NOAEL Studies Cosmetic Ingredient

Potassium Bicarbonate NOAEL Studies

INCI: POTASSIUM BICARBONATE

CAS: 298-14-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 345 mg/kg bw/day rat oral 1 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 931 mg/kg bw/day rat oral 854 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 941 mg/kg bw/day rat oral 540 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 2000 mg/kg bw/day rat oral 91 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 2500 mg/kg bw/day rat oral 91 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 3133 mg/kg bw/day rat oral 91 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 4000 mg/kg bw/day rat oral 28 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 4300 mg/kg bw/day rat oral 91 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 4385 mg/kg bw/day rat oral 28 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP_ICE_acute_inhalation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_inhalation LC50 >4.88 mg/L - Inhalation Duration=4.5 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=128; Record_ID=acute_inhalation_3018; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0021177; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=4.88; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13190/7/3/3; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021177
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >2000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_5178; row=451; data_type=In Vivo; mixture=Chemical; chemical_name=Potassium bicarbonate; preferred_name=Potassium bicarbonate; dtxsid=DTXSID0021177; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021177; source_file=acute_oral.xlsx
ToxValDB_ECHA_IUCLID 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =2861 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa0ce4b0a7c65d1b407c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15221/7/8?documentUUID=a1755cbb-cd6d-4271-9161-6f8f00508a9f; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID:15816287:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3987a45d2587455db5a63e08b5df9b19
ToxValDB_ECHA_IUCLID NOAEL =3566 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa0ce4b0a7c65d1b407c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15221/7/8?documentUUID=a1755cbb-cd6d-4271-9161-6f8f00508a9f; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID:15816288:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f5cc3e9e99fbe27637c597bc2e07ae5c
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier HM5Z15LEBN UNII - - - chemical {"approval_status":null,"molecular_formula":"CHO3.K","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"HM5Z15LEBN"}
openFDA substances FDA UNII substance identifier HM5Z15LEBN UNII - - - chemical {"approval_status":null,"molecular_formula":"CHO3.K","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"HM5Z15LEBN"}
openFDA substances FDA UNII substance identifier HM5Z15LEBN UNII - - - chemical {"approval_status":null,"molecular_formula":"CHO3.K","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"HM5Z15LEBN"}
openFDA substances FDA UNII substance identifier HM5Z15LEBN UNII - - - chemical {"approval_status":null,"molecular_formula":"CHO3.K","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"HM5Z15LEBN"}