Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
6 study endpoints found for Polyacrylamide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 2500 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 1500 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 2500 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 2500 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| dose_tested | 1500 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
Expert Verdict
Acrylamide monomer is IARC Group 2A (probable human carcinogen) and neurotoxic; batch-level CoA must confirm residual acrylamide. EU limit (0.1 ppm leave-on body) is 50× stricter than US CIR limit (5 ppm).
Regulatory Flags
Frequently Asked Questions
Is Polyacrylamide safe in cosmetics?
Acrylamide monomer is IARC Group 2A (probable human carcinogen) and neurotoxic; batch-level CoA must confirm residual acrylamide. EU limit (0.1 ppm leave-on body) is 50× stricter than US CIR limit (5 ppm). The EU classifies Polyacrylamide as "restricted". Safety rating: GOOD. 6 toxicological study endpoint(s) are available in our database.
Is Polyacrylamide allowed in the EU?
Polyacrylamide EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Polyacrylamide do in cosmetics?
Polyacrylamide functions as: Film forming, stabiliser, viscosity increasing agent, foam builder. It is classified as a cosmetic ingredient in our database. CAS number: 9003-05-8.
What is the Margin of Safety for Polyacrylamide?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Polyacrylamide?
The NOAEL (No Observed Adverse Effect Level) for Polyacrylamide is 2500 mg/kg bw/day based on a Carcinogenicity study via oral route in rat. A total of 6 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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