Polyglyceryl-5 Bis(Hydroxypropyl Ethylhexyl Ether)

INCI: POLYGLYCERYL-5 BIS(HYDROXYPROPYL ETHYLHEXYL ETHER)

CAS Number
Not assigned (polymeric ether)
Function
Skin conditioning – emollient; Surfactant – emulsifying agent
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not prohibited by FDA; limited individual safety data (ether, not ester — not covered under CIR polyglyceryl fatty acid esters report)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Not covered by CIR 274-ingredient polyglyceryl ester assessment; CPSR assessor must justify safety by read-across from structurally analogous polyglyceryl ethers or require supplier-provided toxicology data.

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Concern Level: Moderate

Frequently Asked Questions

Is Polyglyceryl-5 Bis(Hydroxypropyl Ethylhexyl Ether) safe in cosmetics?

Not covered by CIR 274-ingredient polyglyceryl ester assessment; CPSR assessor must justify safety by read-across from structurally analogous polyglyceryl ethers or require supplier-provided toxicology data. The EU classifies Polyglyceryl-5 Bis(Hydroxypropyl Ethylhexyl Ether) as "permitted". Safety rating: MODERATE.

Is Polyglyceryl-5 Bis(Hydroxypropyl Ethylhexyl Ether) allowed in the EU?

Polyglyceryl-5 Bis(Hydroxypropyl Ethylhexyl Ether) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Polyglyceryl-5 Bis(Hydroxypropyl Ethylhexyl Ether) do in cosmetics?

Polyglyceryl-5 Bis(Hydroxypropyl Ethylhexyl Ether) functions as: Skin conditioning – emollient; Surfactant – emulsifying agent. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned (polymeric ether).

What is the Margin of Safety for Polyglyceryl-5 Bis(Hydroxypropyl Ethylhexyl Ether)?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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