NOAEL Studies
Cosmetic Ingredient
Polysorbate 81 NOAEL Studies
INCI: POLYSORBATE 81
CAS: 9005-65-6
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS DB 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | NOAEL | 1000 | mg/kg bw/day | monkey | oral | 355 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 2500 | mg/kg bw/day | rat | oral | 90 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 5000 | mg/kg bw/day | rat | oral | 720 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 7500 | mg/kg bw/day | mouse | oral | 14 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 10000 | mg/kg bw/day | rat | oral | NA | Multigeneration Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
EFSA 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | NOAEL | =2500 | mg/kg bw/day | Rat | oral: unspecified | 721 days | chronic/long term toxicity | EFSA ANS - 2015 - OutputID 2782 - mortality - systemic - Scientific Opinion on the re-evaluation of polyoxyethylene sorbitan monolaurate (E 432), polyoxyethylene sorbitan monooleate (E 433), polyoxyethylene sorbitan monopalmitate (E 434), polyoxyethylene sorbitan monostearate (E 435) and polyoxyethylene sorbitan tristearate (E 436) as food additives - doi:10.2903/j.efsa.2015.4152 |
| EFSA | NOAEL | =2500 | mg/kg bw/day | Rat | oral: unspecified | 721 days | chronic/long term toxicity | EFSA ANS - 2015 - OutputID 2782 - mortality - systemic - Scientific Opinion on the re-evaluation of polyoxyethylene sorbitan monolaurate (E 432), polyoxyethylene sorbitan monooleate (E 433), polyoxyethylene sorbitan monopalmitate (E 434), polyoxyethylene sorbitan monostearate (E 435) and polyoxyethylene sorbitan tristearate (E 436) as food additives - doi:10.2903/j.efsa.2015.4152 |
| EFSA | ADI (group) | =25 | mg/kg bw/day | Consumers | - | - | ADI (group) | EFSA ANS - 2015 - OutputID 2782 - Consumers - Scientific Opinion on the re-evaluation of polyoxyethylene sorbitan monolaurate (E 432), polyoxyethylene sorbitan monooleate (E 433), polyoxyethylene sorbitan monopalmitate (E 434), polyoxyethylene sorbitan monostearate (E 435) and polyoxyethylene sorbitan tristearate (E 436) as food additives - doi:10.2903/j.efsa.2015.4152 |
| EFSA | ADI (group) | =25 | mg/kg bw/day | Consumers | - | - | ADI (group) | EFSA ANS - 2015 - OutputID 2782 - Consumers - Scientific Opinion on the re-evaluation of polyoxyethylene sorbitan monolaurate (E 432), polyoxyethylene sorbitan monooleate (E 433), polyoxyethylene sorbitan monopalmitate (E 434), polyoxyethylene sorbitan monostearate (E 435) and polyoxyethylene sorbitan tristearate (E 436) as food additives - doi:10.2903/j.efsa.2015.4152 |
| EFSA | NOAEL | =2500 | mg/kg bw/day | Rat | oral | chronic; 103 weeks | chronic | LONG_REF=EFSA ANS (2015). Scientific Opinion on the re-evaluation of polyoxyethylene sorbitan monolaurate (E 432), polyoxyethylene sorbitan monooleate (E 433), polyoxyethylene sorbitan monopalmitate (E 434), polyoxyethylene sorbitan monostearate (E 435) and polyoxyethylene sorbitan tristearate (E 436) as food additives. doi:10.2903/j.efsa.2015.4152.; TITLE=Scientific Opinion on the re-evaluation of polyoxyethylene sorbitan monolaurate (E 432), polyoxyethylene sorbitan monooleate (E 433), polyoxyethylene sorbitan monopalmitate (E 434), polyoxyethylene sorbitan monostearate (E 435) and polyoxyethylene sorbitan tristearate (E 436) as food additives; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2015.4152; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2015; ORIGINAL_YEAR=2015; TOXICOLOGICAL_EFFECT=mortality; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=EFSA:15624471:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8e00f56490122fb0c11cfcc86c2b71ca |
NTP ICE cancer 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | POLY-3 lowest dose | 50000 | ppm | Rat | Dosed feed | - | In Vivo; Two year cancer bioassay | sheet=Data; excel_row=415; Record_ID=cancer_4806; Data_Type=In Vivo; Formulation_Name=Polysorbate 80 (glycol); Mixture=Chemical; DTXSID=DTXSID0021175; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=50000; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Male; Route=Dosed feed; Level_of_Evidence=Equivocal evidence; Tissue=Adrenal gland medulla; Lesion=Pheochromocytoma(Benign, complex, malignant); Reference=TR-415; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr415/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP ICE cancer | Top dose | 5 | % | Rat | Dosed feed | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=408; Record_ID=cancer_4809; Data_Type=In Vivo; Formulation_Name=Polysorbate 80 (Glycol); Mixture=Chemical; DTXSID=DTXSID0021175; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=5; Response_Unit=%; Species=Rat; Strain=F344/N; Sex=Female; Route=Dosed feed; Reference=TR-415; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr415/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=13520; RecordID=ARPathway2016_1698; DatasetName=ARPathway2016; DTXSID=DTXSID0021175; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
NTP ICE eye irritation 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE eye irritation | Draize rabbit irritation score | 0 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=76; Record_ID=eye_irritation_178; Data_Type=In Vivo; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=0; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP ICE eye irritation | EPA Classification | 4 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=74; Record_ID=eye_irritation_178; Data_Type=In Vivo; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=4; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP ICE eye irritation | Intensity | 0.02 | %/sec | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=78; Record_ID=eye_irritation_1307; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=Vitrigel; Endpoint=Intensity; Response=0.02; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP ICE eye irritation | Lag time | >180 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=77; Record_ID=eye_irritation_1307; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=Vitrigel; Endpoint=Lag time; Response_Modifier=>; Response=180; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP ICE eye irritation | Plateau level | 0 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=79; Record_ID=eye_irritation_1307; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=Vitrigel; Endpoint=Plateau level; Response=0; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
NTP ICE skin irritation 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin irritation | Positive reaction | 3.5 | % | Human | Dermal | - | In Vivo; Four-hour Human Patch Test | sheet=Data_invivo; excel_row=79; Record_ID=skin_irritation_invivo_81; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=Four-hour Human Patch Test; Endpoint=Positive reaction; Response=3.5; Response_Unit=%; Species=Human; Reference=Basketter et al. 2004; 15291823; 10.1111/j.0105-1873.2004.00385.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP ICE skin irritation | Positive reaction | 3.8 | % | Human | Dermal | - | In Vivo; Four-hour Human Patch Test | sheet=Data_invivo; excel_row=80; Record_ID=skin_irritation_invivo_82; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=Four-hour Human Patch Test; Endpoint=Positive reaction; Response=3.8; Response_Unit=%; Species=Human; Reference=Robinson et al. 2001; 11422260; 10.1034/j.1600-0536.2001.045001001.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
NTP ICE skin sensitization 18 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | CD86, EC150 | 8.73 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8636; Record_ID=skin_sensitization_invitro_2388; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=8.73; Reported_Response_Unit=ug/mL; Response=8.73; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP ICE skin sensitization | CV70 | >200 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8634; Record_ID=skin_sensitization_invitro_2388; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=U-SENS; Endpoint=CV70; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=200; Reported_Response_Unit=ug/mL; Response=200; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP ICE skin sensitization | CV75 | 5000 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; h-CLAT | sheet=Data_invitro; excel_row=1670; Record_ID=skin_sensitization_invitro_461; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=h-CLAT; Endpoint=CV75; Reported_Response=5000; Reported_Response_Unit=ug/mL; Response=5000; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP ICE skin sensitization | Depletion Cys | 10.2 | % | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; DPRA | sheet=Data_invitro; excel_row=246; Record_ID=skin_sensitization_invitro_67; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=10.2; Reported_Response_Unit=%; Response=10.2; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP ICE skin sensitization | Depletion Lys | 0 | % | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; DPRA | sheet=Data_invitro; excel_row=220; Record_ID=skin_sensitization_invitro_67; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0; Reported_Response_Unit=%; Response=0; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP ICE skin sensitization | EC1.5 | <65.91 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=8015; Record_ID=skin_sensitization_invitro_1812; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=LuSens; Endpoint=EC1.5; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=65.91; Reported_Response_Unit=uM; Response=65.91; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP ICE skin sensitization | EC1.5 | 115.4742 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; KeratinoSens | sheet=Data_invitro; excel_row=6911; Record_ID=skin_sensitization_invitro_1636; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=115.4742; Reported_Response_Unit=uM; Response=115.4742; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP ICE skin sensitization | EC1.5 | 115.5 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=6913; Record_ID=skin_sensitization_invitro_1637; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=115.5; Reported_Response_Unit=uM; Response=115.5; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP ICE skin sensitization | EC3 | 677.4 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=6915; Record_ID=skin_sensitization_invitro_1637; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=KeratinoSens; Endpoint=EC3; Reported_Response=677.4; Reported_Response_Unit=uM; Response=677.4; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP ICE skin sensitization | IC50 | >164 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7644; Record_ID=skin_sensitization_invitro_1812; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=LuSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=164; Reported_Response_Unit=uM; Response=164; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP ICE skin sensitization | IC50 | 813.1 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=6919; Record_ID=skin_sensitization_invitro_1637; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=813.1; Reported_Response_Unit=uM; Response=813.1; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP ICE skin sensitization | IC50 | 4000 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; KeratinoSens | sheet=Data_invitro; excel_row=6917; Record_ID=skin_sensitization_invitro_1636; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=4000; Reported_Response_Unit=uM; Response=4000; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP ICE skin sensitization | Imax | 3.08 | ratio | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=6921; Record_ID=skin_sensitization_invitro_1637; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=3.08; Reported_Response_Unit=Unitless; Response=3.08; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP ICE skin sensitization | Imax | 3.085 | ratio | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; KeratinoSens | sheet=Data_invitro; excel_row=6923; Record_ID=skin_sensitization_invitro_1636; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=3.08456; Reported_Response_Unit=Unitless; Response=3.085; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP ICE skin sensitization | Imax | 3.764 | ratio | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7546; Record_ID=skin_sensitization_invitro_1812; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=LuSens; Endpoint=Imax; Reported_Response=3.764048241; Reported_Response_Unit=Unitless; Response=3.764; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=10984; Record_ID=skin_sensitization_invivo_2401; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Magnusson and Kligman 1969; 5774356; 10.1038/jid.1969.42|Gad et al. 1986; 3715870; 10.1016/0041-008X(86)90419-9|Basketter et al. 2014; 24407057; 10.1097/der.0000000000000003; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP ICE skin sensitization | Induction dose per skin area | 15520 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=10982; Record_ID=skin_sensitization_invivo_2401; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=15520; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Magnusson and Kligman 1969; 5774356; 10.1038/jid.1969.42|Gad et al. 1986; 3715870; 10.1016/0041-008X(86)90419-9|Basketter et al. 2014; 24407057; 10.1097/der.0000000000000003; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
| NTP ICE skin sensitization | Relative reliability score | 1 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=10988; Record_ID=skin_sensitization_invivo_2401; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021175; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=1; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Magnusson and Kligman 1969; 5774356; 10.1038/jid.1969.42|Gad et al. 1986; 3715870; 10.1016/0041-008X(86)90419-9|Basketter et al. 2014; 24407057; 10.1097/der.0000000000000003; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021175; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021175 |
EPA ToxRefDB v3 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA ToxRefDB v3 | LEL | >2500 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 2 year | CHR | study_id=7412; toxval_study_source_id=studyid7412_Adult_F0_F_NA; dose_level=2; study_year=1992; study_citation=NTP. (1992) Toxicology and Carcinogenesis Studies of Polysorbate 80 (CAS No. 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP TR 415, NIH Publication No. 92-3146. (Chronic rat); dsstox_substance_id=DTXSID0021175; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =7500 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 2 year | CHR | study_id=7411; toxval_study_source_id=studyid7411_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-stomach-hyperplasia|pathology microscopic-stomach-ulcer|pathology microscopic-stomach-inflammation|in life observation-body weight-body weight; dose_level=2; study_year=1992; study_citation=NTP. (1992) Toxicology and Carcinogenesis Studies of Polysorbate 80 (CAS No. 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP TR 415, NIH Publication No. 92-3146. (Chronic mouse); dsstox_substance_id=DTXSID0021175; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =1250 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 2 year | CHR | study_id=7412; toxval_study_source_id=studyid7412_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-spleen-hematopoietic cell proliferation erythrocytic|pathology microscopic-adrenal gland-pheochromocytoma benign; dose_level=1; study_year=1992; study_citation=NTP. (1992) Toxicology and Carcinogenesis Studies of Polysorbate 80 (CAS No. 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP TR 415, NIH Publication No. 92-3146. (Chronic rat); dsstox_substance_id=DTXSID0021175; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =3750 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 2 year | CHR | study_id=7411; toxval_study_source_id=studyid7411_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|pathology microscopic-stomach-hyperplasia|pathology microscopic-stomach-inflammation|pathology microscopic-stomach-ulcer; dose_level=1; study_year=1992; study_citation=NTP. (1992) Toxicology and Carcinogenesis Studies of Polysorbate 80 (CAS No. 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP TR 415, NIH Publication No. 92-3146. (Chronic mouse); dsstox_substance_id=DTXSID0021175; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB ECOTOX 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | NOEL | =0.5 | % | Mouse | injection | acute; 0.6667 days | acute | LONG_REF=Teratog. Carcinog. Mutagen.19(5): 323-327 Przybojewska,B. Assessment of Aniline Derivatives-Induced DNA Damage in the Liver Cells of B6C3F1 Mice Using the Alkaline Single Cell Gel Electrophoresis (\"Comet\") Assay 1999; TITLE=Assessment of Aniline Derivatives-Induced DNA Damage in the Liver Cells of B6C3F1 Mice Using the Alkaline Single Cell Gel Electrophoresis ("Comet") Assay; AUTHOR=Przybojewska,B.; DOI=10.1002/(sici)1520-6866(1999)19:5<323::aid-tcm2>3.0.co;2-c; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=111819; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=Genetics: Damage; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15602277:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b308da6db3651a466efc4b4396e06768 |
ToxValDB HESS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HESS | NOEL | =4800 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0defe4b0a676289de90e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; STUDY_GROUP=HESS:15638662:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_43b1c007b42122c973f92dea1ff1415d |
ToxValDB ToxRefDB 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ToxRefDB | LEL | =7500 | mg/kg bw/day | Mouse | oral | chronic; 2 years | chronic | LONG_REF=NTP. (1992) Toxicology and Carcinogenesis Studies of Polysorbate 80 (CAS No. 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP TR 415, NIH Publication No. 92-3146. (Chronic mouse); TITLE=Toxicology and Carcinogenesis Studies of Polysorbate 80 (CAS No. 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies); AUTHOR=NTP; EXTERNAL_SOURCE_ID=7411; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-stomach-hyperplasia|systemic: pathology microscopic-stomach-inflammation|systemic: pathology microscopic-stomach-ulcer|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15712594_15712595_15712596_15712597:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7c4f8629f82108336e68a52f51d4f1d4 |
| ToxValDB ToxRefDB | NEL | =1250 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | LONG_REF=NTP. (1992) Toxicology and Carcinogenesis Studies of Polysorbate 80 (CAS No. 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP TR 415, NIH Publication No. 92-3146. (Chronic rat); TITLE=Toxicology and Carcinogenesis Studies of Polysorbate 80 (CAS No. 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies); AUTHOR=NTP; EXTERNAL_SOURCE_ID=7412; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-spleen-hematopoietic cell proliferation erythrocytic|systemic: pathology microscopic-adrenal gland-pheochromocytoma benign; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15712606_15712607_15712608_15712609:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2b79cad9f9b28c28b23b3192bd8c4fc6 |
| ToxValDB ToxRefDB | NEL | =3750 | mg/kg bw/day | Mouse | oral | chronic; 2 years | chronic | LONG_REF=NTP. (1992) Toxicology and Carcinogenesis Studies of Polysorbate 80 (CAS No. 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP TR 415, NIH Publication No. 92-3146. (Chronic mouse); TITLE=Toxicology and Carcinogenesis Studies of Polysorbate 80 (CAS No. 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies); AUTHOR=NTP; EXTERNAL_SOURCE_ID=7411; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-stomach-inflammation|systemic: pathology microscopic-stomach-hyperplasia|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-stomach-ulcer; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15712594_15712595_15712596_15712597:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cc55bdc6a3568bca705b4d597168954b |
openFDA substances 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 2MSF640LWM | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"2MSF640LWM"} |
| openFDA substances | FDA UNII substance identifier | 2MSF640LWM | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"2MSF640LWM"} |
| openFDA substances | FDA UNII substance identifier | 2MSF640LWM | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"2MSF640LWM"} |
| openFDA substances | FDA UNII substance identifier | 2MSF640LWM | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"2MSF640LWM"} |
| openFDA substances | FDA UNII substance identifier | 58O7V09UCI | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"58O7V09UCI"} |
| openFDA substances | FDA UNII substance identifier | 58O7V09UCI | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"58O7V09UCI"} |
| openFDA substances | FDA UNII substance identifier | 58O7V09UCI | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"58O7V09UCI"} |
| openFDA substances | FDA UNII substance identifier | 58O7V09UCI | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"58O7V09UCI"} |
| openFDA substances | FDA UNII substance identifier | 6OZP39ZG8H | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"6OZP39ZG8H"} |
| openFDA substances | FDA UNII substance identifier | 6OZP39ZG8H | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"6OZP39ZG8H"} |
| openFDA substances | FDA UNII substance identifier | 6OZP39ZG8H | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"6OZP39ZG8H"} |
| openFDA substances | FDA UNII substance identifier | 6OZP39ZG8H | UNII | - | - | - | polymer | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"6OZP39ZG8H"} |