NOAEL Studies
Cosmetic Ingredient
Phthalic Anhydride NOAEL Studies
INCI: PHTHALIC ANHYDRIDE
CAS: 85-44-9
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
EPA_IRIS_iris_rfd_systems.csv 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA_IRIS_iris_rfd_systems.csv | LOAEL | =1562 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system PoD | row_hash=f3cbb66737852492; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=LOAEL : 1.562e3 mg/kg-day; system=Urinary, Respiratory; basis=Lung and kidney histopathology; point_of_departure=LOAEL : 1.562e3 mg/kg-day; composite_uf=1000; confidence=Medium; dtxsid=DTXSID2021159; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=308; rfd_last_updated=09/07/1988; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0308_summary.pdf |
| EPA_IRIS_iris_rfd_systems.csv | RfD | =2 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system | row_hash=02e65e9ebd2a16da; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=2; system=Urinary, Respiratory; basis=Lung and kidney histopathology; point_of_departure=LOAEL : 1.562e3 mg/kg-day; composite_uf=1000; confidence=Medium; dtxsid=DTXSID2021159; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=308; rfd_last_updated=09/07/1988; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0308_summary.pdf |
NTP_ICE_acute_inhalation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_inhalation | LC50 | >0.21 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1369; Record_ID=acute_inhalation_3044; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2021159; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=0.21; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021159; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021159 |
NTP_ICE_acute_oral 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | <1600 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_10948; row=3896; data_type=In Vivo; mixture=Chemical; chemical_name=Phthalic anhydride; preferred_name=Phthalic anhydride; dtxsid=DTXSID2021159; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021159; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021159; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =1530 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_10946; row=3897; data_type=In Vivo; mixture=Chemical; chemical_name=Phthalic anhydride; preferred_name=Phthalic anhydride; dtxsid=DTXSID2021159; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021159; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021159; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >1500 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_10944; row=3898; data_type=In Vivo; mixture=Chemical; chemical_name=Phthalic anhydride; preferred_name=Phthalic anhydride; dtxsid=DTXSID2021159; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021159; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021159; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | <2000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_10950; row=3899; data_type=In Vivo; mixture=Chemical; chemical_name=Phthalic anhydride; preferred_name=Phthalic anhydride; dtxsid=DTXSID2021159; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021159; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021159; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >2500 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_10952; row=3900; data_type=In Vivo; mixture=Chemical; chemical_name=Phthalic anhydride; preferred_name=Phthalic anhydride; dtxsid=DTXSID2021159; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021159; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021159; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =4020 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_10954; row=3901; data_type=In Vivo; mixture=Chemical; chemical_name=Phthalic anhydride; preferred_name=Phthalic anhydride; dtxsid=DTXSID2021159; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021159; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021159; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =4500 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_10956; row=3902; data_type=In Vivo; mixture=Chemical; chemical_name=Phthalic anhydride; preferred_name=Phthalic anhydride; dtxsid=DTXSID2021159; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021159; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021159; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | <5000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_10958; row=3903; data_type=In Vivo; mixture=Chemical; chemical_name=Phthalic anhydride; preferred_name=Phthalic anhydride; dtxsid=DTXSID2021159; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021159; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021159; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >800 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_10942; row=3904; data_type=In Vivo; mixture=Chemical; chemical_name=Phthalic anhydride; preferred_name=Phthalic anhydride; dtxsid=DTXSID2021159; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021159; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021159; source_file=acute_oral.xlsx |
NTP_ICE_cancer 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_cancer | Top dose | 15000 | ppm | Rat | - | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=2594; Record_ID=cancer_4497; Data_Type=In Vivo; Formulation_Name=Phthalic anhydride; Mixture=Chemical; DTXSID=DTXSID2021159; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=15000; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Female; Reference=TR-159; URL=https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr159/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021159; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021159 |
| NTP_ICE_cancer | Top dose | 32692 | ppm | Mouse | - | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=2598; Record_ID=cancer_4493; Data_Type=In Vivo; Formulation_Name=Phthalic anhydride; Mixture=Chemical; DTXSID=DTXSID2021159; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=32692; Response_Unit=ppm; Species=Mouse; Strain=B6C3F1; Sex=Male; Reference=TR-159; URL=https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr159/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021159; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021159 |
| NTP_ICE_cancer | Top dose | 24038 | ppm | Mouse | - | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=2601; Record_ID=cancer_4494; Data_Type=In Vivo; Formulation_Name=Phthalic anhydride; Mixture=Chemical; DTXSID=DTXSID2021159; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=24038; Response_Unit=ppm; Species=Mouse; Strain=B6C3F1; Sex=Female; Reference=TR-159; URL=https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr159/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021159; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021159 |
NTP_ICE_skin_sensitization 21 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | CD86, EC150 | 160 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; U-SENS | sheet=Data_invitro; excel_row=8333; Record_ID=skin_sensitization_invitro_2310; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID2021159; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=1080.227118; Reported_Response_Unit=uM; Conversion_Factor_Value=148.117; Conversion_Factor_Source=EPA Dashboard; Converted_Response=160; Converted_Response_Unit=ug/mL; Response=160; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021159; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021159 |
| NTP_ICE_skin_sensitization | CV75 | 416.7 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3114; Record_ID=skin_sensitization_invitro_725; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID2021159; Assay=h-CLAT; Endpoint=CV75; Reported_Response=416.7; Reported_Response_Unit=ug/mL; Response=416.7; Response_Unit=ug/mL; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021159; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021159 |
| NTP_ICE_skin_sensitization | CV75 | 400 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3157; Record_ID=skin_sensitization_invitro_723; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID2021159; Assay=h-CLAT; Endpoint=CV75; Reported_Response=400; Reported_Response_Unit=ug/mL; Response=400; Response_Unit=ug/mL; Reference=Ashikaga et al. 2010; 20822320; 10.1177/026119291003800403|Nukada et al. 2012; 22796097; 10.1016/j.tiv.2012.07.001|Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021159; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021159 |
| NTP_ICE_skin_sensitization | Depletion Cys | 16.7 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=994; Record_ID=skin_sensitization_invitro_272; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID2021159; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=16.7; Reported_Response_Unit=%; Response=16.7; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021159; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021159 |
| NTP_ICE_skin_sensitization | Depletion Cys | 1.9 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=998; Record_ID=skin_sensitization_invitro_273; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID2021159; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=1.9; Reported_Response_Unit=%; Response=1.9; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021159; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021159 |
| NTP_ICE_skin_sensitization | Depletion Cys | 0 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1002; Record_ID=skin_sensitization_invitro_274; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID2021159; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=0; Reported_Response_Unit=%; Response=0; Response_Unit=%; Reference=Jaworska 2011; 23670904; 10.1002/jat.2869; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021159; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021159 |
| NTP_ICE_skin_sensitization | Depletion Cys | -7 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1006; Record_ID=skin_sensitization_invitro_275; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID2021159; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=-7; Reported_Response_Unit=%; Response=-7; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021159; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021159 |
| NTP_ICE_skin_sensitization | Depletion Lys | 31.3 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=993; Record_ID=skin_sensitization_invitro_272; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID2021159; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=31.3; Reported_Response_Unit=%; Response=31.3; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021159; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021159 |
| NTP_ICE_skin_sensitization | Depletion Lys | 75 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=997; Record_ID=skin_sensitization_invitro_273; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID2021159; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=75; Reported_Response_Unit=%; Response=75; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021159; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021159 |
| NTP_ICE_skin_sensitization | Depletion Lys | 37 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1005; Record_ID=skin_sensitization_invitro_275; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID2021159; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=37; Reported_Response_Unit=%; Response=37; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021159; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021159 |
| NTP_ICE_skin_sensitization | Depletion Lys + Cys | 24 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=995; Record_ID=skin_sensitization_invitro_272; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID2021159; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=24; Reported_Response_Unit=%; Response=24; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021159; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021159 |
| NTP_ICE_skin_sensitization | Depletion Lys + Cys | 38.4 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=999; Record_ID=skin_sensitization_invitro_273; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID2021159; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=38.4; Reported_Response_Unit=%; Response=38.4; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021159; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021159 |
| NTP_ICE_skin_sensitization | Depletion Lys + Cys | 37.5 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1003; Record_ID=skin_sensitization_invitro_274; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID2021159; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=37.5; Reported_Response_Unit=%; Response=37.5; Response_Unit=%; Reference=Jaworska 2011; 23670904; 10.1002/jat.2869; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021159; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021159 |
| NTP_ICE_skin_sensitization | Depletion Lys + Cys | 19 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1007; Record_ID=skin_sensitization_invitro_275; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID2021159; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=19; Reported_Response_Unit=%; Response=19; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021159; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021159 |
| NTP_ICE_skin_sensitization | EC1.5 | 13.8 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6856; Record_ID=skin_sensitization_invitro_1622; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID2021159; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=13.8; Reported_Response_Unit=uM; Response=13.8; Response_Unit=uM; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021159; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021159 |
| NTP_ICE_skin_sensitization | EC1.5 | >2000 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6858; Record_ID=skin_sensitization_invitro_1623; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID2021159; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response=No induction; Reported_Response_Unit=Unitless; Conversion_Factor=Text to numeric; Conversion_Factor_Value=No induction assumed >2000 uM; Conversion_Factor_Source=Manually calculated; Converted_Response_Modifier=>; Converted_Response=2000; Converted_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021159; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021159 |
| NTP_ICE_skin_sensitization | EC1.5 | >2400 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7612; Record_ID=skin_sensitization_invitro_1854; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID2021159; Assay=LuSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2400; Reported_Response_Unit=uM; Response=2400; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021159; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021159 |
| NTP_ICE_skin_sensitization | EC3 | 0.16 | % | Mouse | Dermal | - | In Vivo; Urbisch_SkinSensitization2020; LLNA | sheet=Data_invivo; excel_row=12815; Record_ID=skin_sensitization_invivo_2813; Data_Type=In Vivo; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID2021159; Assay=LLNA; Endpoint=EC3; Response=0.16; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021159; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021159 |
| NTP_ICE_skin_sensitization | Imax | 1.3 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6868; Record_ID=skin_sensitization_invitro_1623; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID2021159; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.3; Reported_Response_Unit=Unitless; Response=1.3; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021159; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021159 |
| NTP_ICE_skin_sensitization | Imax | 1.54 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6870; Record_ID=skin_sensitization_invitro_1622; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID2021159; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.54; Reported_Response_Unit=Unitless; Response=1.54; Response_Unit=Ratio; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021159; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021159 |
| NTP_ICE_skin_sensitization | Imax | 0.3302 | ratio | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7731; Record_ID=skin_sensitization_invitro_1854; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID2021159; Assay=LuSens; Endpoint=Imax; Reported_Response=0.330228588; Reported_Response_Unit=Unitless; Response=0.3302; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021159; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021159 |
ToxRefDB_ToxRefDB_v3_pod.csv 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | >750 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 105 week | CHR | study_id=7494; toxval_study_source_id=studyid7494_Adult_F0_F_NA; dose_level=2; study_year=1979; study_citation=BIOASSAY OF PHTHALIC ANHYDRIDE FOR POSSIBLE CARCINOGENICITY, CAS No. 85-44-9. Study No NCI-CG-TR-159. (Rat portion); dsstox_substance_id=DTXSID2021159; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =1803 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 104 week | CHR | study_id=7495; toxval_study_source_id=studyid7495_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=1; study_year=1979; study_citation=NTP. BIOASSAY OF PHTHALIC ANHYDRIDE FOR POSSIBLE CARCINOGENICITY, CAS No. 85-44-9. Study No NCI-CG-TR-159. (Mouse portion); dsstox_substance_id=DTXSID2021159; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =2452 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 104 week | CHR | study_id=7495; toxval_study_source_id=studyid7495_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=1; study_year=1979; study_citation=NTP. BIOASSAY OF PHTHALIC ANHYDRIDE FOR POSSIBLE CARCINOGENICITY, CAS No. 85-44-9. Study No NCI-CG-TR-159. (Mouse portion); dsstox_substance_id=DTXSID2021159; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =375 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 105 week | CHR | study_id=7494; toxval_study_source_id=studyid7494_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=1; study_year=1979; study_citation=BIOASSAY OF PHTHALIC ANHYDRIDE FOR POSSIBLE CARCINOGENICITY, CAS No. 85-44-9. Study No NCI-CG-TR-159. (Rat portion); dsstox_substance_id=DTXSID2021159; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | >0 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 104 week | CHR | study_id=7495; toxval_study_source_id=studyid7495_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=0; study_year=1979; study_citation=NTP. BIOASSAY OF PHTHALIC ANHYDRIDE FOR POSSIBLE CARCINOGENICITY, CAS No. 85-44-9. Study No NCI-CG-TR-159. (Mouse portion); dsstox_substance_id=DTXSID2021159; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB_Cal_OEHHA_REL_derivations 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_Cal_OEHHA_REL_derivations | LOAEL | =6.5 | mg/m3 | Human | inhalation | chronic; 13.3 years | occupational | LONG_REF=Nielsen J, Bensryd I, Almquist H, Dahlqvist M, Welinder H, Alexandersson R, and Skerfving S. 1991. Serum IgE and lung function in workers exposed to phthalic anhydride. Int. Arch. Occup. Environ. Health 63:199-204; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32ce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd3final.pdf; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Increased incidence of conjunctivitis, rhinitis, asthma, and chronic bronchitis; STUDY_GROUP=Cal OEHHA REL derivations:15952131:-:-occupationally-exposed workers; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ab24a85d578c492c558955d79360847f |
ToxValDB_ECHA_IUCLID 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | NOAEL | =1000 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab77e4b0a7c65d1ba745; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10004/7/9/2?documentUUID=cdc5c29e-c6b2-4c01-a64b-dd89a2d80f86; YEAR=1968; ORIGINAL_YEAR=1968; STUDY_GROUP=ECHA IUCLID:15861435:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3c803c7c152fbb889e44a77ac067228a |
| ToxValDB_ECHA_IUCLID | NOAEL | =1785 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab77e4b0a7c65d1ba73f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10004/7/9/2?documentUUID=cdc5c29e-c6b2-4c01-a64b-dd89a2d80f86; YEAR=1968; ORIGINAL_YEAR=1968; STUDY_GROUP=ECHA IUCLID:15861442:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f7dfa9dd329ea024351982cd16f9dd6d |
| ToxValDB_ECHA_IUCLID | NOAEL | =3570 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab77e4b0a7c65d1ba73f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10004/7/9/2?documentUUID=cdc5c29e-c6b2-4c01-a64b-dd89a2d80f86; YEAR=1968; ORIGINAL_YEAR=1968; STUDY_GROUP=ECHA IUCLID:15861875:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9163eee5589af45168f213508297abbd |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =49.4 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634180:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e03754c36a20fddcd27e704be3554d6b |
ToxValDB_IRIS 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_IRIS | LOAEL | =1562 | mg/kg bw/day | Mouse | oral | chronic; 104 weeks | chronic | LONG_REF=NCI (National Cancer Institute). 1979. Bioassay of phthalic anhydride for possible carcinogenicity. NCI Carcinogenesis Tech. Rep. Ser. No. 159. NTIS PB293594.; TITLE=Bioassay of phthalic anhydride for possible carcinogenicity; AUTHOR=NCI (National Cancer Institute); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a3be4b045b9ff7a571e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=308; TOXICOLOGICAL_EFFECT=lung and kidney histopathology; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=IRIS:15645534:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e5e8d1ea0411d1ac236699c60168ea8e |
| ToxValDB_IRIS | RfD | =2 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=NCI (National Cancer Institute). 1979. Bioassay of phthalic anhydride for possible carcinogenicity. NCI Carcinogenesis Tech. Rep. Ser. No. 159. NTIS PB293594.; TITLE=Bioassay of phthalic anhydride for possible carcinogenicity; AUTHOR=NCI (National Cancer Institute); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a3be4b045b9ff7a571e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=308; TOXICOLOGICAL_EFFECT=Lung and kidney histopathology in female mice; STUDY_GROUP=IRIS:15645299:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0f369817359dec97af97a8b2b874b2d8 |
ToxValDB_Pennsylvania_DEP_ToxValues 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_Pennsylvania_DEP_ToxValues | RfC | =0.02 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67599fbae4b0a7c65d37b2e3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://files.dep.state.pa.us/EnvironmentalCleanupBrownfields/LandRecyclingProgram/LandRecyclingProgramPortalFiles/GuidanceTechTools/VaporIntrusion/November_2021/Table%205a.pdf; STUDY_GROUP=Pennsylvania DEP ToxValues:15650307:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_31359a942de5e1ad43cf2c924539c0c8 |
ToxValDB_RSL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_RSL | RfC | =0.12 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15663725:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_97887847a65a5a3ed4c61a5aa6779849 |
ToxValDB_ToxRefDB 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ToxRefDB | LEL | >750 | mg/kg bw/day | Rat | oral | chronic; 105 weeks | chronic | LONG_REF=BIOASSAY OF PHTHALIC ANHYDRIDE FOR POSSIBLE CARCINOGENICITY, CAS No. 85-44-9. Study No NCI-CG-TR-159. (Rat portion); TITLE=BIOASSAY OF PHTHALIC ANHYDRIDE FOR POSSIBLE CARCINOGENICITY, CAS No. 85-44-9; AUTHOR=NCI; EXTERNAL_SOURCE_ID=7494; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=ToxRefDB_dup_-_15712755_15712756_15712757_15712758:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_122e5d9a8c6a99f0ac6c9f020440ea5e |
| ToxValDB_ToxRefDB | LEL | =1803 | mg/kg bw/day | Mouse | oral | chronic; 104 weeks | chronic | LONG_REF=NTP. BIOASSAY OF PHTHALIC ANHYDRIDE FOR POSSIBLE CARCINOGENICITY, CAS No. 85-44-9. Study No NCI-CG-TR-159. (Mouse portion); TITLE=BIOASSAY OF PHTHALIC ANHYDRIDE FOR POSSIBLE CARCINOGENICITY, CAS No. 85-44-9; AUTHOR=NTP; EXTERNAL_SOURCE_ID=7495; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15712763_15712764:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2799aa03321755b421eed152617b5c14 |
| ToxValDB_ToxRefDB | LEL | =2452 | mg/kg bw/day | Mouse | oral | chronic; 104 weeks | chronic | LONG_REF=NTP. BIOASSAY OF PHTHALIC ANHYDRIDE FOR POSSIBLE CARCINOGENICITY, CAS No. 85-44-9. Study No NCI-CG-TR-159. (Mouse portion); TITLE=BIOASSAY OF PHTHALIC ANHYDRIDE FOR POSSIBLE CARCINOGENICITY, CAS No. 85-44-9; AUTHOR=NTP; EXTERNAL_SOURCE_ID=7495; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15712765_15712766:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8432bcd476b4e1f902ee57d9075a457f |
| ToxValDB_ToxRefDB | NEL | =375 | mg/kg bw/day | Rat | oral | chronic; 105 weeks | chronic | LONG_REF=BIOASSAY OF PHTHALIC ANHYDRIDE FOR POSSIBLE CARCINOGENICITY, CAS No. 85-44-9. Study No NCI-CG-TR-159. (Rat portion); TITLE=BIOASSAY OF PHTHALIC ANHYDRIDE FOR POSSIBLE CARCINOGENICITY, CAS No. 85-44-9; AUTHOR=NCI; EXTERNAL_SOURCE_ID=7494; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15712759_15712760_15712761_15712762:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3205bd76ee05be820afa4c3d9eded6c1 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | UVL263I5BJ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H4O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"UVL263I5BJ"} |
| openFDA substances | FDA UNII substance identifier | UVL263I5BJ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H4O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"UVL263I5BJ"} |
| openFDA substances | FDA UNII substance identifier | UVL263I5BJ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H4O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"UVL263I5BJ"} |
| openFDA substances | FDA UNII substance identifier | UVL263I5BJ | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H4O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"UVL263I5BJ"} |