Polyglycerin-4

INCI: POLYGLYCERIN-4

CAS Number
25618-55-7 (general polyglycerin CAS)
Function
Humectant; skin conditioning; emulsifying (as esters)
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not explicitly included in the 2023 CIR polyglycerin report (which covered -3, -6, -10), but structurally intermediate; read-across applicable

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Falls between CIR-reviewed Polyglycerin-3 and -6; read-across justification is strong but should be documented in CPSR

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Concern Level: Low

Frequently Asked Questions

Is Polyglycerin-4 safe in cosmetics?

Falls between CIR-reviewed Polyglycerin-3 and -6; read-across justification is strong but should be documented in CPSR The EU classifies Polyglycerin-4 as "permitted". Safety rating: GOOD.

Is Polyglycerin-4 allowed in the EU?

Polyglycerin-4 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Polyglycerin-4 do in cosmetics?

Polyglycerin-4 functions as: Humectant; skin conditioning; emulsifying (as esters). It is classified as a cosmetic ingredient in our database. CAS number: 25618-55-7 (general polyglycerin CAS).

What is the Margin of Safety for Polyglycerin-4?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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