Punica Granatum Fruit Extract

INCI: PUNICA GRANATUM FRUIT EXTRACT; COSING REF 58770

CAS Number
84961-57-9
Function
Skin Conditioning; Antioxidant
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not restricted; GRAS as food extract; CIR conclusion: Safe in present practices of use and concentration

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Genotoxicity signals at high concentrations: positive Ames at ≥2 mg/plate; chromosomal aberrations in CHO cells ≥45 µg/ml; micronucleus increase >70 mg/kg IP in vivo; dose-dependent sperm abnormalities >70 mg/kg – all at concentrations vastly exceeding cosmetic use levels

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Concern Level: Moderate

Regulatory Flags

plant-extract

Frequently Asked Questions

Is Punica Granatum Fruit Extract safe in cosmetics?

Genotoxicity signals at high concentrations: positive Ames at ≥2 mg/plate; chromosomal aberrations in CHO cells ≥45 µg/ml; micronucleus increase >70 mg/kg IP in vivo; dose-dependent sperm abnormalities >70 mg/kg – all at concentrations vastly exceeding cosmetic use levels The EU classifies Punica Granatum Fruit Extract as "permitted". Safety rating: GOOD.

Is Punica Granatum Fruit Extract allowed in the EU?

Punica Granatum Fruit Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Punica Granatum Fruit Extract do in cosmetics?

Punica Granatum Fruit Extract functions as: Skin Conditioning; Antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 84961-57-9.

What is the Margin of Safety for Punica Granatum Fruit Extract?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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