Regulatory Status
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Safety Data
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Expert Verdict
Short-term IV doses up to 4 g/kg caused hepatocellular vacuolization and renal tubular dilation (irrelevant at cosmetic dermal use levels); impurity control required.
Frequently Asked Questions
Is Poloxamer 108 safe in cosmetics?
Short-term IV doses up to 4 g/kg caused hepatocellular vacuolization and renal tubular dilation (irrelevant at cosmetic dermal use levels); impurity control required. The EU classifies Poloxamer 108 as "permitted". Safety rating: GOOD.
Is Poloxamer 108 allowed in the EU?
Poloxamer 108 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Poloxamer 108 do in cosmetics?
Poloxamer 108 functions as: Surfactant, emulsifying agent, solubilizing agent. It is classified as a cosmetic ingredient in our database. CAS number: 9003-11-6 (generic for all Poloxamers).
What is the Margin of Safety for Poloxamer 108?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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