Moderate Cosmetic Ingredient

Poloxamer 338/PPG-51/SMDI Copolymer

INCI: POLOXAMER 338/PPG-51/SMDI COPOLYMER

CAS Number
Not assigned / not publicly listed (distinct from generic 9003-11-6; this is a modified copolymer)
Function
Emulsion stabilising
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not individually reviewed by CIR (the parent Poloxamer 338 is CIR-reviewed as safe as used); no specific FDA restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Key concern: Residual unreacted SMDI (isocyanate) monomer must be verified below detection limits by supplier CoA. Trace 1,4-dioxane/EO/PO from ethoxylation. Newer ingredient with limited independent safety data — CPSR assessor may require additional supplier toxicological data.

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Concern Level: Moderate

Frequently Asked Questions

Is Poloxamer 338/PPG-51/SMDI Copolymer safe in cosmetics?

Key concern: Residual unreacted SMDI (isocyanate) monomer must be verified below detection limits by supplier CoA. Trace 1,4-dioxane/EO/PO from ethoxylation. Newer ingredient with limited independent safety data — CPSR assessor may require additional supplier toxicological data. The EU classifies Poloxamer 338/PPG-51/SMDI Copolymer as "permitted". Safety rating: MODERATE.

Is Poloxamer 338/PPG-51/SMDI Copolymer allowed in the EU?

Poloxamer 338/PPG-51/SMDI Copolymer EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Poloxamer 338/PPG-51/SMDI Copolymer do in cosmetics?

Poloxamer 338/PPG-51/SMDI Copolymer functions as: Emulsion stabilising. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned / not publicly listed (distinct from generic 9003-11-6; this is a modified copolymer).

What is the Margin of Safety for Poloxamer 338/PPG-51/SMDI Copolymer?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Poloxamer 338/PPG-51/SMDI Copolymer compliance across multiple jurisdictions:

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Ingredient Decoder
Paste a full ingredient list for instant analysis
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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