Poloxamer 185

INCI: POLOXAMER 185

CAS Number
9003-11-6 (generic for all poloxamers); 691397-13-4 (specific)
Function
Surfactant, emulsifying agent, cleansing agent, solubilizing agent
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes FDA VCRP/MoCRA reported; CIR: safe as used (2008); 9 product uses at 0.5–9%

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Residual impurities: 1,4-dioxane (≤5 ppm), ethylene oxide (≤1 ppm), propylene oxide (≤5 ppm) per USP limits

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Concern Level: Low

Frequently Asked Questions

Is Poloxamer 185 safe in cosmetics?

Residual impurities: 1,4-dioxane (≤5 ppm), ethylene oxide (≤1 ppm), propylene oxide (≤5 ppm) per USP limits The EU classifies Poloxamer 185 as "permitted". Safety rating: GOOD.

Is Poloxamer 185 allowed in the EU?

Poloxamer 185 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Poloxamer 185 do in cosmetics?

Poloxamer 185 functions as: Surfactant, emulsifying agent, cleansing agent, solubilizing agent. It is classified as a cosmetic ingredient in our database. CAS number: 9003-11-6 (generic for all poloxamers); 691397-13-4 (specific).

What is the Margin of Safety for Poloxamer 185?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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