NOAEL Studies
Active Ingredient
Quercetin NOAEL Studies
INCI: QUERCETIN
CAS: 117-39-5
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
IARC Monographs 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1998 | IARC Monographs | - |
NTP ICE adme parameters 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 75.2 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=1589; Record_ID=adme_parameters_639; Data_Type=Measured; DTXSID=DTXSID4021218; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=75.2; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021218; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4021218 |
| NTP ICE adme parameters | Fu | 0.0176 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=1588; Record_ID=adme_parameters_639; Data_Type=Measured; DTXSID=DTXSID4021218; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.0176; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021218; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4021218 |
NTP ICE cancer 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | IARC group | 3 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=4580; Record_ID=cancer_5890; Data_Type=WOE; Formulation_Name=Quercetin; Mixture=Chemical; DTXSID=DTXSID4021218; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/139; http://publications.iarc.fr/91; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021218; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4021218 |
| NTP ICE cancer | POLY-3 lowest dose | 40000 | ppm | Rat | Dosed feed | - | In Vivo; Two year cancer bioassay | sheet=Data; excel_row=4575; Record_ID=cancer_5887; Data_Type=In Vivo; Formulation_Name=Quercetin; Mixture=Chemical; DTXSID=DTXSID4021218; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=40000; Response_Unit=ppm; Species=Rat; Strain=F344/N; Sex=Male; Route=Dosed feed; Level_of_Evidence=Some evidence; Tissue=Kidney; Location=Renal tubule; Lesion=Carcinoma or adenoma; Reference=TR-409; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr409/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021218; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4021218 |
| NTP ICE cancer | Top dose | 4 | % | Rat | Dosed feed | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=4574; Record_ID=cancer_5887; Data_Type=In Vivo; Formulation_Name=Quercetin; Mixture=Chemical; DTXSID=DTXSID4021218; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=4; Response_Unit=%; Species=Rat; Strain=F344/N; Sex=Male; Route=Dosed feed; Reference=TR-409; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr409/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021218; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4021218 |
NTP ICE endocrine 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | AC50 | 18.0041706558517 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=13948; RecordID=ERPathway2016_232; DatasetName=ERPathway2016; DTXSID=DTXSID4021218; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=18.0041706558517; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021218; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4021218 |
| NTP ICE endocrine | ACC | 14.525819346872 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=13949; RecordID=ERPathway2016_232; DatasetName=ERPathway2016; DTXSID=DTXSID4021218; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=14.525819346872; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021218; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4021218 |
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=13944; RecordID=ARPathway2016_637; DatasetName=ARPathway2016; DTXSID=DTXSID4021218; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021218; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4021218 |
| NTP ICE endocrine | Model Score | 0.101 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=13950; RecordID=ERPathway2016_232; DatasetName=ERPathway2016; DTXSID=DTXSID4021218; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.101; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021218; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID4021218 |
EPA ToxRefDB v3 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA ToxRefDB v3 | LEL | =400 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 104 week | CHR | study_id=5638; toxval_study_source_id=studyid5638_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-intestine small-pigmentation|pathology microscopic-stomach-pigmentation|in life observation-clinical signs-urine staining - perineum|pathology microscopic-mammary gland-fibroadenoma|pathology microscopic-intestine small-[other]|in life observation-body weight-body weight|organ weight-liver-relative to body weight|organ weight-kidney-relative to body weight|pathology microscopic-bone-pigmentation|in life observation-body weight-body weight gain; dose_level=2; study_year=1992; study_citation=NTP_1992_Toxicology and Carcinogenesis Studies of Quercetin (CAS No. 117-39-5) in F344/N Rats (Feed Studies); dsstox_substance_id=DTXSID4021218; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =1600 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 104 week | CHR | study_id=5638; toxval_study_source_id=studyid5638_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-body weight-body weight gain; dose_level=3; study_year=1992; study_citation=NTP_1992_Toxicology and Carcinogenesis Studies of Quercetin (CAS No. 117-39-5) in F344/N Rats (Feed Studies); dsstox_substance_id=DTXSID4021218; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =40 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 104 week | CHR | study_id=5638; toxval_study_source_id=studyid5638_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-relative to body weight|pathology microscopic-stomach-pigmentation|organ weight-kidney-relative to body weight|in life observation-body weight-body weight|pathology microscopic-intestine small-[other]|pathology microscopic-intestine small-pigmentation|pathology microscopic-mammary gland-fibroadenoma|in life observation-body weight-body weight gain|in life observation-clinical signs-urine staining - perineum|pathology microscopic-bone-pigmentation; dose_level=1; study_year=1992; study_citation=NTP_1992_Toxicology and Carcinogenesis Studies of Quercetin (CAS No. 117-39-5) in F344/N Rats (Feed Studies); dsstox_substance_id=DTXSID4021218; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | >0 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 104 week | CHR | study_id=5638; toxval_study_source_id=studyid5638_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-kidney-hyperplasia|organ weight-liver-relative to body weight|pathology microscopic-stomach-pigmentation|pathology microscopic-bone-pigmentation|pathology microscopic-intestine small-pigmentation|urinalysis-sediment microscopic-crystalluria|in life observation-clinical signs-urine staining - perineum|organ weight-kidney-relative to body weight|pathology microscopic-kidney-nephropathy|pathology microscopic-kidney-adenoma|pathology microscopic-intestine small-[other]|in life observation-body weight-body weight gain|pathology microscopic-parathyroid gland-hyperplasia; dose_level=0; study_year=1992; study_citation=NTP_1992_Toxicology and Carcinogenesis Studies of Quercetin (CAS No. 117-39-5) in F344/N Rats (Feed Studies); dsstox_substance_id=DTXSID4021218; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ECHA 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | NOAEL | =3120 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c80fe4b0a7c65d21670a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/32880/7/8?documentUUID=c4926f48-a808-448b-b105-5ccfffb7de7a; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15820051_15820111:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ab6df47ff08ca444997a9f0f3b117537 |
| ECHA | NOAEL | =780 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c841e4b0a7c65d217967; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/32880/7/8?documentUUID=c4926f48-a808-448b-b105-5ccfffb7de7a; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=kidney | body weight and weight gain | gross pathology | histopathology: neoplastic | histopathology: non-neoplastic | organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|gross pathology|nonneoplastic histopathology|organ weight|other; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15820093_15820095:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_654108de2111588a8f1aa95ffcceb703 |
ToxValDB ECOTOX 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =20 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | LONG_REF=- | Food Chem. Toxicol.55:549-556 Uzun,F.G., and Y. Kalender Chlorpyrifos Induced Hepatotoxic and Hematologic Changes in Rats: The Role of Quercetin and Catechin 2013; TITLE=Chlorpyrifos Induced Hepatotoxic and Hematologic Changes in Rats: The Role of Quercetin and Catechin; AUTHOR=Uzun,F.G., and Y. Kalender; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=160364; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=Kupffer cell proliferation; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX:15613086:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=2a217b43805ea70be5186f8367e44444 |
ToxValDB ToxRefDB 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ToxRefDB | LEL | =400 | mg/kg bw/day | Rat | oral | chronic; 104 weeks | chronic | LONG_REF=NTP_1992_Toxicology and Carcinogenesis Studies of Quercetin (CAS No. 117-39-5) in F344/N Rats (Feed Studies); TITLE=Toxicology and Carcinogenesis Studies of Quercetin (CAS No. 117-39-5) in F344/N Rats (Feed Studies); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5638; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-mammary gland-fibroadenoma|systemic: pathology microscopic-intestine small-pigmentation|systemic: pathology microscopic-stomach-pigmentation|systemic: in life observation-clinical signs-urine staining - perineum|systemic: pathology microscopic-intestine small-[other]|systemic: pathology microscopic-bone-pigmentation|systemic: organ weight-kidney-relative to body weight|systemic: organ weight-liver-relative to body weight|systemic: in life observation-body weight-body weight|systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15709737_15709738_15709739_15709740:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6f8e60045d4b07d8ef4c21fa4631c543 |
| ToxValDB ToxRefDB | LOAEL | =1600 | mg/kg bw/day | Rat | oral | chronic; 104 weeks | chronic | LONG_REF=NTP_1992_Toxicology and Carcinogenesis Studies of Quercetin (CAS No. 117-39-5) in F344/N Rats (Feed Studies); TITLE=Toxicology and Carcinogenesis Studies of Quercetin (CAS No. 117-39-5) in F344/N Rats (Feed Studies); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5638; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15709737_15709738_15709739_15709740:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_466f3b4f2d5365cb6b79d2de9f53b781 |
| ToxValDB ToxRefDB | NEL | =40 | mg/kg bw/day | Rat | oral | chronic; 104 weeks | chronic | LONG_REF=NTP_1992_Toxicology and Carcinogenesis Studies of Quercetin (CAS No. 117-39-5) in F344/N Rats (Feed Studies); TITLE=Toxicology and Carcinogenesis Studies of Quercetin (CAS No. 117-39-5) in F344/N Rats (Feed Studies); AUTHOR=NTP; EXTERNAL_SOURCE_ID=5638; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-stomach-pigmentation|systemic: organ weight-liver-relative to body weight|systemic: pathology microscopic-intestine small-pigmentation|systemic: organ weight-kidney-relative to body weight|systemic: in life observation-body weight-body weight gain|systemic: in life observation-body weight-body weight|systemic: in life observation-clinical signs-urine staining - perineum|systemic: pathology microscopic-mammary gland-fibroadenoma|systemic: pathology microscopic-intestine small-[other]|systemic: pathology microscopic-bone-pigmentation; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15709737_15709738_15709739_15709740:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_485c224d0f65c769427f46711da6e2dc |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 9IKM0I5T1E | UNII | - | - | - | chemical | - |