Polyglyceryl-3 Sorbityl Glycyrrhetinate

INCI: POLYGLYCERYL-3 SORBITYL GLYCYRRHETINATE

CAS Number
Not publicly assigned
Function
Skin conditioning agent (sorbityl + glycyrrhetinic acid conjugate provides anti-inflammatory/soothing benefit)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes Not specifically restricted by FDA; no dedicated CIR assessment (hybrid conjugate outside the 274-ester CIR scope)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Glycyrrhetinic acid at high systemic levels can cause pseudoaldosteronism; in a cosmetic context this is unlikely at typical use levels (<2%), but no ingredient-specific dermal margin of safety is published.

โš ๏ธ
Concern Level: Moderate

Frequently Asked Questions

Is Polyglyceryl-3 Sorbityl Glycyrrhetinate safe in cosmetics?

Glycyrrhetinic acid at high systemic levels can cause pseudoaldosteronism; in a cosmetic context this is unlikely at typical use levels (<2%), but no ingredient-specific dermal margin of safety is published. The EU classifies Polyglyceryl-3 Sorbityl Glycyrrhetinate as "restricted". Safety rating: MODERATE.

Is Polyglyceryl-3 Sorbityl Glycyrrhetinate allowed in the EU?

Polyglyceryl-3 Sorbityl Glycyrrhetinate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Polyglyceryl-3 Sorbityl Glycyrrhetinate do in cosmetics?

Polyglyceryl-3 Sorbityl Glycyrrhetinate functions as: Skin conditioning agent (sorbityl + glycyrrhetinic acid conjugate provides anti-inflammatory/soothing benefit). It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned.

What is the Margin of Safety for Polyglyceryl-3 Sorbityl Glycyrrhetinate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

๐Ÿ“ฑ

Is Polyglyceryl-3 Sorbityl Glycyrrhetinate in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Polyglyceryl-3 Sorbityl Glycyrrhetinate in your formulation.