Moderate Cosmetic Ingredient

rh-Polypeptide-7

INCI: RH-POLYPEPTIDE-7

CAS Number
Not assigned as cosmetic CAS; the parent protein (human growth hormone/somatotropin) has CAS 12629-01-5
Function
Skin conditioning; this is a recombinant human growth hormone (hGH/somatotropin) analog — promotes fibroblast proliferation, collagen production via IGF-1 pathway
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status permitted
US Notes No specific cosmetic listing; permitted under FDCA general provisions, but growth hormone claims could trigger drug classification

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

MAJOR FLAG: This is recombinant somatotropin. Known trade name: CG-hGH. Growth factor activity raises regulatory and safety concerns in both EU and potentially US markets. EU Annex II/416 likely applies

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Concern Level: Moderate

Frequently Asked Questions

Is rh-Polypeptide-7 safe in cosmetics?

MAJOR FLAG: This is recombinant somatotropin. Known trade name: CG-hGH. Growth factor activity raises regulatory and safety concerns in both EU and potentially US markets. EU Annex II/416 likely applies The EU classifies rh-Polypeptide-7 as "prohibited". Safety rating: MODERATE.

Is rh-Polypeptide-7 allowed in the EU?

rh-Polypeptide-7 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does rh-Polypeptide-7 do in cosmetics?

rh-Polypeptide-7 functions as: Skin conditioning; this is a recombinant human growth hormone (hGH/somatotropin) analog — promotes fibroblast proliferation, collagen production via IGF-1 pathway. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned as cosmetic CAS; the parent protein (human growth hormone/somatotropin) has CAS 12629-01-5.

What is the Margin of Safety for rh-Polypeptide-7?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check rh-Polypeptide-7 compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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