Polyglyceryl-3 PCA

INCI: POLYGLYCERYL-3 PCA

CAS Number
Not assigned (ester of pyrrolidone carboxylic acid and polyglycerin-3)
Function
Humectant; skin-conditioning agent. PCA is pyroglutamic acid, a natural moisturizing factor component.
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes FDA: no specific restrictions; not in the CIR polyglyceryl fatty acid ester group review as PCA is not a fatty acid.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Not included in CIR 274-ingredient group assessment; limited published toxicological data available. Supplier CPSR-grade safety dossier recommended.

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Concern Level: Moderate

Frequently Asked Questions

Is Polyglyceryl-3 PCA safe in cosmetics?

Not included in CIR 274-ingredient group assessment; limited published toxicological data available. Supplier CPSR-grade safety dossier recommended. The EU classifies Polyglyceryl-3 PCA as "permitted". Safety rating: GOOD.

Is Polyglyceryl-3 PCA allowed in the EU?

Polyglyceryl-3 PCA EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Polyglyceryl-3 PCA do in cosmetics?

Polyglyceryl-3 PCA functions as: Humectant; skin-conditioning agent. PCA is pyroglutamic acid, a natural moisturizing factor component.. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned (ester of pyrrolidone carboxylic acid and polyglycerin-3).

What is the Margin of Safety for Polyglyceryl-3 PCA?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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