NOAEL Studies Cosmetic Ingredient

Potassium Carbonate NOAEL Studies

INCI: POTASSIUM CARBONATE

CAS: 584-08-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

Back to parent ingredient page
COSMOS DB 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB NOAEL 180 mg/kg bw/day rat oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 290 mg/kg bw/day mouse oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1500 mg/kg bw/day rat oral 224 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP ICE acute inhalation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute inhalation LC50 >4.96 mg/L - Inhalation Duration=4.5 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=1737; Record_ID=acute_inhalation_3619; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2036245; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=4.96; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15221/7/3/3; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2036245
ECHA 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LOEC =31 mg/m3 Rat inhalation short-term; 21 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15221/7/6/3?documentUUID=a1755cbb-cd6d-4271-9161-6f8f00508a9f; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829252_15829253_15829254_15829255_15829256_15829257:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_952c83c06f0fba71e0bf4baa60db8225
ECHA LOEC =100 mg/m3 Rat inhalation short-term; 21 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15221/7/6/3?documentUUID=a1755cbb-cd6d-4271-9161-6f8f00508a9f; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829252_15829253_15829254_15829255_15829256_15829257:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f53c86c11caa9742baaceaa1598f6328
ECHA NOAEC =62 mg/m3 Rat inhalation short-term; 21 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15221/7/6/3?documentUUID=a1755cbb-cd6d-4271-9161-6f8f00508a9f; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829252_15829253_15829254_15829255_15829256_15829257:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_50c06aac77919934fbf17f91e2e2217c
ECHA NOAEC =200 mg/m3 Rat inhalation short-term; 21 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15221/7/6/3?documentUUID=a1755cbb-cd6d-4271-9161-6f8f00508a9f; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829252_15829253_15829254_15829255_15829256_15829257:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_084b99bc268a96c580ece6be6f8d5c4b
ECHA NOEC =123 mg/m3 Rat inhalation short-term; 21 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15221/7/6/3?documentUUID=a1755cbb-cd6d-4271-9161-6f8f00508a9f; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829252_15829253_15829254_15829255_15829256_15829257:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9560c53a43347bc7cca408173ce4ba14
ECHA NOEC =400 mg/m3 Rat inhalation short-term; 21 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15221/7/6/3?documentUUID=a1755cbb-cd6d-4271-9161-6f8f00508a9f; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829252_15829253_15829254_15829255_15829256_15829257:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d4a076e9fd5835219d5ee9582e804d93
ECHA NOEL =180 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac3ee4b0a7c65d1be1b9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15221/7/9/3?documentUUID=a1755cbb-cd6d-4271-9161-6f8f00508a9f; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID:15822703:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5f4b6bdf6eea35df74bea85424e5d49d
ECHA NOEL =290 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac3ee4b0a7c65d1be1b7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15221/7/9/3?documentUUID=a1755cbb-cd6d-4271-9161-6f8f00508a9f; YEAR=2006; ORIGINAL_YEAR=2006; STUDY_GROUP=ECHA IUCLID:15822475:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6dc5b480a8319133133d061b1e6c8888
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL local =10 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634241:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3a1b0709d53bc3edeb89f782dbe47842
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier BQN1B9B9HA UNII - - - chemical -