NOAEL Studies Active Ingredient

Salicylic Acid NOAEL Studies

INCI: SALICYLIC ACID

CAS: 69-72-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
COSMOS DB	LOAEL	75	mg/kg bw/day	rat	oral	8-14 Gestation day	Developmental	SCCNFP; Tanaka S. et a. Studies on teratogenic effects of salicylic acid and aspirin in rats as related to fetal distribution.Congenital Abnormalities. 1973, 13: 73-84.

NTP ICE acute inhalation 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP ICE acute inhalation	LC50	>0.9	mg/L	-	Inhalation	Duration=1 hr	In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity	sheet=Data; excel_row=3993; Record_ID=acute_inhalation_3008; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=0.9; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7026368

NTP ICE adme parameters 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP ICE adme parameters	Fu	0.4	fraction	Rat	-	-	Measured; httk, Rat Plasma Fraction Unbound	sheet=Data; excel_row=2889; Record_ID=adme_parameters_2112; Data_Type=Measured; DTXSID=DTXSID7026368; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.4; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Pearce 2017; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7026368

NTP ICE endocrine 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP ICE endocrine	Model Score	0	unitless	-	-	-	ARPathway2016; AR Pathway Model, Antagonist	sheet=Integrated_approaches; excel_row=14180; RecordID=ARPathway2016_1499; DatasetName=ARPathway2016; DTXSID=DTXSID7026368; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368

NTP ICE skin sensitization 49 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP ICE skin sensitization	CD54, EC200	9	ug/mL	-	Dermal	-	In Vitro; hCLAT2015; h-CLAT	sheet=Data_invitro; excel_row=3240; Record_ID=skin_sensitization_invitro_749; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=9; Reported_Response_Unit=ug/mL; Response=9; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012\|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	CD54, EC200	394.4	ug/mL	-	Dermal	-	In Vitro; hCLAT2015; h-CLAT	sheet=Data_invitro; excel_row=3244; Record_ID=skin_sensitization_invitro_753; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=394.4; Reported_Response_Unit=ug/mL; Response=394.4; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012\|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	CD54, EC200	608.88	ug/mL	-	Dermal	-	In Vitro; CE_hCLAT2018; h-CLAT	sheet=Data_invitro; excel_row=2152; Record_ID=skin_sensitization_invitro_532; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=608.88; Reported_Response_Unit=ug/mL; Response=608.88; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	CD54, EC200	608.9	ug/mL	-	Dermal	-	In Vitro; hCLAT2015; h-CLAT	sheet=Data_invitro; excel_row=3253; Record_ID=skin_sensitization_invitro_755; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=608.9; Reported_Response_Unit=ug/mL; Response=608.9; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012\|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	CD54, EC200	715.6	ug/mL	-	Dermal	-	In Vitro; hCLAT2015; h-CLAT	sheet=Data_invitro; excel_row=3238; Record_ID=skin_sensitization_invitro_751; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=715.6; Reported_Response_Unit=ug/mL; Response=715.6; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012\|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	CD86, EC150	>200	ug/mL	-	Dermal	-	In Vitro; CE_USENSE2018; U-SENS	sheet=Data_invitro; excel_row=8483; Record_ID=skin_sensitization_invitro_2332; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=U-SENS; Endpoint=CD86, EC150; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=200; Reported_Response_Unit=ug/mL; Response=200; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	CD86, EC150	>966.854	ug/mL	-	Dermal	-	In Vitro; Urbisch_SkinSensitization2020; U-SENS	sheet=Data_invitro; excel_row=8191; Record_ID=skin_sensitization_invitro_2214; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=U-SENS; Endpoint=CD86, EC150; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=7000; Reported_Response_Unit=uM; Conversion_Factor_Value=138.122; Conversion_Factor_Source=EPA Dashboard; Converted_Response_Modifier=>; Converted_Response=966.854; Converted_Response_Unit=ug/mL; Response=966.854; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	CV75	974	ug/mL	-	Dermal	-	In Vitro; hCLAT2015; h-CLAT	sheet=Data_invitro; excel_row=3217; Record_ID=skin_sensitization_invitro_746; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=h-CLAT; Endpoint=CV75; Reported_Response=974; Reported_Response_Unit=ug/mL; Response=974; Response_Unit=ug/mL; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	CV75	>1000	ug/mL	-	Dermal	-	In Vitro; CE_hCLAT2018; h-CLAT	sheet=Data_invitro; excel_row=2154; Record_ID=skin_sensitization_invitro_532; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=h-CLAT; Endpoint=CV75; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=1000; Reported_Response_Unit=ug/mL; Response=1000; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Depletion Cys	3.5	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=1108; Record_ID=skin_sensitization_invitro_301; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=3.5; Reported_Response_Unit=%; Response=3.5; Response_Unit=%; Reference=Gerberick et al. 2007; 17400584; 10.1093/toxsci/kfm064; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Depletion Cys	5.2	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=1113; Record_ID=skin_sensitization_invitro_302; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=5.2; Reported_Response_Unit=%; Response=5.2; Response_Unit=%; Reference=Jaworska 2011; 23670904; 10.1002/jat.2869; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Depletion Cys	8.7	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=1100; Record_ID=skin_sensitization_invitro_299; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=8.6999999999999993; Reported_Response_Unit=%; Response=8.7; Response_Unit=%; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030\|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Depletion Lys	0.1	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=1112; Record_ID=skin_sensitization_invitro_302; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0.1; Reported_Response_Unit=%; Response=0.1; Response_Unit=%; Reference=Jaworska 2011; 23670904; 10.1002/jat.2869; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Depletion Lys	1	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=1098; Record_ID=skin_sensitization_invitro_299; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=1; Reported_Response_Unit=%; Response=1; Response_Unit=%; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030\|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Depletion Lys	21.1	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=1118; Record_ID=skin_sensitization_invitro_304; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=21.1; Reported_Response_Unit=%; Response=21.1; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Depletion Lys + Cys	2.65	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=1114; Record_ID=skin_sensitization_invitro_302; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=2.65; Reported_Response_Unit=%; Response=2.65; Response_Unit=%; Reference=Jaworska 2011; 23670904; 10.1002/jat.2869; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Depletion Lys + Cys	4.85	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=1102; Record_ID=skin_sensitization_invitro_299; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=4.8499999999999996; Reported_Response_Unit=%; Response=4.85; Response_Unit=%; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030\|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Depletion Lys + Cys	12.3	%	-	Dermal	-	In Vitro; DPRA2015; DPRA	sheet=Data_invitro; excel_row=1122; Record_ID=skin_sensitization_invitro_304; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=12.3; Reported_Response_Unit=%; Response=12.3; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	EC1.5	>2000	uM	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6540; Record_ID=skin_sensitization_invitro_1547; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response=No induction; Reported_Response_Unit=Unitless; Conversion_Factor=Text to numeric; Conversion_Factor_Value=No induction assumed >2000 uM; Conversion_Factor_Source=Manually calculated; Converted_Response_Modifier=>; Converted_Response=2000; Converted_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	EC3	12.2	%	Mouse	Dermal	-	In Vivo; LLNAdb2013; LLNA	sheet=Data_invivo; excel_row=13608; Record_ID=skin_sensitization_invivo_3840; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=LLNA; Endpoint=EC3; Response=12.2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 1992; 1459374; 10.1016/0272-0590(92)90183-i; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	EC3	>2000	uM	-	Dermal	-	In Vitro; CE_KeratinoSense2018; KeratinoSens	sheet=Data_invitro; excel_row=6567; Record_ID=skin_sensitization_invitro_1550; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=KeratinoSens; Endpoint=EC3; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	IC50	>3000	uM	-	Dermal	-	In Vitro; Urbisch_SkinSensitization2020; LuSens	sheet=Data_invitro; excel_row=7639; Record_ID=skin_sensitization_invitro_1807; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=LuSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=3000; Reported_Response_Unit=uM; Response=3000; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Imax	0.8004	ratio	-	Dermal	-	In Vitro; Urbisch_SkinSensitization2020; LuSens	sheet=Data_invitro; excel_row=7541; Record_ID=skin_sensitization_invitro_1807; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=LuSens; Endpoint=Imax; Reported_Response=0.800440799; Reported_Response_Unit=Unitless; Response=0.8004; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Imax	1.034	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6612; Record_ID=skin_sensitization_invitro_1559; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.034; Reported_Response_Unit=Unitless; Response=1.034; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Imax	1.1	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6614; Record_ID=skin_sensitization_invitro_1554; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.1000000000000001; Reported_Response_Unit=Unitless; Response=1.1; Response_Unit=Ratio; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009\|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Imax	1.107	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6616; Record_ID=skin_sensitization_invitro_1561; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.107; Reported_Response_Unit=Unitless; Response=1.107; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Imax	1.109	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6617; Record_ID=skin_sensitization_invitro_1557; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.109; Reported_Response_Unit=Unitless; Response=1.109; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Imax	1.117	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6618; Record_ID=skin_sensitization_invitro_1556; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.117; Reported_Response_Unit=Unitless; Response=1.117; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Imax	1.125	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6620; Record_ID=skin_sensitization_invitro_1566; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.125; Reported_Response_Unit=Unitless; Response=1.125; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Imax	1.13	ratio	-	Dermal	-	In Vitro; CE_KeratinoSense2018; KeratinoSens	sheet=Data_invitro; excel_row=6622; Record_ID=skin_sensitization_invitro_1550; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.1299999999999999; Reported_Response_Unit=Unitless; Response=1.13; Response_Unit=Ratio; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Imax	1.143	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6624; Record_ID=skin_sensitization_invitro_1558; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.143; Reported_Response_Unit=Unitless; Response=1.143; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Imax	1.197	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6626; Record_ID=skin_sensitization_invitro_1562; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.1970000000000001; Reported_Response_Unit=Unitless; Response=1.197; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Imax	1.202	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6628; Record_ID=skin_sensitization_invitro_1547; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.202; Reported_Response_Unit=Unitless; Response=1.202; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Imax	1.207	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6630; Record_ID=skin_sensitization_invitro_1553; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.2070000000000001; Reported_Response_Unit=Unitless; Response=1.207; Response_Unit=Ratio; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030\|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Imax	1.21	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6619; Record_ID=skin_sensitization_invitro_1552; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.21; Reported_Response_Unit=Unitless; Response=1.21; Response_Unit=Ratio; Reference=Bauch et al. 2011; 21669280; 10.1016/j.tiv.2011.05.030\|Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Imax	1.25	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6621; Record_ID=skin_sensitization_invitro_1549; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.25; Reported_Response_Unit=Unitless; Response=1.25; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Imax	1.282	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6623; Record_ID=skin_sensitization_invitro_1551; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.282; Reported_Response_Unit=Unitless; Response=1.282; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Imax	1.296	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6625; Record_ID=skin_sensitization_invitro_1568; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.296; Reported_Response_Unit=Unitless; Response=1.296; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Imax	1.297	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6627; Record_ID=skin_sensitization_invitro_1555; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.2969999999999999; Reported_Response_Unit=Unitless; Response=1.297; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Imax	1.3	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6629; Record_ID=skin_sensitization_invitro_1565; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.3; Reported_Response_Unit=Unitless; Response=1.3; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Imax	1.4	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6633; Record_ID=skin_sensitization_invitro_1563; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.4; Reported_Response_Unit=Unitless; Response=1.4; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Imax	1.408	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6634; Record_ID=skin_sensitization_invitro_1548; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.4079999999999999; Reported_Response_Unit=Unitless; Response=1.408; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Imax	1.46	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6636; Record_ID=skin_sensitization_invitro_1570; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.46; Reported_Response_Unit=Unitless; Response=1.46; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Imax	1.489	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6638; Record_ID=skin_sensitization_invitro_1560; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.4890000000000001; Reported_Response_Unit=Unitless; Response=1.489; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Imax	1.49	ratio	-	Dermal	-	In Vitro; KeratinoSens2015; KeratinoSens	sheet=Data_invitro; excel_row=6640; Record_ID=skin_sensitization_invitro_1564; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.49; Reported_Response_Unit=Unitless; Response=1.49; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Incidence of positive responses	0	%	Human	Dermal	-	In Vivo; HPPT2020WIP; Human Maximization Test	sheet=Data_invivo; excel_row=9670; Record_ID=skin_sensitization_invivo_2146; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160\|Gad et al. (1986; 3715870; 10.1016/0041-008X(86)90419-9\|Basketter et al. 1994; 8045461; 10.1016/0278-6915(94)90112-0\|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x\|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003\|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002\|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf\|Basketter et al. 2014; 24407057; 10.1097/der.0000000000000003; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Induction dose per skin area	12410	ug/cm2	Human	Dermal	-	In Vivo; HPPT2020WIP; Human Maximization Test	sheet=Data_invivo; excel_row=9668; Record_ID=skin_sensitization_invivo_2146; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=12410; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160\|Gad et al. (1986; 3715870; 10.1016/0041-008X(86)90419-9\|Basketter et al. 1994; 8045461; 10.1016/0278-6915(94)90112-0\|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x\|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003\|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002\|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf\|Basketter et al. 2014; 24407057; 10.1097/der.0000000000000003; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Max stimulation index	2.5	ratio	Mouse	Dermal	-	In Vivo; LLNA2013; LLNA	sheet=Data_invivo; excel_row=12865; Record_ID=skin_sensitization_invivo_490; Data_Type=In Vivo; Internal_Data_Source=LLNA2013; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=LLNA; Endpoint=Max stimulation index; Response=2.5; Response_Unit=Ratio; Species=Mouse; Route=Dermal; Reference=ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368
NTP ICE skin sensitization	Relative reliability score	1	unitless	Human	Dermal	-	In Vivo; HPPT2020WIP; Human Maximization Test	sheet=Data_invivo; excel_row=9674; Record_ID=skin_sensitization_invivo_2146; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7026368; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=1; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160\|Gad et al. (1986; 3715870; 10.1016/0041-008X(86)90419-9\|Basketter et al. 1994; 8045461; 10.1016/0278-6915(94)90112-0\|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x\|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003\|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002\|ICCVAM 2009; Not available; https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf\|Basketter et al. 2014; 24407057; 10.1097/der.0000000000000003; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026368

SCCNFP Opinion 3 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
SCCNFP Opinion	NOAEL	=2	%	rat	oral	-	dermal absorption	p.28
SCCNFP Opinion	NOAEL	=75	mg/kg	rat	oral	-	dermal absorption	p.28
SCCNFP Opinion	NOAEL	=80	mg/kg/day	rat	oral	-	developmental toxicity	Ref. : 115 2, p.18

SCCS Opinion 18 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
SCCS Opinion	NOAEL	=0.1	%	rat	oral	developmental	reproductive toxicity	p.31
SCCS Opinion	NOAEL	=5.3	%	rat	dermal	developmental	developmental toxicity	p.31
SCCS Opinion	NOAEL	=9	-	-	-	-	reproductive toxicity	p.31
SCCS Opinion	NOAEL	=21	-	-	-	-	NOAEL study	p.50
SCCS Opinion	NOAEL	=22	-	-	-	-	NOAEL study	p.50
SCCS Opinion	NOAEL	=30	-	-	-	developmental	reproductive toxicity	p.46
SCCS Opinion	NOAEL	=50	-	-	-	-	NOAEL study	p.51
SCCS Opinion	NOAEL	=60	%	-	oral	developmental	developmental toxicity	p.50
SCCS Opinion	NOAEL	=75	mg/kg/day	rat	oral	-	reproductive toxicity	p.31
SCCS Opinion	NOAEL	=75	mg/kg bw/day	mouse	-	Developmental	reproductive toxicity	p.53
SCCS Opinion	NOAEL	=75	mg/kg bw/d	-	dermal	-	NOAEL study	p.21
SCCS Opinion	NOAEL	=75	mg/kg/day	rat	oral	developmental	reproductive toxicity	p.35
SCCS Opinion	NOAEL	=75	mg/kg bw/day	rat	oral	developmental	developmental toxicity	p.35
SCCS Opinion	NOAEL	=75	mg/kg bw/day	rat	-	developmental	developmental toxicity	p.46
SCCS Opinion	NOAEL	=150	mg/kg	rat	oral	developmental	developmental toxicity	p.33
SCCS Opinion	NOAEL	=150	mg/kg bw/day	rat	oral	developmental	developmental toxicity	p.37
SCCS Opinion	NOAEL	=195	-	-	-	-	NOAEL study	p.51
SCCS Opinion	NOAEL	=2018	-	human	oral	developmental	reproductive toxicity	p.45

ECHA 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ECHA	NOAEL	=100	mg/kg bw/day	Mouse	oral	-	reproduction developmental	QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab47e4b0a7c65d1b98f0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23278/7/9/2?documentUUID=da8d09a8-236b-4588-8c8b-906fd051ede5; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855596_15857571:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d570a0657147ca2f2b69420394f82963

ToxValDB GESTIS DNEL 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB GESTIS DNEL	DNEL local	=5	mg/m3	Human	inhalation	-	Toxicity Value	STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15634603_15634604:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_765c00009980c59efc8a30cf6cc056bd

Regulatory source 32 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
Regulatory source	-	75	mg/kg	rat	oral	-	-	p.28
Regulatory source	dermal absorption	2	%	rat	oral	-	dermal absorption	p.28
Regulatory source	dermal absorption	75	mg/kg	rat	oral	-	dermal absorption	p.28
Regulatory source	dermal absorption	=75	mg/kg bw	rat	oral	-	dermal absorption	p.28
Regulatory source	developmental toxicity	80	mg/kg/day	rat	oral	-	developmental toxicity	p.18
Regulatory source	reproductive toxicity	80	mg/kg/day	rat	oral	200 days	reproductive toxicity	p.26
Regulatory source	-	21	-	-	-	-	-	p.50
Regulatory source	-	22	-	-	-	-	-	p.50
Regulatory source	-	22	-	human	oral	-	-	p.50
Regulatory source	-	50	-	-	-	-	-	p.51
Regulatory source	-	75	mg/kg/day	human	-	-	-	p.51
Regulatory source	-	75	mg/kg/day	-	-	-	-	p.51
Regulatory source	-	75	mg/kg bw/d	-	dermal	-	-	p.21
Regulatory source	-	75	mg/kg	-	-	-	-	p.35
Regulatory source	-	195	-	-	-	-	-	p.51
Regulatory source	developmental toxicity	0.1	%	rabbit	-	developmental	developmental toxicity	p.34
Regulatory source	developmental toxicity	5.3	%	rat	dermal	developmental	developmental toxicity	p.31
Regulatory source	developmental toxicity	60	%	-	oral	developmental	developmental toxicity	p.50
Regulatory source	developmental toxicity	75	mg/kg/day	rat	oral	developmental	developmental toxicity	p.31
Regulatory source	developmental toxicity	75	mg/kg bw/day	rat	oral	developmental	developmental toxicity	p.35
Regulatory source	developmental toxicity	75	mg/kg bw/day	-	-	developmental	developmental toxicity	p.38
Regulatory source	developmental toxicity	75	mg/kg bw/day	-	oral	developmental	developmental toxicity	p.50
Regulatory source	developmental toxicity	150	mg/kg	rat	oral	developmental	developmental toxicity	p.33
Regulatory source	developmental toxicity	150	mg/kg bw/day	rat	oral	developmental	developmental toxicity	p.37
Regulatory source	reproductive toxicity	0.1	%	rat	oral	developmental	reproductive toxicity	p.31
Regulatory source	reproductive toxicity	0.1	%	-	-	-	reproductive toxicity	p.31
Regulatory source	reproductive toxicity	9	-	-	-	-	reproductive toxicity	p.31
Regulatory source	reproductive toxicity	75	mg/kg/day	rat	oral	-	reproductive toxicity	p.31
Regulatory source	reproductive toxicity	75	mg/kg bw/day	mouse	-	Developmental	reproductive toxicity	p.53
Regulatory source	reproductive toxicity	75	mg/kg/day	rat	oral	developmental	reproductive toxicity	p.35
Regulatory source	reproductive toxicity	75	mg/kg bw/day	-	-	Developmental	reproductive toxicity	p.53
Regulatory source	reproductive toxicity	2018	-	human	oral	developmental	reproductive toxicity	p.45

openFDA substances 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
openFDA substances	FDA UNII substance identifier	O414PZ4LPZ	UNII	-	-	-	chemical	-