory source | irritation | 2 | - | rat | inhalation | 5 days | irritation | p.18 |
| Regulatory source | irritation | 1000 | mg/kg bw/day | rat | dermal | 14 days | irritation | p.74 |
| Regulatory source | repeated dose toxicity | 2500 | ppm | rabbit | dermal | Sub-chronic | repeated dose toxicity | p.27 |
| Regulatory source | reproductive toxicity | 0 | - | mouse | oral | 2 years | reproductive toxicity | p.75 |
| Regulatory source | reproductive toxicity | 0.25 | % | mouse | oral | - | reproductive toxicity | p.42 |
| Regulatory source | reproductive toxicity | 0.25 | % | rat | oral | developmental | reproductive toxicity | p.79 |
| Regulatory source | reproductive toxicity | 2.5 | % | mouse | oral | - | reproductive toxicity | p.42 |
| Regulatory source | reproductive toxicity | 75 | - | mouse | oral | 126 days | reproductive toxicity | p.75 |
| Regulatory source | reproductive toxicity | 400 | mg/kg bw/day | mouse | oral | - | reproductive toxicity | p.42 |
| Regulatory source | reproductive toxicity | 400 | mg/kg bw/day | rat | oral | developmental | reproductive toxicity | p.79 |
| Regulatory source | reproductive toxicity | 400 | - | mouse | oral | 126 days | reproductive toxicity | p.75 |
| Regulatory source | reproductive toxicity | 950 | mg/kg bw/day | rat | oral | developmental | reproductive toxicity | p.79 |
| Regulatory source | reproductive toxicity | 2007 | - | mouse | oral | 2 years | reproductive toxicity | p.75 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | HIE492ZZ3T | UNII | - | - | - | chemical | - |