Moderate Cosmetic Ingredient NOAEL Data

Potassium Thioglycolate

CAS Number
34452-51-2
Function
Depilatory; Hair waving or straightening; Reducing agent
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes CIR: SQ - IJT 28(Suppl. 1):68-133, 2009

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

3 study endpoints found for Potassium Thioglycolate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 23 mg/kg bw/day oral - oral REACH
NOAEL >=205 mg/kg bw/day dermal - dermal REACH
NOAEL >=410 mg/kg bw/day dermal - dermal REACH

Expert Verdict

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Concern Level: Low

Frequently Asked Questions

Is Potassium Thioglycolate safe in cosmetics?

Potassium Thioglycolate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 3 toxicological study endpoint(s) are available in our database.

Is Potassium Thioglycolate allowed in the EU?

Potassium Thioglycolate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Potassium Thioglycolate do in cosmetics?

Potassium Thioglycolate functions as: Depilatory; Hair waving or straightening; Reducing agent. It is classified as a cosmetic ingredient in our database. CAS number: 34452-51-2.

What is the Margin of Safety for Potassium Thioglycolate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Potassium Thioglycolate?

The NOAEL (No Observed Adverse Effect Level) for Potassium Thioglycolate is 23 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.

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