Is Propolis Resin Extract safe in cosmetics?
Propolis Resin Extract has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Propolis Resin Extract
INCI: PROPOLIS EXTRACT
Propolis Resin Extract (CAS Propolis extract CAS: varies by preparation; common reference is EINECS 288-130-6) is a cosmetic cosmetic ingredient functioning as Skin conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
Auto-generated CPSR Part A draft with source citations
CAS Number
Propolis extract CAS: varies by preparation; common reference is EINECS 288-130-6
View industrial chemical safety profile →
Function
Skin conditioning
Safety Rating
MODERATE
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; no CIR safety monograph dedicated to propolis but widely used in OTC and cosmetic products.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Propolis Resin Extract.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
10 property records from structured ingredient metadata.
acne
{"cas_number": "85665-41-4", "anti_acne_mechanism": "antibacterial/anti_inflammatory", "comedogenicity_rating_0_to_5": "1", "acne_type_efficacy": "inflammatory", "p_acnes_mic_ug_per_ml": "100-500", "sebum_reduction_pct_clinical": "5-10", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functi…
anti_pollution
{"cas_number": "9009-62-5", "ingredient_class": "antioxidant_pollution_shield", "primary_mechanism": "free_radical_scavenging", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulatio…
concentration
{"min_concentration_pct": "0.5", "max_concentration_pct": "5.0", "typical_concentration_pct": "2.0", "product_type": "Moisturizer", "function_at_concentration": "Antimicrobial, healing", "source": "Clinical literature"}
cost_pricing
{"cost_tier": "mid-range", "estimated_cost_per_kg_usd_low": "45", "estimated_cost_per_kg_usd_high": "85", "natural_premium_markup_pct": "65", "organic_certified_premium_pct": "110", "supply_chain_volatility": "medium", "primary_source_region": "Brazil/New Zealand", "synthetic_vs_natural_cost_ratio": "2.5", "bulk_discount_threshold_kg": "50", "seasonal_price_variation": "medium", "commodity_or_spec…
deodorant
{"cas_number": "9009-62-5", "ingredient_class": "antimicrobial_deodorant", "mechanism_of_action": "bacterial_growth_inhibition", "antiperspirant_efficacy_sweat_reduction_pct": "0", "deodorant_efficacy_hours": "8-12", "odor_reduction_pct": "45-65", "bacteriostatic": "yes", "bactericidal": "yes", "target_bacteria": "broad_spectrum", "microbiome_impact": "selective", "axillary_microbiome_effect": "va…
depigmentation
{"cas_number": "9009-62-5", "ingredient_class": "combined_mechanism", "primary_mechanism_of_action": "Honey/bee product with enzymatic and antioxidant brightening", "secondary_mechanisms": "Variable", "molecular_target": "other", "tyrosinase_inhibition_IC50_uM": "varies", "tyrosinase_inhibition_type": "competitive", "melanin_reduction_pct_in_vitro": "25-45", "melanin_reduction_pct_clinical": "15-3…
microbiome_impact
{"microbiome_effect": "mixed", "prebiotic": "yes", "probiotic_compatible": "limited", "antimicrobial_spectrum": "selective", "preservative_effect_on_microbiome": "Bee product; antimicrobial; antioxidant; moderate selectivity", "skin_flora_disruption": "mild", "gut_microbiome_risk": "low", "microbiome_recovery_time": "5-7 days", "selective_antimicrobial": "yes", "beneficial_bacteria_support": "S. e…
pediatric_safety
{"safe_for_newborn_0_6m": "caution", "safe_for_infant_6_12m": "yes", "safe_for_toddler_1_3y": "yes", "safe_for_child_3_12y": "yes", "safe_for_teen_12_18y": "yes", "pediatric_max_concentration_pct": "5.0", "adult_max_concentration_pct": "5.0", "pediatric_dermal_absorption_factor": "normal", "immature_skin_barrier_risk": "low", "oral_ingestion_risk": "low", "diaper_area_safe": "yes", "pediatric_alle…
Expert Verdict
Expert safety assessment and concern-level summary for Propolis Resin Extract.
Regulatory Flags
plant-extract
potential-allergen
Frequently Asked Questions
Is Propolis Resin Extract allowed in the EU?
Propolis Resin Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Propolis Resin Extract do in cosmetics?
Propolis Resin Extract functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: Propolis extract CAS: varies by preparation; common reference is EINECS 288-130-6.
Compliance Tools
Check Propolis Resin Extract compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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