Polyglyceryl-3 Isostearate

INCI: POLYGLYCERYL-3 ISOSTEARATE

CAS Number
127512-63-4
Function
Surfactant – emulsifying; skin conditioning – emollient
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not restricted by FDA; CIR (2016) — safe in present practices of use when formulated to be non-irritating

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

One of the best-characterized ingredients with no significant safety concerns.

⚠️
Concern Level: Low

Frequently Asked Questions

Is Polyglyceryl-3 Isostearate safe in cosmetics?

One of the best-characterized ingredients with no significant safety concerns. The EU classifies Polyglyceryl-3 Isostearate as "permitted". Safety rating: GOOD.

Is Polyglyceryl-3 Isostearate allowed in the EU?

Polyglyceryl-3 Isostearate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Polyglyceryl-3 Isostearate do in cosmetics?

Polyglyceryl-3 Isostearate functions as: Surfactant – emulsifying; skin conditioning – emollient. It is classified as a cosmetic ingredient in our database. CAS number: 127512-63-4.

What is the Margin of Safety for Polyglyceryl-3 Isostearate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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