NOAEL Studies
Cosmetic Ingredient
Resorcinol NOAEL Studies
INCI: RESORCINOL
CAS: 108-46-3
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS DB 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | LOAEL | 28 | mg/kg bw/day | mouse | oral | 90 day | Subchronic | PAFA; NTP TR 403 (NIH PBL 92-2858), 1992 |
| COSMOS DB | LOAEL | 32 | mg/kg bw/day | rat | oral | 90 day | Subchronic | PAFA; NTP TR 403 (NIH PBL 92-2858), 1992 |
| COSMOS DB | LOAEL | 100 | mg/kg bw/day | rat | oral | 2 year | Chronic | PAFA; NTP TR 403 (NIH PBL 92-2858), 1992 |
| COSMOS DB | LOAEL | 225 | mg/kg bw/day | mouse | oral | 2 year | Chronic | PAFA; NTP TR 403 (NIH PBL 92-2858), 1992 |
| COSMOS DB | NOAEL | 55 | mg/kg bw/day | rat | oral | 17 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 100 | mg/kg bw/day | rat | oral | 721 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 112 | mg/kg bw/day | mouse | oral | 728 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 150 | mg/kg bw/day | mouse | oral | 17 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 260.7 | mg/kg bw/day | rat | oral | 28 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 304 | mg/kg bw/day | rat | oral | NA | Multigeneration Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 400 | mg/kg bw/day | rat | oral | 357 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 420 | mg/kg bw/day | mouse | oral | 91 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 500 | mg/kg bw/day | rat | oral | 10 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 520 | mg/kg bw/day | rat | oral | 91 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
EFSA 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | NOAEL | =36 | mg/kg bw/day | Rat | oral: gavage | 721 days | chronic/long term toxicity | EFSA ANS - 2010 - OutputID 399 - neurology - neurotoxicity - Scientific Opinion on the use of Resorcinol as a food additive - doi:10.2903/j.efsa.2010.1411 |
| EFSA | ADI | =0.12 | mg/kg bw/day | Consumers | - | - | ADI | EFSA ANS - 2010 - OutputID 399 - Consumers - Scientific Opinion on the use of Resorcinol as a food additive - doi:10.2903/j.efsa.2010.1411 |
| EFSA | NOAEL | =36 | mg/kg bw/day | Mouse | - | 728 days | chronic/long term toxicity | ENDPOINTSTUDY_ID 690577; TOX_ID 378 - OP_ID 151 - EFSA FEEDAP - 2012 - Scientific Opinion on the safety and efficacy of phenol derivatives containing ring-alkyl, ring-alkoxy and side-chains with an oxygenated functional group (chemical group 25) when used as flavourings for all species - doi:10.2903/j.efsa.2012.2573 |
| EFSA | NOAEL | =36 | mg/kg bw/day | Mouse | oral | chronic; 104 weeks | chronic | LONG_REF=EFSA FEEDAP (2012). Scientific Opinion on the safety and efficacy of phenol derivatives containing ring-alkyl, ring-alkoxy and side-chains with an oxygenated functional group (chemical group 25) when used as flavourings for all species. doi:10.2903/j.efsa.2012.2573.; TITLE=Scientific Opinion on the safety and efficacy of phenol derivatives containing ring-alkyl, ring-alkoxy and side-chains with an oxygenated functional group (chemical group 25) when used as flavourings for all species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2012.2573; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=clinical signs; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=EFSA:15614316:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_20a9b304e1110fc8e8c17939b55fb263 |
IARC Monographs 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1998 | IARC Monographs | - |
WHO/JECFA 18 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | LOAEL | =1.2 | mg/kg bw | Rat | oral | 30 days | Toxicology study | document_id=cicads_cicads_cicad71; title=Resorcinol (CICADS 71, 2006); path=mirror/documents/cicads/cicads/cicad71.htm; row_hash=19309b504d93ee4a; raw_unit=mg/kg; context=(1979) Rat Oral via drinking-water 30 days Low-iodine, low-protein diet ~510 LOAEL: ~510 Increased thyroid gland weights (~2.5 vs 1.2 mg/kg in controls) T 3 /T 4 levels decr. |
| WHO/JECFA | LOAEL | =32 | mg/kg bw | Rat | - | - | Toxicology study | document_id=cicads_cicads_cicad71; title=Resorcinol (CICADS 71, 2006); path=mirror/documents/cicads/cicads/cicad71.htm; row_hash=3a77af50118f9224; raw_unit=mg/kg; context=Lors dune étude de 13 semaines sur des rats F344 et des souris B6C3F1, on a constaté que les LOAEL (dose la plus faible à laquelle un effet nocif a été observé) relatives au poids des surrénales étaient comprises entre 28 et 32 mg/kg de poids corporel et les NOAEL relatives au poids du foie égales à 32 mg/kg de poids corporel (administration 5 jours par semaine) sans relation dose-réponse bien caractérisée. |
| WHO/JECFA | NOAEL | =4.57142857142857 | mg/kg bw/day | Rat; Mouse | - | 5 days | Subchronic toxicity | document_id=cicads_cicads_cicad71; title=Resorcinol (CICADS 71, 2006); path=mirror/documents/cicads/cicads/cicad71.htm; row_hash=37f560b86279dfee; raw_unit=mg/kg body weight; unit_normalization=converted from weekly dose; context=In a 13-week study in F344 rats and B6C3F1 mice, LOAELs for adrenal gland weight were in the range of 2832 mg/kg body weight and the NOAEL for liver weight was 32 mg/kg body weight (dosing 5 days/week), without a clear doseresponse. |
| WHO/JECFA | NOAEL | =50 | mg/kg bw | - | - | - | Acute toxicity | document_id=cicads_cicads_cicad71; title=Resorcinol (CICADS 71, 2006); path=mirror/documents/cicads/cicads/cicad71.htm; row_hash=cad80c2606c0b205; raw_unit=mg/kg body weight; context=There was a NOAEL of 50 mg/kg body weight for acute clinical signs indicative of effects on the CNS. |
| WHO/JECFA | NOAEL | =3000 | mg/L | - | - | - | Reproductive toxicity | document_id=cicads_cicads_cicad71; title=Resorcinol (CICADS 71, 2006); path=mirror/documents/cicads/cicads/cicad71.htm; row_hash=f5f43915d7009de6; raw_unit=mg/l; context=A NOEL of 1000 mg/l and a NOAEL of 3000 mg/l for parental systemic and reproductive toxicity as well as neonatal toxicity were derived. |
| WHO/JECFA | NOAEL | ~233 | mg/kg bw/day | - | - | - | Reproductive toxicity | document_id=cicads_cicads_cicad71; title=Resorcinol (CICADS 71, 2006); path=mirror/documents/cicads/cicads/cicad71.htm; row_hash=e0605814f82e97bf; raw_unit=mg/kg body weight per day; context=When expressed on a body weight basis (average of F 0 and F 1 animals), the NOAEL corresponded to approximately 233 mg/kg body weight per day for males over the entire generation, 304 mg/kg body weight per day for females during premating and gestation, and 660 mg/kg body weight per day for females during lactation (RTF, 2005). |
| WHO/JECFA | NOAEL | =7.14285714285714 | mg/kg bw/day | - | - | 5 days | Acute toxicity | document_id=cicads_cicads_cicad71; title=Resorcinol (CICADS 71, 2006); path=mirror/documents/cicads/cicads/cicad71.htm; row_hash=298af98145fe6e0c; raw_unit=mg/kg body weight per day; unit_normalization=converted from weekly dose; context=For this reason, the study chosen to derive a tolerable intake was the long-term NTP (1992) study in which a NOAEL of 50 mg/kg body weight per day (about 36 mg/kg body weight per day after correcting for 5 days/week dosing) for neurological effects (acute clinical signs) was derived. |
| WHO/JECFA | NOAEL | =100 | mg/kg bw | - | - | - | Toxicology study | document_id=cicads_cicads_cicad71; title=Resorcinol (CICADS 71, 2006); path=mirror/documents/cicads/cicads/cicad71.htm; row_hash=2cacd5e5cc1372a6; raw_unit=mg/kg body weight; context=A NOAEL of 100 mg/kg body weight was chosen.. |
| WHO/JECFA | NOAEL | =27.5 | mg/kg bw | - | - | - | Toxicology study | document_id=cicads_cicads_cicad71; title=Resorcinol (CICADS 71, 2006); path=mirror/documents/cicads/cicads/cicad71.htm; row_hash=315cbddf783a81b1; raw_unit=mg/kg body weight; context=The NOAEL was 27.5 mg/kg body weight (NTP, 1992). |
| WHO/JECFA | NOAEL | =75 | mg/kg bw | - | - | - | Toxicology study | document_id=cicads_cicads_cicad71; title=Resorcinol (CICADS 71, 2006); path=mirror/documents/cicads/cicads/cicad71.htm; row_hash=611a03599bf60108; raw_unit=mg/kg body weight; context=The NOAEL was 75 mg/kg body weight (NTP, 1992). |
| WHO/JECFA | NOAEL | =50 | mg/kg bw/day | - | - | 5 days | Toxicology study | document_id=cicads_cicads_cicad71; title=Resorcinol (CICADS 71, 2006); path=mirror/documents/cicads/cicads/cicad71.htm; row_hash=bae0192c395081ca; raw_unit=mg/kg body weight; context=The NOAEL was 50 mg/kg body weight (adjusted to 36 mg/kg body weight per day for 5 days/ week dosing). |
| WHO/JECFA | NOAEL | =5.14285714285714 | mg/kg bw/day | - | - | 5 days | Toxicology study | document_id=cicads_cicads_cicad71; title=Resorcinol (CICADS 71, 2006); path=mirror/documents/cicads/cicads/cicad71.htm; row_hash=ec67ed43d57ffcbe; raw_unit=mg/kg body weight per day; unit_normalization=converted from weekly dose; context=NOAEL adjusted for 5 days/week dosing = 36 mg/kg body weight per day). |
| WHO/JECFA | NOAEL | =5 | mg/kg bw | Rat | - | - | Toxicology study | document_id=cicads_cicads_cicad71; title=Resorcinol (CICADS 71, 2006); path=mirror/documents/cicads/cicads/cicad71.htm; row_hash=3036b9ad7a6fd960; raw_unit=mg/kg; context=urs) des rats F344 et des souris B6C3F1 5 jours par semaine à du résorcinol, on a obtenu, pour des signes cliniques consistant en hyperexcitabilité, tachypnée et tremblements, des NOAEL (dose maximale pour laquelle aucun effet na été observé) respectivement égales à 27,5 mg/kg et à 75 mg/kg de poids corporel, les signes observés étant selon toute probabilité imputables à un effet aigu du composé sur le système nerveux central. |
| WHO/JECFA | NOAEL | =32 | mg/kg bw | - | - | - | Toxicology study | document_id=cicads_cicads_cicad71; title=Resorcinol (CICADS 71, 2006); path=mirror/documents/cicads/cicads/cicad71.htm; row_hash=05789abb5d725691; raw_unit=mg/kg; context=staté que les LOAEL (dose la plus faible à laquelle un effet nocif a été observé) relatives au poids des surrénales étaient comprises entre 28 et 32 mg/kg de poids corporel et les NOAEL relatives au poids du foie égales à 32 mg/kg de poids corporel (administration 5 jours par semaine) sans relation dose-réponse bien caractérisée. |
| WHO/JECFA | NOAEL | =233 | mg/kg bw | - | - | - | Toxicology study | document_id=cicads_cicads_cicad71; title=Resorcinol (CICADS 71, 2006); path=mirror/documents/cicads/cicads/cicad71.htm; row_hash=ddb6f252320a925f; raw_unit=mg/kg; context=Rapportée au poids corporel (valeur moyenne pour les animaux des générations F 0 et F 1 ), cette valeur de la NOAEL correspond à une dose journalière denviron 233 mg/kg de poids corporel pour les mâles sur toute une génération, 304 mg/kg pour les femelles pendant la période avant laccouplement et la gestation et 660 mg/kg pour les femelle pendant la période de lactation (RTF, 2005). |
| WHO/JECFA | NOAEL | =520 | mg/kg bw | - | - | - | Toxicology study | document_id=cicads_cicads_cicad71; title=Resorcinol (CICADS 71, 2006); path=mirror/documents/cicads/cicads/cicad71.htm; row_hash=fba8711cfb6d633a; raw_unit=mg/kg; context=En el estudio prolongado (104 semanas), las NOAEL para los efectos en el tiroides fueron de 150520 mg/kg de peso corporal al día (cinco días/semana); sin embargo, estos estudios no tenían por objeto investigar este efecto final. |
| WHO/JECFA | NOEL | =1000 | mg/L | - | - | - | Reproductive toxicity | document_id=cicads_cicads_cicad71; title=Resorcinol (CICADS 71, 2006); path=mirror/documents/cicads/cicads/cicad71.htm; row_hash=c7bd1b67661f6650; raw_unit=mg/l; context=A NOEL of 1000 mg/l and a NOAEL of 3000 mg/l for parental systemic and reproductive toxicity as well as neonatal toxicity were derived. |
| WHO/JECFA | NOEL | =3000 | mg/L | Rat | - | - | Reproductive toxicity | document_id=cicads_cicads_cicad71; title=Resorcinol (CICADS 71, 2006); path=mirror/documents/cicads/cicads/cicad71.htm; row_hash=d027e84b49189e83; raw_unit=mg/l; context=On en a tiré une valeur de 1000 mg/l pour la NOEL (dose sans effet observé) et une valeur de 3000 mg/l pour la NOAEL, les critères retenus étant la toxicité systémique ou les effets toxiques sur la reproduction dans la génération parentale et la toxicité en général chez les rats nouveau-nés. |
NTP ICE acute oral 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | =980 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_743; row=3910; data_type=In Vivo; mixture=Chemical; chemical_name=Resorcinol; preferred_name=Resorcinol; dtxsid=DTXSID2021238; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021238; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =489 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_740; row=3911; data_type=In Vivo; mixture=Chemical; chemical_name=Resorcinol; preferred_name=Resorcinol; dtxsid=DTXSID2021238; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021238; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =301 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_738; row=3912; data_type=In Vivo; mixture=Chemical; chemical_name=Resorcinol; preferred_name=Resorcinol; dtxsid=DTXSID2021238; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021238; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =370 | mg/kg bw | Rat (Male/Female) | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_739; row=3913; data_type=In Vivo; mixture=Chemical; chemical_name=Resorcinol; preferred_name=Resorcinol; dtxsid=DTXSID2021238; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021238; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =510 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | ECHA ChemProp (undated); record_id=acute_oral_741; row=3914; data_type=In Vivo; mixture=Chemical; chemical_name=Resorcinol; preferred_name=Resorcinol; dtxsid=DTXSID2021238; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021238; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =533 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_742; row=3915; data_type=In Vivo; mixture=Chemical; chemical_name=Resorcinol; preferred_name=Resorcinol; dtxsid=DTXSID2021238; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021238; source_file=acute_oral.xlsx |
NTP ICE adme parameters 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE adme parameters | Clint | 14.48 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=821; Record_ID=adme_parameters_254; Data_Type=Measured; DTXSID=DTXSID2021238; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=14.48; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021238 |
| NTP ICE adme parameters | Fu | 0.7448 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=822; Record_ID=adme_parameters_254; Data_Type=Measured; DTXSID=DTXSID2021238; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.7448; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wetmore 2015; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021238 |
NTP ICE cancer 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | IARC group | 3 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=2622; Record_ID=cancer_4745; Data_Type=WOE; Formulation_Name=Resorcinol; Mixture=Chemical; DTXSID=DTXSID2021238; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/33; http://publications.iarc.fr/139; http://publications.iarc.fr/89; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021238 |
| NTP ICE cancer | Top dose | 225 | mg/kg | Rat | Gavage | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=2618; Record_ID=cancer_4743; Data_Type=In Vivo; Formulation_Name=Resorcinol; Mixture=Chemical; DTXSID=DTXSID2021238; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=225; Response_Unit=mg/kg; Species=Rat; Strain=F344/N; Sex=Male; Route=Gavage; Reference=TR-403; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr403/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021238 |
| NTP ICE cancer | Top dose | 150 | mg/kg | Rat | Gavage | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=2625; Record_ID=cancer_4747; Data_Type=In Vivo; Formulation_Name=Resorcinol; Mixture=Chemical; DTXSID=DTXSID2021238; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=150; Response_Unit=mg/kg; Species=Rat; Strain=F344/N; Sex=Female; Route=Gavage; Reference=TR-403; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr403/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021238 |
NTP ICE endocrine 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | AC50 | 32.084017601991 | uM | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=14044; RecordID=ERPathway2016_41; DatasetName=ERPathway2016; DTXSID=DTXSID2021238; Assay=ER Pathway Model, Agonist; Endpoint=AC50; Response=32.084017601991; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021238 |
| NTP ICE endocrine | ACC | 28.6225831546908 | uM | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=14045; RecordID=ERPathway2016_41; DatasetName=ERPathway2016; DTXSID=DTXSID2021238; Assay=ER Pathway Model, Agonist; Endpoint=ACC; Response=28.6225831546908; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021238 |
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=14040; RecordID=ARPathway2016_512; DatasetName=ARPathway2016; DTXSID=DTXSID2021238; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021238 |
| NTP ICE endocrine | Model Score | 0.00321 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=14046; RecordID=ERPathway2016_41; DatasetName=ERPathway2016; DTXSID=DTXSID2021238; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.00321; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021238 |
| NTP ICE endocrine | Model Score | 0.0101 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=14047; RecordID=ERPathway2016_41; DatasetName=ERPathway2016; DTXSID=DTXSID2021238; Assay=ER Pathway Model, Antagonist; Endpoint=Model Score; Response=0.0101; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021238 |
NTP ICE skin sensitization 22 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | CD54, EC200 | 201.5 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2074; Record_ID=skin_sensitization_invitro_516; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID2021238; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=201.5; Reported_Response_Unit=ug/mL; Response=201.5; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021238 |
| NTP ICE skin sensitization | CD54, EC200 | 201 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3190; Record_ID=skin_sensitization_invitro_740; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID2021238; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=201; Reported_Response_Unit=ug/mL; Response=201; Response_Unit=ug/mL; Reference=Ashikaga et al. 2010; 20822320; 10.1177/026119291003800403|Nukada et al. 2011; 21767275; 10.1111/j.1600-0536.2011.01952.x|Nukada et al. 2012; 22796097; 10.1016/j.tiv.2012.07.001|Nukada personal communication (undated)|Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021238 |
| NTP ICE skin sensitization | CD86, EC150 | 29.603 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; U-SENS | sheet=Data_invitro; excel_row=8244; Record_ID=skin_sensitization_invitro_2267; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID2021238; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=268.8465032; Reported_Response_Unit=uM; Conversion_Factor_Value=110.112; Conversion_Factor_Source=EPA Dashboard; Converted_Response=29.603; Converted_Response_Unit=ug/mL; Response=29.603; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021238 |
| NTP ICE skin sensitization | CD86, EC150 | 4.75 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8556; Record_ID=skin_sensitization_invitro_2361; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID2021238; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=4.75; Reported_Response_Unit=ug/mL; Response=4.75; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021238 |
| NTP ICE skin sensitization | CV70 | 172.97 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8555; Record_ID=skin_sensitization_invitro_2361; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID2021238; Assay=U-SENS; Endpoint=CV70; Reported_Response=172.97; Reported_Response_Unit=ug/mL; Response=172.97; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021238 |
| NTP ICE skin sensitization | CV75 | 613.4 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2075; Record_ID=skin_sensitization_invitro_516; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID2021238; Assay=h-CLAT; Endpoint=CV75; Reported_Response=613.4; Reported_Response_Unit=ug/mL; Response=613.4; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021238 |
| NTP ICE skin sensitization | Depletion Cys | 1.6 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1058; Record_ID=skin_sensitization_invitro_288; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID2021238; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=1.6; Reported_Response_Unit=%; Response=1.6; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Jaworska 2011; 23670904; 10.1002/jat.2869; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021238 |
| NTP ICE skin sensitization | Depletion Cys | -1 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1062; Record_ID=skin_sensitization_invitro_289; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID2021238; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=-1; Reported_Response_Unit=%; Response=-1; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021238 |
| NTP ICE skin sensitization | Depletion Lys | -0.8 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1057; Record_ID=skin_sensitization_invitro_288; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID2021238; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=-0.8; Reported_Response_Unit=%; Response=-0.8; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Jaworska 2011; 23670904; 10.1002/jat.2869; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021238 |
| NTP ICE skin sensitization | Depletion Lys | 13.1 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1061; Record_ID=skin_sensitization_invitro_289; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID2021238; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=13.1; Reported_Response_Unit=%; Response=13.1; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021238 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 0.8 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1059; Record_ID=skin_sensitization_invitro_288; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID2021238; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=0.8; Reported_Response_Unit=%; Response=0.8; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064|Jaworska 2011; 23670904; 10.1002/jat.2869; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021238 |
| NTP ICE skin sensitization | Depletion Lys + Cys | 6.6 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1063; Record_ID=skin_sensitization_invitro_289; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID2021238; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=6.6; Reported_Response_Unit=%; Response=6.6; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021238 |
| NTP ICE skin sensitization | EC1.5 | >2000 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=4569; Record_ID=skin_sensitization_invitro_1053; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID2021238; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021238 |
| NTP ICE skin sensitization | EC1.5 | >920.74 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7597; Record_ID=skin_sensitization_invitro_1836; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID2021238; Assay=LuSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=920.74; Reported_Response_Unit=uM; Response=920.74; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021238 |
| NTP ICE skin sensitization | EC3 | 5.92 | % | Mouse | Dermal | - | In Vivo; Urbisch_SkinSensitization2020; LLNA | sheet=Data_invivo; excel_row=12948; Record_ID=skin_sensitization_invivo_2873; Data_Type=In Vivo; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID2021238; Assay=LLNA; Endpoint=EC3; Response=5.92; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021238 |
| NTP ICE skin sensitization | EC3 | 5.5 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=13602; Record_ID=skin_sensitization_invivo_3830; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID2021238; Assay=LLNA; Endpoint=EC3; Response=5.5; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Kern et al. 2010; 20137736; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021238 |
| NTP ICE skin sensitization | IC50 | >1105 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7667; Record_ID=skin_sensitization_invitro_1836; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID2021238; Assay=LuSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=1104.8900000000001; Reported_Response_Unit=uM; Response=1105; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021238 |
| NTP ICE skin sensitization | Imax | 1.02 | ratio | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=4575; Record_ID=skin_sensitization_invitro_1053; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID2021238; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.02; Reported_Response_Unit=Unitless; Response=1.02; Response_Unit=Ratio; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868|Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021238 |
| NTP ICE skin sensitization | Imax | 0.5787 | ratio | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7570; Record_ID=skin_sensitization_invitro_1836; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID2021238; Assay=LuSens; Endpoint=Imax; Reported_Response=0.578706931; Reported_Response_Unit=Unitless; Response=0.5787; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021238 |
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=3357; Record_ID=skin_sensitization_invivo_849; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=15.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2021238; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Basketter et al. 1994; 8045461; 10.1016/0278-6915(94)90112-0|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021238 |
| NTP ICE skin sensitization | Induction dose per skin area | 9310 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=3355; Record_ID=skin_sensitization_invivo_849; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=15.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2021238; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=9310; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Basketter et al. 1994; 8045461; 10.1016/0278-6915(94)90112-0|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021238 |
| NTP ICE skin sensitization | Relative reliability score | 1 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=3362; Record_ID=skin_sensitization_invivo_849; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=15.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2021238; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=1; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Basketter et al. 1994; 8045461; 10.1016/0278-6915(94)90112-0|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021238; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021238 |
SCCS Opinion 37 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =0 | - | - | - | - | NOAEL study | p.28 |
| SCCS Opinion | NOAEL | =0.02 | mg/kg bw | rat | oral | 90-day | dermal absorption | p.26 |
| SCCS Opinion | NOAEL | =1 | - | rat | oral | 2 years | carcinogenicity | p.28 |
| SCCS Opinion | NOAEL | =2 | - | - | - | - | NOAEL study | p.28 |
| SCCS Opinion | NOAEL | =2.06 | µg/cm | rat | oral | prenatal | developmental toxicity | p.31 |
| SCCS Opinion | NOAEL | =5 | % | rat | oral | 90-day | developmental toxicity | p.31 |
| SCCS Opinion | NOAEL | =36 | mg/kg/d | rat | oral | 5-day | reproductive toxicity | p.23 |
| SCCS Opinion | NOAEL | =36 | mg/kg/d | rat | oral | 5-day | carcinogenicity | p.21 |
| SCCS Opinion | NOAEL | =50 | mg/kg bw/day | rat | oral | 30 days | repeated dose toxicity | p.22 |
| SCCS Opinion | NOAEL | =50 | mg/kg bw/day | rat | oral | 5-day | reproductive toxicity | p.23 |
| SCCS Opinion | NOAEL | =50 | mg/kg bw/day | human | oral | 5-day | irritation | p.21 |
| SCCS Opinion | NOAEL | =75 | mg/kg bw/d | rat | oral | Sub-chronic | repeated dose toxicity | p.15 |
| SCCS Opinion | NOAEL | =75 | mg/kg bw/d | rat | oral | 28 days | repeated dose toxicity | p.15 |
| SCCS Opinion | NOAEL | =80 | mg/kg bw/day | - | - | 4 to week | reproductive toxicity | p.15 |
| SCCS Opinion | NOAEL | =80 | mg/kg bw | rat | oral | 90-day | dermal absorption | p.26 |
| SCCS Opinion | NOAEL | =80 | mg/kg bw/day | rat | oral | Sub-chronic | repeated dose toxicity | p.15 |
| SCCS Opinion | NOAEL | =80 | mg/kg bw/d | - | oral | prenatal | developmental toxicity | p.31 |
| SCCS Opinion | NOAEL | =80 | - | - | oral | 90-day | NOAEL study | p.28 |
| SCCS Opinion | NOAEL | =101 | mg/kg bw/d | human | - | - | NOAEL study | p.29 |
| SCCS Opinion | NOAEL | =101 | mg/kg/d | rat | oral | - | NOAEL study | p.30 |
| SCCS Opinion | NOAEL | =112 | mg/kg bw | mouse | oral | - | NOAEL study | p.17 |
| SCCS Opinion | NOAEL | =130 | mg/kg/day | rat | oral | 30 days | NOAEL study | p.23 |
| SCCS Opinion | NOAEL | =173 | mg/kg/d | - | - | - | NOAEL study | p.28 |
| SCCS Opinion | NOAEL | =177 | mg/kg/d | - | - | - | NOAEL study | p.28 |
| SCCS Opinion | NOAEL | =177 | - | - | - | - | reproductive toxicity | p.28 |
| SCCS Opinion | NOAEL | =186 | mg/kg bw/day | rat | oral | - | NOAEL study | p.20 |
| SCCS Opinion | NOAEL | =186 | mg/kg bw/day | - | - | - | NOAEL study | p.24 |
| SCCS Opinion | NOAEL | =186 | mg/kg bw/day | rat | - | - | reproductive toxicity | p.18 |
| SCCS Opinion | NOAEL | =233 | mg/kg bw/day | - | - | - | NOAEL study | p.20 |
| SCCS Opinion | NOAEL | =233 | mg/kg bw/day | - | - | - | reproductive toxicity | p.22 |
| SCCS Opinion | NOAEL | =250 | mg/kg bw/day | rat | oral | developmental | developmental toxicity | p.21 |
| SCCS Opinion | NOAEL | =304 | mg/kg bw/d | - | oral | - | NOAEL study | p.29 |
| SCCS Opinion | NOAEL | =520 | mg/kg bw/day | rat | - | Chronic | repeated dose toxicity | p.18 |
| SCCS Opinion | NOAEL | =520 | mg/kg bw/day | rat | - | - | repeated dose toxicity | p.16 |
| SCCS Opinion | NOAEL | =520 | - | - | oral | 2 years | NOAEL study | p.28 |
| SCCS Opinion | NOAEL | =1992 | - | rat | - | - | NOAEL study | p.17 |
| SCCS Opinion | NOAEL | =1992 | - | rat | - | - | repeated dose toxicity | p.16 |
EPA ToxRefDB v3 11 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA ToxRefDB v3 | LEL | =65 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 13 week | SUB | study_id=4989; toxval_study_source_id=studyid4989_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-relative to body weight|organ weight-liver-absolute|in life observation-mortality-mortality|in life observation-clinical signs-tremors; dose_level=2; study_year=1992; study_citation=(1992). 'Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344 Rats and B6C3F1 Mice (Gavage Studies).' Natl Toxicol Program Tech Rep Ser 403: 1-234. (Subchronic Rat); dsstox_substance_id=DTXSID2021238; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =420 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 13 week | SUB | study_id=4990; toxval_study_source_id=studyid4990_Adult_F0_F_systemic; toxval_effect_list=in life observation-mortality-mortality|in life observation-clinical signs-respiration (dyspnea)|in life observation-clinical signs-prostration|in life observation-clinical signs-tremors; dose_level=5; study_year=1992; study_citation=(1992). 'Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344 Rats and B6C3F1 Mice (Gavage Studies).' Natl Toxicol Program Tech Rep Ser 403: 1-234. (Subchronic Mouse); dsstox_substance_id=DTXSID2021238; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =28 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 13 week | SUB | study_id=4990; toxval_study_source_id=studyid4990_Adult_F0_M_systemic; toxval_effect_list=organ weight-adrenal gland-relative to body weight|organ weight-adrenal gland-absolute|in life observation-mortality-mortality|in life observation-clinical signs-tremors|in life observation-body weight-body weight|in life observation-clinical signs-respiration (dyspnea)|in life observation-clinical signs-prostration; dose_level=1; study_year=1992; study_citation=(1992). 'Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344 Rats and B6C3F1 Mice (Gavage Studies).' Natl Toxicol Program Tech Rep Ser 403: 1-234. (Subchronic Mouse); dsstox_substance_id=DTXSID2021238; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =100 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 2 year | CHR | study_id=4991; toxval_study_source_id=studyid4991_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-prostration|in life observation-clinical signs-tremors|in life observation-clinical signs-ataxia|in life observation-clinical signs-salivation|in life observation-mortality-mortality|in life observation-body weight-body weight; dose_level=2; study_year=1992; study_citation=(1992). "Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344 Rats and B6C3F1 Mice (Gavage Studies)." Natl Toxicol Program Tech Rep Ser 403: 1-234. (Chronic Rat); dsstox_substance_id=DTXSID2021238; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =112 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 2 year | CHR | study_id=4991; toxval_study_source_id=studyid4991_Adult_F0_M_systemic; toxval_effect_list=in life observation-clinical signs-salivation|in life observation-clinical signs-tremors|in life observation-clinical signs-prostration|in life observation-clinical signs-ataxia|in life observation-body weight-body weight|in life observation-mortality-mortality; dose_level=1; study_year=1992; study_citation=(1992). "Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344 Rats and B6C3F1 Mice (Gavage Studies)." Natl Toxicol Program Tech Rep Ser 403: 1-234. (Chronic Rat); dsstox_substance_id=DTXSID2021238; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =225 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 2 year | CHR | study_id=4992; toxval_study_source_id=studyid4992_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-[other]|in life observation-body weight-body weight|in life observation-clinical signs-tremors; dose_level=2; study_year=1992; study_citation=(1992). 'Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344 Rats and B6C3F1 Mice (Gavage Studies).' Natl Toxicol Program Tech Rep Ser 403: 1-234. (Chronic Mouse); dsstox_substance_id=DTXSID2021238; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =32 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 13 week | SUB | study_id=4989; toxval_study_source_id=studyid4989_Adult_F0_F_systemic; toxval_effect_list=in life observation-mortality-mortality|organ weight-liver-relative to body weight|in life observation-clinical signs-tremors|organ weight-liver-absolute; dose_level=1; study_year=1992; study_citation=(1992). 'Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344 Rats and B6C3F1 Mice (Gavage Studies).' Natl Toxicol Program Tech Rep Ser 403: 1-234. (Subchronic Rat); dsstox_substance_id=DTXSID2021238; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | >0 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 13 week | SUB | study_id=4989; toxval_study_source_id=studyid4989_Adult_F0_M_systemic; toxval_effect_list=organ weight-liver-relative to body weight|organ weight-adrenal gland-relative to body weight|organ weight-liver-absolute|in life observation-mortality-mortality|organ weight-adrenal gland-absolute|in life observation-clinical signs-tremors; dose_level=0; study_year=1992; study_citation=(1992). 'Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344 Rats and B6C3F1 Mice (Gavage Studies).' Natl Toxicol Program Tech Rep Ser 403: 1-234. (Subchronic Rat); dsstox_substance_id=DTXSID2021238; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =225 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 13 week | SUB | study_id=4990; toxval_study_source_id=studyid4990_Adult_F0_F_systemic; toxval_effect_list=in life observation-mortality-mortality|in life observation-clinical signs-prostration|in life observation-clinical signs-respiration (dyspnea)|in life observation-clinical signs-tremors; dose_level=4; study_year=1992; study_citation=(1992). 'Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344 Rats and B6C3F1 Mice (Gavage Studies).' Natl Toxicol Program Tech Rep Ser 403: 1-234. (Subchronic Mouse); dsstox_substance_id=DTXSID2021238; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =50 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 2 year | CHR | study_id=4991; toxval_study_source_id=studyid4991_Adult_F0_F_systemic; toxval_effect_list=in life observation-mortality-mortality|in life observation-clinical signs-ataxia|in life observation-clinical signs-salivation|in life observation-clinical signs-prostration|in life observation-body weight-body weight|in life observation-clinical signs-tremors; dose_level=1; study_year=1992; study_citation=(1992). "Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344 Rats and B6C3F1 Mice (Gavage Studies)." Natl Toxicol Program Tech Rep Ser 403: 1-234. (Chronic Rat); dsstox_substance_id=DTXSID2021238; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =112 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 2 year | CHR | study_id=4992; toxval_study_source_id=studyid4992_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-clinical signs-[other]|in life observation-clinical signs-tremors; dose_level=1; study_year=1992; study_citation=(1992). 'Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344 Rats and B6C3F1 Mice (Gavage Studies).' Natl Toxicol Program Tech Rep Ser 403: 1-234. (Chronic Mouse); dsstox_substance_id=DTXSID2021238; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB DOE Protective Action Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Protective Action Criteria | LEL | =63050.1 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=DOE Protective Action Criteria:15519182:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4d5024ed5b4ba0e9639f067f28f47049 |
ECHA 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | NOAEL | =110 | mg/kg bw/day | Rat | oral | short-term; 17 days | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cc1be4b0a7c65d229040; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12506/7/6/2?documentUUID=e97a6203-6393-40bc-88ed-f53c5f4a10ee; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15847859:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bfbd166793f2858ec9655fd90bbae36b |
| ECHA | NOAEL | =75 | mg/kg bw/day | Mouse | oral | short-term; 17 days | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cc1be4b0a7c65d229048; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12506/7/6/2?documentUUID=e97a6203-6393-40bc-88ed-f53c5f4a10ee; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15848038:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8bd96cb608fc2852c68c8493423c02e4 |
| ECHA | NOAEL | =225 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf61e4b0a7c65d1cda92; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12506/7/6/2?documentUUID=e97a6203-6393-40bc-88ed-f53c5f4a10ee; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15848308:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_90857317c1fd0763e103be50da02a11c |
| ECHA | NOAEL | =27.5 | mg/kg bw/day | Rat | oral | short-term; 17 days | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cc1be4b0a7c65d229040; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12506/7/6/2?documentUUID=e97a6203-6393-40bc-88ed-f53c5f4a10ee; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15848520:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_af2a41ae5b93223990c77117a2112796 |
| ECHA | NOAEL | =150 | mg/kg bw/day | Mouse | oral | short-term; 17 days | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cc1be4b0a7c65d229048; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12506/7/6/2?documentUUID=e97a6203-6393-40bc-88ed-f53c5f4a10ee; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15849035:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e55eaaf611ed0cdf5e865f7de6a1fead |
ToxValDB ECOTOX 15 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =0.1 | mmol | Rat | injection | acute; 0.0833 days | acute | LONG_REF=Biochem. J. (Lond.)50:473-479 Arnott,D.G., and I. Doniach The Effect of Compounds Allied to Resorcinol upon the Uptake of Radioactive Iodine (131I) by the Thyroid of the Rat 1952; TITLE=The Effect of Compounds Allied to Resorcinol upon the Uptake of Radioactive Iodine (131I) by the Thyroid of the Rat; AUTHOR=Arnott,D.G., and I. Doniach; DOI=10.1042/bj0500473; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=97800; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1952; ORIGINAL_YEAR=1952; TOXICOLOGICAL_EFFECT=Physiology: Iodine uptake; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595289_15597614:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=29638e5fc48c5a0490417b1524cd949c |
| ToxValDB ECOTOX | LOEL | =0.06 | mmol | Rat | injection | acute; 0.0833 days | acute | LONG_REF=Biochem. J. (Lond.)50:473-479 Arnott,D.G., and I. Doniach The Effect of Compounds Allied to Resorcinol upon the Uptake of Radioactive Iodine (131I) by the Thyroid of the Rat 1952; TITLE=The Effect of Compounds Allied to Resorcinol upon the Uptake of Radioactive Iodine (131I) by the Thyroid of the Rat; AUTHOR=Arnott,D.G., and I. Doniach; DOI=10.1042/bj0500473; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=97800; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1952; ORIGINAL_YEAR=1952; TOXICOLOGICAL_EFFECT=Physiology: Iodine uptake; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595289_15597614:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b8c1669f39c24bbbd9a01f88837caf5a |
| ToxValDB ECOTOX | LOEL | =1000 | mg/L | Rat | oral | chronic; 157 days | reproduction developmental | LONG_REF=Int. J. Toxicol.27(1): 43-57 Welsch,F., M.D. Nemec, and W.B. Lawrence Two-Generation Reproductive Toxicity Study of Resorcinol Administered via Drinking Water to Crl:CD(SD) Rats 2008; TITLE=Two-Generation Reproductive Toxicity Study of Resorcinol Administered via Drinking Water to Crl:CD(SD) Rats; AUTHOR=Welsch,F., M.D. Nemec, and W.B. Lawrence; DOI=10.1080/10915810701876679; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=108047; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=Reproduction: Number of implantations; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15603300_15603301_15603302_15610984:M/F:F1-; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a8628c21a0fa715ee19cd6073a7a1142 |
| ToxValDB ECOTOX | LOEL | =420 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | LONG_REF=- | Technical Report, TR-403,National Toxicology Program, Research Triangle Park, NC:246 p. National Toxicology Program (NTP) Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1992; TITLE=Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies); AUTHOR=National Toxicology Program (NTP); QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=107915; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=relative kidney weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX:15612982:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=9ebf607ef40d703d8cdb50dbfdcebea2 |
| ToxValDB ECOTOX | LOEL | =450 | mg/kg bw/day | Rat | oral | short-term; 17 days | short-term | LONG_REF=- | Technical Report, TR-403,National Toxicology Program, Research Triangle Park, NC:246 p. National Toxicology Program (NTP) Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1992; TITLE=Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies); AUTHOR=National Toxicology Program (NTP); QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=107915; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Relative and absolute thymus weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX:15613051:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=0ce0b7bc08d7e2fedf8dec16430b32ba |
| ToxValDB ECOTOX | LOEL | =112 | mg/kg bw/day | Rat | oral | chronic; 15 months | chronic | LONG_REF=- | Technical Report, TR-403,National Toxicology Program, Research Triangle Park, NC:246 p. National Toxicology Program (NTP) Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1992; TITLE=Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies); AUTHOR=National Toxicology Program (NTP); QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=107915; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=decreased body weight and increased relative brain weight; TOXICOLOGICAL_EFFECT_CATEGORY=multiple; STUDY_GROUP=ECOTOX:15613072:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=7a685254693e31b919039e2a502aefe4 |
| ToxValDB ECOTOX | LOEL | =32 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=- | Technical Report, TR-403,National Toxicology Program, Research Triangle Park, NC:246 p. National Toxicology Program (NTP) Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1992; TITLE=Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies); AUTHOR=National Toxicology Program (NTP); QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=107915; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=relative liver weight, relative and and absolute thymus weight|clinical chemistry: total protein; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|organ weight; STUDY_GROUP=ECOTOX:15613523:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=80a8abf7c7d9f9c0b19c6bad3e5ef4fe |
| ToxValDB ECOTOX | LOEL | =28 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | LONG_REF=- | Technical Report, TR-403,National Toxicology Program, Research Triangle Park, NC:246 p. National Toxicology Program (NTP) Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1992; TITLE=Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies); AUTHOR=National Toxicology Program (NTP); QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=107915; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=body weight decrease, relative liver weight increase, relative kidney weight increase, absolute adrenal gland decrease, relative adrenal gland decrease | hematology: monocytes; TOXICOLOGICAL_EFFECT_CATEGORY=hematology|multiple; STUDY_GROUP=ECOTOX:15613589:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=4d0dc8c5bec293db0ec88a909b3e7ae3 |
| ToxValDB ECOTOX | NOEL | =3000 | mg/L | Rat | oral | chronic; 157 days | reproduction developmental | LONG_REF=Int. J. Toxicol.27(1): 43-57 Welsch,F., M.D. Nemec, and W.B. Lawrence Two-Generation Reproductive Toxicity Study of Resorcinol Administered via Drinking Water to Crl:CD(SD) Rats 2008; TITLE=Two-Generation Reproductive Toxicity Study of Resorcinol Administered via Drinking Water to Crl:CD(SD) Rats; AUTHOR=Welsch,F., M.D. Nemec, and W.B. Lawrence; DOI=10.1080/10915810701876679; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=108047; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=Growth: Weight gain|Hormone(s): Thyrotropin|Morphology: Weight|Physiology: Estrous cycle|Reproduction: Motility; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|other|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15603300_15603301_15603302_15610984:M/F:F1-; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=91b062eebb18874ff6daac8b4e40cf6d |
| ToxValDB ECOTOX | NOEL | =360 | mg/L | Rat | oral | chronic; 157 days | reproduction developmental | LONG_REF=Int. J. Toxicol.27(1): 43-57 Welsch,F., M.D. Nemec, and W.B. Lawrence Two-Generation Reproductive Toxicity Study of Resorcinol Administered via Drinking Water to Crl:CD(SD) Rats 2008; TITLE=Two-Generation Reproductive Toxicity Study of Resorcinol Administered via Drinking Water to Crl:CD(SD) Rats; AUTHOR=Welsch,F., M.D. Nemec, and W.B. Lawrence; DOI=10.1080/10915810701876679; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=108047; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=Reproduction: Number of implantations; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15603300_15603301_15603302_15610984:M/F:F1-; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8639b6cae253e7aa8186ebc7ca7f783b |
| ToxValDB ECOTOX | NOEL | =0.8 | % | Rat | oral | chronic; 273 days | chronic | LONG_REF=Cancer Lett.58(3): 241-246 Nakamura,A., T. Shirai, S. Takahashi, K. Ogawa, M. Hirose, and N. Ito Lack of Modification by Naturally Occurring Antioxidants of 3,2\'-Dimethyl-4-Aminobiphenyl-Initiated Rat Prostate Carcinogenesis 1991; TITLE=Lack of Modification by Naturally Occurring Antioxidants of 3,2'-Dimethyl-4-Aminobiphenyl-Initiated Rat Prostate Carcinogenesis; AUTHOR=Nakamura,A., T. Shirai, S. Takahashi, K. Ogawa, M. Hirose, and N. Ito; DOI=10.1016/0304-3835(91)90107-s; QUALITY=Control type: Positive control; EXTERNAL_SOURCE_ID=109132; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15608712:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=07133b2235257c6f104b0fbe576cfe22 |
| ToxValDB ECOTOX | NOEL | =120 | mg/L | Rat | oral | chronic; 157 days | reproduction developmental | LONG_REF=Int. J. Toxicol.27(1): 43-57 Welsch,F., M.D. Nemec, and W.B. Lawrence Two-Generation Reproductive Toxicity Study of Resorcinol Administered via Drinking Water to Crl:CD(SD) Rats 2008; TITLE=Two-Generation Reproductive Toxicity Study of Resorcinol Administered via Drinking Water to Crl:CD(SD) Rats; AUTHOR=Welsch,F., M.D. Nemec, and W.B. Lawrence; DOI=10.1080/10915810701876679; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=108047; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=Histology: Histological changes, general; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15603300_15603301_15603302_15610984:M/F:F1-; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=82f50b188fccc773245e3ab99f34a01c |
| ToxValDB ECOTOX | NOEL | =300 | mg/kg bw/day | Mouse | oral | short-term; 17 days | short-term | LONG_REF=- | Technical Report, TR-403,National Toxicology Program, Research Triangle Park, NC:246 p. National Toxicology Program (NTP) Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1992; TITLE=Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies); AUTHOR=National Toxicology Program (NTP); QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=107915; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Growth: Weight |Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|organ weight; STUDY_GROUP=ECOTOX:15613081:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=4ca723c59f087e0a96764aa3314af1c5 |
| ToxValDB ECOTOX | NOEL | =50 | mg/kg bw/day | Rat | oral | chronic; 15 months | chronic | LONG_REF=- | Technical Report, TR-403,National Toxicology Program, Research Triangle Park, NC:246 p. National Toxicology Program (NTP) Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1992; TITLE=Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies); AUTHOR=National Toxicology Program (NTP); QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=107915; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Enzyme(s): Sorbitol dehydrogenase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX:15613561:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=7c8509ce1abbcd0b2127bfdcc7f09ca6 |
| ToxValDB ECOTOX | NOEL | =112 | mg/kg bw/day | Mouse | oral | chronic; 15 months | chronic | LONG_REF=- | Technical Report, TR-403,National Toxicology Program, Research Triangle Park, NC:246 p. National Toxicology Program (NTP) Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1992; TITLE=Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies); AUTHOR=National Toxicology Program (NTP); QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=107915; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Enzyme(s): Alkaline phosphatase (ALP); TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX:15613590:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=68e1e43728bffda8bde51cfd316f1156 |
ToxValDB GESTIS DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL local | =132.8 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15634595_15634596:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c509ae52f613cef79dea5a80939ba76e |
| ToxValDB GESTIS DNEL | DNEL systemic | =5.6 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15634595_15634596:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_53b3b96af85ffbc91b0d6dcb1147b03b |
ToxValDB Pennsylvania DEP ToxValues 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Pennsylvania DEP ToxValues | RfD | =2 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67599fbae4b0a7c65d37b2e3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://files.dep.state.pa.us/EnvironmentalCleanupBrownfields/LandRecyclingProgram/LandRecyclingProgramPortalFiles/GuidanceTechTools/VaporIntrusion/November_2021/Table%205a.pdf; STUDY_GROUP=Pennsylvania DEP ToxValues:15650330:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cb5cd500b66c2a6a12818291394a96a6 |
ToxValDB ToxRefDB 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ToxRefDB | LEL | =65 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=(1992). \'Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344 Rats and B6C3F1 Mice (Gavage Studies).\' Natl Toxicol Program Tech Rep Ser 403: 1-234. (Subchronic Rat); TITLE=Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344 Rats and B6C3F1 Mice (Gavage Studies); AUTHOR=NTP; EXTERNAL_SOURCE_ID=4989; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-absolute|systemic: organ weight-liver-relative to body weight|systemic: in life observation-clinical signs-tremors|systemic: in life observation-mortality-mortality; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|mortality/survival|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15708159_15708160:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_24c5a0af83925317ba0f06c5c3bb1eda |
| ToxValDB ToxRefDB | LEL | =100 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | LONG_REF=(1992). \"Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344 Rats and B6C3F1 Mice (Gavage Studies).\" Natl Toxicol Program Tech Rep Ser 403: 1-234. (Chronic Rat); TITLE=Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344 Rats and B6C3F1 Mice (Gavage Studies); AUTHOR=NTP; EXTERNAL_SOURCE_ID=4991; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-ataxia|systemic: in life observation-clinical signs-prostration|systemic: in life observation-clinical signs-salivation|systemic: in life observation-clinical signs-tremors|systemic: in life observation-mortality-mortality|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|mortality/survival; STUDY_GROUP=ToxRefDB_dup_-_15708165_15708166_15708167_15708168:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_36e20c34d695ad8b02346b3ab941c08d |
| ToxValDB ToxRefDB | LEL | =225 | mg/kg bw/day | Mouse | oral | chronic; 2 years | chronic | LONG_REF=(1992). \'Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344 Rats and B6C3F1 Mice (Gavage Studies).\' Natl Toxicol Program Tech Rep Ser 403: 1-234. (Chronic Mouse); TITLE=Toxicology and Carcinogenesis Studies of Resorcinol (CAS No. 108-46-3) in F344 Rats and B6C3F1 Mice (Gavage Studies); AUTHOR=NTP; EXTERNAL_SOURCE_ID=4992; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-[other]|systemic: in life observation-body weight-body weight|systemic: in life observation-clinical signs-tremors; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs; STUDY_GROUP=ToxRefDB_dup_-_15708170_15708171_15708172_15708173:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7c4396e6df06cd873ca4e9b03bb85900 |
Regulatory source 57 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | 0 | - | - | - | - | - | p.28 |
| Regulatory source | - | 2 | - | - | - | - | - | p.28 |
| Regulatory source | - | 80 | mg/kg bw/day | rat | oral | 4 to week | - | p.32 |
| Regulatory source | - | 80 | - | - | oral | 90-day | - | p.28 |
| Regulatory source | - | 101 | mg/kg bw/d | human | - | - | - | p.29 |
| Regulatory source | - | 101 | mg/kg/d | rat | oral | - | - | p.30 |
| Regulatory source | - | 101 | mg/kg bw/d | - | - | - | - | p.34 |
| Regulatory source | - | 101 | - | - | - | - | - | p.28 |
| Regulatory source | - | 112 | mg/kg bw | mouse | oral | - | - | p.17 |
| Regulatory source | - | 130 | mg/kg/day | rat | oral | 30 days | - | p.23 |
| Regulatory source | - | 130 | mg/kg bw/d | rat | oral | 13-week | - | p.32 |
| Regulatory source | - | 173 | mg/kg/d | - | - | - | - | p.28 |
| Regulatory source | - | 173 | - | - | - | - | - | p.28 |
| Regulatory source | - | 177 | mg/kg/d | - | - | - | - | p.28 |
| Regulatory source | - | 177 | - | - | - | - | - | p.28 |
| Regulatory source | - | ~186 | mg/kg bw/day | rat | oral | - | - | p.20 |
| Regulatory source | - | ~186 | mg/kg bw/day | - | - | - | - | p.24 |
| Regulatory source | - | ~233 | mg/kg bw/day | - | - | - | - | p.20 |
| Regulatory source | - | 304 | mg/kg bw/d | - | oral | - | - | p.29 |
| Regulatory source | - | 520 | - | - | oral | 2 years | - | p.28 |
| Regulatory source | - | 1992 | - | rat | - | - | - | p.17 |
| Regulatory source | carcinogenicity | 1 | - | rat | oral | 2 years | carcinogenicity | p.28 |
| Regulatory source | carcinogenicity | 36 | mg/kg/d | rat | oral | 5-day | carcinogenicity | p.21 |
| Regulatory source | dermal absorption | =0.02 | mg/kg bw | rat | oral | 90-day | dermal absorption | p.26 |
| Regulatory source | dermal absorption | =80 | mg/kg bw | rat | oral | 90-day | dermal absorption | p.26 |
| Regulatory source | developmental toxicity | =2.06 | µg/cm | rat | oral | prenatal | developmental toxicity | p.31 |
| Regulatory source | developmental toxicity | 5 | % | rat | oral | 90-day | developmental toxicity | p.31 |
| Regulatory source | developmental toxicity | 50 | mg/kg bw/day | rat | oral | developmental | developmental toxicity | p.23 |
| Regulatory source | developmental toxicity | 80 | mg/kg bw/day | rat | oral | developmental | developmental toxicity | p.21 |
| Regulatory source | developmental toxicity | 80 | mg/kg bw/d | - | oral | prenatal | developmental toxicity | p.31 |
| Regulatory source | developmental toxicity | =80 | mg/kg bw/d | rat | oral | 90-day | developmental toxicity | p.31 |
| Regulatory source | developmental toxicity | 250 | mg/kg bw/day | rat | oral | developmental | developmental toxicity | p.21 |
| Regulatory source | irritation | 50 | mg/kg bw/day | human | oral | 5-day | irritation | p.21 |
| Regulatory source | repeated dose toxicity | 50 | mg/kg bw/day | rat | oral | 30 days | repeated dose toxicity | p.22 |
| Regulatory source | repeated dose toxicity | 50 | mg/kg bw/day | - | - | sub-chronic | repeated dose toxicity | p.27 |
| Regulatory source | repeated dose toxicity | 50 | mg/kg bw/day | rat | oral | 90-day | repeated dose toxicity | p.28 |
| Regulatory source | repeated dose toxicity | 75 | mg/kg bw/d | rat | oral | Sub-chronic | repeated dose toxicity | p.15 |
| Regulatory source | repeated dose toxicity | 75 | mg/kg bw/d | rat | oral | 28 days | repeated dose toxicity | p.15 |
| Regulatory source | repeated dose toxicity | 75 | mg/kg bw/d | rat | oral | 17-day | repeated dose toxicity | p.15 |
| Regulatory source | repeated dose toxicity | 80 | mg/kg bw/day | - | oral | 90-day | repeated dose toxicity | p.23 |
| Regulatory source | repeated dose toxicity | 80 | mg/kg bw/day | rat | oral | 90-day | repeated dose toxicity | p.23 |
| Regulatory source | repeated dose toxicity | 80 | mg/kg bw/day | rat | oral | Sub-chronic | repeated dose toxicity | p.15 |
| Regulatory source | repeated dose toxicity | 520 | mg/kg bw/day | rat | - | Chronic | repeated dose toxicity | p.18 |
| Regulatory source | repeated dose toxicity | 520 | mg/kg bw/day | rat | - | - | repeated dose toxicity | p.16 |
| Regulatory source | repeated dose toxicity | 1992 | - | rat | - | - | repeated dose toxicity | p.16 |
| Regulatory source | reproductive toxicity | 36 | mg/kg/d | rat | oral | 5-day | reproductive toxicity | p.23 |
| Regulatory source | reproductive toxicity | 36 | mg/kg/d | - | oral | 5-day | reproductive toxicity | p.33 |
| Regulatory source | reproductive toxicity | 50 | mg/kg bw/day | rat | oral | 5-day | reproductive toxicity | p.23 |
| Regulatory source | reproductive toxicity | 80 | mg/kg bw/day | - | - | 4 to week | reproductive toxicity | p.15 |
| Regulatory source | reproductive toxicity | 80 | mg/kg bw/day | rat | oral | prenatal | reproductive toxicity | p.23 |
| Regulatory source | reproductive toxicity | 80 | mg/kg bw/day | rat | oral | 13-week | reproductive toxicity | p.16 |
| Regulatory source | reproductive toxicity | 80 | mg/kg bw/day | rat | oral | developmental | reproductive toxicity | p.33 |
| Regulatory source | reproductive toxicity | 177 | - | - | - | - | reproductive toxicity | p.28 |
| Regulatory source | reproductive toxicity | ~186 | mg/kg bw/day | rat | - | - | reproductive toxicity | p.18 |
| Regulatory source | reproductive toxicity | ~233 | mg/kg bw/day | - | - | - | reproductive toxicity | p.22 |
| Regulatory source | reproductive toxicity | 250 | mg/kg bw/day | rat | oral | prenatal | reproductive toxicity | p.23 |
| Regulatory source | reproductive toxicity | 250 | mg/kg bw/day | rat | oral | developmental | reproductive toxicity | p.33 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | YUL4LO94HK | UNII | - | - | - | chemical | - |