Good Cosmetic Ingredient NOAEL Data

Quillaja Saponaria Wood Extract

INCI: QUILLAJA SAPONARIA WOOD EXTRACT

CAS Number
68990-67-0
Function
Skin conditioning; also used as cleansing, emulsifying, and foaming agent (saponin-rich)
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted for cosmetic use; no specific FDA restriction; generally recognized as a botanical extract

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

5 study endpoints found for Quillaja Saponaria Wood Extract. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 25 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 2200 mg/kg bw/day oral mouse Carcinogenicity COSMOS_DB
NOAEL 1180 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 1175 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
dose_tested 25 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB

Expert Verdict

Can be irritating to eyes and mucous membranes; avoid ingestion; potential mild sensitization in sensitive individuals

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Concern Level: Moderate

Regulatory Flags

plant-extract potential-allergen ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Quillaja Saponaria Wood Extract safe in cosmetics?

Can be irritating to eyes and mucous membranes; avoid ingestion; potential mild sensitization in sensitive individuals The EU classifies Quillaja Saponaria Wood Extract as "restricted". Safety rating: GOOD. 5 toxicological study endpoint(s) are available in our database.

Is Quillaja Saponaria Wood Extract allowed in the EU?

Quillaja Saponaria Wood Extract EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Quillaja Saponaria Wood Extract do in cosmetics?

Quillaja Saponaria Wood Extract functions as: Skin conditioning; also used as cleansing, emulsifying, and foaming agent (saponin-rich). It is classified as a cosmetic ingredient in our database. CAS number: 68990-67-0.

What is the Margin of Safety for Quillaja Saponaria Wood Extract?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Quillaja Saponaria Wood Extract?

The NOAEL (No Observed Adverse Effect Level) for Quillaja Saponaria Wood Extract is 25 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 5 study endpoints are available. Source: COSMOS_DB.

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