Polydatin

INCI: POLYDATIN

CAS Number
27208-80-6 (also reported: 65914-17-2)
Function
Antioxidant; skin conditioning agent
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes No CIR review; no specific FDA restriction. Widely studied as resveratrol precursor.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Dual CAS numbers in literature—verify supplier CAS. More bioavailable than resveratrol; dose-response should be considered at higher concentrations. Photostability data recommended.

⚠️
Concern Level: Low

Frequently Asked Questions

Is Polydatin safe in cosmetics?

Dual CAS numbers in literature—verify supplier CAS. More bioavailable than resveratrol; dose-response should be considered at higher concentrations. Photostability data recommended. The EU classifies Polydatin as "permitted". Safety rating: GOOD.

Is Polydatin allowed in the EU?

Polydatin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Polydatin do in cosmetics?

Polydatin functions as: Antioxidant; skin conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 27208-80-6 (also reported: 65914-17-2).

What is the Margin of Safety for Polydatin?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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