NOAEL Studies
Preservative
Propylparaben NOAEL Studies
INCI: PROPYLPARABEN
CAS: 94-13-3
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS DB 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | LOAEL | 12 | mg/kg bw/day | rat | oral | 31 day | Short Term Toxicity | SCCS; Food Chemical Toxicology 40: 1807-1813; 2002: Oishi S. |
| COSMOS DB | NOAEL | 12 | mg/kg bw/day | rat | oral | 28 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 100 | mg/kg bw/day | mouse | oral | 3 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 1000 | mg/kg bw/day | rat | oral | 10 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 1500 | mg/kg bw/day | rat | oral | 547 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 3000 | mg/kg bw/day | rat | oral | 28 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 4000 | mg/kg bw/day | rat | oral | 9 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 5700 | mg/kg bw/day | rat | oral | 672 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
NTP ICE adme parameters 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 246 | uL/min/10^6 cells | Rat | - | - | Measured; httk, Rat Hepatic Intrinsic Clearance | sheet=Data; excel_row=1632; Record_ID=adme_parameters_379; Data_Type=Measured; DTXSID=DTXSID4022527; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=246.0; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Honda 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE adme parameters | Clint | 38 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=1634; Record_ID=adme_parameters_379; Data_Type=Measured; DTXSID=DTXSID4022527; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=38.0; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE adme parameters | Fu | 0.07639 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=1633; Record_ID=adme_parameters_379; Data_Type=Measured; DTXSID=DTXSID4022527; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.07639; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE adme parameters | Fu | 0.0241 | fraction | Rat | - | - | Measured; httk, Rat Plasma Fraction Unbound | sheet=Data; excel_row=1635; Record_ID=adme_parameters_379; Data_Type=Measured; DTXSID=DTXSID4022527; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.0241; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Honda 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
NTP ICE endocrine 15 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | AC50 | 20.5833466843994 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=13820; RecordID=ERPathway2016_199; DatasetName=ERPathway2016; DTXSID=DTXSID4022527; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=20.5833466843994; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE endocrine | AC50/EC50/IC50 | 970000 | nM | - | - | - | In Vitro; AR Binding | sheet=Data_invitro; excel_row=182; Record_ID=endocrine_invitro_176; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=970000; Reported_Response_Unit=nM; Response=970000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Kim et al. 2010; 20371976; 10.2131/jts.35.239; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE endocrine | AC50/EC50/IC50 | 310000 | nM | - | - | - | In Vitro; AR Binding | sheet=Data_invitro; excel_row=183; Record_ID=endocrine_invitro_177; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=AR Binding; Endpoint=AC50/EC50/IC50; Reported_Response=310000; Reported_Response_Unit=nM; Response=310000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Fang et al. 2003; 14565775; 10.1021/tx030011g; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE endocrine | AC50/EC50/IC50 | 70100 | nM | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=13258; Record_ID=endocrine_invitro_4101; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=70100; Reported_Response_Unit=nM; Response=70100; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Ermler et al. 2011; 21945941; 10.1016/j.taap.2011.09.005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE endocrine | AC50/EC50/IC50 | 86000 | nM | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=13260; Record_ID=endocrine_invitro_4103; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=86000; Reported_Response_Unit=nM; Response=86000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE endocrine | AC50/EC50/IC50 | 39000 | nM | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=13262; Record_ID=endocrine_invitro_4104; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=39000; Reported_Response_Unit=nM; Response=39000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Ma et al. 2014; 24469767; 10.1007/s11356-014-2497-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE endocrine | ACC | 4.28031382304317 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=13821; RecordID=ERPathway2016_199; DatasetName=ERPathway2016; DTXSID=DTXSID4022527; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=4.28031382304317; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE endocrine | IC01 | 32200 | nM | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=13017; Record_ID=endocrine_invitro_4030; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=AR Transactivation-Antagonist; Endpoint=IC01; Reported_Response=32200; Reported_Response_Unit=IC01 (nM); Response=32200; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE endocrine | LEL | 1000 | nM | - | - | - | In Vitro; AR Transactivation-Antagonist | sheet=Data_invitro; excel_row=14962; Record_ID=endocrine_invitro_4395; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=AR Transactivation-Antagonist; Endpoint=LEL; Reported_Response=1000; Reported_Response_Unit=nM; Response=1000; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Chen et al. 2007; 17481686; 10.1016/j.taap.2007.03.015; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE endocrine | LOEL | 65 | mg/kg bw/day | Rat | Subcutaneous | Treatment_Duration=3 days; Age_at_First_Dose=PND 21; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=4 | In Vivo; Uterotrophic-Agonist | sheet=Data_invivo; excel_row=1047; Record_ID=endocrine_invivo_410; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=65; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Wistar; Strain=Wistar; Sex=Female; Route=Subcutaneous; Maximum_Dose=195; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Lemini et al. 2003; 15697177; 10.1191/0748233703th177oa|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=13816; RecordID=ARPathway2016_1736; DatasetName=ARPathway2016; DTXSID=DTXSID4022527; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE endocrine | Model Score | 0.205 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=13822; RecordID=ERPathway2016_199; DatasetName=ERPathway2016; DTXSID=DTXSID4022527; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.205; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE endocrine | RBA | 0.001 | unitless | - | - | - | In Vitro; AR Binding | sheet=Data_invitro; excel_row=1981; Record_ID=endocrine_invitro_177; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=AR Binding; Endpoint=RBA; Reported_Response=-3; Reported_Response_Unit=Unitless; Conversion_Factor=Anti-log; Converted_Response=1E-3; Converted_Response_Unit=Unitless; Response=1E-3; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Fang et al. 2003; 14565775; 10.1021/tx030011g; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE endocrine | RBA | 0.0019 | unitless | - | - | - | In Vitro; AR Binding | sheet=Data_invitro; excel_row=2472; Record_ID=endocrine_invitro_176; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=AR Binding; Endpoint=RBA; Reported_Response=1.9E-3; Reported_Response_Unit=Unitless; Response=1.9E-3; Response_Unit=Unitless; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Kim et al. 2010; 20371976; 10.2131/jts.35.239; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE endocrine | Uterine weight increase vs control | 55 | % | Rat | Subcutaneous | Treatment_Duration=3 days; Age_at_First_Dose=PND 21; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=4 | In Vivo; Uterotrophic-Agonist | sheet=Data_invivo; excel_row=732; Record_ID=endocrine_invivo_410; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=55; Response_Unit=%; Species=Rat; Reported_Strain=Wistar; Strain=Wistar; Sex=Female; Route=Subcutaneous; Maximum_Dose=195; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Estradiol; Reference=Lemini et al. 2003; 15697177; 10.1191/0748233703th177oa|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
NTP ICE skin sensitization 37 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | CD54, EC200 | 70.8 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2295; Record_ID=skin_sensitization_invitro_562; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=70.8; Reported_Response_Unit=ug/mL; Response=70.8; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | CD54, EC200 | 83 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3202; Record_ID=skin_sensitization_invitro_743; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=83; Reported_Response_Unit=ug/mL; Response=83; Response_Unit=ug/mL; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | CD86, EC150 | 61.4 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2293; Record_ID=skin_sensitization_invitro_562; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=61.4; Reported_Response_Unit=ug/mL; Response=61.4; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | CD86, EC150 | 54.001 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; U-SENS | sheet=Data_invitro; excel_row=8158; Record_ID=skin_sensitization_invitro_2181; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=299.6670366; Reported_Response_Unit=uM; Conversion_Factor_Value=180.203; Conversion_Factor_Source=EPA Dashboard; Converted_Response=54.001; Converted_Response_Unit=ug/mL; Response=54.001; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | CD86, EC150 | 23.91 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8761; Record_ID=skin_sensitization_invitro_2387; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=23.91; Reported_Response_Unit=ug/mL; Response=23.91; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | CV70 | 121.71 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8760; Record_ID=skin_sensitization_invitro_2387; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=U-SENS; Endpoint=CV70; Reported_Response=121.71; Reported_Response_Unit=ug/mL; Response=121.71; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | CV75 | 106.7 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2296; Record_ID=skin_sensitization_invitro_562; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=h-CLAT; Endpoint=CV75; Reported_Response=106.7; Reported_Response_Unit=ug/mL; Response=106.7; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | CV75 | 132.6 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3204; Record_ID=skin_sensitization_invitro_743; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=h-CLAT; Endpoint=CV75; Reported_Response=132.6; Reported_Response_Unit=ug/mL; Response=132.6; Response_Unit=ug/mL; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | Concentration, 5% incidence of positive responses | 30.625 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=11574; Record_ID=skin_sensitization_invivo_2513; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Formulation_ID=MIX858; Formulation_Name=Methyl and propyl parabens; Concentration=1.25; Concentration_Units=%; Mixture=Mixture; DTXSID=DTXSID4022527; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=30.625; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available|Marzulli and Maibach 1976; 801606; 10.1111/j.1600-0536.1976.tb02972.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | Concentration, one positive response | 6.25 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=11570; Record_ID=skin_sensitization_invivo_2513; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Formulation_ID=MIX858; Formulation_Name=Methyl and propyl parabens; Concentration=1.25; Concentration_Units=%; Mixture=Mixture; DTXSID=DTXSID4022527; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=6.25; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available|Marzulli and Maibach 1976; 801606; 10.1111/j.1600-0536.1976.tb02972.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | Depletion Cys | -1.5 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1038; Record_ID=skin_sensitization_invitro_283; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=-1.5; Reported_Response_Unit=%; Response=-1.5; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | Depletion Cys | 8.2 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1042; Record_ID=skin_sensitization_invitro_284; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=8.1999999999999993; Reported_Response_Unit=%; Response=8.2; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | Depletion Lys | -1.3 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1037; Record_ID=skin_sensitization_invitro_283; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=-1.3; Reported_Response_Unit=%; Response=-1.3; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | Depletion Lys | -0.2 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1041; Record_ID=skin_sensitization_invitro_284; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=-0.2; Reported_Response_Unit=%; Response=-0.2; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | Depletion Lys | 0.3 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1045; Record_ID=skin_sensitization_invitro_285; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0.3; Reported_Response_Unit=%; Response=0.3; Response_Unit=%; Reference=Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 0 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1039; Record_ID=skin_sensitization_invitro_283; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=0; Reported_Response_Unit=%; Response=0; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 4 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1043; Record_ID=skin_sensitization_invitro_284; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=4; Reported_Response_Unit=%; Response=4; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 0.17 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1047; Record_ID=skin_sensitization_invitro_285; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=0.17; Reported_Response_Unit=%; Response=0.17; Response_Unit=%; Reference=Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | EC1.5 | 14.532 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=7340; Record_ID=skin_sensitization_invitro_1757; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=14.532; Reported_Response_Unit=uM; Response=14.532; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | EC1.5 | 5 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=7345; Record_ID=skin_sensitization_invitro_1758; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=5; Reported_Response_Unit=uM; Response=5; Response_Unit=uM; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | EC1.5 | <65.1 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7963; Record_ID=skin_sensitization_invitro_1799; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=LuSens; Endpoint=EC1.5; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=65.103999999999999; Reported_Response_Unit=uM; Response=65.1; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | EC3 | >2000 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=7352; Record_ID=skin_sensitization_invitro_1757; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=KeratinoSens; Endpoint=EC3; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | EC3 | >50 | % | Mouse | Dermal | - | In Vivo; Urbisch_SkinSensitization2020; LLNA | sheet=Data_invivo; excel_row=12760; Record_ID=skin_sensitization_invivo_2779; Data_Type=In Vivo; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=LLNA; Endpoint=EC3; Response_Modifier=>; Response=50; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | IC50 | 813.17 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=7357; Record_ID=skin_sensitization_invitro_1757; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=813.17; Reported_Response_Unit=uM; Response=813.17; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | IC50 | 817.9 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=7362; Record_ID=skin_sensitization_invitro_1758; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=817.9; Reported_Response_Unit=uM; Response=817.9; Response_Unit=uM; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | IC50 | >162 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7631; Record_ID=skin_sensitization_invitro_1799; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=LuSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=162; Reported_Response_Unit=uM; Response=162; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | Imax | 18.3 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=7368; Record_ID=skin_sensitization_invitro_1758; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=18.3; Reported_Response_Unit=Unitless; Response=18.3; Response_Unit=Ratio; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | Imax | 9.7 | ratio | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=7373; Record_ID=skin_sensitization_invitro_1757; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=9.6999999999999993; Reported_Response_Unit=Unitless; Response=9.7; Response_Unit=Ratio; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | Imax | 3.94 | ratio | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7529; Record_ID=skin_sensitization_invitro_1799; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID4022527; Assay=LuSens; Endpoint=Imax; Reported_Response=3.94; Reported_Response_Unit=Unitless; Response=3.94; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | Incidence of positive responses | 1.02 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=11566; Record_ID=skin_sensitization_invivo_2513; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Formulation_ID=MIX858; Formulation_Name=Methyl and propyl parabens; Concentration=1.25; Concentration_Units=%; Mixture=Mixture; DTXSID=DTXSID4022527; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=1.02; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available|Marzulli and Maibach 1976; 801606; 10.1111/j.1600-0536.1976.tb02972.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=11597; Record_ID=skin_sensitization_invivo_2517; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Formulation_ID=MIX858; Formulation_Name=Methyl and propyl parabens; Concentration=0.05; Concentration_Units=%; Mixture=Mixture; DTXSID=DTXSID4022527; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available|Marzulli and Maibach 1976; 801606; 10.1111/j.1600-0536.1976.tb02972.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | Induction dose per skin area | 4359 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=11565; Record_ID=skin_sensitization_invivo_2513; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Formulation_ID=MIX858; Formulation_Name=Methyl and propyl parabens; Concentration=1.25; Concentration_Units=%; Mixture=Mixture; DTXSID=DTXSID4022527; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=4359; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available|Marzulli and Maibach 1976; 801606; 10.1111/j.1600-0536.1976.tb02972.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | Induction dose per skin area | 174.4 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=11595; Record_ID=skin_sensitization_invivo_2517; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Formulation_ID=MIX858; Formulation_Name=Methyl and propyl parabens; Concentration=0.05; Concentration_Units=%; Mixture=Mixture; DTXSID=DTXSID4022527; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=174.4; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available|Marzulli and Maibach 1976; 801606; 10.1111/j.1600-0536.1976.tb02972.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | Induction dose per skin area | 871.9 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=11611; Record_ID=skin_sensitization_invivo_2521; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Formulation_ID=MIX858; Formulation_Name=Methyl and propyl parabens; Concentration=0.25; Concentration_Units=%; Mixture=Mixture; DTXSID=DTXSID4022527; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=871.9; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available|Marzulli and Maibach 1976; 801606; 10.1111/j.1600-0536.1976.tb02972.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | Induction dose per skin area | 6975 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=11624; Record_ID=skin_sensitization_invivo_2511; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Formulation_ID=MIX858; Formulation_Name=Methyl and propyl parabens; Concentration=10.0; Concentration_Units=%; Mixture=Mixture; DTXSID=DTXSID4022527; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=6975; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available|Marzulli and Maibach 1976; 801606; 10.1111/j.1600-0536.1976.tb02972.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | Induction dose per skin area, 5% incidence of positive responses | 21360 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=11576; Record_ID=skin_sensitization_invivo_2513; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Formulation_ID=MIX858; Formulation_Name=Methyl and propyl parabens; Concentration=1.25; Concentration_Units=%; Mixture=Mixture; DTXSID=DTXSID4022527; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=21360; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available|Marzulli and Maibach 1976; 801606; 10.1111/j.1600-0536.1976.tb02972.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
| NTP ICE skin sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=11556; Record_ID=skin_sensitization_invivo_2511; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Formulation_ID=MIX858; Formulation_Name=Methyl and propyl parabens; Concentration=10.0; Concentration_Units=%; Mixture=Mixture; DTXSID=DTXSID4022527; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available|Marzulli and Maibach 1976; 801606; 10.1111/j.1600-0536.1976.tb02972.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4022527; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4022527 |
SCCS Opinion 25 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =-9 | - | - | - | - | NOAEL study | p.35 |
| SCCS Opinion | NOAEL | =0 | - | - | - | - | NOAEL study | p.35 |
| SCCS Opinion | NOAEL | =0.036 | - | - | - | - | NOAEL study | p.35 |
| SCCS Opinion | NOAEL | =1 | - | mouse | - | - | NOAEL study | p.35 |
| SCCS Opinion | NOAEL | =2 | mg/kg/day | rat | - | 394 days | reproductive toxicity | p.23 |
| SCCS Opinion | NOAEL | =2 | mg/kg | rat | - | - | repeated dose toxicity | p.42 |
| SCCS Opinion | NOAEL | =2 | - | - | - | - | NOAEL study | p.35 |
| SCCS Opinion | NOAEL | =6.5 | - | mouse | - | - | NOAEL study | p.35 |
| SCCS Opinion | NOAEL | =9 | - | - | - | - | NOAEL study | p.35 |
| SCCS Opinion | NOAEL | =12.4 | mg/kg/day | - | - | - | NOAEL study | p.22 |
| SCCS Opinion | NOAEL | =17 | mg/kg | - | - | - | NOAEL study | p.35 |
| SCCS Opinion | NOAEL | =20 | mg/kg bw | rat | - | - | NOAEL study | p.35 |
| SCCS Opinion | NOAEL | =33 | mg/kg bw | - | - | - | NOAEL study | p.35 |
| SCCS Opinion | NOAEL | =38 | % | - | - | - | NOAEL study | p.35 |
| SCCS Opinion | NOAEL | =43 | mg/kg bw | mouse | - | - | NOAEL study | p.35 |
| SCCS Opinion | NOAEL | =50 | - | mouse | - | - | NOAEL study | p.35 |
| SCCS Opinion | NOAEL | =62.5 | mg/kg/day | rat | - | - | NOAEL study | p.36 |
| SCCS Opinion | NOAEL | =100 | mg/kg | rat | oral | - | NOAEL study | p.35 |
| SCCS Opinion | NOAEL | =195 | mg/kg | - | - | - | NOAEL study | p.35 |
| SCCS Opinion | NOAEL | =250 | mg/kg bw/day | - | - | 3 days | NOAEL study | p.35 |
| SCCS Opinion | NOAEL | =980 | mg/kg bw/d | - | - | - | reproductive toxicity | p.21 |
| SCCS Opinion | NOAEL | =1000 | mg/kg | rat | dermal | 28 days | repeated dose toxicity | p.22 |
| SCCS Opinion | NOAEL | =1000 | mg/kg/day | rat | - | 422 days | reproductive toxicity | p.23 |
| SCCS Opinion | NOAEL | =1000 | mg/kg bw/day | - | - | 8 weeks | reproductive toxicity | p.25 |
| SCCS Opinion | NOAEL | =1290 | mg/kg/day | rat | oral | 21 days | reproductive toxicity | p.36 |
ECHA 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | NOAEL | =1084 | mg/kg bw/day | Mouse | injection | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d24be4b0a7c65d232696; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13890/7/9/3?documentUUID=28408dfc-2a89-4561-beff-c4cd89e87438; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID:15821523:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_516f23d7c3b592efc360809e60d00f36 |
| ECHA | NOAEL | =1000 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac93e4b0a7c65d1bfcce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13890/7/9/3?documentUUID=28408dfc-2a89-4561-beff-c4cd89e87438; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15824775_15824776:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_518ce070671874fb81c99d16a10ffe1d |
| ECHA | NOAEL | =12.4 | mg/kg bw/day | Rat | dermal | subchronic; 13 weeks | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61e9fe4b096bca877a71c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13890/7/6/4?documentUUID=28408dfc-2a89-4561-beff-c4cd89e87438; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID:15826576:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7ba2415b771760f743ecfc4df6b77489 |
| ECHA | NOAEL | >=5500 | mg/kg bw/day | Rat | oral | chronic; 96 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf7fe4b0a7c65d1ce170; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13890/7/6/2?documentUUID=28408dfc-2a89-4561-beff-c4cd89e87438; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID:15850005:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_91948b034455b03d9214b93ebb228ca9 |
| ECHA | NOAEL | >760.5 | mg/kg bw/day | Rat | oral | short-term; 14 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cc27e4b0a7c65d2292d2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13890/7/6/2?documentUUID=28408dfc-2a89-4561-beff-c4cd89e87438; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID:15850006:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b56efad2d41e68f441ecdbfdc32f8e6a |
| ECHA | NOAEL | >745.4 | mg/kg bw/day | Rat | oral | short-term; 14 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cc27e4b0a7c65d2292d2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13890/7/6/2?documentUUID=28408dfc-2a89-4561-beff-c4cd89e87438; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=ECHA IUCLID:15850007:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_954fc63ed01d07e0de43896e87e58ba8 |
| ECHA | NOAEL | =980.9 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa71e4b0a7c65d1b5d8e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13843/7/9/2?documentUUID=5d187420-ccbf-4439-a44f-786ba7ccf43b; YEAR=1978; ORIGINAL_YEAR=1978; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15860619_15863073:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_50fd361022f674d05cc1c73568861b75 |
| ECHA | NOAEL | =1124.6 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa71e4b0a7c65d1b5d8e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13843/7/9/2?documentUUID=5d187420-ccbf-4439-a44f-786ba7ccf43b; YEAR=1978; ORIGINAL_YEAR=1978; STUDY_GROUP=ECHA IUCLID:15860771:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_acd0a7a9d08da9d7e7c20802b90fbd38 |
| ECHA | NOAEL | =1076.4 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa71e4b0a7c65d1b5d8e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13843/7/9/2?documentUUID=5d187420-ccbf-4439-a44f-786ba7ccf43b; YEAR=1978; ORIGINAL_YEAR=1978; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15861874_15863072:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0f4f6ad4662627e34b67af12ad6d38c5 |
ToxValDB ECOTOX 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | NOEL | =2000 | mg/kg bw/day | Mouse | oral | acute; 1 days | acute | LONG_REF=Mutat. Res.519(1/2): 103-119 Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives 2002; TITLE=The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives; AUTHOR=Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda; DOI=10.1016/s1383-5718(02)00128-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75840; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Genetics: Damage; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15607001:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5fea27c092a079c0155ed293bdea8197 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =88.2 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634396:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a42b3ea001378b083fbe450880c032cc |
ToxValDB Uterotrophic Hershberger DB 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Uterotrophic Hershberger DB | LEL | =20 | mg/kg bw/day | Mouse | injection | short-term; 3 days | uterotrophic | LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713539_15713583:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ec6c04c0493047ecf7d53ecaea5e5ea5 |
| ToxValDB Uterotrophic Hershberger DB | LEL | =65 | mg/kg bw/day | Rat | injection | short-term; 3 days | uterotrophic | LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713582:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4766d22e47533ca2268070a9160710d8 |
Regulatory source 44 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | -9 | - | - | - | - | - | p.35 |
| Regulatory source | - | 0 | - | - | - | - | - | p.35 |
| Regulatory source | - | 0.036 | - | - | - | - | - | p.35 |
| Regulatory source | - | 1 | - | mouse | - | - | - | p.35 |
| Regulatory source | - | 2 | - | - | - | - | - | p.35 |
| Regulatory source | - | 6.5 | - | mouse | - | - | - | p.35 |
| Regulatory source | - | 9 | - | - | - | - | - | p.35 |
| Regulatory source | - | 12.4 | mg/kg/day | - | - | - | - | p.22 |
| Regulatory source | - | 17 | mg/kg | - | - | - | - | p.35 |
| Regulatory source | - | 17 | - | - | - | - | - | p.35 |
| Regulatory source | - | 20 | mg/kg bw | rat | - | - | - | p.35 |
| Regulatory source | - | 33 | mg/kg bw | - | - | - | - | p.35 |
| Regulatory source | - | 38 | % | - | - | - | - | p.35 |
| Regulatory source | - | 43 | mg/kg bw | mouse | - | - | - | p.35 |
| Regulatory source | - | 50 | - | mouse | - | - | - | p.35 |
| Regulatory source | - | 50 | - | rat | - | - | - | p.35 |
| Regulatory source | - | 62.5 | mg/kg/day | rat | - | - | - | p.36 |
| Regulatory source | - | 100 | mg/kg | rat | oral | - | - | p.35 |
| Regulatory source | - | 100 | mg/kg | mouse | oral | - | - | p.35 |
| Regulatory source | - | 195 | mg/kg | - | - | - | - | p.35 |
| Regulatory source | - | 250 | mg/kg bw/day | - | - | 3 days | - | p.35 |
| Regulatory source | - | 1000 | mg/kg | - | - | - | - | p.22 |
| Regulatory source | - | 1000 | mg/kg/day | mouse | oral | 8 weeks | - | p.36 |
| Regulatory source | - | 1000 | mg/kg/day | - | - | - | - | p.37 |
| Regulatory source | repeated dose toxicity | 2 | mg/kg | rat | - | - | repeated dose toxicity | p.42 |
| Regulatory source | repeated dose toxicity | 980 | mg/kg bw/d | rat | - | - | repeated dose toxicity | p.42 |
| Regulatory source | repeated dose toxicity | 1000 | mg/kg | rat | dermal | 28 days | repeated dose toxicity | p.22 |
| Regulatory source | repeated dose toxicity | 1000 | mg/kg bw/day | rat | - | - | repeated dose toxicity | p.42 |
| Regulatory source | reproductive toxicity | 2 | mg/kg/day | rat | - | 394 days | reproductive toxicity | p.23 |
| Regulatory source | reproductive toxicity | 980 | mg/kg bw/d | - | - | - | reproductive toxicity | p.21 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg/day | rat | - | 422 days | reproductive toxicity | p.23 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg/day | rat | - | 2012d | reproductive toxicity | p.23 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg/day | rat | oral | - | reproductive toxicity | p.24 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg bw/day | - | - | 8 weeks | reproductive toxicity | p.25 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg bw/day | - | oral | 8 weeks | reproductive toxicity | p.25 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg | rat | - | developmental | reproductive toxicity | p.25 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg | - | - | developmental | reproductive toxicity | p.25 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg | rat | - | - | reproductive toxicity | p.26 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg/day | rat | - | - | reproductive toxicity | p.26 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg/day | rat | oral | 8 weeks | reproductive toxicity | p.36 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg/day | - | - | - | reproductive toxicity | p.39 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg/day | - | oral | - | reproductive toxicity | p.39 |
| Regulatory source | reproductive toxicity | 1000 | mg/kg bw/day | human | - | - | reproductive toxicity | p.43 |
| Regulatory source | reproductive toxicity | 1290 | mg/kg/day | rat | oral | 21 days | reproductive toxicity | p.36 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | Z8IX2SC1OH | UNII | - | - | - | chemical | - |