NOAEL Studies Cosmetic Ingredient

Phenylbenzimidazole Sulfonic Acid NOAEL Studies

INCI: PHENYLBENZIMIDAZOLE SULFONIC ACID

CAS: 27503-81-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB NOAEL 1000 mg/kg bw/day rat oral 91 day Subchronic SCCP; E.Bomhard et al. (Bayer AG, Institute of Toxicology):'Novantisolsaeure – Subchronic Toxicity Study in Rats'. Report no. 7780. 06-09-78
SCCS Opinion 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.125 mg/kg rat oral 90-day dermal absorption p.29
SCCS Opinion NOAEL =4 % rat oral 90-day dermal absorption p.29
SCCS Opinion NOAEL =40 mg/kg bw rat oral 90-day dermal absorption p.29
SCCS Opinion NOAEL =200 mg/kg bw rat oral 90-day dermal absorption p.29
SCCS Opinion NOAEL =1000 mg/kg bw/day - - Chronic genotoxicity p.18
SCCS Opinion NOAEL =1000 mg/kg bw rat oral - NOAEL study p.21
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =7 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634079:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ef0426372325e7c97762b2bd6dfcd78a
Regulatory source 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 200 mg/kg bw rat oral 13 week - p.29
Regulatory source - 1000 mg/kg bw rat oral - - p.21
Regulatory source - 1000 mg/kg bw/day rat oral 90-day - p.29
Regulatory source - 1000 mg/kg bw rat oral 90-day - p.29
Regulatory source dermal absorption =0.125 mg/kg rat oral 90-day dermal absorption p.29
Regulatory source dermal absorption 4 % rat oral 90-day dermal absorption p.29
Regulatory source dermal absorption =40 mg/kg bw rat oral 90-day dermal absorption p.29
Regulatory source dermal absorption 200 mg/kg bw rat oral 90-day dermal absorption p.29
Regulatory source genotoxicity 1000 mg/kg bw/day - - Chronic genotoxicity p.18
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 9YQ9DI1W42 UNII - - - chemical -