NOAEL Studies
Humectant
Propylene Glycol NOAEL Studies
INCI: PROPYLENE GLYCOL
CAS: 57-55-6
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
Regulatory source 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | LOAEL | =158.727 | mg/m3 | Rat (Sprague Dawley; M/F) | inhalation | subchronic; 13 weeks | subchronic | ATSDR MRLs; row_hash=016d05a31d5cd16a; source_hash=ToxValhc_9792394795abc0dfb835bb0d4b2790a8; raw_endpoint_type=LOAEL; raw_endpoint_subtype=; raw_value=51; raw_unit=ppm; method=nose only; effect=respiratory; effect_category=clinical signs; file=toxval_ATSDR_MRLs.xlsx; long_ref=Suber RL, Deskin R, Nikiforov I, et al. 1989. Subchronic nose-only inhalation study of propylene glycol in Sprague-Dawley rats. Food Chem Toxicol 27(9):573-584.; stored_source_record=https://clowder.edap-cluster.com/files/6568f4f4e4b063812d5857e9 |
COSMOS DB 22 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | LOAEL | 5000 | mg/kg bw/day | dog | oral | 104 week | Subchronic | REACH; Food Cosmet. Toxicol. 9: 479-490. |
| COSMOS DB | NOAEL | 730 | mg/kg bw/day | rat | oral | 1 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 735 | mg/kg bw/day | rat | oral | 1 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 1230 | mg/kg bw/day | rabbit | oral | NA | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 1350 | mg/kg bw/day | cat | oral | 87 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 1550 | mg/kg bw/day | hamster | oral | NA | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 1600 | mg/kg bw/day | mouse | oral | NA | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 2000 | mg/kg bw/day | dog | oral | 728 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 2100 | mg/kg bw/day | rat | oral | 105 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 2450 | mg/kg bw/day | rat | oral | 365 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 2750 | mg/kg bw/day | cat | oral | 91 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 2940 | mg/kg bw/day | rat | oral | 30 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 4144 | mg/kg bw/day | rat | oral | 30 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 4662 | mg/kg bw/day | dog | oral | 3 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 5000 | mg/kg bw/day | dog | oral | 270 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 6400 | mg/kg bw/day | rat | oral | 14 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 9325 | mg/kg bw/day | rat | oral | 3 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 10000 | mg/kg bw/day | rat | oral | 140 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 10610 | mg/kg bw/day | mink | oral | 7 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 13300 | mg/kg bw/day | rat | oral | 140 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 15000 | mg/kg bw/day | rat | oral | NA | Multigeneration Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 16400 | mg/kg bw/day | syrian hamster | oral | 10 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
EFSA 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | NOEL | =2500 | mg/kg bw/day | Rat | - | 730 days | chronic/long term toxicity | EFSA ANS - 2018 - OutputID 3046 - Re-evaluation of propane-1,2-diol (E 1520) as a food additive - doi:10.2903/j.efsa.2018.5235 |
| EFSA | ADI | =25 | mg/kg bw/day | Consumers | - | - | ADI | EFSA ANS - 2018 - OutputID 3046 - Consumers - Re-evaluation of propane-1,2-diol (E 1520) as a food additive - doi:10.2903/j.efsa.2018.5235 |
| EFSA | NOEL | =2500 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | LONG_REF=EFSA CEF (2010). Scientific Opinion on Flavouring Group Evaluation 92 (FGE.92): Consideration of aliphatic acyclic diols, triols, and related substances evaluated by JECFA (68th meeting) structurally related to aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones evaluated by EFSA in FGE.10Rev1 (2009). EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF). doi:10.2903/j.efsa.2010.1453.; TITLE=Scientific Opinion on Flavouring Group Evaluation 92 (FGE.92): Consideration of aliphatic acyclic diols, triols, and related substances evaluated by JECFA (68th meeting) structurally related to aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones evaluated by EFSA in FGE.10Rev1 (2009). EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); AUTHOR=EFSA CEF; DOI=doi:10.2903/j.efsa.2010.1453; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2010; ORIGINAL_YEAR=2010; STUDY_GROUP=EFSA_dup_-_15614454_15614455_15614456:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ae60bfbfdfd88231e6366c9b260812de |
WHO/JECFA 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | ADI | =25 | mg/kg bw/day | Human | oral | - | Health guidance value | document_id=pims_chemical_pim443; title=Propylene glycol (PIM 443); path=mirror/documents/pims/chemical/pim443.htm; row_hash=0681938644a91229; raw_unit=mg/kg; context=7.2 Toxicity 7.2.1 Human data 7.2.1.1 Adults The estimated acceptable daily intake is 25 mg/kg (17th Report of the Joint FAO/WHO Expert Committee on Food Additives, 1974). |
| WHO/JECFA | ADI | <=25 | mg/kg | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650af042e4b0d99f5a86d460; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/786; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=WHO JECFA ADI:15715239:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ce8b589bc3432fb14016a2ad228c7960 |
NTP ICE acute oral 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =20000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_7848; row=455; data_type=In Vivo; mixture=Chemical; chemical_name=1,2-Propylene glycol; preferred_name=1,2-Propylene glycol; dtxsid=DTXSID0021206; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021206; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0021206; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >21000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_7849; row=456; data_type=In Vivo; mixture=Chemical; chemical_name=1,2-Propylene glycol; preferred_name=1,2-Propylene glycol; dtxsid=DTXSID0021206; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021206; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0021206; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =22000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_7850; row=454; data_type=In Vivo; mixture=Chemical; chemical_name=1,2-Propylene glycol; preferred_name=1,2-Propylene glycol; dtxsid=DTXSID0021206; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021206; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0021206; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | <33700 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_7851; row=457; data_type=In Vivo; mixture=Chemical; chemical_name=1,2-Propylene glycol; preferred_name=1,2-Propylene glycol; dtxsid=DTXSID0021206; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021206; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID0021206; source_file=acute_oral.xlsx |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=586; RecordID=ARPathway2016_1346; DatasetName=ARPathway2016; DTXSID=DTXSID0021206; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021206; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021206 |
NTP ICE eye irritation 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE eye irritation | Draize rabbit irritation score | 1.3 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=80; Record_ID=eye_irritation_138; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID0021206; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=1.3; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021206; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021206 |
| NTP ICE eye irritation | EPA Classification | 4 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=86; Record_ID=eye_irritation_138; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID0021206; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=4; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021206; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021206 |
| NTP ICE eye irritation | Lag time | >180 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=85; Record_ID=eye_irritation_1217; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0021206; Assay=Vitrigel; Endpoint=Lag time; Response_Modifier=>; Response=180; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021206; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021206 |
| NTP ICE eye irritation | Plateau level | 0 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=83; Record_ID=eye_irritation_1217; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0021206; Assay=Vitrigel; Endpoint=Plateau level; Response=0; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021206; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021206 |
NTP ICE skin irritation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin irritation | Positive reaction | 6.25 | % | Human | Dermal | - | In Vivo; Four-hour Human Patch Test | sheet=Data_invivo; excel_row=83; Record_ID=skin_irritation_invivo_84; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID0021206; Assay=Four-hour Human Patch Test; Endpoint=Positive reaction; Response=6.25; Response_Unit=%; Species=Human; Reference=Basketter et al. 2004; 15291823; 10.1111/j.0105-1873.2004.00385.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021206; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021206 |
NTP ICE skin sensitization 24 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | CD86, EC150 | >200 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8757; Record_ID=skin_sensitization_invitro_2428; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID0021206; Assay=U-SENS; Endpoint=CD86, EC150; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=200; Reported_Response_Unit=ug/mL; Response=200; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021206; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021206 |
| NTP ICE skin sensitization | CD86, EC150 | >532.665 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; U-SENS | sheet=Data_invitro; excel_row=8140; Record_ID=skin_sensitization_invitro_2163; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID0021206; Assay=U-SENS; Endpoint=CD86, EC150; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=7000; Reported_Response_Unit=uM; Conversion_Factor_Value=76.095; Conversion_Factor_Source=EPA Dashboard; Converted_Response_Modifier=>; Converted_Response=532.665; Converted_Response_Unit=ug/mL; Response=532.665; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021206; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021206 |
| NTP ICE skin sensitization | CV75 | 833.3 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3185; Record_ID=skin_sensitization_invitro_739; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID0021206; Assay=h-CLAT; Endpoint=CV75; Reported_Response=833.3; Reported_Response_Unit=ug/mL; Response=833.3; Response_Unit=ug/mL; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021206; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021206 |
| NTP ICE skin sensitization | CV75 | <1000 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3193; Record_ID=skin_sensitization_invitro_741; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID0021206; Assay=h-CLAT; Endpoint=CV75; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=1000; Reported_Response_Unit=ug/mL; Response=1000; Response_Unit=ug/mL; Reference=Ashikaga et al. 2010; 20822320; 10.1177/026119291003800403|Nukada et al. 2012; 22796097; 10.1016/j.tiv.2012.07.001|Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021206; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021206 |
| NTP ICE skin sensitization | CV75 | 5000 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2283; Record_ID=skin_sensitization_invitro_560; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID0021206; Assay=h-CLAT; Endpoint=CV75; Reported_Response=5000; Reported_Response_Unit=ug/mL; Response=5000; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021206; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021206 |
| NTP ICE skin sensitization | Depletion Cys | -3 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1022; Record_ID=skin_sensitization_invitro_279; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID0021206; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=-3; Reported_Response_Unit=%; Response=-3; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021206; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021206 |
| NTP ICE skin sensitization | Depletion Cys | -0.9 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1026; Record_ID=skin_sensitization_invitro_280; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID0021206; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=-0.9; Reported_Response_Unit=%; Response=-0.9; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021206; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021206 |
| NTP ICE skin sensitization | Depletion Cys | 0 | % | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; DPRA | sheet=Data_invitro; excel_row=236; Record_ID=skin_sensitization_invitro_62; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID0021206; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=0; Reported_Response_Unit=%; Response=0; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021206; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021206 |
| NTP ICE skin sensitization | Depletion Lys | 0 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1021; Record_ID=skin_sensitization_invitro_279; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID0021206; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0; Reported_Response_Unit=%; Response=0; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021206; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021206 |
| NTP ICE skin sensitization | Depletion Lys | 0.6 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1025; Record_ID=skin_sensitization_invitro_280; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID0021206; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0.6; Reported_Response_Unit=%; Response=0.6; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021206; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021206 |
| NTP ICE skin sensitization | Depletion Lys | 1.8 | % | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; DPRA | sheet=Data_invitro; excel_row=214; Record_ID=skin_sensitization_invitro_62; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID0021206; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=1.8; Reported_Response_Unit=%; Response=1.8; Response_Unit=%; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021206; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021206 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 0.3 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1035; Record_ID=skin_sensitization_invitro_282; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID0021206; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=0.3; Reported_Response_Unit=%; Response=0.3; Response_Unit=%; Reference=Gerberick et al. 2007; 15254333; 10.1093/toxsci/kfh213|Jaworska 2011; 23670904; 10.1002/jat.2869|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021206; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021206 |
| NTP ICE skin sensitization | EC1.5 | >2000 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=6079; Record_ID=skin_sensitization_invitro_1443; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID0021206; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021206; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021206 |
| NTP ICE skin sensitization | IC50 | >2400 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7623; Record_ID=skin_sensitization_invitro_1791; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID0021206; Assay=LuSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2400; Reported_Response_Unit=uM; Response=2400; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021206; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021206 |
| NTP ICE skin sensitization | Imax | 1.15 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6084; Record_ID=skin_sensitization_invitro_1444; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID0021206; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.1499999999999999; Reported_Response_Unit=Unitless; Response=1.15; Response_Unit=Ratio; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021206; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021206 |
| NTP ICE skin sensitization | Imax | 1.209 | ratio | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7517; Record_ID=skin_sensitization_invitro_1791; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID0021206; Assay=LuSens; Endpoint=Imax; Reported_Response=1.209177029; Reported_Response_Unit=Unitless; Response=1.209; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021206; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021206 |
| NTP ICE skin sensitization | Imax | 1.24 | ratio | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=6085; Record_ID=skin_sensitization_invitro_1443; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID0021206; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.24; Reported_Response_Unit=Unitless; Response=1.24; Response_Unit=Ratio; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021206; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021206 |
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=8263; Record_ID=skin_sensitization_invivo_1869; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=12.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021206; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021206; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021206 |
| NTP ICE skin sensitization | Induction dose per skin area | 9300 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=8261; Record_ID=skin_sensitization_invivo_1869; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=12.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021206; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=9300; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021206; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021206 |
| NTP ICE skin sensitization | Induction dose per skin area | 15520 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=8300; Record_ID=skin_sensitization_invivo_1867; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021206; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=15520; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Gad et al. (1986; 3715870; 10.1016/0041-008X(86)90419-9|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021206; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021206 |
| NTP ICE skin sensitization | Induction dose per skin area | 41850 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=8269; Record_ID=skin_sensitization_invivo_1871; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=60.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021206; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=41850; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021206; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021206 |
| NTP ICE skin sensitization | Relative reliability score | 1 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=8259; Record_ID=skin_sensitization_invivo_1867; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021206; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=1; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Gad et al. (1986; 3715870; 10.1016/0041-008X(86)90419-9|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021206; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021206 |
| NTP ICE skin sensitization | Relative reliability score | 2 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=8275; Record_ID=skin_sensitization_invivo_1871; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=60.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021206; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=2; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1974; 4459237; 10.1016/0015-6264(74)90367-8|Gerberick et al. 2001; 11526521; 10.1053/ajcd.2001.23926; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021206; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021206 |
| NTP ICE skin sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=8267; Record_ID=skin_sensitization_invivo_1869; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=12.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0021206; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0021206; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0021206 |
ToxValDB ATSDR MRLs 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ATSDR MRLs | LOAEL | =158.727 | mg/m3 | Rat | inhalation | subchronic; 13 weeks | subchronic | LONG_REF=Suber RL, Deskin R, Nikiforov I, et al. 1989. Subchronic nose-only inhalation study of propylene glycol in Sprague-Dawley rats. Food Chem Toxicol 27(9):573-584.; TITLE=Subchronic nose-only inhalation study of propylene glycol in Sprague-Dawley rats; AUTHOR=Suber RL; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f4e4b063812d5857e9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp189.pdf; TOXICOLOGICAL_EFFECT=respiratory; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs:15447781:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9792394795abc0dfb835bb0d4b2790a8 |
| ToxValDB ATSDR MRLs | MRL | =0.0280106 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=respiratory in male/female rats; STUDY_GROUP=ATSDR MRLs:15447217:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_882ac6687e3aecd1809a7db66ed9332d |
ToxValDB DOE Protective Action Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Protective Action Criteria | LEL | =80919.4 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=DOE Protective Action Criteria:15519104:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f617014510e330fdb8a1d0458334026e |
ECHA 17 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LEL | =5000 | mg/m3 | Dog | inhalation | - | acute | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16001/7/3/3?documentUUID=ac373698-264b-4461-8541-9710a44a0fc6; YEAR=1971; ORIGINAL_YEAR=1971; STUDY_GROUP=ECHA IUCLID:15797782:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0e2960041aaa4edd2c6c60788bb053b0 |
| ECHA | LEL | =41000 | mg/m3 | Rat | inhalation | - | acute | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16001/7/3/3?documentUUID=ac373698-264b-4461-8541-9710a44a0fc6; YEAR=1971; ORIGINAL_YEAR=1971; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Inhalation_15796522_15799029:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_35d1903aec369f1d0111d587e630ffd5 |
| ECHA | LOEC | =160 | mg/m3 | Rat | inhalation | subchronic; 90 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16001/7/6/3?documentUUID=ac373698-264b-4461-8541-9710a44a0fc6; YEAR=1971; ORIGINAL_YEAR=1971; STUDY_GROUP=ECHA IUCLID:15828359:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_31e9cd891f626ce50a7a37ec699625d6 |
| ECHA | NOAEC | >350 | mg/m3 | Rat | inhalation | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216ea2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16001/7/8?documentUUID=ac373698-264b-4461-8541-9710a44a0fc6; YEAR=1971; ORIGINAL_YEAR=1971; STUDY_GROUP=ECHA IUCLID:15816201:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_674258e2075b7993c05080d6921cdad4 |
| ECHA | NOAEC | =1000 | mg/m3 | Rat | inhalation | subchronic; 90 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16001/7/6/3?documentUUID=ac373698-264b-4461-8541-9710a44a0fc6; YEAR=1971; ORIGINAL_YEAR=1971; STUDY_GROUP=ECHA IUCLID:15828357:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bed771711f4b84b4d7de9de9d1d98e90 |
| ECHA | NOAEC | =1040 | mg/kg bw/day | Mouse | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac3ee4b0a7c65d1be171; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16001/7/9/3?documentUUID=ac373698-264b-4461-8541-9710a44a0fc6; YEAR=1971; ORIGINAL_YEAR=1971; STUDY_GROUP=ECHA IUCLID:15820974:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_af4610e3eec46dd6c24f8da6a17a4ba3 |
| ECHA | NOAEC | =2200 | mg/m3 | Rat | inhalation | subchronic; 90 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16001/7/6/3?documentUUID=ac373698-264b-4461-8541-9710a44a0fc6; YEAR=1971; ORIGINAL_YEAR=1971; STUDY_GROUP=ECHA IUCLID:15828358:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b32e7257376e2b9f3d594aca4e668134 |
| ECHA | NOAEL | =443 | mg/kg bw/day | Cat | oral | acute; 1 days | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb56e4b0a7c65d225d08; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16001/7/6/2?documentUUID=ac373698-264b-4461-8541-9710a44a0fc6; YEAR=1971; ORIGINAL_YEAR=1971; STUDY_GROUP=ECHA IUCLID:15839871:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_afecc8e6accb9682266ef1b7abc6b669 |
| ECHA | NOAEL | =520 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac3ee4b0a7c65d1be171; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16001/7/9/3?documentUUID=ac373698-264b-4461-8541-9710a44a0fc6; YEAR=1971; ORIGINAL_YEAR=1971; TOXICOLOGICAL_EFFECT=maternal: water consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECHA IUCLID:15822310:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3551ac10e93707405c6bb32146ce116a |
| ECHA | NOAEL | =1700 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae72e4b0a7c65d1c948a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16001/7/6/2?documentUUID=ac373698-264b-4461-8541-9710a44a0fc6; YEAR=1971; ORIGINAL_YEAR=1971; STUDY_GROUP=ECHA IUCLID:15839955:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6f139253bfc83f82a64a239affe579f0 |
| ECHA | NOAEL | =2000 | mg/kg bw/day | Dog | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa0ce4b0a7c65d1b406a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16001/7/8?documentUUID=ac373698-264b-4461-8541-9710a44a0fc6; YEAR=1971; ORIGINAL_YEAR=1971; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819077_15819078:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b223b5e7e9374fc16c9a74a72d977ba0 |
| ECHA | NOAEL | =2100 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae72e4b0a7c65d1c948a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16001/7/6/2?documentUUID=ac373698-264b-4461-8541-9710a44a0fc6; YEAR=1971; ORIGINAL_YEAR=1971; STUDY_GROUP=ECHA IUCLID:15839956:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8ee33ce1b9548ade8e16197c91e523b5 |
| ECHA | NOAEL | =5000 | mg/kg bw/day | Dog | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa0ce4b0a7c65d1b406a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16001/7/8?documentUUID=ac373698-264b-4461-8541-9710a44a0fc6; YEAR=1971; ORIGINAL_YEAR=1971; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15819077_15819078:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_904e479d6530a523264e33f731f30dc9 |
| ECHA | NOAEL | =10100 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab19e4b0a7c65d1b8c84; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16001/7/9/2?documentUUID=ac373698-264b-4461-8541-9710a44a0fc6; YEAR=1971; ORIGINAL_YEAR=1971; STUDY_GROUP=ECHA IUCLID:15857410:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_03200b18396c11da285e965fe414be84 |
| ECHA | NOAEL | =13200 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa0ce4b0a7c65d1b4068; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16001/7/8?documentUUID=ac373698-264b-4461-8541-9710a44a0fc6; YEAR=1971; ORIGINAL_YEAR=1971; STUDY_GROUP=ECHA IUCLID:15818606:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ee86586d0f4968eca71cd1de6600c9a0 |
| ECHA | NOEL | ~6.05 | mg/kg bw/day | Dog | inhalation | short-term; 28 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16001/7/6/3?documentUUID=ac373698-264b-4461-8541-9710a44a0fc6; YEAR=1971; ORIGINAL_YEAR=1971; STUDY_GROUP=ECHA IUCLID:15827962:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_83461f41c627c034081f4a7d6adc13f9 |
| ECHA | NOEL | ~20 | mg/kg bw/day | Rat | inhalation | short-term; 28 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61fb0e4b096bca877e6df; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16001/7/6/3?documentUUID=ac373698-264b-4461-8541-9710a44a0fc6; YEAR=1971; ORIGINAL_YEAR=1971; STUDY_GROUP=ECHA IUCLID:15826965:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b1d5b56bebcd31d641aa3a6d71788e55 |
ToxValDB ECOTOX 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | NOEL | =5 | % | Mouse | oral | chronic; 361 days | chronic | LONG_REF=Fundam. Appl. Toxicol.39(1): 1-10 Bolon,B., T.J. Bucci, A.R. Warbritton, J.J. Chen, D.R. Mattison, and J.J. Heindel Differential Follicle Counts as a Screen for Chemically Induced Ovarian Toxicity in Mice: Results from Continuous Breeding Bioassays 1997; TITLE=Differential Follicle Counts as a Screen for Chemically Induced Ovarian Toxicity in Mice: Results from Continuous Breeding Bioassays; AUTHOR=Bolon,B., T.J. Bucci, A.R. Warbritton, J.J. Chen, D.R. Mattison, and J.J. Heindel; DOI=10.1006/faat.1997.2338; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=151647; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Reproduction: Number of ovarian follicles; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX:15609952:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f15e511366958f11b01ad7b81c2759b8 |
| ToxValDB ECOTOX | NOEL | =10000 | mg/kg bw/day | Mouse | oral | short-term (developmental); 5 days | reproduction developmental | LONG_REF=Teratog. Carcinog. Mutagen.7(1): 7-16 Kavlock,R.J., R.D.,Jr. Short, and N. Chernoff Further Evaluation of an In Vivo Teratology Screen 1987; TITLE=Further Evaluation of an In Vivo Teratology Screen; AUTHOR=Kavlock,R.J., R.D.,Jr. Short, and N. Chernoff; DOI=10.1002/tcm.1770070104; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=70488; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Growth: Weight|Mortality: Mortality|Mortality: Survival|Reproduction: Pregnant females in a population|Reproduction: Resorbed embryos; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|mortality/survival|reproduction; STUDY_GROUP=ECOTOX:15611639:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=c7942bf5d693ecd32e23e53d1716c4ab |
ToxValDB GESTIS DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL local | =10 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15634326_15634327:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a886a2c8a4953834073a5c45db01ce59 |
| ToxValDB GESTIS DNEL | DNEL systemic | =168 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15634326_15634327:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_22fa7a5532584cc553df9fe234940096 |
ToxValDB PPRTV (CPHEA) 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB PPRTV (CPHEA) | LOAEL | =5200 | mg/kg bw/day | Rat | oral | subchronic; 5 weeks | subchronic | LONG_REF=Vaille et al. 1971; AUTHOR=Vaille et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754fce4b08a6b3934bd58; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1867; TOXICOLOGICAL_EFFECT=reduced rbc counts and hyperglycemia; TOXICOLOGICAL_EFFECT_CATEGORY=multiple; STUDY_GROUP=PPRTV (CPHEA):15654106:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0a6cf95169a20b688db90f64f49844bc |
| ToxValDB PPRTV (CPHEA) | RfD (provisional) | =20 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=Vaille et al. 1971; AUTHOR=Vaille et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754fce4b08a6b3934bd58; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1867; TOXICOLOGICAL_EFFECT=Reduced RBC counts and hyperglycemia in male rats; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653908_15653909:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ecb7afecd443d8e4c5559e69afe6e419 |
ToxValDB RSL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB RSL | RfC | =0.0280123 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15663750:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0f6bf2d2038c3fd030299338810ecf9c |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 6DC9Q167V3 | UNII | - | - | - | chemical | - |