Good Cosmetic Ingredient NOAEL Data

PPG-15-Buteth-20

INCI: PPG-15-BUTETH-20

CAS Number
9038-95-3
Function
Hair conditioning, skin conditioning, solvent, emulsifier, antistatic agent
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted; CIR assessed PPG-Buteth series (PPG-12-Buteth-16, PPG-26-Buteth-26, PPG-28-Buteth-35 etc.) as safe as used

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for PPG-15-Buteth-20. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1000 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 616 mg/kg bw/day oral dog Chronic COSMOS_DB
NOAEL 500 mg/kg bw/day oral rat Chronic COSMOS_DB
NOAEL 500 mg/kg bw/day oral rat Chronic COSMOS_DB
NOAEL 500 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 500 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 610 mg/kg bw/day oral dog Chronic COSMOS_DB
dose_tested 616 mg/kg bw/day oral dog Chronic COSMOS_DB
dose_tested 500 mg/kg bw/day oral rat Chronic COSMOS_DB
dose_tested 500 mg/kg bw/day oral rat Chronic COSMOS_DB

Expert Verdict

Formulate to be non-irritating per CIR recommendation. Verify supplier Certificate of Analysis for 1,4-dioxane and ethylene oxide residuals from ethoxylation process.

⚠️
Concern Level: Low

Regulatory Flags

eu_children_restricted ifra_fragrance fda_food_additive

Frequently Asked Questions

Is PPG-15-Buteth-20 safe in cosmetics?

Formulate to be non-irritating per CIR recommendation. Verify supplier Certificate of Analysis for 1,4-dioxane and ethylene oxide residuals from ethoxylation process. The EU classifies PPG-15-Buteth-20 as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.

Is PPG-15-Buteth-20 allowed in the EU?

PPG-15-Buteth-20 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does PPG-15-Buteth-20 do in cosmetics?

PPG-15-Buteth-20 functions as: Hair conditioning, skin conditioning, solvent, emulsifier, antistatic agent. It is classified as a cosmetic ingredient in our database. CAS number: 9038-95-3.

What is the Margin of Safety for PPG-15-Buteth-20?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for PPG-15-Buteth-20?

The NOAEL (No Observed Adverse Effect Level) for PPG-15-Buteth-20 is 1000 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check PPG-15-Buteth-20 compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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