Moderate Cosmetic Ingredient

r-Sleeping Chironomid Polypeptide-2

INCI: R-SLEEPING CHIRONOMID POLYPEPTIDE-2

CAS Number
Not assigned
Function
Humectant, Skin Conditioning
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes No specific regulation

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Novel LEA2 protein — no use history in cosmetics; Glycosylation increases immunogenicity potential; Disulfide bonds may affect stability and skin interaction; Also used in fusion with silkworm proteins (CosIng lists silkworm combination)

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Concern Level: Moderate

Frequently Asked Questions

Is r-Sleeping Chironomid Polypeptide-2 safe in cosmetics?

Novel LEA2 protein — no use history in cosmetics; Glycosylation increases immunogenicity potential; Disulfide bonds may affect stability and skin interaction; Also used in fusion with silkworm proteins (CosIng lists silkworm combination) The EU classifies r-Sleeping Chironomid Polypeptide-2 as "permitted". Safety rating: MODERATE.

Is r-Sleeping Chironomid Polypeptide-2 allowed in the EU?

r-Sleeping Chironomid Polypeptide-2 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does r-Sleeping Chironomid Polypeptide-2 do in cosmetics?

r-Sleeping Chironomid Polypeptide-2 functions as: Humectant, Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned.

What is the Margin of Safety for r-Sleeping Chironomid Polypeptide-2?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check r-Sleeping Chironomid Polypeptide-2 compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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