Polyglyceryl-4 Hydroxypropyl Ethylhexyl Ether

INCI: POLYGLYCERYL-4 HYDROXYPROPYL ETHYLHEXYL ETHER

CAS Number
Not widely published (reaction product of polyglycerin-4 + 2-ethylhexyl glycidyl ether)
Function
Cleansing agent; surfactant – cleansing; surfactant – emulsifying
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not restricted by FDA; not covered by CIR 2023 ester report (ether class)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Glycidyl ether precursor in synthesis — confirm residual epoxide levels; limited CIR data for CPSR substantiation; may require additional toxicology studies.

⚠️
Concern Level: Moderate

Frequently Asked Questions

Is Polyglyceryl-4 Hydroxypropyl Ethylhexyl Ether safe in cosmetics?

Glycidyl ether precursor in synthesis — confirm residual epoxide levels; limited CIR data for CPSR substantiation; may require additional toxicology studies. The EU classifies Polyglyceryl-4 Hydroxypropyl Ethylhexyl Ether as "permitted". Safety rating: MODERATE.

Is Polyglyceryl-4 Hydroxypropyl Ethylhexyl Ether allowed in the EU?

Polyglyceryl-4 Hydroxypropyl Ethylhexyl Ether EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Polyglyceryl-4 Hydroxypropyl Ethylhexyl Ether do in cosmetics?

Polyglyceryl-4 Hydroxypropyl Ethylhexyl Ether functions as: Cleansing agent; surfactant – cleansing; surfactant – emulsifying. It is classified as a cosmetic ingredient in our database. CAS number: Not widely published (reaction product of polyglycerin-4 + 2-ethylhexyl glycidyl ether).

What is the Margin of Safety for Polyglyceryl-4 Hydroxypropyl Ethylhexyl Ether?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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