Pyrroloquinoline Quinone (PQQ)

INCI: PYRROLOQUINOLINE QUINONE

CAS Number
72909-34-3
Function
Antioxidant, Humectant, Skin conditioning, Skin protecting
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Has GRAS status as dietary ingredient; not specifically restricted in cosmetics; permitted under general provisions

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Light and temperature sensitive โ€” formulation stability critical . Quinone structure can be a potential sensitizer at high concentrations. Redox-active compound โ€” verify compatibility with other actives (especially reducing agents). Color contribution (orange-red) may affect final product appearance

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Concern Level: Moderate

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Pyrroloquinoline Quinone (PQQ) safe in cosmetics?

Light and temperature sensitive โ€” formulation stability critical . Quinone structure can be a potential sensitizer at high concentrations. Redox-active compound โ€” verify compatibility with other actives (especially reducing agents). Color contribution (orange-red) may affect final product appearance The EU classifies Pyrroloquinoline Quinone (PQQ) as "permitted". Safety rating: GOOD.

Is Pyrroloquinoline Quinone (PQQ) allowed in the EU?

Pyrroloquinoline Quinone (PQQ) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Pyrroloquinoline Quinone (PQQ) do in cosmetics?

Pyrroloquinoline Quinone (PQQ) functions as: Antioxidant, Humectant, Skin conditioning, Skin protecting. It is classified as a cosmetic ingredient in our database. CAS number: 72909-34-3.

What is the Margin of Safety for Pyrroloquinoline Quinone (PQQ)?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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Is Pyrroloquinoline Quinone (PQQ) in Your Products?

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