Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Polysilicone-4. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 300 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 150 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
Expert Verdict
CIR determined safety when used as metal oxide coating, but insufficient data exist for independent use as standalone ingredient outside of TiO₂/ZnO encapsulation applications.
Regulatory Flags
Frequently Asked Questions
Is Polysilicone-4 safe in cosmetics?
CIR determined safety when used as metal oxide coating, but insufficient data exist for independent use as standalone ingredient outside of TiO₂/ZnO encapsulation applications. The EU classifies Polysilicone-4 as "permitted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.
Is Polysilicone-4 allowed in the EU?
Polysilicone-4 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Polysilicone-4 do in cosmetics?
Polysilicone-4 functions as: Hair conditioning agent; surface modifier; viscosity increasing agent (nonaqueous). It is classified as a cosmetic ingredient in our database. CAS number: 9004-73-3.
What is the Margin of Safety for Polysilicone-4?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Polysilicone-4?
The NOAEL (No Observed Adverse Effect Level) for Polysilicone-4 is 300 mg/kg bw/day based on a Chronic study via oral route in dog. A total of 2 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check Polysilicone-4 compliance across multiple jurisdictions:
Related Ingredients
Is Polysilicone-4 in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Polysilicone-4 in your formulation.