NOAEL Studies Cosmetic Ingredient

Phenyl Methyl Pyrazolone NOAEL Studies

INCI: PHENYL METHYL PYRAZOLONE

CAS: 89-25-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP ICE acute oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =1915 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_11168; row=15371; data_type=In Vivo; mixture=Chemical; chemical_name=1-Phenyl-3-methyl-5-pyrazolone; preferred_name=1-Phenyl-3-methyl-5-pyrazolone; dtxsid=DTXSID9021130; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021130; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9021130; source_file=acute_oral.xlsx
NTP ICE adme parameters 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE adme parameters Clint 2 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=3536; Record_ID=adme_parameters_620; Data_Type=Measured; DTXSID=DTXSID9021130; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=2.0; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Williamson 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021130; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021130
NTP ICE adme parameters Fu 0.89 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=3535; Record_ID=adme_parameters_620; Data_Type=Measured; DTXSID=DTXSID9021130; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.89; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Lombardo 2018; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021130; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021130
NTP ICE cancer 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE cancer Top dose 5000 ppm Rat - - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=9813; Record_ID=cancer_4694; Data_Type=In Vivo; Formulation_Name=1-Phenyl-3-methyl-5-pyrazolone; Mixture=Chemical; DTXSID=DTXSID9021130; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=5000; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Female; Reference=TR-141; URL=https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr141/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021130; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021130
NTP ICE cancer Top dose 15000 ppm Mouse - - In Vivo; NTP Carcinogenicity sheet=Data; excel_row=9817; Record_ID=cancer_4691; Data_Type=In Vivo; Formulation_Name=1-Phenyl-3-methyl-5-pyrazolone; Mixture=Chemical; DTXSID=DTXSID9021130; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=15000; Response_Unit=ppm; Species=Mouse; Strain=B6C3F1; Sex=Female; Reference=TR-141; URL=https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr141/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021130; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021130
NTP ICE skin sensitization 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization CV75 417 ug/mL - Dermal - In Vitro; Urbisch_SkinSensitization2020; h-CLAT sheet=Data_invitro; excel_row=1666; Record_ID=skin_sensitization_invitro_459; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9021130; Assay=h-CLAT; Endpoint=CV75; Reported_Response=417; Reported_Response_Unit=ug/mL; Response=417; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021130; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021130
NTP ICE skin sensitization EC1.5 4000 uM - Dermal - In Vitro; Urbisch_SkinSensitization2020; KeratinoSens sheet=Data_invitro; excel_row=6875; Record_ID=skin_sensitization_invitro_1628; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9021130; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=4000; Reported_Response_Unit=uM; Response=4000; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021130; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021130
NTP ICE skin sensitization EC3 8.3 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13451; Record_ID=skin_sensitization_invivo_3601; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID9021130; Assay=LLNA; Endpoint=EC3; Response=8.3; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kern et al. 2010; 20137736; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021130; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021130
NTP ICE skin sensitization EC3 8.5 % Mouse Dermal - In Vivo; Urbisch_SkinSensitization2020; LLNA sheet=Data_invivo; excel_row=12933; Record_ID=skin_sensitization_invivo_2862; Data_Type=In Vivo; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9021130; Assay=LLNA; Endpoint=EC3; Response=8.5; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021130; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021130
NTP ICE skin sensitization Imax 1.2 ratio - Dermal - In Vitro; Urbisch_SkinSensitization2020; KeratinoSens sheet=Data_invitro; excel_row=6878; Record_ID=skin_sensitization_invitro_1628; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID9021130; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.199586113; Reported_Response_Unit=Unitless; Response=1.2; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021130; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021130
SCCS Opinion 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.003 mg/kg bw rat dermal 28-day dermal absorption p.5
SCCS Opinion NOAEL =20 mg/kg/day - - Chronic NOAEL study p.15
SCCS Opinion NOAEL =20 mg/kg bw rat - Chronic genotoxicity p.15
SCCS Opinion NOAEL =100 mg/kg bw rat oral 13-week dermal absorption p.25
SCCS Opinion NOAEL =100 mg/kg/day rat oral 13 weeks developmental toxicity p.25
SCCS Opinion NOAEL =200 mg/kg/day human - developmental developmental toxicity p.24
SCCS Opinion NOAEL =1000 mg/kg/day rat dermal 13 weeks developmental toxicity p.25
Regulatory source 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 20 mg/kg/day - - Chronic - p.15
Regulatory source dermal absorption 0.003 mg/kg bw rat dermal 28-day dermal absorption p.5
Regulatory source dermal absorption =100 mg/kg bw rat oral 13-week dermal absorption p.25
Regulatory source developmental toxicity 100 mg/kg/day rat oral 13 weeks developmental toxicity p.25
Regulatory source developmental toxicity 200 mg/kg/day human - developmental developmental toxicity p.24
Regulatory source developmental toxicity 1000 mg/kg/day rat dermal 13 weeks developmental toxicity p.25
Regulatory source genotoxicity 20 mg/kg bw rat - Chronic genotoxicity p.15
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier S798V6YJRP UNII - - - chemical -