Is Polyquaternium-4 (HEC/DMDAAC Copolymer) safe in cosmetics?
Polyquaternium-4 (HEC/DMDAAC Copolymer) has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. This ingredient has been reviewed by cir.
Polyquaternium-4 (HEC/DMDAAC Copolymer)
INCI: POLYQUATERNIUM-4
Polyquaternium-4 (HEC/DMDAAC Copolymer) (CAS 55963-33-2) is a cosmetic cosmetic ingredient functioning as Antistatic, film forming, hair conditioning. EU Regulation 1223/2009 status: permitted; 1 safety opinion reviewed (cir). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in food safety data.
View industrial chemical safety profile for CAS 55963-33-2 →
Auto-generated CPSR Part A draft with source citations
Function
Antistatic, film forming, hair conditioning
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no FDA restriction; CIR has reviewed polyquaternium class ingredients
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Polyquaternium-4 (HEC/DMDAAC Copolymer).
Calculate MoS for your specific formulation with the MoS Calculator.
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
cir
Verdict: safe
ailable data and concluded that these ingredients are safe in cosmetics in the present practices of use and concentrations described in this safety assessment. Keywords Safety, Cosmetics, Cosmetic Ingredient Review, Expert Panel for Cosmetic Ingredient Safety, Distarch Phosphate, Distarch Phosph
Additional Ingredient Properties
5 property records from structured ingredient metadata.
cost_pricing
{"cost_tier": "mid-range", "estimated_cost_per_kg_usd_low": "30", "estimated_cost_per_kg_usd_high": "55", "natural_premium_markup_pct": "0", "organic_certified_premium_pct": "0", "supply_chain_volatility": "low", "primary_source_region": "Global", "bulk_discount_threshold_kg": "100", "seasonal_price_variation": "low", "commodity_or_specialty": "specialty", "substitute_ingredients": "Polyquaternium…
ecotoxicity
{"biodegradable": "no", "biodegradation_days": "365+", "bioaccumulative": "yes", "aquatic_toxicity_level": "moderate", "coral_reef_safe": "unknown", "marine_toxicity": "moderate toxicity", "freshwater_toxicity": "persistent", "endocrine_disruptor": "no", "persistent_organic_pollutant": "yes", "microplastic": "no", "nano_particle": "no", "hawaii_banned": "no", "eu_restricted_environmental": "yes", …
hair_care
{"hair_function": "styling", "hair_type_suitability": "all", "curl_pattern_suitability": "all", "porosity_suitability": "all", "protein_sensitivity": "neutral", "moisture_protein_balance": "yes", "cg_method_approved": "not-a-silicone", "silicone_type": "not-a-sulfate", "sulfate_type": "no", "drying_alcohol": "no", "fatty_alcohol": "no", "heat_protectant": "yes", "color_safe": "neutral", "keratin_b…
hair_conditioning
{"cas_number": "107985-78-0", "ingredient_class": "cationic_conditioner", "chemical_type": "polyquaternium", "charge_density_meq_g": "4.0", "substantivity_to_hair": "excellent", "deposition_from_shampoo": "yes", "deposition_from_conditioner": "yes", "conditioning_mechanism": "electrostatic", "hair_penetration": "surface_only", "molecular_weight_effect_on_penetration": "high_MW_limited_penetration"…
polymer
{"cas_number": "92183-41-0", "ingredient_class": "film_former/conditioning", "polymer_type": "synthetic_copolymer", "chemical_backbone": "vinyl", "molecular_weight_Da_range": "400000-2000000", "ionic_character": "cationic", "charge_density_meq_g": "2.5-4.5", "pH_viscosity_sensitivity": "moderate", "salt_tolerance": "moderate", "electrolyte_effect_on_viscosity": "moderate", "temperature_viscosity_s…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Absorbent
Anti-caking agent
Binder
Regulatory List Membership (1)
EU Regulated in Personal Care
Expert Verdict
Expert safety assessment and concern-level summary for Polyquaternium-4 (HEC/DMDAAC Copolymer).
Chemical Function
Absorbent
Binder
Anti-caking agent
Regulatory Lists
Europe; Personal care
Europe; Personal care
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Distarch phosphate
E Number
E1412
ADI
NOT SPECIFIED mg/kg bw
Food Category
emulsifier
Frequently Asked Questions
Is Polyquaternium-4 (HEC/DMDAAC Copolymer) allowed in the EU?
Polyquaternium-4 (HEC/DMDAAC Copolymer) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Polyquaternium-4 (HEC/DMDAAC Copolymer) do in cosmetics?
Polyquaternium-4 (HEC/DMDAAC Copolymer) functions as: Antistatic, film forming, hair conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 55963-33-2.
Is Polyquaternium-4 (HEC/DMDAAC Copolymer) used outside cosmetics?
Polyquaternium-4 (HEC/DMDAAC Copolymer) also appears in food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Polyquaternium-4 (HEC/DMDAAC Copolymer) compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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Solvent
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Light Stabilizer
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